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公开(公告)号：US07378546B2
公开(公告)日：2008-05-27
申请号：US11573583
申请日：2005-08-03
申请人： Kazuhiro Yamada , Norio Fushimi
发明人： Kazuhiro Yamada , Norio Fushimi
IPC分类号： C07C229/00
CPC分类号： C07C227/16 , C07C229/56
摘要： A method for producing 2-amino-5-iodobenzoic acid which comprises bringing 2-aminobenzoic acid (A) and molecular iodine (B) into reaction with each other in the liquid phase in the presence of an oxidizing agent. Hydrogen peroxide is preferable as the oxidizing agent. This method does not require a step for purifying 2-amino-5-iodobenzoic acid or a step for recovering iodine, and 2-amino-5-iodobenzoic acid having excellent quality can be produced economically advantageously with a great yield. The product can be advantageously used as an intermediate for drugs, an agricultural chemical and a raw material for functional chemicals.
摘要翻译： 一种2-氨基-5-碘苯甲酸的制备方法，其包括使2-氨基苯甲酸（A）和分子碘（B）在液相中在氧化剂存在下相互反应。 作为氧化剂，优选过氧化氢。 该方法不需要纯化2-氨基-5-碘苯甲酸的步骤或回收碘的步骤，可以以高产率有利地经济地生产具有优良品质的2-氨基-5-碘苯甲酸。 该产品可有利地用作药物，农药和功能性化学品原料的中间体。
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公开(公告)号：US20060167312A1
公开(公告)日：2006-07-27
申请号：US10563088
申请日：2004-07-01
IPC分类号： C07C63/04
CPC分类号： C07C51/363 , C07C63/70
摘要： The present invention provides a process for producing 5-iodo-2-methylbenzoic acid through iodination of 2-methylbenzoic acid, the process including, as essential steps, a reaction step of iodinating 2-methylbenzoic acid in the presence of a microporous compound, iodine, an oxidizing agent, and acetic anhydride, and a purification step including sublimation, distillation, crystallization, or a combination of two or more of these. According to the present invention, 5-iodo-2-methylbenzoic acid, which is useful for producing functional chemicals such as drugs, can be produced at high purity and high yield in a simple manner. Since the production process includes a simple reaction step and a simple separation/purification step, the load of purification is mitigated. In addition, the microporous compound such as a zeolite catalyst which has been separated and recovered from the reaction mixture can be repeatedly employed after performing of a simple treatment. Thus, the production process ensures a long service life of catalysts and high efficiency.
摘要翻译： 本发明提供了通过2-甲基苯甲酸碘化生产5-碘-2-甲基苯甲酸的方法，该方法包括作为必要步骤的步骤，在微孔化合物存在下碘化2-甲基苯甲酸，碘 ，氧化剂和乙酸酐，以及包括升华，蒸馏，结晶或这些中的两种或更多种的组合的纯化步骤。 根据本发明，可以以高纯度和高产率以简单的方式制备可用于制备功能性化学物质如药物的5-碘-2-甲基苯甲酸。 由于生产过程包括简单的反应步骤和简单的分离/纯化步骤，减轻了纯化负荷。 此外，在进行简单处理之后，可以重复使用从反应混合物中分离回收的微孔化合物如沸石催化剂。 因此，生产过程确保催化剂的使用寿命长，效率高。
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公开(公告)号：US07642374B2
公开(公告)日：2010-01-05
申请号：US10563088
申请日：2004-07-01
IPC分类号： C07C51/42
CPC分类号： C07C51/363 , C07C63/70
摘要： The present invention provides a process for producing 5-iodo-2-methylbenzoic acid through iodination of 2-methylbenzoic acid, the process including, as essential steps, a reaction step of iodinating 2-methylbenzoic acid in the presence of a microporous compound, iodine, an oxidizing agent, and acetic anhydride, and a purification step including sublimation, distillation, crystallization, or a combination of two or more of these. According to the present invention, 5-iodo-2-methylbenzoic acid, which is useful for producing functional chemicals such as drugs, can be produced at high purity and high yield in a simple manner. Since the production process includes a simple reaction step and a simple separation/purification step, the load of purification is mitigated. In addition, the microporous compound such as a zeolite catalyst which has been separated and recovered from the reaction mixture can be repeatedly employed after performing of a simple treatment. Thus, the production process ensures a long service life of catalysts and high efficiency.
