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19 条记录 (耗时 0.029 秒)

    Treatment of periodontal disease
    5.
    发明申请
    Treatment of periodontal disease 有权
    治疗牙周病

    公开(公告)号：US20050209171A1

    公开(公告)日：2005-09-22

    申请号：US11004677

    申请日：2004-12-03

    申请人： Leo Romanczyk ,  Harold Schmitz

    发明人： Leo Romanczyk ,  Harold Schmitz

    IPC分类号： A23G1/32 ,  A23G3/36 ,  A23K1/16 ,  A23K1/18 ,  A61K9/20 ,  A61K9/48 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/185 ,  A61K45/06 ,  C07D311/32 ,  C07D311/62 ,  C07D311/64 ,  C07H17/06 ,  C11B5/00

    CPC分类号： C07H17/06 ,  A23G1/32 ,  A23G3/36 ,  A23K20/111 ,  A23K50/40 ,  A61K9/2018 ,  A61K9/2068 ,  A61K9/4858 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/185 ,  A61K45/06 ,  C07D311/32 ,  C07D311/62 ,  C07D311/64 ,  C11B5/0035 ,  A61K2300/00

    摘要： Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula An, wherein A is a monomer of the formula: wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R is 3-(α)-OH, 3-(β)-OH, 3-(α)-O-sugar, or 3-(β)-O-sugar; bonding between adjacent monomers takes place at positions 4, 6 or 8; a bond of an additional monomeric unit in position 4 has alpha or beta stereochemistry; X, Y and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to the at least one terminal monomeric unit, bonding of the additional monomeric unit thereto (the bonding of the additional monomeric unit adjacent to the terminal monomeric unit) is at position 4 and optionally Y=Z=hydrogen; the sugar is optionally substituted with a phenolic moiety, at any position on the sugar, for instance via an ester bond, and pharmaceutically acceptable salts or derivatives thereof (including oxidation products).

    摘要翻译： 公开并要求保护的是可可提取物，化合物，其组合和含有它们的组合物，例如多酚或原花青素，制备此类提取物的方法，化合物和组合物，以及它们的用途，特别是式A的< 其中A是下式的单体：其中n是2至18的整数，使得存在至少一个末端单体单元A和一个或多个另外的单体单元; R是3-（α）-OH，3-（β）-OH，3-（α）-O-糖或3-（β）-O-糖; 相邻单体之间的结合发生在位置4,6或8; 位置4的附加单体单元的键具有α或β立体化学; X，Y和Z选自单体单元A，氢和糖，条件是对于至少一个末端单体单元，附加单体单元与其结合（附加单体单元的键合 邻近末端单体单元的单元）在位置4且任选地Y = Z =氢; 糖任选被酚部分取代，在糖上的任何位置，例如通过酯键，及其药学上可接受的盐或衍生物（包括氧化产物）。

    Compositions and methods of use of dimer digallates
    8.
    发明申请
    Compositions and methods of use of dimer digallates 审中-公开
    二聚物二氧化物的组合物和使用方法

    公开(公告)号：US20050277600A1

    公开(公告)日：2005-12-15

    申请号：US11153698

    申请日：2005-06-14

    申请人： Harold Schmitz ,  Catherine Kwik-Uribe ,  Mark Kelm ,  John Hammerstone ,  Leo Romanczyk

    发明人： Harold Schmitz ,  Catherine Kwik-Uribe ,  Mark Kelm ,  John Hammerstone ,  Leo Romanczyk

    IPC分类号： A61K31/353 ,  A61K31/7048

    CPC分类号： A61K31/7048 ,  A61K31/353

    摘要： The invention relates to compositions, such as pharmaceuticals, foods, food additives, or dietary supplements, containing dimer digallates, and methods of use thereof, for prophylactic or therapeutic treatment of a human or a veterinary animal to treat or prevent NO-responsive health conditions, treat hypertension, cardiovascular disease, coronary artery disease, diabetes, cognitive dysfunction or disorder and/or vascular circulation disorders, prevent or reduce the risk of heart attack, stroke, congestive heart failure and/or kidney failure, or to improve blood flow, for example renal blood flow. The composition may optionally contain an additional NO modulating agent and/or a vascular-protective or therapeutic agent, or may be administered in combination with such an agent.

    摘要翻译： 本发明涉及包含二聚物二胆酸盐的组合物，例如药物，食品，食品添加剂或膳食补充剂及其使用方法，用于预防或治疗人类或兽医动物治疗或预防NO反应性健康状况 治疗高血压，心血管疾病，冠状动脉疾病，糖尿病，认知功能障碍或障碍和/或血管循环障碍，预防或降低心脏病发作，中风，充血性心力衰竭和/或肾衰竭的风险，或改善血流量， 例如肾血流量。 组合物可以任选地含有另外的NO调节剂和/或血管保护性或治疗剂，或者可以与这种药物组合施用。