公开(公告)号：US07494657B2

公开(公告)日：2009-02-24

申请号：US10644221

申请日：2003-08-19

申请人： Hitoshi Nagaoka

发明人： Hitoshi Nagaoka

IPC分类号： A61K35/84 ,  A23L2/38

CPC分类号： A61K36/06 ,  C12P1/02 ,  C12R1/645

摘要： The inhibitor of Hepatitis B virus and HIV activity according to the present invention comprises a Lentinus edodes mycelium extract obtained by the steps of inoculating Lentinus edodes fungus in a solid culture medium comprising bagasse, then disentangling the solid culture medium containing the proliferated mycelium, adding water and at least one enzyme selected from a group consisting of cellulase, protease and glucosidase to the disentangled solid culture medium with keeping the solid culture medium at 30 to 50° C., grinding and milling the solid culture medium in the presence of the enzyme to obtain a Lentinus edodes mycelium extract, and then heating the extract to a temperature of not higher than 95° C. to inactivate the enzyme and sterilize the extract.

摘要翻译： 根据本发明的乙型肝炎病毒和HIV活性的抑制剂包括通过以下步骤获得的香菇菌丝体提取物，所述香菇菌丝体提取物在包含甘蔗渣的固体培养基中接种香菇菌体，然后将含有增殖菌丝体的固体培养基解开，加入水 和至少一种选自纤维素酶，蛋白酶和葡糖苷酶的酶至分离的固定培养基中，同时保持固体培养基在30至50℃，在酶存在下研磨和研磨固体培养基至 获得香菇菌丝体提取物，然后将提取物加热至不高于95℃的温度以灭活酶并对提取物进行灭菌。

公开(公告)号：US20050196409A1

公开(公告)日：2005-09-08

申请号：US10949178

申请日：2004-09-24

申请人： James Dao ,  Jeffrey Dao

发明人： James Dao ,  Jeffrey Dao

IPC分类号： A61K36/537 ,  A61K36/539 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G01N33/574 ,  G06F19/00 ,  A61K35/84 ,  A61K35/78

CPC分类号： A61K36/539 ,  A61K36/074 ,  A61K36/537 ,  A61K36/61 ,  Y02A90/26 ,  A61K2300/00

摘要： Methods for diagnosis of malignancy associated changes (MAC) using Automated Quantitative Cytometry (AQC) and treatment using compositions, extracts and compounds comprising botanical extracts. Use of such compounds in the prevention and therapy of cancer diagnosed by the AQC MAC test are also provided as well as methods for treatment using the compositions of this invention. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Compositions further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.

摘要翻译： 使用自动定量细胞计数（AQC）诊断恶性肿瘤相关变化（MAC）的方法和使用包含植物提取物的组合物，提取物和化合物进行治疗。 还提供了这些化合物在通过AQC MAC测试诊断的癌症的预防和治疗中的用途以及使用本发明组合物治疗的方法。 提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。 公开了在组合疗法中使用这些化合物的新的协同效应。 还提供还包含治疗有效量的至少一种化学治疗剂的组合物。

公开(公告)号：US06900240B2

公开(公告)日：2005-05-31

申请号：US10137490

申请日：2002-05-01

申请人： Mark Empie ,  Eric Gugger

发明人： Mark Empie ,  Eric Gugger

IPC分类号： A61K31/7042 ,  A23L1/30 ,  A23L1/304 ,  A61K31/00 ,  A61K31/704 ,  A61K31/7048 ,  A61K36/00 ,  A61K36/18 ,  A61K36/185 ,  A61K36/48 ,  A61K36/488 ,  A61K36/55 ,  A61K36/68 ,  A61K36/82 ,  A61K36/899 ,  A61P15/00 ,  A61P15/02 ,  A61P19/00 ,  A61P19/10 ,  A61P25/20 ,  C07D311/36 ,  A61K35/84 ,  A01N65/00

