公开(公告)号：US4835287A

公开(公告)日：1989-05-30

申请号：US75616

申请日：1987-07-20

申请人： Katsuhiko Nagaoka ,  Masaru Matsumoto ,  Koichi Yokoi ,  Junji Oono ,  Kenichi Kukita ,  Toshiaki Nakashima

发明人： Katsuhiko Nagaoka ,  Masaru Matsumoto ,  Koichi Yokoi ,  Junji Oono ,  Kenichi Kukita ,  Toshiaki Nakashima

IPC分类号： C07G11/00 ,  A61K31/396 ,  A61K31/40 ,  A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07D487/04 ,  C07D487/08 ,  C12P1/06 ,  C12P17/18 ,  C12R1/465

CPC分类号： C07D487/08

摘要： A substance SS42227 represented by the following formula (I): ##STR1## in which X represents >CH.sub.2 or >C=CHOH. The substance has antimicrobial and antitumor activities, and thus is useful as a medicine.

摘要翻译： 由下式（I）表示的物质SS42227：其中X表示> CH2或> C = CHOH。 该物质具有抗菌和抗肿瘤活性，因此作为药物有用。

公开(公告)号：US4584377A

公开(公告)日：1986-04-22

申请号：US639113

申请日：1984-08-09

申请人： Koichi Yokoi ,  Hiroshi Hasegawa ,  Tadashi Narita ,  Takemitsu Asaoka ,  Kenichi Kukita ,  Seiji Ishizeki ,  Toshiaki Nakashima

发明人： Koichi Yokoi ,  Hiroshi Hasegawa ,  Tadashi Narita ,  Takemitsu Asaoka ,  Kenichi Kukita ,  Seiji Ishizeki ,  Toshiaki Nakashima

IPC分类号： C07D221/20 ,  C07D221/18

CPC分类号： C07D221/20

摘要： Disclosed herein are Fredericamycin A derivatives, each, represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or acyl group, A denotes ##STR2## and dotted bonds are optional, with a proviso that when A is ##STR3## or the dotted bonds are contained, R is other than hydrogen atom. They have excellent antibacterial and antitumor activities and at the same time, are extremely stable compared with Fredericamycin A.

摘要翻译： 本文公开的是由以下通式（I）表示的弗雷德里霉素A衍生物：其中R表示氢原子或酰基，A表示“IMAGE”，虚线键是任选的，条件是 当A为或包含点状键时，R不为氢原子。 它们具有优异的抗菌和抗肿瘤活性，同时与弗雷德霉素A相比非常稳定。

公开(公告)号：US4501752A

公开(公告)日：1985-02-26

申请号：US487829

申请日：1983-04-22

申请人： Koichi Yokoi ,  Koichi Tachibana ,  Kazuo Isomae ,  Toshiaki Nakashima

发明人： Koichi Yokoi ,  Koichi Tachibana ,  Kazuo Isomae ,  Toshiaki Nakashima

IPC分类号： C07D487/08 ,  A61K31/40 ,  A61P1/04 ,  A61K31/395

CPC分类号： A61K31/40

摘要： An antiulcer drug comprising Ikarugamycin as its active ingredient is disclosed.

摘要翻译： 公开了包含伊卡霉素作为其活性成分的抗溃疡药物。

公开(公告)号：US5008419A

公开(公告)日：1991-04-16

申请号：US451637

申请日：1989-12-18

申请人： Koichi Yokoi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Koichi Yokoi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum complex having the following formula (I) is disclosed, ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each independently represents a methyl group or an ethyl group, and the configuration of 1,2-diaminocyclohexane is either cis-, trans-l-, trans-d-, or trans-dl-.The compound possess excellent antitumor activity with a high therapeutic index and abundant water solubility, and thus are effective as an antitumor agent.

公开(公告)号：US5585511A

公开(公告)日：1996-12-17

申请号：US578490

申请日：1995-12-26

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Hidehiko Kohya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato ,  Tadayuki Kuraishi

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Hidehiko Kohya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato ,  Tadayuki Kuraishi

IPC分类号： A61K33/24 ,  A61K31/28 ,  A61K31/282 ,  A61P35/00 ,  C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum complex represented by the following formula (1): ##STR1## wherein the all symbols are defined in the disclosure; and a malignant tumor treating drug which contains the complex as an active ingredient. The platinum complex is excellent in antitumor effects and safety and is highly soluble in water, and therefore it is useful as an agent for use in the treatment of various malignant tumors.

摘要翻译： 由下式（1）表示的铂络合物：其中全部符号在本公开中定义; 和含有复合物作为活性成分的恶性肿瘤治疗药物。 铂络合物具有优异的抗肿瘤效果和安全性，并且高度可溶于水，因此可用作治疗各种恶性肿瘤的药剂。

公开(公告)号：US4968825A

公开(公告)日：1990-11-06

申请号：US418169

申请日：1989-10-06

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.

