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公开(公告)号：US20050236317A1
公开(公告)日：2005-10-27
申请号：US11062113
申请日：2005-02-18
CPC分类号： B01L3/50255 , B01L2200/025 , B01L2200/0642 , B01L2300/0829 , B01L2300/0851 , B01L2400/022 , B01L2400/024 , B01L2400/049
摘要： The present invention relates to a multiwell filtration plate system formed of a multiwell filter plate, an underdrain, preferably having spouts as the outlet from the underdrain and a collection device such as a collection plate and the use of a mechanical device such as a fixture in the form of a post, a ramp, a rib, a spout protector ring and the like formed in the collection plate wells or on the outside of the underdrain or both for contacting a forming pendant drop formed on the spout of the underdrain and transferring it to the collection plate well.
摘要翻译： 本发明涉及一种多孔过滤板系统，该多孔过滤板系统由多孔过滤板形成，底部划痕优选具有作为出口的出口，以及收集装置如收集板，以及诸如固定装置之类的机械装置 形成在收集板井中或在缺水或两者的外部形成的柱，斜坡，肋，喷口保护环等的形式，用于接触形成在漏斗的喷口上的成形侧滴并将其转移 到收集盘好。
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公开(公告)号：US20050236318A1
公开(公告)日：2005-10-27
申请号：US11062115
申请日：2005-02-18
CPC分类号： B01L3/50255 , B01L2200/0615 , B01L2200/141 , B01L2300/0829 , B01L2300/165 , B01L2400/049
摘要： The present invention provides a device in a multiwell plate that allows for one to obtain substantially all of the liquid that has flowed through the filter thereby reducing hold up volume. This is accomplished by forming at least one hydrophobic area in the hydrophilic filter in each well. After the filtration has occurred, air is allowed to enter the underdrain of the plate through the hydrophobic area(s) which causes any residual fluid held by surface tension to be released and to flow out of the underdrain to the outside environment.
摘要翻译： 本发明提供了一种多孔板中的装置，其允许人们获得基本上已经流过过滤器的所有液体，从而减小了保持体积。 这通过在每个孔中的亲水过滤器中形成至少一个疏水区域来实现。 在发生过滤之后，允许空气通过疏水区域进入板的暗处，从而使得由表面张力保持的任何残留液体被释放并从暗处流出外部环境。
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公开(公告)号：US20050236319A1
公开(公告)日：2005-10-27
申请号：US11062116
申请日：2005-02-18
申请人： Marc Emerick , Christopher Scott , Steven Sheridan
发明人： Marc Emerick , Christopher Scott , Steven Sheridan
CPC分类号： B01L3/50255 , B01L2200/0684 , B01L2300/0829 , B01L2400/024 , B01L2400/049
摘要： The present invention is to a filter plate and a collection system having an upper filter plate and a lower collection plate. Each has two or more wells in register with each other. The filter plate has an underdrain containing a spout. The spout is offcenter of the centerpoint of the wells between which it resides. The spout is close to at least one wall of the well of the collection device but set off from that wall by a distance sufficient to ensure easy assembly and disassembly of the devices without contact or damage of the spout with the well of the collection device. In this manner, any drop that begins to form contacts the adjacent well wall and travels down it into the collection device.
摘要翻译： 本发明涉及一种具有上过滤板和下收集板的过滤板和收集系统。 每个都有两个或更多个井相互注册。 过滤板具有含有喷口的缺油。 喷口位于其所在井之间的中心点的中心。 喷嘴靠近收集装置的井的至少一个壁，但从该壁离开足够的距离，足以确保装置的容易装配和拆卸，而不会与收集装置的井接触或损坏喷口。 以这种方式，任何开始形成的液滴与相邻的井壁接触并向下传播到收集装置中。
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公开(公告)号：US20050095175A1
公开(公告)日：2005-05-05
申请号：US10961778
申请日：2004-10-08
CPC分类号： B01L3/50255 , B01L2200/141 , B01L2300/0829 , B01L2400/049
摘要： Underdrain design for a multiwell device that when fixed to the device (either as an integral or removable component thereof), allows for adequate venting during filtration, minimizes or prevents air lock, and has improved structural integrity. Also disclosed is a laboratory device designed particularly for a multiplate format that includes a plate or tray having a plurality of wells, and an underdrain in fluid communication with each of the plurality of wells. The underdrain can be a separate, removable piece, or can be an integral unitary structure with the plate or tray forming a one-piece design. The design is preferably in compliance with SBS format.