摘要翻译： 本发明提供了通过2-甲基苯甲酸碘化生产5-碘-2-甲基苯甲酸的方法，该方法包括作为必要步骤的步骤，在微孔化合物存在下碘化2-甲基苯甲酸，碘 ，氧化剂和乙酸酐，以及包括升华，蒸馏，结晶或这些中的两种或更多种的组合的纯化步骤。 根据本发明，可以以高纯度和高产率以简单的方式制备可用于制备功能性化学物质如药物的5-碘-2-甲基苯甲酸。 由于生产过程包括简单的反应步骤和简单的分离/纯化步骤，减轻了纯化负荷。 此外，在进行简单处理之后，可以重复使用从反应混合物中分离回收的微孔化合物如沸石催化剂。 因此，生产过程确保催化剂的使用寿命长，效率高。
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公开(公告)号：US20070219396A1
公开(公告)日：2007-09-20
申请号：US11573583
申请日：2005-08-03
申请人： Kazuhiro Yamada , Norio Fushimi
发明人： Kazuhiro Yamada , Norio Fushimi
IPC分类号： C07C227/14
CPC分类号： C07C227/16 , C07C229/56
摘要： A method for producing 2-amino-5-iodobenzoic acid which comprises bringing 2-aminobenzoic acid (A) and molecular iodine (B) into reaction with each other in the liquid phase in the presence of an oxidizing agent. Hydrogen peroxide is preferable as the oxidizing agent. This method does not require a step for purifying 2-amino-5-iodobenzoic acid or a step for recovering iodine, and 2-amino-5-iodobenzoic acid having excellent quality can be produced economically advantageously with a great yield. The product can be advantageously used as an intermediate for drugs, an agricultural chemical and a raw material for functional chemicals.
摘要翻译： 一种2-氨基-5-碘苯甲酸的制备方法，其包括使2-氨基苯甲酸（A）和分子碘（B）在液相中在氧化剂存在下相互反应。 作为氧化剂，优选过氧化氢。 该方法不需要纯化2-氨基-5-碘苯甲酸的步骤或回收碘的步骤，可以以高产率有利地经济地生产具有优良品质的2-氨基-5-碘苯甲酸。 该产品可有利地用作药物，农药和功能性化学品原料的中间体。
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公开(公告)号：US07297821B2
公开(公告)日：2007-11-20
申请号：US11297408
申请日：2005-12-09
IPC分类号： C07C211/00
CPC分类号： C07F9/54 , C07B39/00 , C07C17/16 , C07C17/18 , C07C211/29 , C07C251/30 , C07C271/20 , C07F9/5004 , Y02P20/582
摘要： A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used for uses of surface treatment, cleaning and coating. Further, after the fluorination reaction, the above compound is recovered and can be reused as a starting material for producing the above fluorine compound, and it is useful for various fluorination processes. (wherein X represents a nitrogen or phosphorus atom; R0, R1, and R2 represent hydrogen, an alkyl group or aryl group which may have a substituent, and they each may be the same or different; and R0, R1, and R2 may be combined with each other to form a ring).
