公开(公告)号：US5175209A

公开(公告)日：1992-12-29

申请号：US648808

申请日：1991-01-31

申请人： Kenneth L. Beattie ,  James D. Frost, III

发明人： Kenneth L. Beattie ,  James D. Frost, III

IPC分类号： B01J19/00 ,  C07H21/00 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14

CPC分类号： C07H21/00 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00322 ,  B01J2219/00391 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00461 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00722 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14

摘要： A wafer for synthesizing biopolymers which includes a solid phase support material, a reaction chamber which receives and retains the support material and at least one inert porous material which allows flow through the wafer. Also included is a segmented wafer synthesis device comprising at least one, and preferably numerous, wafers for the simultaneous synthesis of multiple defined-sequenced biopolymers. Further there are process steps for synthesizing a variety of biopolymers. Synthetic polynucleotides have played a key role in studies of genetic organization through their use as primers for DNA sequencing and as hybridization probes, linkers and adapters in the cloning of genes.

摘要翻译： 用于合成生物聚合物的晶片，其包括固相支持材料，接收并保持载体材料的反应室和允许流过晶片的至少一种惰性多孔材料。 还包括分段晶片合成装置，其包括用于同时合成多个定义顺序的生物聚合物的至少一个，优选多个晶片。 此外，还有用于合成各种生物聚合物的方法步骤。 合成多核苷酸在遗传组织的研究中起着关键的作用，它们用作DNA测序的引物，以及作为克隆基因的杂交探针，接头和衔接子。