摘要:
The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).
摘要:
The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).
摘要:
A touch switch outlet mechanism has a fixation unit and a switch unit. The fixation unit includes an inlet waterway connected to the water source, a water diversion cavity connected to the inlet waterway, N number of water diversion holes connected to the water diversion cavity and several outlet functions with same number as the water diversion holes and one to one corresponding to the water diversion holes, N is equal to or more than 2; The switch unit includes N−1 number of sealing balls and N touch buttons, the N touch buttons are separately disposed with a touch end inside the water diversion cavity and a controlled end controlled by the user, the touch ends of the N touch buttons corresponding to N water diversion holes and sliding connected to the fixation unit, the N−1 sealing balls can close N−1 of the N water diversion holes.
摘要:
A device using the live welding method for aluminum electrolytic cell overhauling under series full current consists of short-circuit buses at the bottom of the cell (1), pillar buses (2), an anode bus (3), a balance bus (4), a inter-cell standby bus (5), a door-shaped pillar clamp (6), an arcuate clamp (7) of anode buses, a current conversion switch (8, a mechanical switching device (9) for the short-circuit port, a voltage sensor and wires thereof (10), a temperature sensor and wires thereof (11), a system (12) for data acquiring, displaying, analyzing and alarming, an A-side welding area (13), a B-side welding area (14) and compression-joint points (15) on pillar soft belts of overhauling cells; and the live welding method comprises the following steps: when welding is required to be performed in some zone, the currents of short-circuit buses at the bottom of the cell (1) and pillar buses (2) which influence the welding area most are cut off, the serial currents are shunted to other pillar buses (2), other buses at the bottom of the cell (1) and the inter-cell standby buses (5) such that the magnetic field intensity at the welding area can be lowered to the extent that welding can be performed so as to perform welding, and such a device and method can achieve live welding of aluminum electrolytic cells overhauling under series full current.
摘要:
An auto-rebound switching apparatus has: a body provided with a water-separating apparatus, an upper cover rotatably arranged on the rear side of the body, a passive disc rotatably arranged between the rear side of the body and the upper cover, a clutch mechanism comprising a bi-directional ratchet gear and a bi-directional pawl matching the ratchet gear, the ratchet gear being rotatably arranged on the rear side of the body and transmissively connected to the water-separating apparatus, thus allowing the ratchet gear, when rotating, to drive the water-separating apparatus into motion to allow switching, the bi-directional pawl, the upper cover, and the passive disc being interconnected, allowing the upper cover to rotate relative to the passive disc thus driving the bi-directional pawl to move between a forward rotation position, a reverse rotation position, and a detached position, and a rebound apparatus.
摘要:
A three-phase 48-pulse rectifier transformer consists of two 24-pulse rectifier transformers phase-shifted through valve-side output windings. Each 24-pulse rectifier transformer comprises two sets of grid-side input windings and four sets of valve-side output windings. The two sets of grid-side input windings are connected in parallel and axially arranged in a split manner. Among the four sets of valve-side output windings, two sets of valve-side output windings are radially arranged in a split manner corresponding to one set of grid-side input windings, and the other two sets of valve-side output windings are also radially arranged in a split manner corresponding to the other set of grid-side input windings. The two sets of valve-side output windings that are radially split and the other two sets of valve-side output windings that are radially split are axially arranged in a split manner. The grid-side input windings of the two 24-pulse rectifier transformers are phase-shifted with respect to each other. In this way, a uniform difference of 7.5° is produced in voltages of the eight sets of valve-side output windings of the two 24-pulse rectifier transformers, and the eight sets of valve-side output windings of the two 24-pulse rectifier transformers are correspondingly connected to rectifiers to form a uniform 48-pulse rectifier transformer, which not only reduces the harmonic current generated by the rectifier, but also improves the load capacity of the rectifier.
摘要:
A ball arm switching shower has a fixed unit and a switching mechanism. The fixed unit is provided with multiple outlet functions, a assembling slot and a water inlet passage, each outlet function is provided with a water division hole. The switching mechanism comprises a connecting part, a handle, a switching plate, a transmission shaft and a sealing piece. The connecting part can be mounted in the assembling slot in a sliding and swinging manner. The handle is fixedly connected to the connecting part. The transmission shaft can fixedly connect to the connecting part and the switching plate, so that the switching plate can be driven to swing and slide through the movement of the handle.
摘要:
Described is a method for controlling the wavelength of a laser in a wavelength division multiplexed (WDM) system. The method includes generating broadband light having a dithered optical power and a wavelength spectrum that includes a plurality of WDM wavelengths. The broadband light is spectrally filtered to generate a spectrally-sliced optical signal having a wavelength spectrum that includes one of the WDM wavelengths. The spectrally-sliced optical signal is injected into a laser and a dithered optical power of the laser is determined. A parameter of the laser is controlled in response to the determination of the dithered optical power to thereby align a wavelength of the laser to the wavelength spectrum of the spectrally-sliced optical signal.
摘要:
The embodiments of the present invention disclose an event detection method and device. The method includes: predefining event-based detection rules with a predicative context-free grammar; generating by parsing the detection rules a parsing table of pushdown automaton which supports parallel parsing; receiving an event to be detected; and analyzing by a controller the event to be detected according to the parsing table, to obtain a detection result. The present invention is especially applicable to detection of network attack events. The embodiments of the present invention detect the attacks with a predicative context-free grammar on the basis of events, and ensure a close combination of a protocol parsing process and an attack detection process, as well as a close combination of multiple attack detection rules, thus decreasing unnecessary calculations. In addition, with an optimized parallel pushdown automaton, the embodiments of the present invention can efficiently analyze the predicative context-free grammar. Consequently, besides hierarchical processing capability and state description capability, the embodiments of the present invention deliver high efficiency.
摘要:
The embodiments of the present invention disclose an event detection method and device. The method includes: predefining event-based detection rules with a predicative context-free grammar; generating by parsing the detection rules a parsing table of pushdown automaton which supports parallel parsing; receiving an event to be detected; and analyzing by a controller the event to be detected according to the parsing table, to obtain a detection result. The present invention is especially applicable to detection of network attack events. The embodiments of the present invention detect the attacks with a predicative context-free grammar on the basis of events, and ensure a close combination of a protocol parsing process and an attack detection process, as well as a close combination of multiple attack detection rules, thus decreasing unnecessary calculations. In addition, with an optimized parallel pushdown automaton, the embodiments of the present invention can efficiently analyze the predicative context-free grammar. Consequently, besides hierarchical processing capability and state description capability, the embodiments of the present invention deliver high efficiency.