利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

30 条记录 (耗时 0.031 秒)

    Ether and amide compounds preparation thereof composition containing same and use thereof as antidiadetics
    9.
    发明授权
    Ether and amide compounds preparation thereof composition containing same and use thereof as antidiadetics 失效
    醚和酰胺化合物的制备方法含有它们的组合物及其用途作为抗病毒药物

    公开(公告)号：US06414001B2

    公开(公告)日：2002-07-02

    申请号：US09756701

    申请日：2001-01-10

    申请人： Tsuyoshi Tomiyama ,  Akira Tomiyama ,  Hiroshi Tomiyama ,  Keiko Kuroiwa

    发明人： Tsuyoshi Tomiyama ,  Akira Tomiyama ,  Hiroshi Tomiyama ,  Keiko Kuroiwa

    IPC分类号： A61K3142

    CPC分类号： C07D213/30 ,  C07D213/74 ,  C07D263/32 ,  C07D409/12 ,  C07D413/12

    摘要： Ether and amide derivatives are disclosed, which are represented by the following formula (I) and its pharmaceutical acceptable salt, and which are useful for the treatment of diabetes. R1—A—R2  (I) wherein (with the provisos that (i) when A is —O—, then n is 2 or 3 (ii) when then n is 1 or 2. R3 is OH—, CH3SO2NH—, CF3SO2NH—, CH3SO2NHCH2—, CF3SO2NHCH2—, HOOC—, CH3OOC—, HOOC—CH2SO2NH—, CF3—CH2SO2NH—,  R8—NHSO2—, R8—NHSO2—CH2—, HOOC—CH2—O—, HSO3N═CH—, or R9—SO2NHCO—; R4 is H, OH, O-alkyl or O—CH2OCH3; R5 is H, halogen atom, —CH2COOH or OH; R6 and R7 are hydrogen, t-butyl or pyrolidyl; R8 is hydrogen or lower alkyl; R9 is alkyl or thienyl; R10 is lower alkyl) or a pharmaceutically acceptable salt.

    摘要翻译： 公开了醚和酰胺衍生物，其由下式（I）及其药学上可接受的盐表示，并且其可用于治疗糖尿病。其中（条件是（i）当A为-O-时，则 R3是OH-，CH3SO2NH-，CF3SO2NH-，CH3SO2NHCH2-，CF3SO2NHCH2-，HOOC-，CH3OOC-，HOOC-CH2SO2NH-，CF3-CH2SO2NH-，R8-NHSO2 - ，R8-NHSO2-CH2-，HOOC-CH2-O-，HSO3N = CH-或R9-SO2NHCO-; R4是H，OH，O-烷基或O-CH2OCH3; R5是H，卤素原子，-CH2COOH 或OH; R 6和R 7为氢，叔丁基或吡咯烷基; R 8为氢或低级烷基; R 9为烷基或噻吩基; R 10为低级烷基）或其药学上可接受的盐。

    Benzofuran and benzothiophene derivatives, anti-hyperuricemia agents
    10.
    发明授权
    Benzofuran and benzothiophene derivatives, anti-hyperuricemia agents 失效
    苯并呋喃和苯并噻吩衍生物，抗高尿酸血症药

    公开(公告)号：US5274000A

    公开(公告)日：1993-12-28

    申请号：US873353

    申请日：1992-04-21

    申请人： Tsuyoshi Tomiyama ,  Akira Tomiyama ,  Koichi Kubota

    发明人： Tsuyoshi Tomiyama ,  Akira Tomiyama ,  Koichi Kubota

    IPC分类号： C07D307/80 ,  C07D333/56 ,  C07D405/12 ,  C07D307/87 ,  A61K31/34

    CPC分类号： C07D405/12 ,  C07D307/80 ,  C07D333/56

    摘要： A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic acid derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

    摘要翻译： 公开了一系列新的苯并呋喃和苯并噻吩衍生物。 这些化合物具有通过用取代的苯衍生物，衣康酸衍生物或取代的苯氧基甲基四唑衍生物代替2-低级烷基 - 苯并呋喃或2-低级烷基 - 苯并噻吩的第三位而获得的结构。 它们可用作利尿剂，无升高血清尿酸水平的副作用，可用于治疗高尿酸血症。