公开(公告)号：US4584377A

公开(公告)日：1986-04-22

申请号：US639113

申请日：1984-08-09

申请人： Koichi Yokoi ,  Hiroshi Hasegawa ,  Tadashi Narita ,  Takemitsu Asaoka ,  Kenichi Kukita ,  Seiji Ishizeki ,  Toshiaki Nakashima

发明人： Koichi Yokoi ,  Hiroshi Hasegawa ,  Tadashi Narita ,  Takemitsu Asaoka ,  Kenichi Kukita ,  Seiji Ishizeki ,  Toshiaki Nakashima

IPC分类号： C07D221/20 ,  C07D221/18

CPC分类号： C07D221/20

摘要： Disclosed herein are Fredericamycin A derivatives, each, represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or acyl group, A denotes ##STR2## and dotted bonds are optional, with a proviso that when A is ##STR3## or the dotted bonds are contained, R is other than hydrogen atom. They have excellent antibacterial and antitumor activities and at the same time, are extremely stable compared with Fredericamycin A.

摘要翻译： 本文公开的是由以下通式（I）表示的弗雷德里霉素A衍生物：其中R表示氢原子或酰基，A表示“IMAGE”，虚线键是任选的，条件是 当A为或包含点状键时，R不为氢原子。 它们具有优异的抗菌和抗肿瘤活性，同时与弗雷德霉素A相比非常稳定。

公开(公告)号：US4835287A

公开(公告)日：1989-05-30

申请号：US75616

申请日：1987-07-20

申请人： Katsuhiko Nagaoka ,  Masaru Matsumoto ,  Koichi Yokoi ,  Junji Oono ,  Kenichi Kukita ,  Toshiaki Nakashima

发明人： Katsuhiko Nagaoka ,  Masaru Matsumoto ,  Koichi Yokoi ,  Junji Oono ,  Kenichi Kukita ,  Toshiaki Nakashima

IPC分类号： C07G11/00 ,  A61K31/396 ,  A61K31/40 ,  A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07D487/04 ,  C07D487/08 ,  C12P1/06 ,  C12P17/18 ,  C12R1/465

CPC分类号： C07D487/08

摘要： A substance SS42227 represented by the following formula (I): ##STR1## in which X represents >CH.sub.2 or >C=CHOH. The substance has antimicrobial and antitumor activities, and thus is useful as a medicine.

摘要翻译： 由下式（I）表示的物质SS42227：其中X表示> CH2或> C = CHOH。 该物质具有抗菌和抗肿瘤活性，因此作为药物有用。

公开(公告)号：US4849512A

公开(公告)日：1989-07-18

申请号：US177483

申请日：1988-04-01

申请人： Minoru Tokizawa ,  Mari Otsuka ,  Kazuhiko Irinoda ,  Seiji Ishizeki ,  Fumio Ishii ,  Kenichi Kukita ,  Hideaki Matsuda ,  Tatsuhiko Katori

发明人： Minoru Tokizawa ,  Mari Otsuka ,  Kazuhiko Irinoda ,  Seiji Ishizeki ,  Fumio Ishii ,  Kenichi Kukita ,  Hideaki Matsuda ,  Tatsuhiko Katori

IPC分类号： C07H13/06 ,  A61K31/70 ,  A61K31/7024 ,  A61P35/00 ,  C07H9/04 ,  C07H13/04

CPC分类号： C07H13/04 ,  C07H9/04

摘要： Derivatives of 3-acylamino-3-deoxyallose represented by the following formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen atoms, or R.sup.1 and R.sup.2, and R.sup.3 and R.sup.4 may be in combination an isopropylidene group, R.sup.5 represents a hydrogen atom or alkyl group, and R.sup.6 represents a hydrogen atom or acyl group, are disclosed. One of the typical compound 3-deoxy-3-(3-tetradecanoyloxytetradecanoylamino)-1,2:5,6-di-O-isopropylidene- .alpha.-D-allofuranose is prepared by reacting 3-tetradecanoyloxytetradecanoic acid and 3-amino-3-deoxy-1,2:5,6-di-O-isopropylidene-.alpha.-D-allofuranose in the presence of N,N'-dicyclohexylcarbodiimide, as a dehydrating agent. The compound has an excellent carcinostatic activity.

公开(公告)号：US4684719A

公开(公告)日：1987-08-04

申请号：US734198

申请日：1985-05-15

申请人： Yoshihiro Nishikawa ,  Kimihiro Kanemitsu ,  Tatsuhiko Katori ,  Akihiro Shibata ,  Kenichi Kukita

发明人： Yoshihiro Nishikawa ,  Kimihiro Kanemitsu ,  Tatsuhiko Katori ,  Akihiro Shibata ,  Kenichi Kukita

IPC分类号： B01F17/42 ,  A61K31/70 ,  A61K31/7024 ,  A61K31/7028 ,  A61P31/04 ,  A61P35/00 ,  B01F17/56 ,  C07H13/06 ,  C07H15/18 ,  C07H13/02

CPC分类号： C07H13/06

摘要： Disclosed herein are novel .alpha.,.alpha.-trehalose fatty acid diester derivatives useful as carcinostatic substances and surface-activating materials and represented by the general formula (I): ##STR1## wherein R.sup.1 means an alkyl group having 1-21 carbon atoms, R.sup.2 denotes a hydrogen atom or carbobenzoxy group, and R.sup.3 stands for a hydrogen atom or benzyl group. Their preparation processes are also disclosed.

摘要翻译： 本文公开了可用作制癌物质和表面活化材料并由通式（I）表示的新型α，α-海藻糖脂肪酸二酯衍生物：其中R 1表示具有1-21个碳原子的烷基 R2表示氢原子或苄氧羰基，R3表示氢原子或苄基。 还公开了它们的制备方法。