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公开(公告)号：US06933308B2
公开(公告)日：2005-08-23
申请号：US10730781
申请日：2003-12-09
Applicant: Kenneth M. Boy , Yong-Jin Wu
Inventor： Kenneth M. Boy , Yong-Jin Wu
IPC: A61P25/06 , A61P25/08 , A61P25/18 , A61P25/22 , C07D277/56 , C07D417/12 , C07D417/14 , C07D277/20 , A61K31/427 , C07D213/02 , C07D295/02
CPC classification number: C07D417/12 , C07D277/56 , C07D417/14
Abstract: Novel aminoalkylthiazole derivatives of Formula I are described which are openers of KCNQ potassium channels and are useful in the treatment of disorders responsive to the opening of the KCNQ potassium channels, including pain and migraine.
Abstract translation: 描述了式I的新型氨基烷基噻唑衍生物，其是KCNQ钾通道的开放剂，并且可用于治疗响应于KCNQ钾通道开放的病症，包括疼痛和偏头痛。
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公开(公告)号：US08349880B2
公开(公告)日：2013-01-08
申请号：US12683791
申请日：2010-01-07
Applicant: Lawrence R. Marcin , Lorin A. Thompson, III , Kenneth M. Boy , Jason M. Guernon , Mendi A. Higgins , Jianliang Shi , Yong-Jin Wu , Yunhui Zhang , John E. Macor
Inventor： Lawrence R. Marcin , Lorin A. Thompson, III , Kenneth M. Boy , Jason M. Guernon , Mendi A. Higgins , Jianliang Shi , Yong-Jin Wu , Yunhui Zhang , John E. Macor
IPC: A61K31/41 , A61K31/425 , C07D249/00 , C07D277/82
CPC classification number: C07D487/04 , C07D417/12 , C07D471/04 , C07D513/10
Abstract: The present disclosure provides a series of compounds of the formula (I) which reduce β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列式（I）的化合物，其减少β-淀粉状蛋白肽（＆bgr--AP）产生，并且可用于治疗阿尔茨海默氏病和其它受β-淀粉状蛋白肽（＆bgr; -AP）生产。
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公开(公告)号：US20120028994A1
公开(公告)日：2012-02-02
申请号：US13013373
申请日：2011-01-25
Applicant: Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC: A61K31/517 , C07D401/14 , A61P35/00 , A61P25/28 , A61P25/00 , A61P27/02 , C07D403/12 , C07D401/12
CPC classification number: A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/052 , C07D491/08 , C07D491/107 , C07D491/113
Abstract: The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列式（I）的化合物，其调节和淀粉样蛋白肽（＆bgr; -AP）产生，并且可用于治疗阿尔茨海默氏病和其它受β-淀粉状蛋白肽（＆bgr; -AP）生产。
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公开(公告)号：US07273866B2
公开(公告)日：2007-09-25
申请号：US10731854
申请日：2003-12-09
Applicant: Kenneth M. Boy , Yong-Jin Wu , Jason M. Guernon
Inventor： Kenneth M. Boy , Yong-Jin Wu , Jason M. Guernon
IPC: A61K31/5375 , A61K31/427 , A61K31/426 , C07D413/12 , C07D413/14
CPC classification number: C07D417/14 , C07D277/56 , C07D417/04 , C07D417/10 , C07D417/12
Abstract: Novel 2-arylthiazole derivatives of Formula I are described which are openers of KCNQ potassium channels and are useful in the treatment of disorders that are responsive to the opening of the KCNQ potassium channels, including pain and migraine
Abstract translation: 描述了式I的新型2-芳基噻唑衍生物，其是KCNQ钾通道的开放剂，并且可用于治疗对KCNQ钾通道开放有响应的病症，包括疼痛和偏头痛
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公开(公告)号：US08486952B2
公开(公告)日：2013-07-16
申请号：US12845045
申请日：2010-07-28
Applicant: Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC: A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/497 , A61K31/00 , A61K31/535 , C07D239/70 , C07D491/00 , C07D495/00 , C07D471/00 , C07D413/00
CPC classification number: C07D403/12 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/14 , C07D407/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/08 , C07D491/107 , C07D491/113
Abstract: The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列调节β-淀粉样肽（β-AP）产生的式（I）化合物，并且可用于治疗阿尔茨海默病和其它受β-淀粉样蛋白肽（β-AP）产生影响的病症 。
