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公开(公告)号：US20140141996A1
公开(公告)日：2014-05-22
申请号：US14127913
申请日：2012-06-23
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , G01N33/57407 , G01N33/57415 , G01N33/57484
摘要： Embodiments of the disclosure are directed to methods of diagnosis, prognosis and treatment of cancer. In some embodiments, the methods include targeting a marker that is expressed at abnormal levels in bladder cancer tissue in comparison to normal somatic tissue. Some embodiments are directed to methods of treating cancer comprising administering a composition including a therapeutic that affects the expression or function of a target marker. Some embodiments are directed to methods of detecting cancer comprising detecting a level of a target marker associated with the cancer,
摘要翻译： 本公开的实施方案涉及癌症的诊断，预后和治疗方法。 在一些实施方案中，所述方法包括靶向与正常体细胞组织相比在膀胱癌组织中以异常水平表达的标记。 一些实施方案涉及治疗癌症的方法，包括施用包含影响靶标志的表达或功能的治疗剂的组合物。 一些实施方案涉及检测癌症的方法，包括检测与癌症相关的靶标志的水平，
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2.发明申请Methods and Compositions for the Treatment and Diagnosis of Colorectal Cancer 审中-公开用于治疗和诊断结直肠癌的方法和组合公开(公告)号：US20140221244A1
公开(公告)日：2014-08-07
申请号：US14240512
申请日：2012-08-31
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , G01N33/57419
摘要： The invention provides methods, compositions and kits relating to the detection, diagnosis, treatment of colorectal cancer.
摘要翻译： 本发明提供了与结肠直肠癌的检测，诊断，治疗相关的方法，组合物和试剂盒。
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公开(公告)号：US20140206574A1
公开(公告)日：2014-07-24
申请号：US14240698
申请日：2012-08-31
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria J. Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria J. Prendes
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57488 , C12Q1/6886 , G01N33/57484 , G01N33/6893
摘要： The invention relates to methods of detecting cancer in a sample obtained from a subject. The invention also provides kits and reagents for detecting cancer as well as therapeutics and methods of treating cancer.
摘要翻译： 本发明涉及从受试者获得的样品中检测癌症的方法。 本发明还提供用于检测癌症的试剂盒和试剂，以及治疗和治疗癌症的方法。
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4.发明申请公开(公告)号：US20140154691A1
公开(公告)日：2014-06-05
申请号：US14127895
申请日：2012-06-22
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/57407 , G01N2800/60
摘要： Embodiments of the disclosure are directed to methods of diagnosis, prognosis and treatment of cancer. The methods are particularly suited for bladder cancer. The methods include targeting a marker that is expressed at abnormal levels in bladder cancer tissue in comparison to normal somatic tissue. Also disclosed are methods of treating cancer comprising administering a composition including a therapeutic that affects the expression or function of a target marker.
摘要翻译： 本公开的实施方案涉及癌症的诊断，预后和治疗方法。 该方法特别适用于膀胱癌。 所述方法包括靶向与正常体细胞组织相比在膀胱癌组织中以异常水平表达的标记物。 还公开了治疗癌症的方法，包括施用包含影响靶标志的表达或功能的治疗剂的组合物。
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5.发明申请公开(公告)号：US20140235486A1
公开(公告)日：2014-08-21
申请号：US14238726
申请日：2012-08-16
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： The invention provides for methods of diagnosis, prognosis and treatment of cancer including, but not limited to, breast cancer.
摘要翻译： 本发明提供了诊断，预后和治疗癌症的方法，包括但不限于乳腺癌。
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6.发明申请公开(公告)号：US20140315743A1
公开(公告)日：2014-10-23
申请号：US14348930
申请日：2012-10-03
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to methods, compositions and kits for the diagnosis, detection, and treatment of ovarian cancer.
摘要翻译： 本发明涉及用于诊断，检测和治疗卵巢癌的方法，组合物和试剂盒。
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7.发明申请Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby 审中-公开从多能干细胞和由此获得的细胞中加速分离新细胞株的方法公开(公告)号：US20080070303A1
公开(公告)日：2008-03-20
申请号：US11604047
申请日：2006-11-21
申请人： Michael West , Geoffrey Sargent , James Murai , Steven Kessler , Karen Chapman
发明人： Michael West , Geoffrey Sargent , James Murai , Steven Kessler , Karen Chapman
CPC分类号： C12N5/0662 , A61K35/30 , A61K35/34 , A61K35/39 , A61K35/407 , C12N5/0606 , C12N5/0619 , C12N5/0652 , C12N5/0657 , C12N5/067 , C12N5/0676 , C12N2506/02
摘要： This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
摘要翻译： 本发明一般涉及区分多能干细胞（例如胚胎干，胚胎胚芽或胚源性细胞）的方法，以从细胞的不均匀混合物获得细胞亚群，其中与原始多能性相比，细胞亚群具有降低的分化潜能 干细胞和亚群能够传播的地方。
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公开(公告)号：US20060112438A1
公开(公告)日：2006-05-25
申请号：US11028345
申请日：2005-01-03
申请人： Michael West , Karen Chapman , Irina Klimanskaya
发明人： Michael West , Karen Chapman , Irina Klimanskaya
IPC分类号： A01K67/027 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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公开(公告)号：US20060031955A1
公开(公告)日：2006-02-09
申请号：US11211174
申请日：2005-08-24
申请人： Michael West , Karen Chapman , Irina Klimanskaya
发明人： Michael West , Karen Chapman , Irina Klimanskaya
IPC分类号： C12N5/06 , C12N5/08 , A01K67/027
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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公开(公告)号：US20140178994A1
公开(公告)日：2014-06-26
申请号：US14172765
申请日：2014-02-04
申请人： Michael West , Hal Sternberg , Karen Chapman
发明人： Michael West , Hal Sternberg , Karen Chapman
IPC分类号： C12N5/077
CPC分类号： C12N5/0655 , C12N2506/02
摘要： Aspects of the present invention include methods and compositions related to the production, identification and use of embryonic progenitor cell lines that are capable of undergoing chondrogenesis. A number of exemplary chondrogenic cell lines derived from primordial stem cells are disclosed. The chondrogenic cell lines described herein are robust, can expand for >40 passages, and have site-specific purity, thus providing for compositions and methods of producing diverse cartilage types with unique molecular compositions for use in research and therapy.
摘要翻译： 本发明的方面包括与能够进行软骨形成的胚胎祖细胞系的生产，鉴定和使用相关的方法和组合物。 公开了一些衍生自原始干细胞的示例性软骨形成细胞系。 本文描述的软骨形成细胞系是稳健的，可以扩增> 40代，并且具有位点特异性的纯度，从而提供用于研究和治疗的具有独特分子组成的多种软骨类型的组合物和方法。
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