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公开(公告)号：US11899025B2
公开(公告)日：2024-02-13
申请号：US16982494
申请日：2019-03-21
发明人： Jae-Sung Bae , Hee Kyung Jin , Ju Youn Lee , Seung Hoon Han
IPC分类号： G01N33/68 , G01N33/50 , G01N33/573 , A61K31/164
CPC分类号： G01N33/6896 , A61K31/164 , G01N33/5008 , G01N33/573 , G01N2333/90241 , G01N2440/10
摘要： The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a COX2 acetylating agent as an active ingredient and, more particularly, to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising, as an active ingredient, a COX2 acetylating agent which exhibits an effect of inhibiting the deposition of amyloid-β in brain neurons, reducing excessive neuroinflammatory responses, and increasing the phagocytosis of amyloid-β in microglial cells. The pharmaceutical composition for preventing or treating neurodegenerative diseases comprising the COX2 acetylating agent as an active ingredient has the effects of alleviating neuroinflammation by promoting COX2 acetylation in neurons and secreting specialized pro-resolving mediators (SPMs) and thus, can be very useful in the development of a preventive or therapeutic agent for neurodegenerative diseases.
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公开(公告)号：US11466305B2
公开(公告)日：2022-10-11
申请号：US16462899
申请日：2017-10-20
申请人： KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) , SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
发明人： Jae-Sung Bae , Hee Kyung Jin , Ju Youn Lee , Seung Hyun Kim , Chang-Seok Ki
摘要： The present invention relates to a amyotrophic lateral sclerosis (ALS) diagnostic composition using acid sphingomyelinase (ASM), and a method for detecting diagnostic markers and, more specifically, to a method and a composition for detecting markers for ALS, the method comprising the steps of: (a) providing a sample of a subject; (b) measuring the ASM expression level or the enzyme activation level in the sample; (c) determining that a subject, of which the ASM expression level or the enzyme activation level is increased compared to that of a normal person, has ALS. According to the investigation of the present inventors, the activity of ASM, among lipids and enzymes related to the sphingolipid metabolism, is specifically increased in a sample of an ALS patient compared to that of a normal person. ASM can be used as a marker for diagnosing ALS, thereby enabling the development of a novel and effective diagnostic reagent.
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公开(公告)号：US11766444B2
公开(公告)日：2023-09-26
申请号：US16634460
申请日：2018-07-11
发明人： Jae Sung Bae , Hee Kyung Jin , Ju Youn Lee , Min Hee Park
IPC分类号： A61K31/661 , A61K47/69 , A61P25/28
CPC分类号： A61K31/661 , A61K47/6917 , A61P25/28
摘要： The present invention relates to a novel use for HDL-ApoM-S1P (a high density lipoprotein in which apolipoprotein M is impregnated with sphingosine-1-phosphate), and more particularly, to using HDL-ApoM-S1P to prevent, improve, or treat degenerative brain disorders (in particular, Alzheimer's disease), cognitive disorders, learning disabilities, and memory disorders, and using HDL-ApoM-S1P to improve cognitive ability, learning ability, and memory.
The HDL-ApoM-S1P according to the present invention not only alleviates neuroinflammation but also significantly exhibits improvement effects of cognitive disorder, learning disability, and memory disorder with respect to individuals suffering from degenerative brain disorders (in particular, Alzheimer's disease), and exhibits an effect of greatly reducing amyloid beta and tau deposition. Moreover, increased HDL-ApoM-S1P in the body also has an excellent effect of improving the cognitive, learning, and memory abilities of non-disabled individuals.-
公开(公告)号：US20240125804A1
公开(公告)日：2024-04-18
申请号：US18395097
申请日：2023-12-22
发明人： Jae-Sung BAE , Hee Kyung Jin , Ju Youn Lee , Seung Hoon Han
IPC分类号： G01N33/68 , A61K31/164 , G01N33/50 , G01N33/573
CPC分类号： G01N33/6896 , A61K31/164 , G01N33/5008 , G01N33/573 , G01N2333/90241 , G01N2440/10
摘要： The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a COX2 acetylating agent as an active ingredient and, more particularly, to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising, as an active ingredient, a COX2 acetylating agent which exhibits an effect of inhibiting the deposition of amyloid-β in brain neurons, reducing excessive neuroinflammatory responses, and increasing the phagocytosis of amyloid-β in microglial cells. The pharmaceutical composition for preventing or treating neurodegenerative diseases comprising the COX2 acetylating agent as an active ingredient has the effects of alleviating neuroinflammation by promoting COX2 acetylation in neurons and secreting specialized pro-resolving mediators (SPMs) and thus, can be very useful in the development of a preventive or therapeutic agent for neurodegenerative diseases.
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公开(公告)号：US20210085697A1
公开(公告)日：2021-03-25
申请号：US16634460
申请日：2018-07-11
发明人： Jae Sung Bae , Hee Kyung Jin , Ju Youn Lee , Min Hee Park
IPC分类号： A61K31/661 , A61K47/69 , A61P25/28
摘要： The present invention relates to a novel use for HDL-ApoM-S1P (a high density lipoprotein in which apolipoprotein M is impregnated with sphingosine-1-phosphate), and more particularly, to using HDL-ApoM-S1P to prevent, improve, or treat degenerative brain disorders (in particular, Alzheimer's disease), cognitive disorders, learning disabilities, and memory disorders, and using HDL-ApoM-S1P to improve cognitive ability, learning ability, and memory.
The HDL-ApoM-S1P according to the present invention not only alleviates neuroinflammation but also significantly exhibits improvement effects of cognitive disorder, learning disability, and memory disorder with respect to individuals suffering from degenerative brain disorders (in particular, Alzheimer's disease), and exhibits an effect of greatly reducing amyloid beta and tau deposition. Moreover, increased HDL-ApoM-S1P in the body also has an excellent effect of improving the cognitive, learning, and memory abilities of non-disabled individuals.
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