公开(公告)号：US20100102474A1

公开(公告)日：2010-04-29

申请号：US12514330

申请日：2007-11-12

申请人： Katashi Nakashima ,  Kazuo Kazama

发明人： Katashi Nakashima ,  Kazuo Kazama

IPC分类号： B32B38/14 ,  A61K9/20

CPC分类号： A61J3/10 ,  A61K9/2077

摘要： Herein provided is a method for easily preparing a sustained release tablet which contains an orally administrable medicinal component, while maintaining the uniformity of the content of the medicinal component.The method comprises mixing (1) a granulated product A obtained by granulating an excipient and an enteric coating agent while spraying thereon with a solution or a suspension containing an orally administrable medicinal component, with (2) a composition B containing a hydrogel-forming substance; and then compressing the resulting mixture into a tablet.

摘要翻译： 本发明提供一种容易地制备含有可口服给药的药物成分的缓释片剂的方法，同时保持药物成分的含量的均匀性。 该方法包括混合（1）通过使赋形剂和肠溶包衣剂制粒而得到的造粒产品A，同时用含有口服药物组分的溶液或悬浮液喷雾，和（2）含有水凝胶形成物质的组合物B ; 然后将所得混合物压片成片剂。

公开(公告)号：US20070092566A1

公开(公告)日：2007-04-26

申请号：US10566503

申请日：2004-08-03

申请人： Ryouichi Hoshino ,  Katashi Nakashima ,  Kazuo Kazama

发明人： Ryouichi Hoshino ,  Katashi Nakashima ,  Kazuo Kazama

IPC分类号： A61K31/4172 ,  A61K9/22

CPC分类号： A61K9/2054 ,  A61K31/4174

摘要： An oral sustained-release tablet is provided, which does not cause initial rapid increases in the bloodlevels of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide (KRP-197) and can maintain constant the blood levels. (Solving means) An oral sustained-release tablet comprises a pharmaceutical composition and a gel-forming material, the pharmaceutical composition containing KRP-197 as an active ingredient.

摘要翻译： 提供口服持续释放片剂，其不引起4-（2-甲基-1-咪唑基）-2,2-二苯基丁基酰胺（KRP-197）的血液水平的初步快速增加，并且可以保持血液水平恒定。 （解决方案）口服缓释片剂包含药物组合物和凝胶形成材料，所述药物组合物含有KRP-197作为活性成分。

公开(公告)号：US08343544B2

公开(公告)日：2013-01-01

申请号：US12855226

申请日：2010-08-12

申请人： Ryouichi Hoshino ,  Katashi Nakashima ,  Kazuo Kazama

发明人： Ryouichi Hoshino ,  Katashi Nakashima ,  Kazuo Kazama

IPC分类号： A61K9/22

CPC分类号： A61K9/2054 ,  A61K31/4174

摘要： (Object) An oral sustained-release tablet is provided, which does not cause initial rapid increases in the bloodlevels of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide (KRP-197) and can maintain constant the blood levels.(Solving means) An oral sustained-release tablet comprises a pharmaceutical composition and a gel-forming material, the pharmaceutical composition containing KRP-197 as an active ingredient.

摘要翻译： （对象）提供口服持续释放片剂，其不会引起4-（2-甲基-1-咪唑基）-2,2-二苯基丁基酰胺（KRP-197）的血液水平的初始快速增加，并且可以保持恒定 血液水平。 （解决方案）口服缓释片剂包含药物组合物和凝胶形成材料，所述药物组合物含有KRP-197作为活性成分。

公开(公告)号：US08202456B2

公开(公告)日：2012-06-19

申请号：US12514330

申请日：2007-11-12

申请人： Katashi Nakashima ,  Kazuo Kazama

发明人： Katashi Nakashima ,  Kazuo Kazama

IPC分类号： B29C43/02

CPC分类号： A61J3/10 ,  A61K9/2077

摘要： Herein provided is a method for easily preparing a sustained release tablet which contains an orally administrable medicinal component, while maintaining the uniformity of the content of the medicinal component.The method comprises mixing (1) a granulated product A obtained by granulating an excipient and an enteric coating agent while spraying thereon with a solution or a suspension containing an orally administrable medicinal component, with (2) a composition B containing a hydrogel-forming substance; and then compressing the resulting mixture into a tablet.