CPC分类号： C07D311/36 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K36/185 ,  A61K36/48 ,  A61K36/488 ,  A61K36/55 ,  A61K36/68 ,  A61K36/82 ,  A61K36/899 ,  Y10S514/823 ,  Y10S514/824 ,  Y10S514/874 ,  Y10S514/899 ,  Y10S514/923 ,  A61K2300/00 ,  A23V2250/2116 ,  A23V2250/2132

摘要： A composition is prepared by extracting and isolating phytochemical fractions from plant matter for treatment of cancer and especially for breast, prostate, skin, colon, urinary and bladder cancer. The composition is enriched preferably with two or more different phytochemical fractions, namely, isoflavones, lignans, saponins and saponogenins, catechins, and phenolic acids. The two selected fractions are different from each other and are combined specifically to form a composition to treat cancer. Soy is the preferred source of these phytochemicals; however, other plants may also be used, such as wheat, psyllium, rice, oats, red clover, kudzu, alfalfa, flax, and cocoa. The composition may be delivered in an easy to use or consume form, such as creams, pills, tablets, capsules, dry powder, health bars, food ingredients and supplements, tablets, soft gels, and the like.

摘要翻译： 通过从植物物质中提取和分离植物化学级分来治疗癌症，特别是对于乳腺癌，前列腺癌，皮肤癌，结肠癌，膀胱癌和癌症，制备组合物。 组合物优选用两种或更多种不同的植物化学级分富集，即异黄酮，木脂素，皂苷和皂角蛋白，儿茶素和酚酸。 两个选择的级分彼此不同，并且特异性组合以形成治疗癌症的组合物。 大豆是这些植物化学物质的首选来源; 然而，也可以使用其它植物，例如小麦，欧车前，大米，燕麦，红三叶草，葛，苜蓿，亚麻和可可。 组合物可以以易于使用或消费形式递送，例如霜剂，丸剂，片剂，胶囊，丸剂，干粉，健康酒吧，食品成分和补品，片剂，软凝胶等。

公开(公告)号：US20050095259A1

公开(公告)日：2005-05-05

申请号：US10699877

申请日：2003-11-04

申请人： Chien Liu

发明人： Chien Liu

IPC分类号： A01N63/04 ,  C12N1/14 ,  C12N3/00 ,  A61K35/84 ,  C12N1/16

CPC分类号： A61K36/062 ,  A01N63/04 ,  C12N1/14 ,  C12N3/00 ,  A01N25/22 ,  A01N2300/00

摘要： A manufacturing method for extomopathogenic fungi includes the following steps. Step A (drying): the cooked rice with the spores of metarhizium anisopliae is dried in a dry in a certain temperature to make the spores have a certain hydrous rate, and step B (sieving): the dried rice is stirred and some powder is added into the dried rice for the spores being easily detached from the dried rice and the dried rice is sieved from the spores and the powder.

摘要翻译： 致病真菌的制造方法包括以下步骤。 步骤A（干燥）：用一定温度的干燥将干燥的含有异青of孢子的米饭干燥，使孢子具有一定的含水率，并进行步骤B（筛分）：搅拌干燥的米，将一些粉末 加入到干米中，使孢子容易从干米中分离，并将干米从孢子和粉末中筛分。

公开(公告)号：US20050002962A1

公开(公告)日：2005-01-06

申请号：US10826559

申请日：2004-04-16

申请人： David Pasco ,  Nirmal Pugh ,  Ikhlas Khan ,  Rita Moraes

发明人： David Pasco ,  Nirmal Pugh ,  Ikhlas Khan ,  Rita Moraes

IPC分类号： A61K36/07 ,  A61K36/10 ,  A61K36/11 ,  A61K36/16 ,  A61K36/17 ,  A61K36/23 ,  A61K36/258 ,  A61K36/28 ,  A61K36/288 ,  A61K36/38 ,  A61K36/48 ,  A61K36/482 ,  A61K36/484 ,  A61K36/52 ,  A61K36/53 ,  A61K36/71 ,  A61K36/734 ,  A61K36/82 ,  A61K36/84 ,  A61K36/889 ,  A61K36/8962 ,  A61K36/9068 ,  A61K35/84 ,  A61K35/78

