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公开(公告)号：US20070026055A1
公开(公告)日：2007-02-01
申请号：US11495603
申请日：2006-07-31
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61F2013/0296 , A61K31/465
摘要： The present invention provides a production method of a nicotine transdermal preparation, which includes a step of forming, on a support, an adhesive layer containing an adhesive and a liquid ingredient compatible with the adhesive, and a step of impregnating the adhesive layer with nicotine by continuously applying nicotine to the adhesive layer. The production method of the present invention permits direct application of nicotine to the adhesive layer, which is not possible by conventional techniques, and the nicotine transdermal preparation provided by the method is associated with less physical skin irritation on peeling off and affords a good feeling during adhesion.
摘要翻译： 本发明提供了一种尼古丁透皮制剂的制造方法，其包括在载体上形成含有粘合剂的粘合剂层和与粘合剂相容的液体成分的工序，以及通过使用尼古丁浸渍粘合剂层的工序 将尼古丁连续地施加到粘合剂层。 本发明的制造方法允许将尼古丁直接施用于粘合剂层，这通过常规技术是不可能的，并且通过该方法提供的尼古丁透皮制剂与剥离时较少的物理皮肤刺激相关联并且在剥离期间提供良好的感觉 附着力。
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公开(公告)号：US20060286160A1
公开(公告)日：2006-12-21
申请号：US11455740
申请日：2006-06-20
IPC分类号： A61K9/70
CPC分类号： A61K31/465 , A61K9/7061
摘要： The present invention provides a nicotine transdermal delivery system including an adhesive layer containing a free base nicotine and a liquid ingredient compatible with the adhesive, wherein the adhesive layer is crosslinked, and the liquid ingredient is contained in a proportion of 20-75 parts by weight, per 100 parts by weight of the adhesive layer as a whole. The nicotine transdermal delivery system has good adhesiveness and cohesion, and simultaneously achieves low irritation to the skin during peeling off and a fine feeling during adhesion.
摘要翻译： 本发明提供了一种尼古丁透皮递送系统，其包括含有游离碱性尼古丁和与粘合剂相容的液体成分的粘合剂层，其中粘合剂层交联，并且液体成分的含量为20-75重量份 ，相对于粘合剂层整体100重量份。 尼古丁透皮递送系统具有良好的粘附性和内聚力，同时在剥离期间对皮肤的刺激性低，并且粘合时的细微感觉。
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公开(公告)号：US20120225110A1
公开(公告)日：2012-09-06
申请号：US13399384
申请日：2012-02-17
申请人： Ryo Hashino , Hidetoshi Kuroda , Satoshi Ameyama , Shiro Satoda , Jun Ishikura
发明人： Ryo Hashino , Hidetoshi Kuroda , Satoshi Ameyama , Shiro Satoda , Jun Ishikura
CPC分类号： A61L15/58 , A61K9/7061 , A61L15/44 , Y10T428/2887 , Y10T428/2891 , C08L33/10
摘要： A patch according to an embodiment of the present invention includes a support and a pressure-sensitive adhesive layer provided on at least one surface of the support. The pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing a monomer mixture containing (a) a (meth)acrylic acid alkyl ester, (b) a hydroxyl group-containing monomer, and (c) a diketone group-containing monomer.
摘要翻译： 根据本发明的实施方式的贴片包括支撑体和设置在支撑体的至少一个表面上的压敏粘合剂层。 压敏粘合剂层含有通过共聚含有（a）（甲基）丙烯酸烷基酯，（b）含羟基单体和（c）含二酮基团的单体）的单体混合物而获得的丙烯酸共聚物。
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公开(公告)号：US20060034901A1
公开(公告)日：2006-02-16
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104Pa.s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译： 本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许 当在期望的特定时间段之后要从皮肤表面剥离时，容易剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体而言，本发明提供了一种粘合剂材料，其包含层压在载体的一个表面上的载体和粘合剂层，其中粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 6 包括两种具有不同流动性的合成橡胶。
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公开(公告)号：US08394404B2
公开(公告)日：2013-03-12
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译： 本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许 当在期望的特定时间段之后要从皮肤表面剥离时，易于剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体地说，本发明提供了一种粘合剂材料，其包含层叠在载体的一个表面上的载体和粘合剂层，其中所述粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 4 Pa·s，并且包含 两种具有不同流动性的合成橡胶。
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公开(公告)号：US08591939B2
公开(公告)日：2013-11-26
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.
摘要翻译： 本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性 种类具有不同分子量的聚异丁烯，增粘剂和有机液体。 具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体 两种聚异丁烯和上述增粘剂。
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公开(公告)号：US20060034900A1
公开(公告)日：2006-02-16
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.
