摘要:
The present invention provides (R)-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine, (R)-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine, compounds analogous to them and pharmaceutical compositions containing such a compound. These compounds are useful for treating or preventing abnormal motor functions of gastrointestinal tracts, particularly irritable bowel syndrome.
摘要:
5,11-dihydrodibenzo[b,e][1,4]oxazepine derivatives of the following general formulae and analogs thereof have a calcium channel-antagonistic effect and they are effective in treating and preventing intestinal diseases such as abnormal motor function of digestive tracts, particularly, irritable bowel syndrome:
摘要:
The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal tracts
摘要:
A method for resolving optically impure 3-oxa-2-oxobicyclo�3.1.0!hexane-1-carboxylic acid esters. A method is provided for producing a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid.N-benzyl-.alpha.-phenylethylamine diastereomer salt. An enantiomer of N-benzyl-.alpha.-phenylethylamine is reacted with a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid to produce a precipitate that is enriched in one diastereomer of the salt. After isolating the optically active salt, the N-benzyl-.alpha.-phenylethylamine may be separated to produce the corresponding 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid. Under acidic conditions, the carboxylic acid and hydroxyl groups undergo ring closure to afford the optically active 3-oxa-2-oxobicyclo�3.1.0!hexane-1-carboxylic acid ester.
摘要:
A steering gear box mounting structure has a flexible support device for mounting a steering gear box to a vehicle body member and a flexible support device mounting portion for mounting the flexible support device to the steering gear box. The flexible support device is composed of an outer sleeve, an inner sleeve and an elastic body. The outer sleeve is conically shaped in its both axial end portions and is cylindrically shaped in its center portion. The inner sleeve is partially conically shaped in its axial end portions and is cylindrically shaped in its center portion. The elastic body is interposed between the outer and inner sleeves with a hollow space left therebetween. In the flexible support device, the outer sleeve is provided with an inclined surface inclined with respect to a direction perpendicular to the axis of the outer sleeve. Hence, the outer sleeve is vertically displaced relative to the inner sleeve in accordance with loads applied to the vehicle in left-to-right directions, thus making it possible to obtain a variable toe curve. The hollow space ensures a certain linear range.