摘要翻译： 提供由式（1）表示的氟化合物。 上述氟化合物有效地将氟原子引入具有活性基团的化合物如含氧官能团，并且其可用于表面处理，清洁和涂覆的用途。 此外，在氟化反应之后，回收上述化合物，可以重复使用作为制备上述氟化合物的原料，可用于各种氟化处理。 （其中X表示氮或磷原子; R 0，R 1，R 2和R 2表示氢，烷基或芳基， 可以具有取代基，并且它们各自可以相同或不同;并且R 0，R 1和R 2可以与 彼此形成一个戒指）。
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6.发明授权公开(公告)号：US08993774B2
公开(公告)日：2015-03-31
申请号：US13996759
申请日：2011-12-22
申请人： Yutaka Kanbara , Takafumi Abe , Norio Fushimi
发明人： Yutaka Kanbara , Takafumi Abe , Norio Fushimi
IPC分类号： C07D211/70 , C07B41/02 , C07C29/00 , C07C41/26 , C07C29/128 , C07D213/30 , C07C213/00 , C07C29/09 , B01J23/04
CPC分类号： C07B41/02 , B01J23/04 , C07C29/00 , C07C29/09 , C07C29/128 , C07C41/26 , C07C213/00 , C07D213/30 , C07C33/18 , C07C33/22 , C07C33/26 , C07C33/20 , C07C43/23 , C07C33/46 , C07C215/68
摘要： A process of production of an aromatic alcohol or a heterocyclic aromatic alcohol, containing a step of reacting an aromatic amine or a heterocyclic aromatic amine having an aromatic ring or a heterocyclic aromatic ring having thereon at least one substituent —CHR1NR2R3 (wherein R1, R2 and R3 each independently represent hydrogen, an alkyl group having from 1 to 4 carbon atoms, or a benzyl group), with an alcohol, in the presence of a basic catalyst.
摘要翻译： 一种制备芳族醇或杂环芳族醇的方法，其包括使芳族胺或具有芳环的杂环芳族胺或其上具有至少一个取代基的杂环芳族环的芳基胺反应的步骤，其中R1，R2和 R 3各自独立地表示氢，具有1至4个碳原子的烷基或苄基）与醇在碱性催化剂的存在下反应。
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公开(公告)号：US07638652B2
公开(公告)日：2009-12-29
申请号：US12373583
申请日：2007-07-11
申请人： Takafumi Yoshimura , Toshio Hidaka , Norio Fushimi
发明人： Takafumi Yoshimura , Toshio Hidaka , Norio Fushimi
IPC分类号： C07C209/50
CPC分类号： C07C249/02 , C07C251/24
摘要： Provided is a one-step efficient production method for an α,α-difluoroamine of a general formula (1) below from an amide compound. The method is an economical method capable of producing the intended α,α-difluoroamine at high yield by reacting a starting amide compound with carbonyl fluoride and/or oxalyl fluoride under a specific condition.Formula (1)
摘要翻译： 本发明提供从酰胺化合物制备下述通式（1）的α，α-二氟胺的一步高效制备方法。 该方法是能够通过在特定条件下使起始酰胺化合物与碳酰氟和/或草酰氟反应而以高产率生产所需的α，α-二氟胺的经济方法。 公式1）
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8.发明授权High-purity (fluoroalkyl)benzene derivative and process for producing the same 失效高纯度（氟烷基）苯衍生物及其制备方法公开(公告)号：US07405331B2
公开(公告)日：2008-07-29
申请号：US10512990
申请日：2003-04-24
IPC分类号： C07C22/08
CPC分类号： C07C45/41 , C07B39/00 , C07C29/147 , C07C39/24 , C07C45/45 , C07C45/63 , C07C47/55 , C07C49/80 , C07C51/04 , C07C51/62 , C07C67/307 , C07C211/29 , C07C233/65 , C07C255/50 , C07C63/72 , C07C63/70 , C07C69/76 , C07C33/46
摘要： The process for producing a (fluoroalkyl)benzene derivative according to the present invention comprises a step of reducing the total content of group 3 to group 12 transition metals in an alkylbenzene derivative to 500 ppm or less in terms of metal atoms; a step of halogenating the branched alkyl group of the purified alkylbenzene derivative by a photohalogenation to obtain a (haloalkyl)benzene derivative; and a step of subjecting the (haloalkyl)benzene derivative to a halogen-fluorine exchange using HF in an amount of 10 mol or higher per one mole of the (haloalkyl)benzene derivative. The (fluoroalkyl)benzene derivative produced by the process is reduced in the content of impurities such as residual halogens and residual metals, and is useful as intermediates for functional chemical products for use in applications such as medicines and electronic materials.