摘要翻译： 本发明提供一种容易地制备含有可口服给药的药物成分的缓释片剂的方法，同时保持药物成分的含量的均匀性。 该方法包括混合（1）通过使赋形剂和肠溶包衣剂制粒而得到的造粒产品A，同时用含有口服药物组分的溶液或悬浮液喷雾，和（2）含有水凝胶形成物质的组合物B ; 然后将所得混合物压片成片剂。

公开(公告)号：US20100305179A1

公开(公告)日：2010-12-02

申请号：US12855226

申请日：2010-08-12

申请人： Ryouichi HOSHINO ,  Katashi Nakashima ,  Kazuo Kazama

发明人： Ryouichi HOSHINO ,  Katashi Nakashima ,  Kazuo Kazama

IPC分类号： A61K31/4174 ,  A61P13/00

CPC分类号： A61K9/2054 ,  A61K31/4174

摘要： (Object) An oral sustained-release tablet is provided, which does not cause initial rapid increases in the bloodlevels of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide (KRP-197) and can maintain constant the blood levels.(Solving means) An oral sustained-release tablet comprises a pharmaceutical composition and a gel-forming material, the pharmaceutical composition containing KRP-197 as an active ingredient.

摘要翻译： （对象）提供口服持续释放片剂，其不会引起4-（2-甲基-1-咪唑基）-2,2-二苯基丁基酰胺（KRP-197）的血液水平的初始快速增加，并且可以保持恒定 血液水平。 （解决方案）口服缓释片剂包含药物组合物和凝胶形成材料，所述药物组合物含有KRP-197作为活性成分。

公开(公告)号：US20080107727A1

公开(公告)日：2008-05-08

申请号：US11795792

申请日：2006-01-30

申请人： Katashi Nakashima ,  Yoshinobu Aoki ,  Kazuo Kazama ,  Toshihiro Ishizaki

发明人： Katashi Nakashima ,  Yoshinobu Aoki ,  Kazuo Kazama ,  Toshihiro Ishizaki

IPC分类号： A61K31/417 ,  A61K9/24 ,  A61K9/52 ,  A61K9/16

CPC分类号： A61K9/1652 ,  A61K9/1617 ,  A61K9/2077 ,  A61K9/5078 ,  A61K31/4164

摘要： A multiple-unit oral sustained release preparation is provided which allows controlled release of imidafenacin [4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide]. The preparation serves to ensure a prolonged effect of imidafenacin and prevent rapid elevation in the blood levels of imidafenacin.Specifically, granules or powders comprising imidafenacin dispersed in a water-insoluble polymer or a higher alcohol are used in the preparation. These preparations achieve sustained release of imidafenacin since the molecular network structure that the water-insoluble polymer or the higher alcohol forms during the preparation of the granules or powders serves to control the rate of diffusion of imidafenacin in water. Granules comprising a core granule having two layers of an inner imidafenacin coating and an outer water-insoluble polymer coating are used in the preparation. The water-insoluble polymer coating serves to control the rate of diffusion of imidafenacin in water and ensure sustained release of imidafenacin. The multiple-unit oral sustained release preparation is provided in the forms of capsules and tablets containing the granules or powders that allow controlled release of imidafenacin. The preparation achieves controlled release of imidafenacin over a prolonged period of time.

