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公开(公告)号：US07438911B2
公开(公告)日：2008-10-21
申请号：US10513148
申请日：2003-04-30
申请人： Kenya Shitara , Kazuyasu Nakamura , Akiko Furuya , Rinpei Niwa , Yuji Ohki , Nobuo Hanai
发明人： Kenya Shitara , Kazuyasu Nakamura , Akiko Furuya , Rinpei Niwa , Yuji Ohki , Nobuo Hanai
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×109 M−1 or more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.
摘要翻译： 为了有效治疗诸如hIGF参与的癌症的疾病，期望开发出与hIGF-1和hIGF-II两者强烈结合并抑制其功能和这些抗体片段的抗体。 本发明提供具有特异性结合人IGF-I和IGF-II从而抑制人IGF-I和IGF-II的功能并具有结合常数为5×10 9的结合活性的抗体， 或者用生物传感器BIACORE测量的更高/更高。 此外，本发明提供了hIGF介导的疾病的诊断，预防措施和补救措施以及由于异常促进的hIGF产生导致使用所述抗体的病理进展的疾病。
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公开(公告)号：US08632996B2
公开(公告)日：2014-01-21
申请号：US13492465
申请日：2012-06-08
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C12P21/00
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US08197814B2
公开(公告)日：2012-06-12
申请号：US12684651
申请日：2010-01-08
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61K39/395
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US06989145B2
公开(公告)日：2006-01-24
申请号：US09796744
申请日：2001-03-02
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US07666418B2
公开(公告)日：2010-02-23
申请号：US11094718
申请日：2005-03-31
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US20050187380A1
公开(公告)日：2005-08-25
申请号：US11094718
申请日：2005-03-31
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61P11/06 , A61P17/00 , A61P27/14 , A61P37/08 , C07K16/28 , C12N15/13 , C12P21/08 , G01N33/543 , C07H21/04 , C07K14/28 , C12N5/06
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US20060165695A1
公开(公告)日：2006-07-27
申请号：US10513148
申请日：2003-04-30
申请人： Kenya Shitara , Kazuyasu Nakamura , Akiko Furuya , Rinpei Niwa , Yuji Ohki
发明人： Kenya Shitara , Kazuyasu Nakamura , Akiko Furuya , Rinpei Niwa , Yuji Ohki
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×109 M−1 or more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.
摘要翻译： 为了有效治疗诸如hIGF参与的癌症的疾病，期望开发出与hIGF-1和hIGF-II两者强烈结合并抑制其功能和这些抗体片段的抗体。 本发明提供具有特异性结合人IGF-I和IGF-II从而抑制人IGF-I和IGF-II的功能并具有结合常数为5×10 9的结合活性的抗体， 或者用生物传感器BIACORE测量的更高/更高。 此外，本发明提供了hIGF介导的疾病的诊断，预防措施和补救措施以及由于异常促进的hIGF产生导致使用所述抗体的病理进展的疾病。
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公开(公告)号：US07241568B2
公开(公告)日：2007-07-10
申请号：US10434469
申请日：2003-05-09
申请人： Nobuo Hanai , Motoo Yamasaki , Akiko Furuya , Akira Tanaka , Kenya Shitara , Naoki Shimada , Kazuyasu Nakamura , Maiko Hirota
发明人： Nobuo Hanai , Motoo Yamasaki , Akiko Furuya , Akira Tanaka , Kenya Shitara , Naoki Shimada , Kazuyasu Nakamura , Maiko Hirota
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/22
摘要： A method for preventing or treating a disease, comprising administering to human or animal in need of such prevention or treatment an effective amount of a monoclonal antibody which specifically binds to FGF-8 and inhibits FGF-8 activity.
摘要翻译： 一种预防或治疗疾病的方法，包括向需要这种预防或治疗的人或动物施用有效量的特异性结合FGF-8并抑制FGF-8活性的单克隆抗体。
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公开(公告)号：US20050031613A1
公开(公告)日：2005-02-10
申请号：US10409608
申请日：2003-04-09
IPC分类号： A61K39/395 , A61P9/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/14 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/08 , A61P43/00 , C07K16/00 , C07K16/18 , C07K16/44 , C12P21/08
CPC分类号： A61K39/395 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/3084 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2319/30
摘要： A medicament for treating FcγRIIIa polymorphism patients who cannot be treated by a medicament comprising as an active ingredient an antibody composition produced by a cell unresistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain, which comprises as an active ingredient an antibody composition produced by a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain.
摘要翻译： 一种用于治疗不能用药物治疗的FcgammaRIIIa多态性患者的药物，所述药物包含作为活性成分的抗细胞因抗细胞因子而产生的抗体组合物，所述抗体组合物识别其中1位的岩藻糖与N位的6-位结合的糖链 乙酰基葡糖胺在还原末端通过复合N-糖苷连接的糖链中的α-键，其包含作为活性成分的抗体组合物，所述抗体组合物是由能够识别糖链的细胞产生的，所述凝集素识别其中1位岩藻糖 通过复合N-糖苷连接的糖链中的α-键在还原末端与N-乙酰氨基葡萄糖的6-位结合。
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公开(公告)号：US07615214B2
公开(公告)日：2009-11-10
申请号：US11250411
申请日：2005-10-17
申请人： Kenya Shitara , Mikito Ito , Nobuo Hanai , Yoko Kawada , Kazuyasu Nakamura , Masabumi Shibuya
发明人： Kenya Shitara , Mikito Ito , Nobuo Hanai , Yoko Kawada , Kazuyasu Nakamura , Masabumi Shibuya
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28
CPC分类号： G01N33/57407 , A61K38/00 , C07K16/2803 , C07K16/2863 , C07K2317/24 , C12N2799/026 , G01N33/6863 , G01N33/6893 , G01N33/74
摘要： The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1. It also provides a means for the diagnosis or treatment of diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.
摘要翻译： 本发明提供了与人VEGF受体Flt-1和细胞表面上表达人VEGF受体Flt-1的细胞免疫反应的抗体或肽，以及抑制人VEGF与人VEGF受体Flt结合的抗体或肽 -1。 它还提供了用于诊断或治疗其病态通过异常血管生成进行的疾病（例如实体瘤的增殖或转移，类风湿性关节炎中的关节炎，糖尿病性视网膜病，早产儿视网膜病，牛皮癣等）的手段。
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