摘要翻译： 用于多孔设备的暗槽设计，当固定到设备（作为其整体或可移除部件）时，允许在过滤期间充分排气，最小化或防止气锁，并且具有改善的结构完整性。 还公开了一种特别设计用于多种格式的实验室装置，其包括具有多个孔的板或托盘，以及与多个孔中的每一个流体连通的暗槽。 下划线可以是单独的可拆卸件，或者可以是整体的单一结构，其中板或托盘形成一体式设计。 该设计优选地符合SBS格式。
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5.发明申请公开(公告)号：US20060286003A1
公开(公告)日：2006-12-21
申请号：US11154171
申请日：2005-06-16
IPC分类号： B01L11/00
CPC分类号： B01L3/50255 , B01L2200/026 , B01L2300/0829 , C12M25/04
摘要： Multiwell filter comprising a filter plate having a plurality of wells, each including a support. Each well has a corresponding adjacent access port providing access to the corresponding feeding/receiver plate well, e.g. via a pipette. When the filter plate is positioned over a feeding/receiver plate having a plurality of wells, each well of the feeding/receiving plate aligns with and communicates with a corresponding filter plate well. Each access port provides access to a respective well in the feeding/receiver plate, and the wells in the filter plate are not centrally located with respect to the feeding/receiver plate wells, but are shifted in the x and y directions relative to the receiver wells in an amount effective for reducing or eliminating capillary holdup in the gap between the filter wells and the feeding/receiver wells. The wells in the feeding/receiver plate preferably are formed in a U-shaped bottom below each access port.
摘要翻译： 多孔滤波器包括具有多个孔的滤板，每个孔包括支撑件。 每个井具有相应的相邻进入端口，提供对相应的进料/接收器板的接触，例如， 通过移液器 当过滤板位于具有多个井的进料/接收板上方时，进料/接收板的每个井与相应的过滤板井对准并与其连通。 每个进入口提供对进料/接收器板中的相应孔的通路，并且过滤板中的孔不相对于进料/接收板孔位于中心位置，而是相对于接收器在x和y方向上移位 孔有效减少或消除过滤器孔和进料/接收器孔之间的间隙中的毛细管滞留量。 馈送/接收板中的阱优选地形成在每个进入端口下方的U形底部。
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公开(公告)号：US20050287046A1
公开(公告)日：2005-12-29
申请号：US11142542
申请日：2005-06-01
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L2200/0615 , B01L2300/0829
摘要： A plate liner detachably engageable onto a microarray plate (or underdrain plate component thereof), suited for preventing or confining pendant drop formation. It is provided either as a stand-alone item, or—preferably—in kit form, within a sanitary package, together with other pre-matched microarray filtration components.
摘要翻译： 可拆卸地接合到微阵列板（或其下划线板部件）上的板衬套，其适于防止或限制侧滴形成。 其与预先匹配的微阵列过滤组件一起作为卫生包装内的独立物品或优选的试剂盒形式提供。
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公开(公告)号：US20100111965A1
公开(公告)日：2010-05-06
申请号：US12445109
申请日：2007-10-11
申请人： James Johnston , Shane Olwill , Jill Brown , Nuala Morgan , Thomas Jaquin , Christopher Scott
发明人： James Johnston , Shane Olwill , Jill Brown , Nuala Morgan , Thomas Jaquin , Christopher Scott
IPC分类号： A61K39/395 , A61K31/7088 , C07K16/00 , A61P35/00 , C12Q1/68
CPC分类号： C12N15/1136 , A61K39/39558 , C07K16/22 , C07K2317/56 , C07K2317/73 , C12N2310/14 , C12N2320/31 , A61K2300/00
摘要： The invention provides a method of treating neoplastic disease in a subject, said method comprising the simultaneous, sequential or separate, administration to said subject of an effective amount of (i) an inhibitor of a first EGF, e.g. HB-EGF and (ii) an inhibitor of a second EGF, e.g. AREG. Also described are novel synergistic combinations of EGF inhibitors with topoisomerase inhibitors which attenuate tumour cell growth. Further described are novel anti AREG antibodies.
