利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

113 条记录 (耗时 0.039 秒)

    Antibody against human insulin-like growth factor
    8.
    发明授权
    Antibody against human insulin-like growth factor 有权
    抗人类胰岛素样生长因子的抗体

    公开(公告)号：US07438911B2

    公开(公告)日：2008-10-21

    申请号：US10513148

    申请日：2003-04-30

    申请人： Kenya Shitara ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Rinpei Niwa ,  Yuji Ohki ,  Nobuo Hanai

    发明人： Kenya Shitara ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Rinpei Niwa ,  Yuji Ohki ,  Nobuo Hanai

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12N5/06 ,  C12N15/00 ,  C12P21/08 ,  C07K16/22

    CPC分类号： C07K16/22 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×109 M−1 or more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.

    摘要翻译： 为了有效治疗诸如hIGF参与的癌症的疾病，期望开发出与hIGF-1和hIGF-II两者强烈结合并抑制其功能和这些抗体片段的抗体。 本发明提供具有特异性结合人IGF-I和IGF-II从而抑制人IGF-I和IGF-II的功能并具有结合常数为5×10 9的结合活性的抗体， 或者用生物传感器BIACORE测量的更高/更高。 此外，本发明提供了hIGF介导的疾病的诊断，预防措施和补救措施以及由于异常促进的hIGF产生导致使用所述抗体的病理进展的疾病。

    Anti-fibroblast growth factor-8 monoclonal antibody
    9.
    发明授权
    Anti-fibroblast growth factor-8 monoclonal antibody 失效
    抗成纤维细胞生长因子-8单克隆抗体

    公开(公告)号：US06310184B1

    公开(公告)日：2001-10-30

    申请号：US09326590

    申请日：1999-06-07

    申请人： Nobuo Hanai ,  Motoo Yamasaki ,  Akiko Furuya ,  Akira Tanaka

    发明人： Nobuo Hanai ,  Motoo Yamasaki ,  Akiko Furuya ,  Akira Tanaka

    IPC分类号： C07K1600

    CPC分类号： C23C14/30 ,  C07K16/22 ,  C07K2317/73 ,  C23C26/00 ,  G02B1/105

    摘要： Described is a monoclonal antibody capable of specifically binding to fibroblast growth factor-8 (FGF-8) which is related to growth factors of hormone-dependent tumor cells such as prostatic cancer and breast cancer, and inhibits the FGF-8 activity. The monoclonal antibody is useful in analyzing the role and biological function of FGF-8 in hormone-dependent tumor cells such as prostatic cancer and breast cancer and can be beneficial in the treatment of these cancers.

    摘要翻译： 描述了能够特异性结合成纤维细胞生长因子-8（FGF-8）的单克隆抗体，其与激素依赖性肿瘤细胞如前列腺癌和乳腺癌的生长因子相关，并且抑制FGF-8活性。 单克隆抗体可用于分析FGF-8在激素依赖性肿瘤细胞如前列腺癌和乳腺癌中的作用和生物学功能，可有助于治疗这些癌症。