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    Compounds useful for inhibiting CHK1
    6.
    发明授权
    Compounds useful for inhibiting CHK1 失效
    可用于抑制CHK1的化合物

    公开(公告)号：US07560462B2

    公开(公告)日：2009-07-14

    申请号：US11630626

    申请日：2005-07-01

    申请人： John Joseph Gaudino ,  Adam Wade Cook

    发明人： John Joseph Gaudino ,  Adam Wade Cook

    IPC分类号： A61K31/497 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D411/10 ,  C07D413/10 ,  C07D417/10 ,  C07D419/10 ,  A61P35/00 ,  C07D241/14 ,  C07D241/16 ,  C07D241/20 ,  C07D211/70 ,  C07D211/84 ,  C07D213/89

    CPC分类号： C07D413/12 ,  C07D401/12 ,  C07D417/12

    摘要： Substituted urea compounds useful in the treatment of diseases and C1-3alkyleneOR3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X1 is null, —O—, —S—, —CH2—, or —N(R1)—; X2 is —O—, . -£>. -, or —N(R1)—,—. . Y xs 0 or S; or =y represents two hydrogen atoms attached to a common carbon atom, —W is selected from the group consisting of heteroaryl, aryl, heterocycloalkyl, cycloalkyl, and C1-6alkyl substituted with a heteroaryl. or aryl group; R6 is —C≡C—R7 or heteroaryl; R8, R9, and R10, independently, are selected from the group consisting of halo, optionally substituted C1-6alkyl, C2-6alkenyl, C2-6alkynyl, OCP3, CF3, NO2, CN, NC, N(R3)2, OR3, CO2R3, C(O)N (R3)2, C(O)R3, N(R1)COR3, N(R1)C(O)OR3, N(R8)C(O)OR3, N(R1)C(O)C1-3alkyleneC(O)R3, N(R1)C(O)C1 -3alkyleneC(O)OR3, N(R1)C(O)C1-3alkyleneOR3, N(R1)C(O)C1-3alkyleneNHC(O)OR3, N(R1)C(O)C1-3alkyleneSO2.NR3, C1-3alkyleneOR3, and SR3; Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

    摘要翻译： 公开了用于治疗疾病的取代的尿素化合物和与DNA复制中的DNA损伤或损伤相关的C1-3亚烷基三氮唑化合物，式（I）其中X 1为零，-O - ， - S - ， - CH 2 - 或-N （R1） - ; X2是-O-，。 - £>。 - 或-N（R 1） - ， - 。 。 Y xs 0或S; 或= y表示连接到共同碳原子上的两个氢原子，-W选自杂芳基，芳基，杂环烷基，环烷基和被杂芳基取代的C 1-6烷基。 或芳基; R6是-C≡C-R7或杂芳基; R 8，R 9和R 10独立地选自卤素，任选取代的C 1-6烷基，C 2-6烯基，C 2-6炔基，OCP 3，CF 3，NO 2，CN，NC，N（R 3）2，OR 3， CO 2 R 3，C（O）N（R 3）2，C（O）R 3，N（R 1）COR 3，N（R 1）C（O）OR 3，N（R 8）C（O）OR 3，N（R 1） O）C 1-3亚烷基C（O）R 3，N（R 1）C（O）C 1-3亚烷基C（O）OR 3，N（R 1）C（O） O）OR 3，N（R 1）C（O）C 1-3亚烷基-SO 2 NR 3，C 1-3亚烷基OR 3和SR 3; 还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗癌症和其它以DNA复制，染色体分离或细胞分裂缺陷为特征的疾病。

    Compounds Useful for Inhibiting Chk1
    7.
    发明申请
    Compounds Useful for Inhibiting Chk1 失效

