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公开(公告)号：US07223858B2
公开(公告)日：2007-05-29
申请号：US11488340
申请日：2006-07-18
申请人： Katy E. Georgiadis , Tara K. Crawford , Kathleen N. Tomkinson , Lisa A. Collins-Racie , Christopher J. Corcoran , Bethany A. Freeman , Edward R. LaVallie
发明人： Katy E. Georgiadis , Tara K. Crawford , Kathleen N. Tomkinson , Lisa A. Collins-Racie , Christopher J. Corcoran , Bethany A. Freeman , Edward R. LaVallie
CPC分类号： C12N9/6421
摘要： Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
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公开(公告)号：US07150983B2
公开(公告)日：2006-12-19
申请号：US10358283
申请日：2003-02-05
申请人： Katy E. Georgiadis , Tara K. Crawford , Kathleen N. Tomkinson , Lisa A. Collins-Racie , Christopher J. Corcoran , Bethany A. Freeman , Edward R. Lavallie
发明人： Katy E. Georgiadis , Tara K. Crawford , Kathleen N. Tomkinson , Lisa A. Collins-Racie , Christopher J. Corcoran , Bethany A. Freeman , Edward R. Lavallie
CPC分类号： C12N9/6421
摘要： Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
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公开(公告)号：US07638604B2
公开(公告)日：2009-12-29
申请号：US10873972
申请日：2004-06-22
申请人： Jing Li , Xiang-Yang Tan , Kathleen N. Tomkinson , Debra D. Pittman , Geertruida M. Veldman , Lynette Fouser
发明人： Jing Li , Xiang-Yang Tan , Kathleen N. Tomkinson , Debra D. Pittman , Geertruida M. Veldman , Lynette Fouser
IPC分类号： C12P21/08 , A61K39/395
CPC分类号： C07K16/244 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N2799/022 , A61K2300/00
摘要： Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL-22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The antibodies disclosed herein are useful in diagnosing, preventing, or treating IL-22-associated immune disorders, e.g., autoimmune disorders (e.g., arthritis).
摘要翻译： 公开了结合白介素22（IL-22），特别是人IL-22的抗体及其抗原结合片段及其在调节IL-22相关免疫应答中的用途。 本文公开的抗体可用于诊断，预防或治疗IL-22相关免疫病症，例如自身免疫性疾病（例如关节炎）。
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公开(公告)号：US20120252884A1
公开(公告)日：2012-10-04
申请号：US13523391
申请日：2012-06-14
IPC分类号： A61K48/00 , C12N15/63 , C12N5/10 , A61P19/08 , A61P21/00 , A61P11/00 , A61P3/00 , C12N15/12 , C07K16/46
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US08222384B2
公开(公告)日：2012-07-17
申请号：US12434758
申请日：2009-05-04
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US07737116B2
公开(公告)日：2010-06-15
申请号：US11614702
申请日：2006-12-21
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US07202210B2
公开(公告)日：2007-04-10
申请号：US10071499
申请日：2002-02-08
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/02 , C12N5/06 , C07K14/475
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US08710025B2
公开(公告)日：2014-04-29
申请号：US13523391
申请日：2012-06-14
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US20100305194A1
公开(公告)日：2010-12-02
申请号：US12434758
申请日：2009-05-04
IPC分类号： A61K31/7088 , C07H21/04 , C07K1/00 , A61P21/00 , A61P3/10 , A61P3/04 , A61P19/02 , C12N15/63 , C12N1/00
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US07560441B2
公开(公告)日：2009-07-14
申请号：US11614594
申请日：2006-12-21
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（例如肌萎缩性侧索硬化症，肌营养不良症，肌肉萎缩，充血性阻塞性肺病，肌肉萎缩综合症，肌营养不良或恶病质），代谢疾病或病症（如2型糖尿病，非胰岛素依赖性糖尿病 高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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