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    Method for producing α-L-aspartyl-L-phenylalanine-β-ester and method for producing α-L-aspartyl-L-phenylalanine-α-methyl ester
    2.
    发明授权
    Method for producing α-L-aspartyl-L-phenylalanine-β-ester and method for producing α-L-aspartyl-L-phenylalanine-α-methyl ester 有权
    制备α-L-天冬氨酰基-L-苯丙氨酸的方法和制备α-L-天冬氨酰基-L-苯丙氨酸-α-甲酯的方法

    公开(公告)号：US07745172B2

    公开(公告)日：2010-06-29

    申请号：US11970203

    申请日：2008-01-07

    申请人： Kenzo Yokozeki ,  Ayako Ohno ,  Seiichi Hara ,  Isao Abe

    发明人： Kenzo Yokozeki ,  Ayako Ohno ,  Seiichi Hara ,  Isao Abe

    IPC分类号： C12P21/06

    CPC分类号： C07K5/0613 ,  A23L27/32 ,  C07K5/06113 ,  C12P21/02 ,  C12P21/06

    摘要： A method for producing an α-L-aspartyl-L-phenylalanine-β-ester (also named α-L-(β-o-substituted aspartyl)-L-phenylalanine), which is an intermediate of an α-L-aspartyl-L-phenylalanine-α-methyl ester (also named α-L-aspartyl-L-phenylalanine methyl ester; product name: aspartame), easily, at high yield and inexpensively without going through a complex synthesis method is provided. Further, an easy, inexpensive and high-yield production method for an α-L-aspartyl-L-phenylalanine-α-methyl ester is provided. α-L-aspartyl-L-phenylalanine-α-methyl ester is produced from a L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to catalyze a reaction in which L-phenylalanine performs no nucleophilic attack on a β-ester site of L-aspartic acid-α,β-diester but performs a nucleophilic attack on an α-ester site thereof.

    摘要翻译： 制备α-L-天冬氨酰基-L-苯丙氨酸 - 酯（也称为α-L- - （取代的天冬氨酰基）-L-苯丙氨酸）的方法，其为α-L 提供了天竺葵酰-L-苯丙氨酸-α-甲酯（也称为α-L-天冬氨酰基-L-苯丙氨酸甲酯;产品名称：阿斯巴甜），容易地以高产率和低成本而不经过复合合成方法。 此外，提供了一种用于α-L-天冬氨酰基-L-苯丙氨酸-α-甲酯的容易且廉价且高产率的制备方法。 使用具有催化反应能力的酶或酶的物质由L-天冬氨酸-α，β-二酯和L-苯丙氨酸制备α-L-天冬氨酰基-L-苯丙氨酸-α-甲酯 其中L-苯丙氨酸对L-天冬氨酸-α，bgr-siester的“酯”位点不发生亲核攻击，但对其α-酯位点进行亲核攻击。

    Method for producing α-L-aspartyl-L-phenylalanine-β-ester and method for producing α-L-aspartyl-L-phenylalanine-α-methyl ester
    3.
    发明授权
    Method for producing α-L-aspartyl-L-phenylalanine-β-ester and method for producing α-L-aspartyl-L-phenylalanine-α-methyl ester 有权
    生产α-L-天冬氨酰-L-苯丙氨酸-β-酯的方法及其制备α-天冬氨酰-L-苯丙氨酸-α-甲酯的方法

