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    Methods and compositions involving immunostimulatory oligodeoxynucleotides
    7.
    发明授权
    Methods and compositions involving immunostimulatory oligodeoxynucleotides 有权
    涉及免疫刺激性寡脱氧核苷酸的方法和组合物

    公开(公告)号：US08568742B2

    公开(公告)日：2013-10-29

    申请号：US10297555

    申请日：2001-06-07

    申请人： Walter Schmidt ,  Karen Lingnau ,  Carola Schellack ,  Alena Egyed

    发明人： Walter Schmidt ,  Karen Lingnau ,  Carola Schellack ,  Alena Egyed

    IPC分类号： A61K47/00 ,  A61K45/00 ,  A61K39/00 ,  A61K48/00 ,  C12N15/11 ,  C07H21/02

    CPC分类号： A61K39/39 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/55516 ,  A61K2039/55561 ,  C07H19/24 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/33 ,  Y02A50/412

    摘要： Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I) wherein any NMP is a 2′ deoxynucleoside monophosphate or monothiophosphate, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, -6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine-monophosphate or -monothiophosphate, NUC is a 2′ deoxynucleoside, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, 6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine, any X is O or S, a and b are integers from 0 to 100 with the proviso that a+b is between 4 and 150, B and E are common groups for 5′ or 3′ ends of nucleic acid molecules, as well as a pharmaceutical composition containing such ODNs.

    摘要翻译： 描述了具有式（I）结构的免疫刺激性寡脱氧核酸酸分子（ODN），其中任何NMP是选自脱氧腺苷，脱氧鸟苷，脱氧肌氨酸，脱氧胞嘧啶，脱氧尿苷的2'脱氧核苷单磷酸或一硫代磷酸酯 - 脱氧胸苷，2-甲基 - 脱氧肌苷，5-甲基 - 脱氧胞嘧啶，脱氧伪嘌呤，脱氧核糖嘌呤，2-氨基 - 脱氧核糖嘌呤，-6-S-脱氧鸟嘌呤，2-二甲基 - 脱氧鸟苷或N-异戊烯基 脱氧腺苷 - 脱氧腺苷，脱氧胸苷，2-甲基 - 脱氧肌苷，5-甲基 - 脱氧肌苷，脱氧腺苷，脱氧腺苷，脱氧肌苷， 脱氧胞嘧啶，脱氧嘌呤，脱氧核糖嘌呤，2-氨基 - 脱氧核糖嘌呤，6-S-脱氧鸟嘌呤，2-二甲基 - 脱氧鸟苷或N-异戊烯基 - 脱氧腺苷，任何X是O或S，a和b是0 到100，附带条件是a + b在4至150之间，B和E是核酸分子的5'或3'末端的常见基团，以及含有这种ODN的药物组合物。

    Immunostimulatory oligodeoxynucleic molecules
    8.
    发明授权
    Immunostimulatory oligodeoxynucleic molecules 失效
    免疫刺激性寡脱氧核糖分子

    公开(公告)号：US07858588B2

    公开(公告)日：2010-12-28

    申请号：US10478771

    申请日：2002-05-17

    申请人： Karen Lingnau ,  Carola Schellack ,  Walter Schmidt

    发明人： Karen Lingnau ,  Carola Schellack ,  Walter Schmidt

    IPC分类号： A01N31/70 ,  A61K39/00 ,  A61K45/00 ,  C12N5/00

    CPC分类号： C12N15/117 ,  A61K2039/55561 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/33

    摘要： Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I), wherein any X is O or S, any NMP is a 2′ deoxynucleoside monophosphate or monothiophosphate, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, -6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine-monophosphate or -monothiophosphate, NUC is a 2′ deoxynucleoside, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, 6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine, any X is O or S, a and b integers from 0 to 100 with the proviso that a+b is between 4 and 150, B and E are common groups for 5′ or 3′ ends of nucleic acid molecules, as well as a pharmaceutical composition containing such ODNs.

    摘要翻译： 描述了具有式（I）结构的免疫刺激性寡脱氧核酸分子（ODN），其中任何X是O或S，任何NMP是2'-脱氧核苷单磷酸或一硫代磷酸酯，其选自脱氧腺苷，脱氧鸟苷 - ，脱氧肌苷，脱氧胞嘧啶，脱氧尿苷，脱氧胸苷，2-甲基脱氧肌苷，5-甲基脱氧胞嘧啶，脱氧嘌呤，脱氧核糖嘌呤，2-氨基 - 脱氧核糖嘌呤，-6-S-脱氧鸟嘌呤， 二甲基脱氧鸟苷或N-异戊烯基 - 脱氧腺苷一磷酸或一硫代磷酸酯，NUC是2'-脱氧核苷，选自脱氧腺苷，脱氧鸟苷，脱氧肌苷，脱氧胞嘧啶，脱氧尿苷，脱氧胸苷，2-甲基 脱氧肌氨酸 - ，5-甲基 - 脱氧胞嘧啶 - ，脱氧伪嘌呤 - ，脱氧核糖嘌呤 - ，2-氨基 - 脱氧核糖嘌呤 - ，6-S-脱氧鸟嘌呤 - ，2-二甲基 - 脱氧鸟苷或N-异戊烯基 - 脱氧腺苷，任何X是O或S ，a和b整数从0到100与t 他的条件是a + b在4到150之间，B和E是核酸分子的5'或3'末端的常见基团，以及含有这种ODN的药物组合物。