CPC分类号： A61K36/23 ,  A61K36/07 ,  A61K36/11 ,  A61K36/16 ,  A61K36/17 ,  A61K36/258 ,  A61K36/28 ,  A61K36/288 ,  A61K36/29 ,  A61K36/38 ,  A61K36/48 ,  A61K36/481 ,  A61K36/482 ,  A61K36/484 ,  A61K36/52 ,  A61K36/53 ,  A61K36/71 ,  A61K36/734 ,  A61K36/80 ,  A61K36/82 ,  A61K36/84 ,  A61K36/889 ,  A61K36/8962 ,  A61K36/9068 ,  A61K2300/00

摘要： A melanin preparation as an immunostimulatory agent from at least one of the following botanicals: Echinacea, American ginseng, black walnut, green tea, Parthenium integrifolium, Korean ginseng, alfalfa sprouts, ginger, goldenseal, red clover, dandelion, black cohosh, licorice, chamomile, milk thistle, alfalfa, horsetail, astragalus, gotu kola, feverfew, valerian, hawthorn, rosemary, saw palmetto, ephedra, pau d'arco, ginkgo, garlic, St. John's wort, Agaricus bisporus (common mushroom), Agaricus bisporus brown strain (portabella mushroom), Lentinus edodes (shiitake mushroom) or Boletus edulis (porcini mushroom). Also disclosed is methods of treating a subject requiring immune mediation comprising administering to said subject a therapeutically effective amount of a melanin preparation from any one of the following botanicals: Echinacea, American ginseng, black walnut, green tea, Parthenium integrifolium, Korean ginseng, alfalfa sprouts, ginger, goldenseal, red clover, dandelion, black cohosh, licorice, chamomile, milk thistle, alfalfa, horsetail, astragalus, gotu kola, feverfew, valerian, hawthorn, rosemary, saw palmetto, ephedra, pau d'arco, ginkgo, garlic, St. John's wort, Agaricus bisporus (common mushroom), Agaricus bisporus brown strain (portabella mushroom), Lentinus edodes (shiitake mushroom), Boletus edulis (porcini mushroom).

摘要翻译： 作为以下植物药中的至少一种植物药物的免疫刺激剂的黑色素制剂：紫锥菊，西洋参，黑胡桃，绿茶，碲化ium，韩国人参，苜蓿芽，姜，金缕梅，红三叶草，蒲公英，黑芋，甘草， 洋甘菊，牛奶蓟，苜蓿，马尾，黄芪，胡萝卜，发烧，缬草，山楂，迷迭香，锯棕榈，麻黄，波尔多，银杏，大蒜，圣约翰麦芽汁，双孢蘑菇（普通蘑菇），双孢蘑菇 棕色菌株（Portabella mushroom），香菇（香菇）或牛肝菌（porcini mushroom）。 还公开了治疗需要免疫介导的受试者的方法，包括向所述受试者施用治疗有效量的以下植物药物中的任一种的黑色素制剂：紫锥菊，西洋参，黑胡桃，绿茶，碲化ium，韩国人参，苜蓿 豆芽，姜，黄金，红三叶草，蒲公英，黑co，甘草，洋甘菊，牛奶蓟，苜蓿，马尾，黄芪，芥菜，发烧，缬草，山楂，迷迭香，锯棕榈，麻黄， 大蒜，圣约翰麦芽汁，双孢蘑菇（普通蘑菇），双孢蘑菇棕色菌株（Portabella mushroom），香菇（香菇），牛肝菌（porcini mushroom）。

