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公开(公告)号:US20070071681A1
公开(公告)日:2007-03-29
申请号:US11377614
申请日:2006-03-15
申请人: Kapil Gadkar , Huub Kreuwel , Thomas Paterson , David Polidori , Saroja Ramanujan , Lisl Katharine Mie Shoda , Chan Whiting , Daniel Young , Yanan Zheng
发明人: Kapil Gadkar , Huub Kreuwel , Thomas Paterson , David Polidori , Saroja Ramanujan , Lisl Katharine Mie Shoda , Chan Whiting , Daniel Young , Yanan Zheng
CPC分类号: G16H50/50 , G01N2800/042 , G06Q50/24 , G16B5/00 , G16B20/00
摘要: The invention encompasses novel methods for developing a computer model of type 1 diabetes in a mammal. In particular, the models can include representations of biological processes associated with a pancreatic lymph node and one or more pancreatic islets. Alternatively, the models can include representations of biological processes associated with at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming, insulitis and hyperglycemia. The invention also provides methods for developing a computer model of a non-insulin replacement treatment of type 1 diabetes. The invention also encompasses computer models of type 1 diabetes, methods of simulating type 1 diabetes and computer systems for simulating type 1 diabetes and the uses thereof.
摘要翻译: 本发明包括用于开发哺乳动物中1型糖尿病计算机模型的新方法。 特别地,模型可以包括与胰腺淋巴结和一个或多个胰岛相关联的生物过程的表示。 或者,模型可以包括与选自自身反应性T细胞产生,自身反应性T细胞引发,胰岛炎和高血糖的至少两种病症相关的生物学过程的表示。 本发明还提供了开发1型糖尿病非胰岛素替代治疗计算机模型的方法。 本发明还包括1型糖尿病的计算机模型,模拟1型糖尿病的方法和用于模拟1型糖尿病的计算机系统及其用途。
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2.
公开(公告)号:US20100021460A1
公开(公告)日:2010-01-28
申请号:US12502953
申请日:2009-07-14
申请人: Rong Deng , Paul J. Fielder , Henry B. Lowman , Eric Stefanich , Yanan Zheng
发明人: Rong Deng , Paul J. Fielder , Henry B. Lowman , Eric Stefanich , Yanan Zheng
IPC分类号: A61K39/395 , A61P37/00
CPC分类号: C07K16/2812 , A61K2039/505 , A61K2039/545 , C07K2317/41 , C07K2317/51 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要: Methods of treating autoimmune disorders in mammalian subjects using non-depleting CD4 antibodies, alone or in combination with other compounds, are provided.
摘要翻译: 提供了使用非消耗性CD4抗体单独或与其它化合物组合治疗哺乳动物受试者自身免疫性疾病的方法。
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公开(公告)号:US20120156194A1
公开(公告)日:2012-06-21
申请号:US13328830
申请日:2011-12-16
申请人: Joseph R. Arron , Richard W. Erickson , Michelle Freemer , Meredith Hazen , Guiquan Jia , John G. Matthews , Wendy Putnam , Heleen Scheerens , Yanan Zheng
发明人: Joseph R. Arron , Richard W. Erickson , Michelle Freemer , Meredith Hazen , Guiquan Jia , John G. Matthews , Wendy Putnam , Heleen Scheerens , Yanan Zheng
IPC分类号: A61K39/395 , A61P11/06 , C07H21/04 , C07K16/18 , G01N33/577 , G01N33/566
CPC分类号: G01N33/6884 , A61K31/522 , A61K31/573 , A61K39/3955 , A61K39/39566 , A61K45/06 , C07K16/18 , C07K16/244 , C07K16/28 , G01N33/6887 , G01N33/6893 , G01N2333/475 , G01N2800/122 , G01N2800/52
摘要: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
摘要翻译: 提供了诊断和治疗与TH2抑制有关的疾病的方法,包括但不限于哮喘。 还提供了选择或鉴定患者以治疗TH2途径抑制剂的某些治疗剂的方法。
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