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1.发明申请公开(公告)号：US20140162296A1
公开(公告)日：2014-06-12
申请号：US13828901
申请日：2013-03-14
申请人： Katherine E. Varley , Richard M. Myers , Brian S. Roberts , Jason Gertz , Donald J. Buchsbaum , Andres Forero-Torres , Albert F. LoBuglio
发明人： Katherine E. Varley , Richard M. Myers , Brian S. Roberts , Jason Gertz , Donald J. Buchsbaum , Andres Forero-Torres , Albert F. LoBuglio
CPC分类号： C07K14/47 , C07K14/4748 , G01N33/57415
摘要： The present disclosure provides for and relates to novel fusion proteins and polypeptides expressed by breast cancer and other cancer cells, and to compositions, materials and methods for detecting, characterizing and treating said breast and other cancers. In one embodiment, the fusion polypeptides are read-through fusion transcripts.
摘要翻译： 本公开提供并涉及由乳腺癌和其他癌细胞表达的新型融合蛋白和多肽，以及用于检测，表征和治疗所述乳腺癌和其它癌症的组合物，材料和方法。 在一个实施方案中，融合多肽是透过融合转录物。
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公开(公告)号：US20170267733A1
公开(公告)日：2017-09-21
申请号：US15354423
申请日：2016-11-17
申请人： Katherine E. Varley , Richard M. Myers , Brian S. Roberts , Jason Gertz , Donald J. Buchsbaum , Andres Forero-Torres , Albert F. LoBuglio
发明人： Katherine E. Varley , Richard M. Myers , Brian S. Roberts , Jason Gertz , Donald J. Buchsbaum , Andres Forero-Torres , Albert F. LoBuglio
IPC分类号： C07K14/47 , G01N33/574
CPC分类号： C07K14/47 , C07K14/4748 , G01N33/57415
摘要： The present disclosure provides for and relates to novel fusion proteins and polypeptides expressed by breast cancer and other cancer cells, and to compositions, materials and methods for detecting, characterizing and treating said breast and other cancers. In one embodiment, the fusion polypeptides are read-through fusion transcripts.
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公开(公告)号：US20110104143A1
公开(公告)日：2011-05-05
申请号：US12940746
申请日：2010-11-05
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00 , G01N33/574
CPC分类号： C07K16/2878 , A61K9/0019 , A61K31/337 , A61K31/5517 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/42 , C07K2317/34 , C07K2317/73
摘要： Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are methods of screening a breast cancer cell for responsiveness to a DR5 agonist. Further provided herein are antibodies that selectively bind an N-terminal CARD of DDX3, a DDX3 lacking an N-terminal CARD, and an 80 kDa baculovirus TAP repeat (BIR).
摘要翻译： 本文提供了用癌症治疗受试者的方法，包括向受试者施用死亡受体激动剂。 本文还提供筛选乳腺癌细胞以响应DR5激动剂的方法。 本文进一步提供选择性结合DDX3的N末端CARD，缺乏N端CARD的DDX3和80kDa杆状病毒TAP重复（BIR）的抗体。
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公开(公告)号：US20130004521A1
公开(公告)日：2013-01-03
申请号：US13634401
申请日：2011-03-18
IPC分类号： A61K39/395 , G01N33/573 , A61N5/10 , A61P35/00 , A61P35/04 , G01N33/574 , A61K31/7105
CPC分类号： C07K16/2878 , C07K2317/75
摘要： Provided is a method of determining the level of resistance or sensitivity of cancer stem cells to a death receptor agonist. The method includes detecting the level of IAP in one or more DR5/DDX3/IAP complexes in or from the cancer stem cells. Also provided is a method of killing cancer stem cells in a subject and a method of reducing the risk of cancer recurrence in a subject.
摘要翻译： 提供了确定癌症干细胞对死亡受体激动剂的抗性或敏感性水平的方法。 该方法包括检测在癌干细胞中或来自癌干细胞的一种或多种DR5 / DDX3 / IAP复合物中IAP的水平。 还提供了一种杀死受试者中的癌症干细胞的方法和降低受试者中癌症复发风险的方法。
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公开(公告)号：US08703712B2
公开(公告)日：2014-04-22
申请号：US13634401
申请日：2011-03-18
IPC分类号： A61K39/00 , A61P35/00 , A61K39/395 , C12N5/095 , C07K16/30
CPC分类号： C07K16/2878 , C07K2317/75
摘要： Provided is a method of determining the level of resistance or sensitivity of cancer stem cells to a death receptor agonist. The method includes detecting the level of IAP in one or more DR5/DDX3/IAP complexes in or from the cancer stem cells. Also provided is a method of killing cancer stem cells in a subject and a method of reducing the risk of cancer recurrence in a subject.
