公开(公告)号：US09795774B2

公开(公告)日：2017-10-24

申请号：US13696621

申请日：2012-06-28

申请人： Kanji Takada ,  Ichiro Ono

发明人： Kanji Takada ,  Ichiro Ono

IPC分类号： A61M37/00 ,  A61K9/70 ,  A61K45/06 ,  A61K9/00 ,  A61K38/18

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/70 ,  A61K38/1825 ,  A61K45/06 ,  A61M2037/0046

摘要： A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.

公开(公告)号：US20130072902A1

公开(公告)日：2013-03-21

申请号：US13696621

申请日：2012-06-28

申请人： Kanji Takada ,  Ichiro Ono

发明人： Kanji Takada ,  Ichiro Ono

IPC分类号： A61M37/00

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/70 ,  A61K38/1825 ,  A61K45/06 ,  A61M2037/0046

摘要： A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.

摘要翻译： 本发明要解决的问题是提供一种药物制剂和施用活性成分的方法，所述活性成分允许活性成分以高效率均匀地输送到皮肤中的作用部位，同时确保活性成分的稳定性 很长时间，容易处理，对患者压力较小。 解决问题的意思是用于皮肤处理的微针组装配方，其包括平台和形成在平台上的多个锥形或金字塔形微针，其包含由生物可溶和线形成聚合物物质组成的基质和保留在 碱，其中目标物质是有效预防或治疗皮肤衰老的物质，或治疗皮肤瘢痕。

公开(公告)号：US20110127690A1

公开(公告)日：2011-06-02

申请号：US12674745

申请日：2010-01-15

申请人： Kenshin Honda ,  Masashi Motoi ,  Kanji Takada

发明人： Kenshin Honda ,  Masashi Motoi ,  Kanji Takada

IPC分类号： B29C67/00 ,  B29C35/02

CPC分类号： A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C59/02

摘要： Microneedle sheets are produced by injecting a needle raw material into a stamper formed with a concavity in a base material. However, it was not easy to increase the degree of sharpness of the concavity which corresponds to the stamper tips. A method for producing a stamper including the steps of heating a sheet-like base material and an original plate having a conical protrusion, inserting the protrusion of the original plate into the base material to form a conical concavity in the original plate, cooling the original plate with the original plate still inserted in the base material, releasing the original plate from the base material, and heating the base material.

摘要翻译： 通过将针状原料注入形成有基材的凹部的压模来制造微针片。 然而，增加对应于压模尖端的凹度的锐度的程度并不容易。 一种制造压模的方法，包括加热片状基材和具有锥形突起的原版的步骤，将原版的突起插入基材中以在原版中形成锥形凹部，冷却原稿 板上的原板仍插入基材中，将原板从基材上释放出来，加热基材。

公开(公告)号：US20110192562A1

公开(公告)日：2011-08-11

申请号：US12674716

申请日：2010-01-15

申请人： Masashi Motoi ,  Kenshin Honda ,  Toyoharu Terada ,  Tatsuya Okada ,  Yoshitomo Satouchi ,  Kanji Takada

发明人： Masashi Motoi ,  Kenshin Honda ,  Toyoharu Terada ,  Tatsuya Okada ,  Yoshitomo Satouchi ,  Kanji Takada

IPC分类号： B21G3/18 ,  B21G1/00 ,  B21D31/00

CPC分类号： A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C59/02

摘要： Microneedle sheets are produced by injecting a needle raw material into a stamper formed with a concavity in a base material. However, because the stamper concavity is very small, there is the problem that air cannot escape due to air and surface tension of the material, thereby preventing a needle from being formed in part. The present invention provides a stamper for producing a microneedle sheet. The stamper comprises a sheet-like base material including a conical concavity formed from a first surface of the sheet-like base material toward a second surface thereof; and a through-hole formed from a bottom of the concavity toward the second surface. Air can escape via this through-hole, allowing a microneedle sheet which is filled with a needle raw material as far as the bottom of the concavity to be obtained.

摘要翻译： 通过将针状原料注入形成有基材的凹部的压模来制造微针片。 然而，由于压模凹度非常小，所以存在由于空气和材料的表面张力而不能逸出的空气，从而防止针部分形成的问题。 本发明提供一种用于制造微针片的压模。 压模包括片状基材，其包括由片状基材的第一表面朝向其第二表面形成的锥形凹部; 以及从凹部的底部朝向第二表面形成的通孔。 空气可以通过该通孔逸出，从而可以获得填充有针原料的微针片至达凹部的底部。

公开(公告)号：US07097851B1

公开(公告)日：2006-08-29

申请号：US09831901

申请日：1999-11-26

申请人： Kanji Takada

发明人： Kanji Takada

IPC分类号： A61F13/00 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K9/48

CPC分类号： A61K9/2086 ,  A61K9/4808 ,  A61K9/4891

摘要： An oral formulation for gastrointestinal drug delivery which comprises an adhesion site-controlling layer for attaching the formulation to the selected site in the digestive tract, a drug-carrying layer for containing a drug and an adhesive and a protecting layer for protecting the drug in the drug-carrying layer, wherein the drug-carrying layer exists between the protecting layer and the adhesion site-controlling layer, and the adhesion site-controlling layer may attach to the protecting layer. The formulation can improve bioavailability of drugs which have low bioavailability.

