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公开(公告)号：US20120064092A1
公开(公告)日：2012-03-15
申请号：US13274054
申请日：2011-10-14
申请人： Kareem Graham , Brian A. Zabel , Eugene C. Butcher
发明人： Kareem Graham , Brian A. Zabel , Eugene C. Butcher
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/02 , C40B30/06 , A61K31/713 , A61P29/00
CPC分类号： C07K16/2866 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2330/51 , G01N33/5029 , G01N33/5058 , G01N2800/285
摘要： Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a subject.
摘要翻译： 通过抑制趋化因子样受体1（CMKLR1）的活性，提供减少受试者脱髓鞘性炎性疾病的方法。 还提供了用于筛选用于治疗受试者中脱髓鞘性炎性疾病的试剂的方法。
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公开(公告)号：US08038992B2
公开(公告)日：2011-10-18
申请号：US12463840
申请日：2009-05-11
申请人： Kareem Graham , Brian A. Zabel , Eugene C. Butcher
发明人： Kareem Graham , Brian A. Zabel , Eugene C. Butcher
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2330/51 , G01N33/5029 , G01N33/5058 , G01N2800/285
摘要： Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a subject.
摘要翻译： 通过抑制趋化因子样受体1（CMKLR1）的活性，提供减少受试者脱髓鞘性炎性疾病的方法。 还提供了用于筛选用于治疗受试者中脱髓鞘性炎性疾病的试剂的方法。
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公开(公告)号：US20090280113A1
公开(公告)日：2009-11-12
申请号：US12463840
申请日：2009-05-11
申请人： Kareem Graham , Brian A. Zabel , Eugene C. Butcher
发明人： Kareem Graham , Brian A. Zabel , Eugene C. Butcher
IPC分类号： A61K39/395 , A61K38/00 , C12Q1/02 , C12Q1/68
CPC分类号： C07K16/2866 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2330/51 , G01N33/5029 , G01N33/5058 , G01N2800/285
摘要： Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a subject.
摘要翻译： 通过抑制趋化因子样受体1（CMKLR1）的活性，提供减少受试者脱髓鞘性炎性疾病的方法。 还提供了用于筛选用于治疗受试者中脱髓鞘性炎性疾病的试剂的方法。
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公开(公告)号：US20100092974A1
公开(公告)日：2010-04-15
申请号：US12541056
申请日：2009-08-13
IPC分类号： C12Q1/68
CPC分类号： G01N33/566 , G01N2333/7158 , G01N2500/02 , G01N2500/10
摘要： The invention provides methods and compositions for identifying a modulator of CCRL2 and chemerin. The present invention also provides methods and compositions for treating an inflammatory disease by administering a compound that modulates the interaction of CCRL2 with chemerin.
摘要翻译： 本发明提供用于鉴定CCRL2和凯美瑞调节剂的方法和组合物。 本发明还提供了通过施用调节CCRL2与凯莫林的相互作用的化合物来治疗炎性疾病的方法和组合物。
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5.发明授权公开(公告)号：US08383116B2
公开(公告)日：2013-02-26
申请号：US12587879
申请日：2009-10-13
IPC分类号： A61K39/395 , A61K49/00 , C07K16/00
CPC分类号： A61K39/3955 , C07K16/2821 , C07K16/2836 , C07K16/2842 , C07K16/2845 , C07K16/2854 , C07K16/2896 , C07K2317/76
摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
摘要翻译： 提供了预防和治疗癫痫发作和癫痫的方法。 这里显示白细胞募集在癫痫的发病机理中起关键作用。 用抑制白细胞募集的药物进行治疗具有阻止复发性癫痫发作和癫痫的治疗和预防作用。
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6.发明授权公开(公告)号：US07682613B2
公开(公告)日：2010-03-23
申请号：US11811245
申请日：2007-06-06
IPC分类号： A61K39/395 , A61K49/00 , C07K16/00
CPC分类号： A61K39/3955 , C07K16/2821 , C07K16/2836 , C07K16/2842 , C07K16/2845 , C07K16/2854 , C07K16/2896 , C07K2317/76
摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
摘要翻译： 提供了预防和治疗癫痫发作和癫痫的方法。 这里显示白细胞募集在癫痫的发病机理中起关键作用。 用抑制白细胞募集的药物进行治疗具有阻止复发性癫痫发作和癫痫的治疗和预防作用。
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公开(公告)号：US07266458B2
公开(公告)日：2007-09-04
申请号：US10236558
申请日：2002-09-05
申请人： Ivan Plavec , Ellen L. Berg , Eugene C. Butcher
发明人： Ivan Plavec , Ellen L. Berg , Eugene C. Butcher
IPC分类号： G06F19/00
CPC分类号： G01N33/5091 , C12N15/1089 , G01N33/5008 , G01N33/5011 , G01N33/5023 , G01N33/5041 , G01N33/5044 , G01N33/5064 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N2510/00 , G06F19/12
摘要： The involvement of an expression product in a cell in a pathway is determined by genetically modifying the cell, incubating the cell with predetermined factors in induce a physiological state and measuring parameters affected by the pathway. Changes in the levels of the parameters as a result of the presence of the expressed product indicate that the expression product is involved with the pathway.