    公开(公告)号：US07361458B2

    公开(公告)日：2008-04-22

    申请号：US10876673

    申请日：2004-06-28

    申请人： Kenzo Yokozeki ,  Ayako Ohno ,  Seiichi Hara ,  Isao Abe

    发明人： Kenzo Yokozeki ,  Ayako Ohno ,  Seiichi Hara ,  Isao Abe

    IPC分类号： C12P21/06 ,  C12Q1/00 ,  C12Q1/68

    CPC分类号： C07K5/0613 ,  A23L27/32 ,  C07K5/06113 ,  C12P21/02 ,  C12P21/06

    摘要： A method for producing an α-L-aspartyl-L-phenylalanine-β-ester (also named α-L-(β-o-substituted aspartyl)-L-phenylalanine), which is an intermediate of an α-L-aspartyl-L-phenylalanine-α-methyl ester (also named α-L-aspartyl-L-phenylalanine methyl ester; product name: aspartame), easily, at high yield and inexpensively without going through a complex synthesis method is provided. Further, an easy, inexpensive and high-yield production method for an α-L-aspartyl-L-phenylalanine-α-methyl ester is provided. α-L-aspartyl-L-phenylalanine-α-methyl ester is produced from a L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to catalyze a reaction in which L-phenylalanine performs no nucleophilic attack on a β-ester site of L-aspartic acid-α,β-diester but performs a nucleophilic attack on an α-ester site thereof.

    摘要翻译： 制备α-L-天冬氨酰基-L-苯丙氨酸-β-酯（也称为α-L-（β-邻位取代的天冬氨酰基）-L-苯丙氨酸）的方法，其为α-L-天冬氨酰基 提供了L-苯丙氨酸-α-甲酯（也称为α-L-天冬氨酰基-L-苯丙氨酸甲酯;商品名：阿斯巴甜），容易地以高产率和低成本地经历复合合成方法。 此外，提供了一种用于α-L-天冬氨酰基-L-苯丙氨酸-α-甲酯的容易，便宜且高产量的制备方法。 使用具有催化反应能力的酶或含酶物质由L-天冬氨酸-α，β-二酯和L-苯丙氨酸生产α-L-天冬氨酰基-L-苯丙氨酸-α-甲酯，其中 L-苯丙氨酸不对L-天冬氨酸-α，β-二酯的β-酯位点进行亲核攻击，但对其α-酯位点进行亲核攻击。

    METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER
    10.
    发明申请
    METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER 有权
    生产ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER的方法及生产ALPHA-L-ASPARTYL-L-苯乙胺 - 阿魏酸酯的方法

    公开(公告)号：US20090191600A1

    公开(公告)日：2009-07-30

    申请号：US11970203

    申请日：2008-01-07

    申请人： Kenzo YOKOZEKI ,  Ayako Ohno ,  Seiichi Hara ,  Isao Abe

    发明人： Kenzo YOKOZEKI ,  Ayako Ohno ,  Seiichi Hara ,  Isao Abe

    IPC分类号： C12P13/22

    CPC分类号： C07K5/0613 ,  A23L27/32 ,  C07K5/06113 ,  C12P21/02 ,  C12P21/06

    摘要： A method for producing an α-L-aspartyl-L-phenylalanine-β-ester (also named α-L-(β-o-substituted aspartyl)-L-phenylalanine), which is an intermediate of an α-L-aspartyl-L-phenylalanine-α-methyl ester (also named α-L-aspartyl-L-phenylalanine methyl ester; product name: aspartame), easily, at high yield and inexpensively without going through a complex synthesis method is provided. Further, an easy, inexpensive and high-yield production method for an α-L-aspartyl-L-phenylalanine-α-methyl ester is provided. α-L-aspartyl-L-phenylalanine-α-methyl ester is produced from a L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to catalyze a reaction in which L-phenylalanine performs no nucleophilic attack on a β-ester site of L-aspartic acid-α,β-diester but performs a nucleophilic attack on an α-ester site thereof.

    摘要翻译： 制备α-L-天冬氨酰基-L-苯丙氨酸-β-酯（也称为α-L-（β-邻位取代的天冬氨酰基）-L-苯丙氨酸）的方法，其为α-L-天冬氨酰基 提供了L-苯丙氨酸-α-甲酯（也称为α-L-天冬氨酰基-L-苯丙氨酸甲酯;商品名：阿斯巴甜），容易地以高产率和低成本地经历复合合成方法。 此外，提供了一种用于α-L-天冬氨酰基-L-苯丙氨酸-α-甲酯的容易，便宜且高产量的制备方法。 使用具有催化反应能力的酶或含酶物质由L-天冬氨酸-α，β-二酯和L-苯丙氨酸生产α-L-天冬氨酰基-L-苯丙氨酸-α-甲酯，其中 L-苯丙氨酸不对L-天冬氨酸-α，β-二酯的β-酯位点进行亲核攻击，但对其α-酯位点进行亲核攻击。