摘要翻译： 一种用于胃肠药物递送的口服制剂，其包含用于将制剂连接到消化道中的选定部位的粘附位点控制层，用于容纳药物的药物载体层和粘合剂以及用于保护药物的保护层 药物载体层，其中药物载体层存在于保护层和粘附位点控制层之间，并且粘附位点控制层可附着于保护层。 该制剂可以提高具有低生物利用度的药物的生物利用度。

公开(公告)号：US20050266303A1

公开(公告)日：2005-12-01

申请号：US11194869

申请日：2005-08-01

申请人： Eiji Kadouchi ,  Kanji Takada

发明人： Eiji Kadouchi ,  Kanji Takada

IPC分类号： H02J7/02 ,  B60L11/14 ,  H01M2/10 ,  H01M10/44 ,  H02J7/00 ,  H01M10/48 ,  B60L11/18 ,  H01M10/46

CPC分类号： H02J7/0019 ,  B60L3/0046 ,  B60L11/14 ,  B60L11/1861 ,  B60L11/1866 ,  B60L2240/545 ,  B60L2240/547 ,  B60L2240/549 ,  Y02T10/70 ,  Y02T10/7005 ,  Y02T10/7044 ,  Y02T10/7055 ,  Y02T10/7061 ,  Y02T10/7077

摘要： The battery assembly system 100 includes a battery assembly including a plurality of storage batteries C1 to Cn connected in series, a voltage detector 3 for detecting respectively voltages generated in the storage batteries, a current detector 4 for detecting a current flowing in the plurality of storage batteries, a state-of-charge (SOC) calculator 2 for calculating the state of charge (SOC) of the storage batteries, respectively, based on the voltages detected respectively by the voltage detectors 3 and the current detected by the current detector 4, and a charging/discharging unit 1 for charging or discharging at least one of the plurality of storage batteries so as to equalize the SOC of the storage batteries calculated respectively by the SOC calculator 2.

摘要翻译： 电池组件系统100包括：电池组件，其包括串联连接的多个蓄电池C 1〜C n;电压检测器3，分别检测在蓄电池中产生的电压;电流检测器4，用于检测在多个 蓄电池，分别基于由电压检测器3分别检测的电压和由电流检测器4检测的电流分别计算蓄电池的充电状态（SOC）的充电状态（SOC）计算器2 以及用于对多个蓄电池中的至少一个充电或放电的充电/放电单元1，以便均衡由SOC计算器2分别计算出的蓄电池的SOC。

公开(公告)号：US5637319A

公开(公告)日：1997-06-10

申请号：US396715

申请日：1995-03-01

申请人： Kanji Takada

发明人： Kanji Takada

IPC分类号： A61K9/00 ,  A61K9/48

CPC分类号： A61K9/4808 ,  A61K9/0004 ,  Y10S514/962

摘要： The invention provides oral controlled-release preparations suitable to deliver drugs to different sites of gastrointestinal tract and suitable to control the release rate of drugs. As a first function, targeting of drugs to the lower part of the small intestine or colon is possible with two technologies. One is a time-controlled release system comprising adjusting the balance of the tolerability and thickness of a water-insoluble material membrane and the amount of a swellable substance. The other one is an intestinal pressure controlled-release system comprising adjusting the thickness of a water-insoluble material membrane. As a second function, by adjusting pore number, pore size and the amount of gel-forming substance, a sustained-release preparation of extremely water-soluble, hydrophilic, low-molecular weight drug is possible.

摘要翻译： 本发明提供了适于将药物递送到胃肠道的不同部位并适于控制药物释放速率的口服缓释制剂。 作为第一个功能，可以通过两种技术将药物靶向小肠或结肠的下部。 一种是时间控制释放系统，其包括调节水不溶性材料膜的耐受性和厚度的平衡以及可溶胀物质的量。 另一种是肠调压释放系统，其包括调节水不溶性材料膜的厚度。 作为第二功能，通过调节孔数，孔径和形成凝胶的物质的量，可以使极端水溶性，亲水性，低分子量药物的缓释制剂。

公开(公告)号：US08491534B2

公开(公告)日：2013-07-23

申请号：US12734755

申请日：2008-11-21

申请人： Kanji Takada

发明人： Kanji Takada

IPC分类号： A61M5/00 ,  A61M37/00 ,  A61M5/32 ,  B28B11/08 ,  A61K9/00

CPC分类号： A61K31/07 ,  A61K9/0021 ,  A61K9/703 ,  A61K31/196 ,  A61K31/375 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/436 ,  A61K31/496 ,  A61K31/7048 ,  A61K31/727 ,  A61K38/21 ,  A61K47/36 ,  A61M37/0015 ,  A61M2037/0053 ,  Y02A50/465