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Patent Agency Ranking
公开(公告)号：US08637525B2
公开(公告)日：2014-01-28
申请号：US13013373
申请日：2011-01-25
Applicant: Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC: A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519 , A01N43/64 , A61K31/41
CPC classification number: A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/052 , C07D491/08 , C07D491/107 , C07D491/113
Abstract: The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列调节β-淀粉样肽（β-AP）产生的式（I）化合物，并且可用于治疗阿尔茨海默病和其它受β-淀粉样蛋白肽（β-AP）产生影响的病症 。
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公开(公告)号：US20110212937A1
公开(公告)日：2011-09-01
申请号：US12845045
申请日：2010-07-28
Applicant: Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC: A61K31/397 , C07D401/12 , A61K31/517 , C07D239/70 , C07D403/12 , C07D403/14 , C07D471/04 , A61K31/519 , C07D491/052 , C07D413/14 , A61K31/5377 , A61K31/496 , A61K31/5386 , A61P25/28
CPC classification number: C07D403/12 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/14 , C07D407/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/08 , C07D491/107 , C07D491/113
Abstract: The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列式（I）的化合物，其调节和淀粉样蛋白肽（＆bgr; -AP）产生，并且可用于治疗阿尔茨海默氏病和其它受β-淀粉状蛋白肽（＆bgr; -AP）生产。
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公开(公告)号：US20110015175A1
公开(公告)日：2011-01-20
申请号：US12683791
申请日：2010-01-07
Applicant: Lawrence R. Marcin , Lorin A. Thompson, III , Kenneth M. Boy , Jason M. Guernon , Mendi A. Higgins , Jianliang Shi , Yong-Jin Wu , Yunhui Zhang , John E. Macor
Inventor： Lawrence R. Marcin , Lorin A. Thompson, III , Kenneth M. Boy , Jason M. Guernon , Mendi A. Higgins , Jianliang Shi , Yong-Jin Wu , Yunhui Zhang , John E. Macor
IPC: A61K31/55 , C07D487/04 , C07D417/12 , C07D491/20 , A61K31/437 , A61K31/428 , A61K31/4439 , A61P25/28 , A61P25/00 , A61P27/02 , A61P35/00
CPC classification number: C07D487/04 , C07D417/12 , C07D471/04 , C07D513/10
Abstract: The present disclosure provides a series of compounds of the formula (I) which reduce β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列式（I）的化合物，其减少β-淀粉状蛋白肽（＆bgr--AP）产生，并且可用于治疗阿尔茨海默氏病和其它受β-淀粉状蛋白肽（＆bgr; -AP）生产。
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公开(公告)号：US08710061B2
公开(公告)日：2014-04-29
申请号：US13358822
申请日：2012-01-26
Applicant: Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC: A61K31/497 , A01N43/54 , A01N43/90
CPC classification number: C07D239/70 , A61K31/517 , A61K31/519 , C07D401/04 , C07D471/04 , C07D487/10 , C07D491/048 , C07D491/10
Abstract: The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列式（I）的化合物，其调节和淀粉样蛋白肽（＆bgr; -AP）产生，并且可用于治疗阿尔茨海默氏病和其它受β-淀粉状蛋白肽（＆bgr; -AP）生产。
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公开(公告)号：US08637523B2
公开(公告)日：2014-01-28
申请号：US13180623
申请日：2011-07-12
Applicant: Kenneth M. Boy , Jason M. Guernon , John E. Macor , Lorin A. Thompson, III , Yong-Jin Wu , Yunhui Zhang
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Lorin A. Thompson, III , Yong-Jin Wu , Yunhui Zhang
IPC: A61P27/02 , A61P35/00 , C07D498/04 , A61P25/28
CPC classification number: C07D487/06 , A61K31/33 , C07D487/16 , C07D498/06 , C07D498/16
Abstract: Compounds of the formula (I) are provided, including pharmaceutically acceptable salts thereof: which modulate β-amyloid peptide (β-AP) production, and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 提供式（I）化合物，包括其药学上可接受的盐：其调节β-淀粉样肽（β-AP）产生，并且可用于治疗阿尔茨海默病和其它受β-淀粉样蛋白肽（β- AP）生产。
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