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公开(公告)号：US5750650A
公开(公告)日：1998-05-12
申请号：US67180
申请日：1993-05-24
摘要： A novel peptide having molecular weight of 31,000 (SDS-PAGE) is obtained from aqueous extract of Natto or the culture of Bacillus natto by purification procedures including alcohol fractionation and/or salting out and hydrophobic chromatography, and the physicochemical properties, including the amino acid sequence, of the peptide are determined. The peptide is active in fibrinolysis, exhibits strong thrombolytic activity by oral administration and is useful as an oral thrombolytic agent.
摘要翻译： 通过包括醇分馏和/或盐析和疏水色谱法的纯化方法从Natto的水提取物或纳豆芽孢杆菌的培养物获得分子量为31,000的新型肽（SDS-PAGE），并且包括氨基酸的物理化学性质 确定肽的序列。 该肽在纤维蛋白溶解中有活性，通过口服给药具有强烈的溶栓活性，可用作口服溶栓剂。
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公开(公告)号：US5296223A
公开(公告)日：1994-03-22
申请号：US960259
申请日：1992-10-13
申请人： Koichiro Nakanishi , Hajime Hiratani , Kazuo Kato
发明人： Koichiro Nakanishi , Hajime Hiratani , Kazuo Kato
IPC分类号： A61K38/46 , A61K9/48 , A61K38/48 , A61P7/02 , A61K37/547
CPC分类号： A61K38/482
摘要： There are provided thrombolytic agents suited for oral administration. The agent comprises a proteolytic enzyme of subtilisin family, such as subtilisin BPN', subtilisin Carsberg, subtilisin amylosacchariticus, etc., produced by microorganisms belonging to genus Bacillus, such as Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens, etc. and, even when administered orally, exhibits thrombolytic activity.
摘要翻译： 提供适合口服给药的溶栓剂。 该试剂包括枯草杆菌蛋白酶家族的蛋白水解酶，如枯草杆菌蛋白酶BPN'，枯草杆菌蛋白酶Carsberg，枯草杆菌蛋白酶淀粉酵母等，由属于芽孢杆菌属的微生物如枯草芽孢杆菌，地衣芽孢杆菌，解淀粉芽孢杆菌等产生，并且即使 口服给药，具有溶栓活性。
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3.发明授权Process for preparing a heat-stable aqueous solution of human urine kallikrein and product prepared 失效制备人尿激肽释放酶热稳定水溶液的方法和制备的产品
公开(公告)号：US4500514A
公开(公告)日：1985-02-19
申请号：US557107
申请日：1983-12-01
IPC分类号： C12N9/96 , A61K38/48 , A61L2/00 , A61K37/553
CPC分类号： A61L2/0023 , A61K38/4853
摘要： Human urine kallikrein dissolved in water is made heat-stable by the addition of a citric acid salt such as sodium citrate, so that an aqueous solution containing the kallikrein and the citric acid salt can be sterilized at 60.degree. to 70.degree. C.
摘要翻译： 溶解在水中的人尿激肽释放酶通过加入柠檬酸钠等柠檬酸盐而使其稳定，使得含有激肽释放酶和柠檬酸盐的水溶液可以在60℃至70℃下灭菌。
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公开(公告)号：US4946785A
公开(公告)日：1990-08-07
申请号：US208156
申请日：1988-06-17
CPC分类号： C12N9/6462 , C12N9/96 , C12Y304/21073
摘要： The thermal degradation of urokinase in an aqueous solution is suppressed by heating an aqueous solution containing urokinase in the presence of citric acid or a water-soluble salt thereof such as sodium, potassium or lithium citrate at about 60.degree. C. for about 10 hours.