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公开(公告)号：US08758312B2
公开(公告)日：2014-06-24
申请号：US13542994
申请日：2012-07-06
CPC分类号： A61K9/7061
摘要： The present invention provides a patch preparation that has an extremely low moisture permeability, has a sufficient ODT effect, is excellent in drug releasability and in anchoring property of its drug-containing pressure-sensitive adhesive layer, and has a preferred patch feeling. The patch preparation of the present invention includes a support; and a pressure-sensitive adhesive layer containing an adherent polymer and a drug on one surface of the support, wherein: the support has a polyester base layer, an inorganic oxide layer, and a polyester nonwoven fabric layer in the stated order; the polyester base layer has a thickness of 1.0 μm to 16 μm; and the pressure-sensitive adhesive layer is laminated on the polyester nonwoven fabric layer.
摘要翻译： 本发明提供一种具有极低的透湿性，足够的ODT效果，药物释放性和药物含粘合剂层的锚定性优异的贴片制剂，并且具有优选的贴片感。 本发明的贴片制剂包括支持体; 以及在载体的一个表面上含有粘着性聚合物和药物的粘合剂层，其中：所述载体具有所述顺序的聚酯基层，无机氧化物层和聚酯无纺布层; 聚酯基层的厚度为1.0μm〜16μm; 并且将压敏粘合剂层层压在聚酯无纺布层上。
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9.发明授权Transdermal patch having a pressure-sensitive adhesive comprising (meth)acrylic acid alkyl ester, N-hydroxyalkyl(meth)acrylamide, and vinyl monomers 有权具有包含（甲基）丙烯酸烷基酯，N-羟烷基（甲基）丙烯酰胺和乙烯基单体的压敏粘合剂的透皮贴剂公开(公告)号：US08361493B2
公开(公告)日：2013-01-29
申请号：US12945198
申请日：2010-11-12
申请人： Jun Ishikura , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Ryo Hashino , Satoshi Ameyama , Hidetoshi Kuroda
发明人： Jun Ishikura , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Ryo Hashino , Satoshi Ameyama , Hidetoshi Kuroda
CPC分类号： A61L15/585 , C09J133/26 , Y10T428/2887 , Y10T428/2891
摘要： The patch according to an embodiment of the present invention includes: a support; and a pressure-sensitive adhesive layer on at least one surface of the support, wherein: the pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing monomer components containing (a) at least one kind of a monomer of a (meth)acrylic acid alkyl ester and (b) at least one kind of a monomer of an N-hydroxyalkyl(meth)acrylamide; a content of the (meth)acrylic acid alkyl ester monomer (a) with respect to a total amount of the monomer components is 50 wt % to 90 wt % and a content of the N-hydroxyalkyl(meth)acrylamide monomer (b) with respect to the total amount is 1 wt % to 20 wt %; and the monomer components are substantially free of a monomer having a carboxyl group.
摘要翻译： 根据本发明的实施例的贴片包括：支撑件; 和压敏粘合剂层，其中：所述压敏粘合剂层含有丙烯酸共聚物，所述丙烯酸共聚物通过共聚含有（a）至少一种（甲基）丙烯酸单体的单体成分而得到的丙烯酸共聚物 酸性烷基酯和（b）至少一种N-羟烷基（甲基）丙烯酰胺的单体; 相对于单体成分的总量，（甲基）丙烯酸烷基酯单体（a）的含量为50重量％〜90重量％，N-羟烷基（甲基）丙烯酰胺单体（b）的含量与 相对于总量为1重量％〜20重量％ 并且单体组分基本上不含具有羧基的单体。
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公开(公告)号：US07056526B2
公开(公告)日：2006-06-06
申请号：US10230495
申请日：2002-08-29
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61L15/58 , Y10T428/28 , C08L39/06
摘要： The present invention provides a medical adhesive tape and a tape preparation for percutaneous absorption, both having an adhesive layer that resists glue remainder and stickiness upon peeling off of the tape even after adhesion to the human skin for a long time, and a medical adhesive composition to be used for such tapes. The medical adhesive composition of the present invention includes, as essential elements, (A) a copolymer containing (a) alkyl (meth)acrylate, wherein the alkyl moiety has 4 to 18 carbon atoms, in a proportion of not less than 50 wt % of the copolymer and (b) a carboxyl group-containing vinyl compound in a proportion of 0.1 wt %–10 wt % of the copolymer, (B) an alkoxide or a chelate compound of at least a metal selected from titanium, zirconium, zinc and aluminum, and (C) a polyol compound in a proportion of 0.2 wt %–5 wt % of the aforementioned medical adhesive composition. The medical adhesive tape of the present invention and tape preparation for percutaneous absorption are characterized in that the adhesive layer contains the above-mentioned medical adhesive composition of the present invention.
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