摘要翻译： 本发明的（氟代烷基）苯衍生物的制造方法包括使烷基苯衍生物中的第1族第1族过渡金属的含量以金属原子换算为500ppm以下的步骤; 通过光卤化来卤化纯化的烷基苯衍生物的支链烷基以获得（卤代烷基）苯衍生物的步骤; 以及使用每10摩尔（卤代烷基）苯衍生物为10摩尔以上的HF的（卤代烷基）苯衍生物进行卤 - 氟交换的工序。 通过该方法制备的（氟代烷基）苯衍生物的残留卤素和残余金属等杂质含量降低，可用作药物和电子材料等应用中的功能性化学产品的中间体。
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公开(公告)号：US07777081B2
公开(公告)日：2010-08-17
申请号：US12299980
申请日：2007-05-08
CPC分类号： C07C5/2246 , C07B2200/07 , C07C45/49 , C07C45/67 , C07C45/82 , C07C45/83 , C07C45/85 , C07C47/546 , C07C2527/1206 , C07C2527/1213 , C07C2601/14 , C07C13/28
摘要： A process for effectively producing a 4-(4-alkylcyclohexyl)benzaldehyde, 4-(cyclohexyl)benzaldehyde, a 4-(trans-4-alkylcyclohexyl)benzaldehyde and a (trans-4-alkylcyclohexyl)benzene useful for electronic material applications such as liquid crystals and for pharmaceutical and agrochemical applications, etc., are disclosed. The present invention provides (1) a process for producing a 4-(4-alkylcyclohexyl)benzaldehyde or 4-(cyclohexyl)benzaldehyde by formylating a (4-alkylcyclohexyl)benzene or cyclohexylbenzene with carbon monoxide, (2) a process for producing a 4-(trans-4-alkylcyclohexyl)benzaldehyde by formylating a (4-alkylcyclohexyl)benzene having a cis/trans molar ratio of 0.3 or less with carbon monoxide, and (3) a process for producing a (trans-4-alkylcyclohexyl)benzene by isomerizing a mixture of the cis and trans isomers of a (4-alkylcyclohexyl)benzene, all of the processes being performed in the presence of HF and BF3.
摘要翻译： 用于电子材料应用的4-（4-烷基环己基）苯甲醛，4-（环己基）苯甲醛，4-（反-4-烷基环己基）苯甲醛和（反式-4-烷基环己基）苯的方法， 液晶，药用和农用化学品等。 本发明提供（1）通过用一氧化碳使（4-烷基环己基）苯或环己基苯甲酰化制备4-（4-烷基环己基）苯甲醛或4-（环己基）苯甲醛的方法，（2） 通过将顺式/反式摩尔比为0.3以下的（4-烷基环己基）苯与一氧化碳甲酰化，得到4-（反-4-烷基环己基）苯甲醛，（3）制备（反式-4-烷基环己基）苯甲醛的方法， 苯通过使（4-烷基环己基）苯的顺式和反式异构体的混合物异构化，所有方法都在HF和BF 3存在下进行。
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公开(公告)号：US07019173B2
公开(公告)日：2006-03-28
申请号：US10433412
申请日：2002-08-22
IPC分类号： C07C211/00
CPC分类号： C07F9/54 , C07B39/00 , C07C17/16 , C07C17/18 , C07C211/29 , C07C251/30 , C07C271/20 , C07F9/5004 , Y02P20/582
摘要： A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used for uses of surface treatment, cleaning and coating. Further, after the fluorination reaction, the above compound is recovered and can be reused as a starting material for producing the above fluorine compound, and it is useful for various fluorination processes. (wherein X represents a nitrogen or phosphorus atom; R0, R1, and R2 represent hydrogen, an alkyl group or aryl group which may have a substituent, and they each may be the same or different; and R0, R1, and R2 may be combined with each other to form a ring).
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