公开(公告)号：US20050002961A1

公开(公告)日：2005-01-06

申请号：US10491229

申请日：2002-10-08

申请人： Hans-Peter Wild ,  Matthias Sass

发明人： Hans-Peter Wild ,  Matthias Sass

IPC分类号： A23L2/38 ,  A23F3/16 ,  A23L2/385 ,  A23L2/52 ,  A23L33/105 ,  A61K31/352 ,  A61K31/375 ,  A61K31/7028 ,  A61K36/00 ,  A61K36/07 ,  A61K36/18 ,  A61K36/185 ,  A61K36/82 ,  A61K36/87 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  A61P39/06 ,  A61K35/84 ,  A61K35/78

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/07 ,  A61K36/185 ,  A61K36/82 ,  A61K36/88 ,  A61K2300/00 ,  A23V2250/214 ,  A23V2250/21

摘要： The present invention relates to a concentrate of vegetable extracts, comprising green-tea, grape-skin extract, and grape-seed extract. The concentrate of the invention can be used for the production of beverages having, despite a high polyphenol content, a low degree of bitterness acceptable to the consumer. The present invention further relates to a process for the production of said concentrate.

摘要翻译： 本发明涉及植物提取物的浓缩物，其包含绿茶，葡萄皮提取物和葡萄籽提取物。 本发明的浓缩物可以用于生产尽管多酚含量高的消费者可接受的低度苦味的饮料。 本发明还涉及生产所述浓缩物的方法。

公开(公告)号：US20060002954A1

公开(公告)日：2006-01-05

申请号：US11155682

申请日：2005-06-20

申请人： Akira Tabata ,  Takumi Nakamura

发明人： Akira Tabata ,  Takumi Nakamura

IPC分类号： A61K35/84 ,  A61K35/78

CPC分类号： A61K45/06 ,  A61K36/062 ,  A61K36/48 ,  A61K36/899 ,  A61K36/8994 ,  A61K2236/19 ,  A61K2300/00

摘要： The object of the present invention is to provide a composition which is capable of going into erythrocyte or into cells, trapping not only oxygen radicals but also hydroxyl radicals, and preventing or improving various symptoms including hypertension, excessive sensitivity to cold, diabetes, Parkinson's disease, menstrual disorder, brain infarct, atopic dermatitis, hay fever, articular rheumatism, autonomic ataxia, and the like by oral intake. The present invention relates to an invention of a composition trapping radicals in organism comprising the steps of: roasting soy bean, wheat germ, adlay, husked rice germ, and rice bran, which are materials at a temperature of 50 to 150° C. independently, followed by steaming them independently, and fermenting them independently with each of said materials by adding at least one species of edible microbes selected from microbes belonging to Aspergilius oryzae, and after fermentation, adding fine powders of at least green tea powders, sesame, rosemary, acerola, yuzu, carrot, Gymnema Sylvestre and green barley to each of said materials thereafter mixing, further followed by making the mixture ultra fine powders with 30 to 50 μm.

摘要翻译： 本发明的目的是提供能够进入红细胞或细胞的组合物，不仅捕获氧自由基而且捕获羟基，并且预防或改善各种症状，包括高血压，对感冒的过度敏感性，糖尿病，帕金森病 月经紊乱，脑梗死，特应性皮炎，花粉症，关节风湿病，自主性共济失调等。 本发明涉及一种在生物体中捕获自由基的组合物的发明，其包括以下步骤：独立地焙烧大豆，小麦胚芽，阿德莱，脱壳米胚芽和米糠，它们是温度在50至150℃的材料 ，然后独立地蒸煮，并通过加入至少一种选自属于米曲霉的微生物的食用微生物，每种所述材料进行发酵，发酵后加入至少绿茶粉末，芝麻，迷迭香的细粉 ，槭树，柚子，胡萝卜，Gymnema Sylvestre和绿色大麦，然后混合，然后混合超细粉末30-50um。

公开(公告)号：US20050238655A1

公开(公告)日：2005-10-27

申请号：US11029861

申请日：2005-01-04

申请人： Paul Stamets

发明人： Paul Stamets

IPC分类号： A61K36/06 ,  A61P31/12 ,  A61P31/18 ,  A61K35/84

CPC分类号： A61K36/07 ,  A61K36/074 ,  C12N2760/12211

摘要： Compounds having unique antiviral properties are prepared from medicinal mushroom mycelium, extracts and derivatives. The compositions are derived from Fomitopsis, Piptoporus, Ganoderma resinaceum and blends of medicinal mushroom species and are useful in preventing and treating viruses including Pox and HIV viruses.