摘要翻译： 提供了确定癌症干细胞对死亡受体激动剂的抗性或敏感性水平的方法。 该方法包括检测在癌干细胞中或来自癌干细胞的一种或多种DR5 / DDX3 / IAP复合物中IAP的水平。 还提供了一种杀死受试者中的癌症干细胞的方法和降低受试者中癌症复发风险的方法。
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6.发明授权公开(公告)号：US07981421B2
公开(公告)日：2011-07-19
申请号：US12686659
申请日：2010-01-13
申请人： Tong Zhou , Kimihisa Ichikawa , Robert P. Kimberly , William J. Koopman , Jun Ohsumi , Albert F. LoBuglio , Donald J. Buchsbaum
发明人： Tong Zhou , Kimihisa Ichikawa , Robert P. Kimberly , William J. Koopman , Jun Ohsumi , Albert F. LoBuglio , Donald J. Buchsbaum
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/519 , A61K39/39541 , A61K41/00 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
摘要翻译： 本发明的抗体与人DR5或与人DR4相互作用以在受体下游产生激动或拮抗作用，包括抑制细胞增殖和细胞凋亡。 详细描述了任选与各种治疗剂组合的抗体的方法和用途，包括治疗凋亡相关疾病和治疗失调的细胞生长。
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7.发明申请Combinations of Antibodies Selective for a Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor and Other Therapeutic Agents 有权针对肿瘤坏死因子相关凋亡诱导配体受体和其他治疗剂的选择性抗体的组合公开(公告)号：US20090022707A1
公开(公告)日：2009-01-22
申请号：US11752153
申请日：2007-05-22
申请人： Robert P. Kimberly , William J. Koopman , Albert F. LoBuglio , Tong Zhou , Donald J. Buchsbaum , Kimihisa Ichikawa , Jun Oshumi
发明人： Robert P. Kimberly , William J. Koopman , Albert F. LoBuglio , Tong Zhou , Donald J. Buchsbaum , Kimihisa Ichikawa , Jun Oshumi
IPC分类号： A61K39/395 , A61P29/00 , A61P31/00
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/519 , A61K39/39541 , A61K41/00 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
摘要翻译： 本发明的抗体与人DR5或与人DR4相互作用以在受体下游产生激动或拮抗作用，包括抑制细胞增殖和细胞凋亡。 详细描述了任选与各种治疗剂组合的抗体的方法和用途，包括治疗凋亡相关疾病和治疗失调的细胞生长。
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公开(公告)号：US07279160B2
公开(公告)日：2007-10-09
申请号：US10281479
申请日：2002-10-25
申请人： Tong Zhou , Kimihisa Ichikawa , Robert P. Kimberly , William J. Koopman , Jun Ohsumi , Albert F. Lobuglio , Donald J. Buchsbaum
发明人： Tong Zhou , Kimihisa Ichikawa , Robert P. Kimberly , William J. Koopman , Jun Ohsumi , Albert F. Lobuglio , Donald J. Buchsbaum
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/519 , A61K39/39541 , A61K41/00 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
摘要翻译： 本发明的抗体与人DR5或与人DR4相互作用以在受体下游产生激动或拮抗作用，包括抑制细胞增殖和细胞凋亡。 详细描述了任选与各种治疗剂组合的抗体的方法和用途，包括治疗凋亡相关疾病和治疗失调的细胞生长。
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公开(公告)号：US09527915B2
公开(公告)日：2016-12-27
申请号：US12940746
申请日：2010-11-05
IPC分类号： A61K39/395 , G01N33/50 , C07K16/28
CPC分类号： C07K16/2878 , A61K9/0019 , A61K31/337 , A61K31/5517 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/42 , C07K2317/34 , C07K2317/73
摘要： Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are methods of screening a breast cancer cell for responsiveness to a DR5 agonist. Further provided herein are antibodies that selectively bind an N-terminal CARD of DDX3, a DDX3 lacking an N-terminal CARD, and an 80 kDa baculovirus TAP repeat (BIR).
摘要翻译： 本文提供了用癌症治疗受试者的方法，包括向受试者施用死亡受体激动剂。 本文还提供筛选乳腺癌细胞以响应DR5激动剂的方法。 本文进一步提供选择性结合DDX3的N末端CARD，缺乏N端CARD的DDX3和80kDa杆状病毒TAP重复（BIR）的抗体。
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10.发明申请公开(公告)号：US20110002887A1
公开(公告)日：2011-01-06
申请号：US12686659
申请日：2010-01-13
申请人： Robert P. Kimberly , William J. Koopman , Albert F. LoBuglio , Tong Zhou , Donald J. Buchsbaum , Kimihisa Ichikawa , Jun Ohsumi
发明人： Robert P. Kimberly , William J. Koopman , Albert F. LoBuglio , Tong Zhou , Donald J. Buchsbaum , Kimihisa Ichikawa , Jun Ohsumi
IPC分类号： A61K38/21 , A61K38/19 , A61K39/395 , C12N5/071 , A61P29/00 , A61P35/00 , A61P37/02 , C12N13/00
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/519 , A61K39/39541 , A61K41/00 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
摘要翻译： 本发明的抗体与人DR5或与人DR4相互作用以在受体下游产生激动或拮抗作用，包括抑制细胞增殖和细胞凋亡。 详细描述了任选与各种治疗剂组合的抗体的方法和用途，包括治疗凋亡相关疾病和治疗失调的细胞生长。
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