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5.发明授权Process for concentrating and separating trypsin inhibitor and kallidinogenase in human urine 失效浓缩和分离人尿中胰蛋白酶抑制剂和杀鼠肽素酶的方法
公开(公告)号：US4780209A
公开(公告)日：1988-10-25
申请号：US104634
申请日：1987-10-02
CPC分类号： C12N9/6445 , C07K14/8114 , Y10S435/814 , Y10S435/815
摘要： Two components, trypsin and kallidinogenase, in human urine are concentrated simultaneously by allowing human urine at neutral pH, collecting bubbles thus formed to obtain the concentrate of the two components, adjusting the concentrate to weak acidity, contacting the acidified concentrate with chitosan to allow the two components to be adsorbed onto chitosan, eluting the components from the adsorbent with aqueous ammonia solution, and neutralizing and heating the eluate at about 60.degree. C. for about 10 hours to make the eluate virus-free, followed by separating the components from the eluate.
摘要翻译： 将人尿中的两种成分，胰蛋白酶和杀鼠肽素酶同时浓缩，使人尿液处于中性pH值，收集形成的气泡，得到两种成分的浓缩物，将浓缩物调节至弱酸性，将酸化浓缩物与壳聚糖接触， 吸附在壳聚糖上的两种组分，用氨水溶液从吸附剂中洗脱组分，并在约60℃下中和并加热洗脱液约10小时，使洗脱液无病毒，然后将组分从 洗脱液
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公开(公告)号：US4510248A
公开(公告)日：1985-04-09
申请号：US509030
申请日：1983-06-29
CPC分类号： C12N9/6445
摘要： Human urinary kallikrein is concentrated and purified by the following procedures; (a) Human urine is contacted with chitosan, a high molecular agglutinant obtained from chitin, at a pH from 4.0 to 7.0, thereby kallikrein is adsorbed on the chitosan and (b) kallikrein is eluted from the chitosan with an aqueous alkaline solution having a pH from 8.0 to 12.0.
摘要翻译： 人尿激肽释放酶通过以下程序浓缩和纯化; （a）将人尿与壳多糖（几丁质获得的高分子凝集素）在4.0至7.0的pH下接触，由此激肽释放酶被吸附在壳聚糖上，（b）激肽释放酶用含有碱性溶液的水溶性脱乙酰壳多糖 pH 8.0〜12.0。
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公开(公告)号：US5371196A
公开(公告)日：1994-12-06
申请号：US115458
申请日：1993-09-01
申请人： Yoshikazu Yuki , Motoko Baba , Mitsuo Shimizu , Kazuo Kato , Hajime Hiratani
发明人： Yoshikazu Yuki , Motoko Baba , Mitsuo Shimizu , Kazuo Kato , Hajime Hiratani
CPC分类号： C07K16/04 , A61L2/0023 , A61K38/00 , Y10S530/861
摘要： Secretory immunoglobulin A preparations substantially not containing virus are produced by a process wherein secretory immunoglobulin A which might be contaminated with viruses is (1) heated about 60.degree. C. for about 10 hours, or (2) subjected to the reaction with tri-n-butyl phosphate and a surfactant and the heating as mentioned above, as liquidized form in an aqueous medium, and then polymerized matters are precipitated from the resulting solution by adding polyethyleneglycol thereto.