摘要翻译： 本发明提供一种治疗受试者的肿瘤疾病的方法，所述方法包括向所述受试者施用有效量的（i）第一EGF的抑制剂，例如， HB-EGF和（ii）第二EGF的抑制剂，例如。 AREG。 还描述了EGF抑制剂与拓扑异构酶抑制剂的新的协同组合，其减弱肿瘤细胞生长。 进一步描述的是新的抗AREG抗体。
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公开(公告)号：US20150317909A1
公开(公告)日：2015-11-05
申请号：US14698953
申请日：2015-04-29
摘要： A device for training medical personnel to measure a simulated patient's temperature is provided. The device includes at least one sensor configured to measure an attribute of the device's motion. A display and a wireless communications device are provided. A controller is electrically coupled to the at least one sensor, the display and the wireless communications device, the controller having a processor that is responsive to executable computer instructions to display a value on the display in response to the at least one sensor measuring the attribute.
摘要翻译： 提供了一种用于培训医务人员以测量模拟患者体温的装置。 该装置包括至少一个被配置成测量装置的运动属性的传感器。 提供了显示器和无线通信设备。 控制器电耦合到所述至少一个传感器，所述显示器和所述无线通信设备，所述控制器具有处理器，所述处理器响应于可执行计算机指令，以响应于所述至少一个传感器测量所述属性来显示值 。
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9.发明申请Lubricated part having partial hard coating allowing reduced amounts of antiwear additive 审中-公开润滑部分具有部分硬涂层，允许减少量的抗磨添加剂公开(公告)号：US20070197407A1
公开(公告)日：2007-08-23
申请号：US10570084
申请日：2004-09-03
申请人： Ewa Bardasz , Christopher Scott
发明人： Ewa Bardasz , Christopher Scott
IPC分类号： C10M141/12
CPC分类号： C10M165/00 , C10M159/20 , C10M159/22 , C10M159/24 , C10M163/00 , C10M167/00 , C10M2203/1006 , C10M2203/1025 , C10M2205/02 , C10M2205/0206 , C10M2205/026 , C10M2207/026 , C10M2207/028 , C10M2207/262 , C10M2207/289 , C10M2209/086 , C10M2209/101 , C10M2215/28 , C10M2219/046 , C10M2219/089 , C10M2223/045 , C10M2227/061 , C10M2229/02 , C10N2210/01 , C10N2210/02 , C10N2230/02 , C10N2230/04 , C10N2230/06 , C10N2230/08 , C10N2230/42 , C10N2230/43 , C10N2230/45 , C10N2230/50 , C10N2240/10 , C10N2240/102 , C10N2250/18 , C10N2260/14
摘要： A lubricated part composition containing (a) a part with at least a partial hard surface coating of average thickness less than about 25 micrometres, said coating containing at least one moiety selected from the group consisting of silicides, nitrides, carbides, borides, oxides, sulphides and mixtures thereof; (b) a detergent selected from at least one of the group consisting of a phenate salt, a sulphonate salt, a salixarate salt and mixtures thereof; and (c) an oil of lubricating viscosity. The invention further relates to the use of the composition to decrease engine wear, decrease sludge formation, filter plugging, decrease sulphur emissions and decrease phosphorus emissions.
摘要翻译： 一种润滑部件组合物，其包含（a）具有平均厚度小于约25微米的至少部分硬表面涂层的部分，所述涂层含有至少一种选自硅化物，氮化物，碳化物，硼化物，氧化物， 硫化物及其混合物; （b）选自苯酚盐，磺酸盐，柳氮磺酸盐及其混合物中的至少一种的洗涤剂; 和（c）具有润滑粘度的油。 本发明还涉及该组合物用于减少发动机磨损，减少污泥形成，过滤堵塞，减少硫排放和减少磷排放的用途。
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公开(公告)号：US20070110761A1
公开(公告)日：2007-05-17
申请号：US10540415
申请日：2003-12-29
申请人： Christopher Scott
发明人： Christopher Scott
CPC分类号： C12N15/70 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C12N9/104 , C12N9/52
摘要： Described is a novel purification tag, SNUT, based on the gene product of a sortase gene, in particular the srtA gene of Staphylococcus aureus and uses thereof. Also provided are expression constructs comprising DNA enoding the tag for the production of recombinant polypeptides. The tag can be used in methods of purifying soluble domains of a number of proteins previously not able to be isolated efficiently and methods of inducing and/or enhancing an immune response to an antigen of interest.
摘要翻译： 描述了基于分选酶基因的基因产物，特别是金黄色葡萄球菌的srtA基因的新型纯化标签SNUT及其用途。 还提供了包含编码用于产生重组多肽的标签的DNA的表达构建体。 该标签可用于纯化先前不能有效分离的许多蛋白质的可溶性结构域的方法，以及诱导和/或增强对感兴趣的抗原的免疫应答的方法。
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