摘要翻译： 提供多单位口服持续释放制剂，其允许控制释放咪达那新[4-（2-甲基-1-咪唑基）-2,2-二苯基丁基酰胺]。 该制剂用于确保咪达达敏的长期作用，并防止咪达那新的血液水平迅速升高。 具体地，在制剂中使用包含分散在水不溶性聚合物或高级醇中的咪达那新的颗粒或粉末。 由于在制备颗粒或粉末期间水不溶性聚合物或高级醇形成的分子网络结构用于控制咪达那新在水中的扩散速率，因此这些制剂实现咪达那新的持续释放。 在制剂中使用包含具有两层内亚胺多沙星涂层和外部水不溶性聚合物涂层的核心颗粒的颗粒。 水不溶性聚合物涂层用于控制咪达那新在水中的扩散速率，并确保咪达那新的持续释放。 多单位口服持续释放制剂以含有允许控制释放咪达那新的颗粒或粉末的胶囊和片剂的形式提供。 该制剂在长时间内实现了咪达那新的控制释放。

公开(公告)号：US20070090144A1

公开(公告)日：2007-04-26

申请号：US11566961

申请日：2006-12-05

申请人： Kazuo Kazama

发明人： Kazuo Kazama

IPC分类号： B26F3/02

CPC分类号： B26D1/385 ,  B26F3/02 ,  Y10T225/243

摘要： A new cling wrap case where even a polyethylene cling wrap film can be easily, assuredly and safely cut off, and concurrently, that is user-friendly, and that enables resource saving generally because this is not disposable but it is repeatably re-usable. This is made form a synthetic resin, and it is equipped with a storage case where a cylindrical cling wrap roll is stored, and a cover, rotatably attached to the storage case, and which can cover over the storage case to be openable, and which concurrently has a cutter member that can cut off a pulled-out cling wrap film; and, the cover is constructed such that when closing the storage case, the pulled-out cling wrap film can be cut off by the cutter member.

摘要翻译： 一种新的保鲜包装盒，其中即使是聚乙烯保鲜膜也可以容易地，可靠和安全地切断，并且同时，这是用户友好的，并且通常由于这不是一次性的而是可重复使用的，所以能够节省资源。 这是由合成树脂制成的，它装有一个储存圆柱形保鲜卷的储物盒，一个可旋转地安装在储物盒上的盖子，它可以覆盖储存盒以便可打开，而哪个 同时具有可切断拉出的保鲜膜的切割器件; 并且，盖被构造成使得当关闭存放箱时，拉出的保鲜膜可以被切割器部件切断。

公开(公告)号：US20090000971A1

公开(公告)日：2009-01-01

申请号：US12202713

申请日：2008-09-02

申请人： Kazuo Kazama

发明人： Kazuo Kazama

IPC分类号： B65H49/08 ,  B26F3/02

CPC分类号： B26D1/385 ,  B26F3/02 ,  Y10T225/243

摘要： A cling wrap case is provided, where even a polyethylene cling wrap film can be easily, assuredly and safely cut off, and concurrently, that is user-friendly, and that enables resource saving generally because this is not disposable but it is repeatably re-usable. The cling wrap case is made form a synthetic resin, and is equipped with a storage case in which a cylindrical cling wrap roll is stored, and a cover, rotatably attached to the storage case, which covers over the storage case to be openable, and which concurrently has a cutter member that cuts off a pulled-out amount of cling wrap film. The cover is constructed so that when the storage case is closed, the pulled-out amount of cling wrap film is cut off by the cutter member.

摘要翻译： 提供了一种保鲜包装盒，其中甚至可以容易地，可靠地和安全地切断聚乙烯保鲜膜，同时，这是用户友好的，并且通常由于这不是一次性的而是能够节省资源， 可用 保鲜包装盒由合成树脂制成，并且装有一个储存盒子，其中存储一个圆筒形保鲜膜;一个盖子，可转动地安装在储存盒上，覆盖在储物箱上可打开;以及 其同时具有切断拉出量的保鲜膜的切割构件。 该盖被构造成使得当储存盒关闭时，保鲜膜的拉出量被切割器部件切断。

公开(公告)号：US5254212A

公开(公告)日：1993-10-19

申请号：US855048

申请日：1992-05-06

申请人： Takahiro Someji ,  Junichi Watanabe ,  Yoshiyuki Watanabe ,  Shigeru Jyoumura ,  Katsuhiko Kojyou ,  Kazuo Kazama ,  Kiyomi Tanaka