摘要翻译： 表达产物参与途径中的细胞通过遗传修饰细胞，用预定因子孵育细胞以诱导生理状态并测量受该途径影响的参数来确定。 由于表达产物的存在，参数水平的变化表明表达产物与途径有关。
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公开(公告)号：US06656695B2
公开(公告)日：2003-12-02
申请号：US09800605
申请日：2001-03-06
IPC分类号： G01N3353
CPC分类号： G01N33/505 , C12Q1/06 , G01N5/00 , G01N33/5008 , G01N33/5023 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5061 , G01N33/5064 , G01N33/5091 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6872 , G01N2333/52 , G01N2333/70503 , G01N2500/10 , G01N2510/00
摘要： A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.
摘要翻译： 基于文化复杂生物反应分析筛选生物活性剂的方法。 提供了选择这种筛选细胞和培养条件的方法，以及鉴定待测量的一组优化的离散参数，以及使用生物分析分析快速鉴定和表征候选药物，遗传序列作用途径和 类似。 本发明的一个特征是同时筛选大量的细胞通路，以及快速鉴定引起细胞反应的化合物。
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公开(公告)号：US20100098714A1
公开(公告)日：2010-04-22
申请号：US12587879
申请日：2009-10-13
IPC分类号： A61K39/395 , A61P25/00
CPC分类号： A61K39/3955 , C07K16/2821 , C07K16/2836 , C07K16/2842 , C07K16/2845 , C07K16/2854 , C07K16/2896 , C07K2317/76
摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
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公开(公告)号：US20100080816A1
公开(公告)日：2010-04-01
申请号：US12566454
申请日：2009-09-24
申请人： Husein Hadeiba , Eugene C. Butcher
发明人： Husein Hadeiba , Eugene C. Butcher
CPC分类号： A61K39/0008 , A61K2035/122 , A61K2039/5154 , C12N5/064
摘要： Tolerogenic populations of dendritic cells are provided, where the dendritic cells are characterized by expression of select tissue-specific homing receptors including the chemokine receptors CCR9; or CMKLR1; or the integrin CD103. The dendritic cells may be conventional/myeloid or plasmacytoid dendritic cells. The cells may be isolated from lymphoid tissue, from blood, or from in vitro culture, e.g. bone marrow culture, etc. Methods are provided for their identification, isolation and targeting in immunotherapeutic interventions in suppressing inflammatory disorders including autoimmunity, transplantation responses and allergic diseases. In some embodiments dendritic cell populations are fixed to render them immunosuppressive, thus allowing the cells to be typed and banked for future use.
摘要翻译： 提供树突状细胞的耐受性种群，其中树突细胞的特征在于选择性组织特异性归巢受体包括趋化因子受体CCR9的表达; 或CMKLR1; 或整合素CD103。 树突状细胞可以是常规/骨髓或浆细胞样树突状细胞。 细胞可以从淋巴组织，血液或体外培养中分离，例如， 骨髓培养等。提供了在免疫治疗干预中鉴别，分离和靶向抑制包括自身免疫，移植反应和过敏性疾病的炎性疾病的方法。 在一些实施方案中，树突状细胞群被固定以使其免疫抑制，从而允许细胞被分型和分组以备将来使用。
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