    公开(公告)号：US20080214573A1

    公开(公告)日：2008-09-04

    申请号：US11630626

    申请日：2005-07-01

    申请人： John Joseph Gaudino ,  Adam Wade Cook

    发明人： John Joseph Gaudino ,  Adam Wade Cook

    IPC分类号： A61K31/497 ,  C07D241/10 ,  A61P35/00

    CPC分类号： C07D413/12 ,  C07D401/12 ,  C07D417/12

    摘要： Substituted urea compounds useful in the treatment of diseases and C1-3alkyleneOR3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X1 is null, —O—, —S—, —CH2—, or —N(R1)—; X2 is —O—,. -£>.-, or —N(R1)—, -.. Y xs 0 or S; or =y represents two hydrogen atoms attached to a common carbon atom, —W is selected from the group consisting or heteroaryl, aryl, heterocycloalkyl, cycloalkyl, and C1-6alkyl substituted with a heteroaryl, or aryl group; R6 is —C≡C—R7 or heteroaryl; R8, R9, and R10, independently, are selected from the group consisting of halo, optionally substituted C1-6alkyl, C2-6alkenyl, C2-6alkynyl, OCP3, CF3, NO2, CN, NC, N(R3)2, OR3, CO2R3, C(O)N (R3)2, C(O)R3, N(R1)COR3, N(R1)C(O)OR3, N(R8)C(O)OR3, N(R1)C(O)C1-3alkyleneC(O)R3, N(R1)C(O)C1-3alkyleneC(O)OR3, N(R1)C(O)C1-3alkyleneOR3, N(R1)C(O)C1-3alkyleneNHC(O)OR3, N(R1)C(O)C1-3alkyleneSO2, NR3, C1-3alkyleneOR3, and SR3; Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed

    Lighted display devices for producing static or animated visual displays, including animated facial features
    8.
    发明授权
    Lighted display devices for producing static or animated visual displays, including animated facial features 有权
    用于产生静态或动画视觉显示器的照明显示设备，包括动画面部特征

    公开(公告)号：US08647167B2

    公开(公告)日：2014-02-11

    申请号：US12907692

    申请日：2010-10-19

    申请人： Valerie J. Heilbron ,  Paul G. Clem ,  Adam Wade Cook

    发明人： Valerie J. Heilbron ,  Paul G. Clem ,  Adam Wade Cook

    IPC分类号： A63H30/00

    CPC分类号： A63H13/005 ,  A63H3/006 ,  A63H3/40 ,  A63H5/00

    摘要： An illuminated display device with a base member with a plurality of cavities therein. Illumination devices illuminate the cavities and emit light through an opening of the cavities in a pattern, and a speaker can emit sounds in synchronization with the pattern. A panel with translucent portions can overly the base member and the cavities. An animated talking character can have an animated mouth cavity complex with multiple predetermined mouth lighting configurations simulative of human utterances. The cavities can be open, or optical waveguide material or positive members can be disposed therein. Reflective material can enhance internal reflectance and light emission.

    摘要翻译： 一种照明显示装置，其具有在其中具有多个空腔的基底构件。 照明装置照亮空腔并通过图案的空腔的开口发光，并且扬声器可以与图案同步地发出声音。 具有半透明部分的面板可以覆盖基部构件和空腔。 动画谈话角色可以具有动画口腔复合物，其具有模拟人类言语的多个预定的嘴部照明配置。 空腔可以是开放的，或者可以将光波导材料或正构件设置在其中。 反光材料可以提高内部反射率和发光。

    Lighted Display Devices for Producing Static or Animated Visual Displays, Including Animated Facial Features
    9.
    发明申请
    Lighted Display Devices for Producing Static or Animated Visual Displays, Including Animated Facial Features 有权
    用于产生静态或动画视觉显示的照明显示设备，包括动画面部特征

    公开(公告)号：US20110092131A1

    公开(公告)日：2011-04-21

    申请号：US12907692

    申请日：2010-10-19

    申请人： Valerie J. Heilbron ,  Paul G. Clem ,  Adam Wade Cook

    发明人： Valerie J. Heilbron ,  Paul G. Clem ,  Adam Wade Cook

    IPC分类号： A63H3/00

    CPC分类号： A63H13/005 ,  A63H3/006 ,  A63H3/40 ,  A63H5/00

    摘要： An illuminated display device with a base member with a plurality of cavities therein. Illumination devices illuminate the cavities and emit light through an opening of the cavities in a pattern, and a speaker can emit sounds in synchronization with the pattern. A panel with translucent portions can overly the base member and the cavities. An animated talking character can have an animated mouth cavity complex with multiple predetermined mouth lighting configurations simulative of human utterances. The cavities can be open, or optical waveguide material or positive members can be disposed therein. Reflective material can enhance internal reflectance and light emission.

    摘要翻译： 一种照明显示装置，其具有在其中具有多个空腔的基底构件。 照明装置照亮空腔并通过图案的空腔的开口发光，并且扬声器可以与图案同步地发出声音。 具有半透明部分的面板可以覆盖基部构件和空腔。 动画谈话角色可以具有动画口腔复合物，其具有模拟人类言语的多个预定的嘴部照明配置。 空腔可以是开放的，或者可以将光波导材料或正构件设置在其中。 反光材料可以提高内部反射率和发光。