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    Truncated aggrecanase molecules
    2.
    发明申请
    Truncated aggrecanase molecules 审中-公开
    截短的聚蛋白聚糖酶分子

    公开(公告)号：US20070161046A1

    公开(公告)日：2007-07-12

    申请号：US11640482

    申请日：2006-12-15

    申请人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    发明人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64 ,  C07K16/40

    CPC分类号： C12N9/6421

    摘要： Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

    摘要翻译： 公开了截短的聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列及其生产方法。 此外，还公开了与野生型或天然聚集蛋白聚糖蛋白聚糖酶相比导致增加的稳定性和表达水平的氨基酸突变的聚集蛋白聚糖蛋白聚糖酶。 本发明的骨灰蛋白酶特别可用于开发用于治疗疾病如骨关节炎的组合物。 还公开了开发聚蛋白聚糖酶的抑制剂的方法和用于治疗以聚集蛋白聚糖降解为特征的病症的酶的抗体的方法。

    Truncated aggrecanase molecules
    3.
    发明申请
    Truncated aggrecanase molecules 失效
    截短的聚蛋白聚糖酶分子

    公开(公告)号：US20060257989A1

    公开(公告)日：2006-11-16

    申请号：US11488340

    申请日：2006-07-18

    申请人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    发明人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    IPC分类号： C12N9/64 ,  C07H21/04 ,  C12P21/06 ,  C07K16/40

    CPC分类号： C12N9/6421

    摘要： Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

    摘要翻译： 公开了截短的聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列及其生产方法。 此外，还公开了与野生型或天然聚集蛋白聚糖蛋白聚糖酶相比导致增加的稳定性和表达水平的氨基酸突变的聚集蛋白聚糖蛋白聚糖酶。 本发明的骨灰蛋白酶特别可用于开发用于治疗疾病如骨关节炎的组合物。 还公开了开发聚蛋白聚糖酶的抑制剂的方法和用于治疗以聚集蛋白聚糖降解为特征的病症的酶的抗体的方法。

    MODIFIED AND STABILIZED GDF PROPEPTIDES AND USES THEREOF
    5.
    发明申请
    MODIFIED AND STABILIZED GDF PROPEPTIDES AND USES THEREOF 失效
    修改和稳定的GDF预测及其用途

    公开(公告)号：US20070238683A1

    公开(公告)日：2007-10-11

    申请号：US11614594

    申请日：2006-12-21

    申请人： Neil Wolfman ,  Soo-Peang Khor ,  Kathleen Tomkinson

    发明人： Neil Wolfman ,  Soo-Peang Khor ,  Kathleen Tomkinson

    IPC分类号： A61K31/7052 ,  C07H21/04 ,  C12N15/00 ,  C12N5/06

    CPC分类号： C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2319/00

    摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).

    摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（例如肌萎缩性侧索硬化症，肌营养不良症，肌肉萎缩，充血性阻塞性肺病，肌肉萎缩综合症，肌营养不良或恶病质），代谢疾病或病症（如2型糖尿病，非胰岛素依赖性糖尿病 高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。

    MODIFIED AND STABILIZED GDF PROPEPTIDES AND USES THEREOF
    6.
    发明申请
    MODIFIED AND STABILIZED GDF PROPEPTIDES AND USES THEREOF 失效
    修改和稳定的GDF预测及其用途

    公开(公告)号：US20070149455A1

    公开(公告)日：2007-06-28

    申请号：US11614702

    申请日：2006-12-21

    申请人： Neil Wolfman ,  Soo-Peang Khor ,  Kathleen Tomkinson

    发明人： Neil Wolfman ,  Soo-Peang Khor ,  Kathleen Tomkinson

    IPC分类号： A61K38/18 ,  C07K14/475

    CPC分类号： C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2319/00

    摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).

    摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。