摘要： It is an objective to provide a microneedle and a microneedle array formed from a self-dissolving base which can realize higher absorption efficiency and a higher pharmacological availability. A preparation 1 for body surface application has two sections divided in the insertion direction, namely, an acral portion 5 and a rear end portion 6. The acral portion 5 is a section including a body surface insertion end 2, and holds a target substance soluble in base. The rear end portion 6 is a section including a pressing end 3, and is formed mainly only from the base. The rear end portion 6 does not hold the target substance. When the preparation 1 for body surface application is inserted into a body surface such as the skin, since the target substance is contained in the acral portion 5, even if part of the rear end side thereof is subsequently not fully inserted into the body surface, high absorption efficiency and high pharmacological effect can be realized where the actual dose of the target substance is not below the desired amount of the drug.

摘要翻译： 目的是提供一种由自溶碱形成的微针和微针阵列，其可以实现更高的吸收效率和更高的药理学可用性。 用于体表应用的制剂1在插入方向上具有两个部分，分别是顶端部分5和后端部分6.顶端部分5是包括体表插入端2的部分，并且保持目标物质可溶 在基地。 后端部6是包括按压端3的部分，并且仅主要由基部形成。 后端部6不保持目标物质。 当用于体表应用的制剂1插入到皮肤的体表中时，由于目标物质被容纳在头部5中，所以即使其后端侧的一部分后来没有完全插入体表中， 当目标物质的实际剂量不低于所需量的药物时，可以实现高吸收效率和高药理作用。

公开(公告)号：US20110028905A1

公开(公告)日：2011-02-03

申请号：US12734755

申请日：2008-11-21

申请人： Kanji Takada

发明人： Kanji Takada

IPC分类号： A61M5/00

CPC分类号： A61K31/07 ,  A61K9/0021 ,  A61K9/703 ,  A61K31/196 ,  A61K31/375 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/436 ,  A61K31/496 ,  A61K31/7048 ,  A61K31/727 ,  A61K38/21 ,  A61K47/36 ,  A61M37/0015 ,  A61M2037/0053 ,  Y02A50/465

摘要： It is an objective to provide a microneedle and a microneedle array formed from a self-dissolving base which can realize higher absorption efficiency and a higher pharmacological availability. A preparation 1 for body surface application has two sections divided in the insertion direction, namely, an acral portion 5 and a rear end portion 6. The acral portion 5 is a section including a body surface insertion end 2, and holds a target substance soluble in base. The rear end portion 6 is a section including a pressing end 3, and is formed mainly only from the base. The rear end portion 6 does not hold the target substance. When the preparation 1 for body surface application is inserted into a body surface such as the skin, since the target substance is contained in the acral portion 5, even if part of the rear end side thereof is subsequently not fully inserted into the body surface, high absorption efficiency and high pharmacological effect can be realized where the actual dose of the target substance is not below the desired amount of the drug.

摘要翻译： 目的是提供一种由自溶碱形成的微针和微针阵列，其可以实现更高的吸收效率和更高的药理学可用性。 用于体表应用的制剂1在插入方向上具有两个部分，分别是顶端部分5和后端部分6.顶端部分5是包括体表插入端2的部分，并且保持目标物质可溶 在基地。 后端部6是包括按压端3的部分，并且仅主要由基部形成。 后端部6不保持目标物质。 当用于体表应用的制剂1插入到皮肤的体表中时，由于目标物质被容纳在头部5中，所以即使其后端侧的一部分后来没有完全插入体表中， 当目标物质的实际剂量不低于所需量的药物时，可以实现高吸收效率和高药理作用。

公开(公告)号：US06984961B2

公开(公告)日：2006-01-10

申请号：US10346614

申请日：2003-01-16

申请人： Eiji Kadouchi ,  Kanji Takada

发明人： Eiji Kadouchi ,  Kanji Takada

IPC分类号： H02J7/00

CPC分类号： H02J7/0019 ,  B60L3/0046 ,  B60L11/14 ,  B60L11/1861 ,  B60L11/1866 ,  B60L2240/545 ,  B60L2240/547 ,  B60L2240/549 ,  Y02T10/70 ,  Y02T10/7005 ,  Y02T10/7044 ,  Y02T10/7055 ,  Y02T10/7061 ,  Y02T10/7077

摘要： The battery assembly system 100 includes a battery assembly including a plurality of storage batteries C1 to Cn connected in series, a voltage detector 3 for detecting respectively voltages generated in the storage batteries, a current detector 4 for detecting a current flowing in the plurality of storage batteries, a state-of-charge (SOC) calculator 2 for calculating the state of charge (SOC) of the storage batteries, respectively, based on the voltages detected respectively by the voltage detectors 3 and the current detected by the current detector 4, and a charging/discharging unit 1 for charging or discharging at least one of the plurality of storage batteries so as to equalize the SOC of the storage batteries calculated respectively by the SOC calculator 2.