摘要翻译： 分泌型免疫球蛋白基本上不含病毒的制剂通过其中可能被病毒污染的分泌型免疫球蛋白A（1）加热约60℃约10小时的方法产生，或（2）与三硝基苯甲酸反应 磷酸丁酯和表面活性剂，并且如上所述的加热，在水性介质中作为液化形式，然后通过向其中加入聚乙二醇从所得溶液中沉淀出聚合物质。
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公开(公告)号：US5403731A
公开(公告)日：1995-04-04
申请号：US162382
申请日：1993-12-03
申请人： Yoshiyuki Nakano , Hajime Hiratani , Kazuo Kato
发明人： Yoshiyuki Nakano , Hajime Hiratani , Kazuo Kato
IPC分类号： A61K8/00 , A61K8/66 , A61K8/72 , A61K8/96 , A61K31/00 , A61K38/44 , A61P5/40 , A61P9/08 , A61P9/10 , A61P25/04 , A61P29/00 , A61P43/00 , C07D233/60 , C07K1/113 , C07K14/00 , C08G65/333 , C12N9/02 , C12N11/08 , C12N9/04 , C12N11/06
CPC分类号： C12N9/0089 , C08G65/33396
摘要： A modified superoxide dismutase represented by the formula: ##STR1## (wherein R is as defined below; SOD is a residue of superoxide dismutase) is produced, in a shortened period of reaction with a high and constant modification ratio, by reacting a polymeric carbonyldiimidazole derivative represented by the formula: ##STR2## (wherein R is a residue of a water soluble polymer having an average molecular weight of about 2,000 to 10,000) with superoxide dismutase in the presence of a buffer having a pH of 9.0 to 11.0 and a concentration of 0.1 M to 0.5 M, preferably 0.2 M to 0.4 M, at a temperature of 30.degree. to 70.degree. C., preferably 45.degree. to 60.degree. C. The modified superoxide dismutase thus produced exhibits a suitably prolonged blood half-life.
摘要翻译： 通过使聚合羰基二咪唑（聚合羰基二咪唑）反应，以缩短的反应速度缩短而制备由下式表示的改性超氧化物歧化酶：其中R定义如下; SOD为超氧化物歧化酶的残基; 在pH为9.0〜11.0的缓冲液和浓度为9.0〜11.0的存在下，用下式表示的衍生物：其中R为平均分子量为约2,000〜10,000的水溶性聚合物的残基，具有超氧化物歧化酶 在30至70℃，优选45-60℃的温度下，0.1M至0.5M，优选0.2M至0.4M。由此制备的改性超氧化物歧化酶表现出适当延长的血液半衰期。
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9.发明授权
公开(公告)号：US5281577A
公开(公告)日：1994-01-25
申请号：US962022
申请日：1992-10-15
申请人： Junichi Koga , Yasuhiro Ohashi , Hajime Hiratani
发明人： Junichi Koga , Yasuhiro Ohashi , Hajime Hiratani
IPC分类号： A61K38/00 , C07K14/375 , A61K37/02 , A61K35/84
CPC分类号： C07K14/375 , A61K38/00
摘要： An inhibitor of the proliferation of herpesviruses and of the recurrence of affections caused by their latent infection, which is an active material obtained by fractional purification of the aqueous extract from cultured Lentinus edodes mycelia.
摘要翻译： 疱疹病毒增生的抑制剂及其潜伏感染引起的感染复发，其是通过从培养的香菇菌丝体中分级纯化水提取物获得的活性物质。
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10.发明授权
公开(公告)号：US4479937A
公开(公告)日：1984-10-30
申请号：US524549
申请日：1983-08-19
申请人： Hiroshi Sato , Koji Sasaki , Kaname Takagi , Hajime Hiratani , Yoshikazu Yuki
发明人： Hiroshi Sato , Koji Sasaki , Kaname Takagi , Hajime Hiratani , Yoshikazu Yuki
CPC分类号： C07K14/8139
摘要： An anti-inflammatory agent comprising as an active component an inhibitor specifically inhibiting a thiol protease, which is obtained from human urine by extraction and purification. This agent has an action of inhibiting a disease caused by a thiol protease. This anti-inflammatory agent is prepared by a process in which a thiol protease inhibitor is extracted and purified from human urine by adopting in combination at least two treatments selected from a treatment with a molecular filter, a treatment with an ion exchanger, a treatment with an adsorber and an affinity chromatographic treatment.
摘要翻译： 一种抗炎剂，其包含通过提取和纯化从人尿获得的特异性抑制硫醇蛋白酶的抑制剂作为活性成分。 该药剂具有抑制由硫醇蛋白酶引起的疾病的作用。 该抗炎剂通过以下方法制备，其中通过组合使用选自以下的至少两种处理组合提取和纯化巯基蛋白酶抑制剂：选自用分子过滤器处理，用离子交换剂处理，用离子交换剂处理， 吸附剂和亲和色谱处理。
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