利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.019 秒)

    Production method of optically active imidazole compound, synthetic intermediate therefor and production method thereof
    1.
    发明授权
    Production method of optically active imidazole compound, synthetic intermediate therefor and production method thereof 失效
    光学活性咪唑化合物的制备方法及其合成中间体及其制备方法

    公开(公告)号：US6166221A

    公开(公告)日：2000-12-26

    申请号：US511782

    申请日：2000-02-23

    申请人： Kazuyuki Kawasaki ,  Haruhito Kobayashi ,  Syuji Ehara ,  Hideaki Sato

    发明人： Kazuyuki Kawasaki ,  Haruhito Kobayashi ,  Syuji Ehara ,  Hideaki Sato

    IPC分类号： A61K31/415 ,  A61P3/10 ,  A61P43/00 ,  C07D233/58 ,  C07D233/60 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： The present invention provides a method for producing an optically active 4-[.alpha.-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid or a pharmaceutically acceptable salt thereof, which includes subjecting a compound of the formula (I) wherein each symbol in the formula is as defined in the specification, to optical resolution by fractional crystallization to give an optically active compound thereof and subjecting the compound to hydrolysis reaction. According to this method, a resolution method useful for industrial large-scale production of the optically active compound of 4-[.alpha.-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid, which is useful as a thromboxane synthetase inhibitor and an agent for the prophylaxis and treatment of diabetic complications, can be obtained.

    摘要翻译： 本发明提供了一种制备光学活性的4- [α-羟基-5-（1-咪唑基）-2-甲基苄基] -3,5-二甲基苯甲酸或其药学上可接受的盐的方法，其包括使 其中式中每个符号如本说明书中所定义的式（I）通过分级结晶得到其光学活性化合物并使该化合物进行水解反应的光学拆分。 根据该方法，可以用于工业大规模生产4- [α-羟基-5-（1-咪唑基）-2-甲基苄基] -3,5-二甲基苯甲酸的光学活性化合物的分辨方法，其为 可用作血栓素合成酶抑制剂和用于预防和治疗糖尿病并发症的药剂。

    Process for producing optically active imidazole compounds, intermediates for synthesizing the same, and process for producing the same
    2.
    发明授权
    Process for producing optically active imidazole compounds, intermediates for synthesizing the same, and process for producing the same 失效
    光学活性咪唑化合物的制造方法，其合成用中间体及其制造方法

    公开(公告)号：US6066739A

    公开(公告)日：2000-05-23

    申请号：US355096

    申请日：1999-07-23

    申请人： Kazuyuki Kawasaki ,  Haruhito Kobayashi ,  Syuji Ehara ,  Hideaki Sato

    发明人： Kazuyuki Kawasaki ,  Haruhito Kobayashi ,  Syuji Ehara ,  Hideaki Sato

    IPC分类号： A61K31/415 ,  A61P3/10 ,  A61P43/00 ,  C07D233/58 ,  C07D233/60 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： The present invention provides a method for producing an optically active 4-[.alpha.-hydro-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid or a pharmaceutically acceptable salt thereof, which includes subjecting a compound of the formula (I) ##STR1## wherein each symbol in the formula is as defined in the specification, to optical resolution by fractional crystallization to give an optically active compound thereof and subjecting the compound to hydrolysis reaction. According to this method, a resolution method useful for industrial large-scale production of the optically active compound of 4-[.alpha.-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid, which is useful as a thromboxane synthetase inhibitor and an agent for the prophylaxis and treatment of diabetic complications, can be obtained.

    摘要翻译： PCT No.PCT / JP98 / 00150 Sec。 371日期：1999年7月23日 102（e）日期1999年7月23日PCT提交1998年1月14日PCT公布。 第WO98 / 32740号公报 日期：1998年7月30日本发明提供了一种光学活性的4- [α-氢-5-（1-咪唑基）-2-甲基苄基] -3,5-二甲基苯甲酸或其药学上可接受的盐的制备方法， 包括使式（I）化合物（其中式中的每个符号如说明书中所定义）通过分级结晶进行光学拆分，得到其光学活性化合物并使化合物进行水解反应。 根据该方法，可以用于工业大规模生产4- [α-羟基-5-（1-咪唑基）-2-甲基苄基] -3,5-二甲基苯甲酸的光学活性化合物的分辨方法，其为 可用作血栓素合成酶抑制剂和用于预防和治疗糖尿病并发症的药剂。

    Method of supplying parts and supplying device
    8.
    发明授权
    Method of supplying parts and supplying device 失效
    供应零件和供应装置的方法

    公开(公告)号：US5609463A

    公开(公告)日：1997-03-11

    申请号：US359894

    申请日：1994-12-20

    申请人： Haruhito Kobayashi ,  Yoshinobu Ohta ,  Shigeharu Nakahira

    发明人： Haruhito Kobayashi ,  Yoshinobu Ohta ,  Shigeharu Nakahira

    IPC分类号： H01R43/00 ,  G06M1/00

    CPC分类号： H01R43/005 ,  Y10T29/53535

    摘要： Recesses 12 are formed on an upper surface 10a of a turntable 10 detachably mountable on a support member 20. The recesses 12 are arranged at a pitch of a specified angle .theta. on a plurality of concentric circles C1 to C4 centered on a longitudinal axis 11. The turntable 10 is slid along an x-axis by an air cylinder 80 and is intermittently rotated by the specified angle .theta. by an air motor 40. In this way, a desired recess 12 can be moved to a receiving position P. The waterproof plugs can be securely supplied. A preparation for changing the kind of the waterproof can be made only by replacing the turntable, with the result that the preparation can be easily made within a short period of time.