公开(公告)号：US4917595A

公开(公告)日：1990-04-17

申请号：US278845

申请日：1988-12-02

申请人： Susumu Nakamura ,  Koichi Yokoi ,  Hajime Nakamura

发明人： Susumu Nakamura ,  Koichi Yokoi ,  Hajime Nakamura

IPC分类号： B29C45/27

CPC分类号： B29C45/1777 ,  B29C45/2701 ,  B29C2045/2796

摘要： A nozzle touch sprue bushing device for a unit-type injection metal mold which includes a molding body such as a metal mold including an inner mold element which is removably mounted on an outer frame mounted on an injecting molding machine, wherein a sprue bush has a nozzle touch provided at a rear end thereof for fitting with an end of a nozzle of an injecting machine, and has a front end formed in such a fitting configuration as to allow fitting engagement thereof with a material admitting portion of a metal mold.

公开(公告)号：US4889480A

公开(公告)日：1989-12-26

申请号：US278855

申请日：1988-12-02

申请人： Susumu Nakamura ,  Koichi Yokoi

发明人： Susumu Nakamura ,  Koichi Yokoi

IPC分类号： B29C45/33

CPC分类号： B29C45/332 ,  Y10S425/058

摘要： A slide core mold for injection molding wherein a slider block provided in its front surface with an undercut core is slidably provided on the side of a core mold, a pressure receiving inclined surface provided with guide grooves in opposite sides being provided at the back thereof, projections fitted into said guide grooves are provided on opposite sides at a corresponding position of a cavity mold corresponding thereto, a block body formed in its front surface with a pressing inclined surface in contact with the pressure receiving inclined surface of the back of the slider block is projected, and the slider block is reciprocated in association with engagement and disengagement of the core mold and the cavity mold.

公开(公告)号：US5511440A

公开(公告)日：1996-04-30

申请号：US288073

申请日：1994-08-10

申请人： Yasushi Watanabe ,  Kiyoshi Okubo ,  Koichi Yokoi

发明人： Yasushi Watanabe ,  Kiyoshi Okubo ,  Koichi Yokoi

IPC分类号： B21C3/02 ,  B21C1/22 ,  B21K1/12 ,  B21K21/12 ,  B62D1/16

CPC分类号： B21K21/12 ,  B21C1/22 ,  B21K1/063 ,  B21K1/12

摘要： A hollow steering shaft having a good quality can be manufactured at a low cost by passing a blank tube having a circular cross section through a preliminary shaping die and then through a finishing shaping die. The blank tube which has passed through the preliminary shaping die is formed with two kinds of convex curve surface portions having different radii of curvature and arranged continuously, circumferentially and alternately. When the blank tube passes through the finishing shaping die, the larger convex curve surface portions are deformed into flat portions. As a result, a steering shaft having an elliptical cross section is manufactured.

摘要翻译： 通过使具有圆形横截面的坯管通过预成型模具然后通过精加工成型模具，可以以低成本制造质量好的中空转向轴。 已经通过预成形模的空白管由具有不同曲率半径的两种凸曲面部分形成，周向和交替地连续布置。 当坯管穿过精加工成型模具时，较大的凸曲面部分变形为平坦部分。 结果，制造了具有椭圆截面的转向轴。

公开(公告)号：US5018899A

公开(公告)日：1991-05-28

申请号：US546945

申请日：1990-07-02

申请人： Ritsuo Kuribara ,  Kiyoshi Okubo ,  Koichi Yokoi ,  Kiyoshi Sadakata

发明人： Ritsuo Kuribara ,  Kiyoshi Okubo ,  Koichi Yokoi ,  Kiyoshi Sadakata

IPC分类号： F16D1/06 ,  B21D17/00 ,  B21D53/86 ,  B62D1/16 ,  F16D1/08 ,  F16D3/26 ,  F16D3/38

CPC分类号： F16D3/387 ,  B62D1/16 ,  F16D1/0864 ,  Y10T403/32041 ,  Y10T403/32918

摘要： A yoke for universal joint is composed of a cylindrical coupling tube formed by pressing a metal plate and having a slit in a radial direction and serrate grooves on the internal periphery; a pair of flanges integrally formed at an end of the coupling tube and positioned on both sides of the slit; and a coupling arm formed by pressing a metal plate. One of the flanges has a screw hole, while the other flange has a hole, coaxial with the screw hole, for passing a bolt to be screwed into the screw hole. The coupling arm has a penetrating hole in the base portion, and mutually coaxial circular holes at its opposite ends. The yoke is assembled by fitting the other end of the coupling tube into the penetrating hole in the base portion, and connecting the other end of the coupling tube with the base portion of the coupling arm.

摘要翻译： 用于万向接头的磁轭由通过压制金属板并且在径向上具有狭缝并且在内周上具有锯齿槽形成的圆柱形联接管构成; 一对凸缘，一体地形成在连接管的端部并且位于狭缝的两侧; 以及通过按压金属板而形成的联接臂。 其中一个法兰具有螺纹孔，另一个法兰具有与螺钉孔同轴的孔，用于将螺栓拧入螺钉孔中。 联接臂在基部具有贯通孔，在其相对端具有相互同轴的圆形孔。 通过将联接管的另一端装配到基部的贯通孔中并将联结管的另一端与联接臂的基部连接而组装轭。