公开(公告)号：US20050180988A1

公开(公告)日：2005-08-18

申请号：US10777652

申请日：2004-02-13

申请人： Chee-Keung Chung ,  Siu-Kan Tong

发明人： Chee-Keung Chung ,  Siu-Kan Tong

IPC分类号： A61K8/97 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  A61K35/84

CPC分类号： A61K36/074 ,  A61K8/9706 ,  A61K2800/75 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  Y10S435/911

摘要： The present invention provides an external preparation for skin which contains, as a major ingredient, oleaginous substances extracted from sporoderm-broken spores from Ganoderma lucidum. The spores are preferably being treated with germination activation. The oleaginous substances are preferred to be extracted by a supercritical fluid-carbon dioxide (SCF-CO2) method. The oleaginous substances prepared by SCF-CO2 is transparent and odorless. They also demonstrates effects on skin smoothening, wrinkles reduction, aging defiance, inflammation lessening, pigmentation lightening, and irritation alleviation. The external preparation can be a cosmetic or a therapeutic composition.

摘要翻译： 本发明提供皮肤外用剂，其含有从灵芝孢子破碎的孢子提取的油质物质作为主要成分。 孢子优选用发芽活化处理。 含油物质优选通过超临界流体二氧化碳（SCF-CO 2 H 2）法萃取。 由SCF-CO 2制备的含油物质是透明和无臭的。 它们还表现出对皮肤平滑化，皱纹减轻，抗衰老，减轻炎症，色素沉着减轻和刺激缓解的作用。 外用制剂可以是化妆品或治疗组合物。

公开(公告)号：US20050158258A1

公开(公告)日：2005-07-21

申请号：US10761810

申请日：2004-01-21

申请人： Louis Fisher

发明人： Louis Fisher

IPC分类号： A61K8/36 ,  A61K8/49 ,  A61K8/67 ,  A61K8/97 ,  A61K8/98 ,  A61K31/385 ,  A61K31/455 ,  A61Q17/00 ,  A61Q19/08 ,  A61K7/021 ,  A61K7/025 ,  A61K35/84

CPC分类号： A61K31/455 ,  A61K8/361 ,  A61K8/4986 ,  A61K8/675 ,  A61K8/97 ,  A61K8/987 ,  A61K31/385 ,  A61K36/07 ,  A61Q17/00 ,  A61Q19/08 ,  A61K2300/00

摘要： The present invention relates to novel methods and compositions comprising a combination of ingredients for treating aged, mature, nutritionally-compromised, or environmentally-damaged skin. These methods and compositions provide improvements in the skin's visual appearance, physiological functions, clinical properties, and biophysical properties. The compositions of the present invention can include, for example, a compound that stimulates microcirculation through the skin, a compound that stimulates the immune system, a compound that reduces ultraviolet light or sun exposure damage, a compound that evens out the pigmentation of the skin, and/or a compound that improves the barrier properties of the skin.

摘要翻译： 本发明涉及新颖的方法和组合物，其包含用于治疗老化，成熟，营养受损或受环境破坏的皮肤的成分的组合。 这些方法和组合物提供了皮肤的视觉外观，生理功能，临床特性和生物物理性质的改善。 本发明的组合物可以包括例如刺激皮肤的微循环的化合物，刺激免疫系统的化合物，减少紫外线或日晒暴露损伤的化合物，能缓解皮肤色素沉着的化合物 ，和/或改善皮肤屏障性能的化合物。