    摘要翻译： 凹部12形成在可拆卸地安装在支撑构件20上的转台10的上表面10a上。凹槽12以指定角度θ的间距布置在以纵向轴线11为中心的多个同心圆C1至C4上。 转盘10通过气缸80沿x轴滑动，并通过气动马达40间歇地旋转指定的角度θ。以这种方式，期望的凹部12可移动到接收位置P.防水塞 可以安全地提供。 只能通过更换转盘来改变防水类型的准备，结果可以在短时间内容易地进行制备。

    Terminal temporary holding jig and an automatic terminal inserting apparatus
    9.
    发明授权
    Terminal temporary holding jig and an automatic terminal inserting apparatus 失效
    终端临时夹具和自动终端插入装置

    公开(公告)号：US06539616B1

    公开(公告)日：2003-04-01

    申请号：US09619433

    申请日：2000-07-19

    申请人： Shigeharu Nakahira ,  Yoshinobu Ota ,  Haruhito Kobayashi

    发明人： Shigeharu Nakahira ,  Yoshinobu Ota ,  Haruhito Kobayashi

    IPC分类号： B23P1900

    CPC分类号： H01R43/20 ,  H01R13/60 ,  H01R2201/26 ,  Y10T29/49208 ,  Y10T29/53174

    摘要： A terminal temporary holding jig (J) is provided for a later-inserted terminal (T). The terminal temporary holding jig (J) includes a terminal holder (1) secured to a base (B) of an automatic terminal inserting apparatus. A lid (2) is provided for opening and closing terminal insertion grooves (5) that extend in forward and backward directions in the terminal holder (1). The lid (2) can be attached magnetically in a closed condition on the terminal holder (1). A locking member (9) is provided in the lid (2) and includes a leaf spring with saw teeth that project obliquely backward into the terminal insertion grooves (5). A later-inserted terminal (T) can be inserted through a front end opening of the terminal insertion groove (5) in this state, and can be locked in the terminal insertion groove (5) by the engagement of a step “b” of the terminal (T) with the leading end of the locking member (9). The terminal (T) is taken out by rotating the base (B) into an inverted position, opening the lid (2) and pushing the terminal (T) and the wire (A) down together.

    摘要翻译： 为后插入端子（T）提供端子临时保持夹具（J）。 终端临时保持夹具（J）包括固定在自动终端插入装置的基座（B）上的端子座（1）。 设置有用于打开和关闭在端子保持器（1）中沿前后方向延伸的端子插入槽（5）的盖（2）。 盖子（2）可以在封闭状态下磁性地安装在端子座（1）上。 锁定构件（9）设置在盖（2）中，并且包括具有向后倾斜地突出到端子插入槽（5）中的锯齿的板簧。 在该状态下，插入端子（T）可以插入端子插入槽（5）的前端开口中，并且可以通过接合端子插入槽（5）的步骤“b” 所述端子（T）与所述锁定构件（9）的前端相连。 端子（T）通过将基座（B）旋转到倒立的位置而取出，打开盖子（2）并将端子（T）和导线（A）向下推到一起。

    Apparatus for fitting terminals and rubber stoppers on wires
    10.
    发明授权
    Apparatus for fitting terminals and rubber stoppers on wires 失效
    端子和橡胶塞在电线上的装置

    公开(公告)号：US4653182A

    公开(公告)日：1987-03-31

    申请号：US722228

    申请日：1985-04-11

    申请人： Michio Fukuda ,  Eiji Fudo ,  Koichi Tani ,  Haruhito Kobayashi

    发明人： Michio Fukuda ,  Eiji Fudo ,  Koichi Tani ,  Haruhito Kobayashi

    IPC分类号： B23P19/00 ,  B23P19/02 ,  H01R43/00

    CPC分类号： H01R43/005 ,  B23P19/007 ,  B23P19/02 ,  H01R13/5205 ,  H01R43/28 ,  Y10T29/49174 ,  Y10T29/4987 ,  Y10T29/53239 ,  Y10T29/53374 ,  Y10T29/53404 ,  Y10T29/53478 ,  Y10T29/53657

    摘要： A method of fitting a rubber stopper for a water-proof connector terminal onto an end portion of an electric wire includes the steps of: successively feeding a group of rubber stoppers aligned in a row in a state wherein each of the rubber stoppers has its longitudinal axis extending vertically; transferring each of the rubber stoppers into a stopper housing portion; retaining the electric wire disposed on an imaginary line passing through the center of the stopper housing portion; and press-fitting the wire into the rubber stopper, whereby the rubber stoppers are successively and continuously fitted on the respective wires. Also disclosed is an apparatus which may be suitably employed to carry out the above-described method. The apparatus includes an aligned stopper successively feeding section, a stopper transfer section, a rotary conveyor section, and a wire press-fitting section. The apparatus is further provided with an automatic control circuit adapted to allow the respective operations of the above-described section to be sequentially interlocked with each other.

    摘要翻译： 将用于防水连接器端子的橡胶塞配合到电线的端部上的方法包括以下步骤：在其中每个橡胶塞具有纵向的状态下，连续地供给一排排列成一排的橡胶塞 轴垂直延伸; 将每个橡胶塞子转移到止动器壳体部分中; 保持设置在通过止动器壳体部分的中心的假想线上的电线; 并将线压入橡胶塞中，由此橡胶塞连续地连续地装配在各个导线上。 还公开了可以适当地用于执行上述方法的装置。 该装置包括对准的塞子连续供给部分，止动器转移部分，旋转传送部分和线压配合部分。 该装置还设置有自动控制电路，其适于允许上述部分的相应操作彼此顺序地互锁。