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    SERUM OR PLASMA MICRORNA AS BIOMARKERS FOR NON-SMALL CELL LUNG CANCER
    1.
    发明申请
    SERUM OR PLASMA MICRORNA AS BIOMARKERS FOR NON-SMALL CELL LUNG CANCER 有权
    血清或血浆MICRORNA作为非小细胞肺癌的生物标志物

    公开(公告)号：US20110117565A1

    公开(公告)日：2011-05-19

    申请号：US12996967

    申请日：2009-12-14

    申请人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    发明人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

    摘要： The present invention provides non-small cell lung cancer markers and the use thereof. The non-small cell lung cancer markers in the present invention include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides a probe combination, kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting microRNAs in the serum of lung cancer patients. By detecting the variations of microRNAs in the serum of lung cancer patients, the disease can be diagnosed in vitro; the progression course of the disease can be predicted; the occurrence of complications, the rate of relapse and the prognosis of the disease can be monitored; the drug efficacy and therapeutic effects can be analyzed. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases, all of which make it an effective means for diagnosing diseases at an early stage.

    摘要翻译： 本发明提供非小细胞肺癌标志物及其用途。 本发明中的非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。 本发明还提供了用于检测非小细胞肺癌标志物的探针组合，试剂盒和生物芯片。 本发明还提供了一种检测肺癌患者血清中微小RNA的方法。 通过检测肺癌患者血清中microRNAs的变化，可以在体外诊断该疾病; 可以预测疾病的进展过程; 可以监测并发症的发生，复发率和预后; 可以分析药物的疗效和治疗效果。 本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。 该方法可应用于疾病综合调查，解决了以前单个标记物所遇到的低特异性和敏感性问题，并大大增加了疾病的临床检出率，这些都成为早期诊断疾病的有效手段 阶段。

    Serum or plasma microRNA as biomarkers for non-small cell lung cancer
    3.
    发明授权
    Serum or plasma microRNA as biomarkers for non-small cell lung cancer 有权
    血清或血浆microRNA作为非小细胞肺癌的生物标志物

    公开(公告)号：US09388470B2

    公开(公告)日：2016-07-12

    申请号：US12996967

    申请日：2009-12-14

    申请人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    发明人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

    摘要： The present invention provides non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides probe combinations, a kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting the said lung cancer markers. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases; it forms an effective means for diagnosing diseases at an early stage.

    摘要翻译： 本发明提供非小细胞肺癌标志物及其在体外诊断和监测疾病中的应用。 非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。 本发明还提供探针组合，用于检测非小细胞肺癌标志物的试剂盒和生物芯片。 本发明还提供了一种用于检测所述肺癌标志物的方法。 本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。 该方法可应用于疾病一般调查，解决了以前单个标记物遇到的低特异性和敏感性问题，大大提高了疾病的临床检出率; 它是早期诊断疾病的有效手段。

    Method for Modulating MicroRNA Content in Living Beings and the Use Thereof
    4.
    发明申请
    Method for Modulating MicroRNA Content in Living Beings and the Use Thereof 有权
    调节生物中微RNA含量的方法及其用途

    公开(公告)号：US20130078225A1

    公开(公告)日：2013-03-28

    申请号：US13641074

    申请日：2010-04-13

    申请人： Ke Zeng ,  Chenyu Zhang ,  Junfeng Zhang ,  Haijin Li

    发明人： Ke Zeng ,  Chenyu Zhang ,  Junfeng Zhang ,  Haijin Li

    IPC分类号： A61K35/14 ,  A61K35/28 ,  A61K35/36

    CPC分类号： A61K35/14 ,  A61K35/28 ,  A61K35/36 ,  C12N15/111 ,  C12N15/88 ,  C12N2310/141 ,  C12N2320/32

    摘要： The present invention relates to a method for modulating miRNA content in living beings and the use thereof, whereof the miRNAs are delivered initiatively and selectively by microparticles/MVs/exosomes to the circulatory system and target cells/tissues to perform various functions. The invention provides a novel combination of molecules that mediates the inter-cellular communication: the miRNAs secreted by cells through cellular MVs. Meanwhile, the present invention also provides a method for preparing cellular MVs entrapping certain miRNAs, and, according to the regulation and modification of gene expression in cells and tissues with the miRNA-entrapping cellular MVs, provides a novel method for modulating miRNA content in living beings, which is effective and adoptable to all cell types.

    摘要翻译： 本发明涉及一种用于调节生物中miRNA含量的方法及其用途，其中miRNA通过微粒/ MV /外来体主动和选择性递送至循环系统和靶细胞/组织以执行各种功能。 本发明提供介导细胞间通讯的分子的新型组合：通过细胞MV分泌细胞的miRNA。 同时，本发明还提供了一种制备截留某些miRNA的细胞MV的方法，并且根据miRNA携带细胞MV对细胞和组织中基因表达的调节和修饰，提供了调节生物中miRNA含量的新方法 生物，对所有细胞类型有效和可应用。