发明人： Takahiro Someji ,  Junichi Watanabe ,  Yoshiyuki Watanabe ,  Shigeru Jyoumura ,  Katsuhiko Kojyou ,  Kazuo Kazama ,  Kiyomi Tanaka

IPC分类号： H01L41/083 ,  H01L41/293 ,  B44C1/22 ,  C23F1/00

CPC分类号： H01L41/293 ,  H01L41/0472 ,  Y10T29/42

摘要： A method of making a layered electrostrictive displacement device by forming sheets of an electrostrictive material alternately with internal electrodes. The laminate formed therefrom has two opposite surfaces at which the ends of the internal electrodes are exposed and two other opposite surfaces at which alternate layers of the internal electrodes are exposed. Temporary external electrodes are formed on the latter mentioned opposite surfaces. Alternate layers of the exposed portions of the internal electrodes are plated at one surface of the laminate with a metal while using a temporary external electrode as a cathode. The exposed portions of the other internal electrodes are plated with metal using another temporary external electrode as a cathode. The non-plated portions of the plated surface are selectively removed to form recesses, and an insulating film is formed on the recesses. Portions of insulating film and the metal deposited are removed to expose the internal electrodes, and external electrodes for connection to the exposed internal electrodes are formed.

摘要翻译： PCT No.PCT / JP91 / 01196 Sec。 371日期：1992年5月6日 102（e）日期1992年5月6日PCT 1991年9月9日PCT公布。 出版物WO92 / 05593 日期：1992年4月2日。一种通过与内部电极交替地形成电致伸缩材料片来制造分层电致伸缩位移装置的方法。 由此形成的层压体具有两个相对的表面，内部电极的端部暴露在两个相对的表面和两个内部电极的交替层被暴露的相反的两个表面。 临时外部电极形成在后面提到的相对表面上。 使用临时外部电极作为阴极，将内部电极的露出部分的交替层用金属镀在层叠体的一个表面。 其他内部电极的露出部分使用另一临时外部电极作为阴极镀金属。 选择性地去除电镀表面的非电镀部分以形成凹部，并且在凹部上形成绝缘膜。 去除绝缘膜和沉积的金属的部分以暴露内部电极，并且形成用于连接到暴露的内部电极的外部电极。

公开(公告)号：US07642970B2

公开(公告)日：2010-01-05

申请号：US11723388

申请日：2007-03-19

申请人： Hiroyuki Aoyama ,  Kazuo Kazama

发明人： Hiroyuki Aoyama ,  Kazuo Kazama

IPC分类号： H01Q1/24

CPC分类号： H01Q21/30 ,  H01Q1/243 ,  H01Q1/362 ,  H01Q5/00 ,  H01Q5/371 ,  H01Q21/28

摘要： An antenna device is provided which is capable of operating in a wider band of frequencies (in a plurality of transmitting and receiving frequency bands), achieving an excellent gain, maintaining non-directivity of vertically polarized waves in each of the transmitting and receiving frequency bands, and saving space. The antenna device includes the first antenna 101 being a chip-type antenna operating in a GSM band, second antenna 102 being a pattern antenna operating in DCS and PCS bands, third antenna 103 being a layer-stacked antenna operating in an UMTS band, all being mounted on a substrate 100. The second antenna 102 is connected to a line 105 extending from a power feeding port 104 connected to the first antenna 101. A gap is interposed between the second antenna 102 and third antenna 103 wherein the second antenna 102 is capacitively coupled to the third antenna 103 on the substrate 100 with no antenna switch being provided.

摘要翻译： 提供一种天线装置，其能够在更宽的频带（在多个发射和接收频带中）工作，实现了优异的增益，保持了发射和接收频带每个中的垂直极化波的非方向性 ，节省空间。 天线装置包括作为GSM频带工作的芯片型天线的第一天线101，第二天线102是以DCS和PCS频带工作的模式天线，第三天线103为在UMTS频带中工作的层叠天线，全部 安装在基板100上。第二天线102连接到从连接到第一天线101的供电端口104延伸的线路105.间隙被插入在第二天线102和第三天线103之间，其中第二天线102是 电容耦合到基板100上的第三天线103，而不提供天线开关。