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公开(公告)号:US06596296B1
公开(公告)日:2003-07-22
申请号:US09632457
申请日:2000-08-04
申请人: Kevin D. Nelson , Andres A. Romero-Sanchez , George M. Smith , Nadir Alikacem , Delia Radulescu , Paula Waggoner , Zhibing Hu
发明人: Kevin D. Nelson , Andres A. Romero-Sanchez , George M. Smith , Nadir Alikacem , Delia Radulescu , Paula Waggoner , Zhibing Hu
IPC分类号: A61F202
CPC分类号: D01F1/10 , A61B17/1128 , A61K9/0024 , A61K9/0051 , A61K9/70 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/604 , D01F6/625 , D01F8/14 , D06M15/03 , D06M16/00 , Y10T428/30 , Y10T442/2525
摘要: The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.
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公开(公告)号:US08672996B2
公开(公告)日:2014-03-18
申请号:US13059968
申请日:2009-08-19
申请人: Kevin D. Nelson , Paula J. Taylor , Brent B. Crow
发明人: Kevin D. Nelson , Paula J. Taylor , Brent B. Crow
IPC分类号: A61F2/88
CPC分类号: A61F2/885 , A61F2/07 , A61F2/88 , A61F2002/075 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2250/006 , A61F2250/0067
摘要: The invention relates to a helical coil comprising multiple reversing sense helical coil units that are capable of drug elution, come in lengths appropriate for long, diffuse lesions, have the ability to have a step-wise tapering diameter, and provide all the benefits of a small closed cell stent design while maintaining high flexibility, high radial force and crush resistance due to an underlying helical coil.
摘要翻译: 本发明涉及一种螺旋线圈,其包括能够药物洗脱的多个反转感测螺旋线圈单元,其长度适合于长的扩散性损伤,具有逐步锥形直径的能力,并提供一个 小型闭孔支架设计,同时保持高柔韧性,高径向力和由于下面的螺旋线圈的抗压性。
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公开(公告)号:US07033603B2
公开(公告)日:2006-04-25
申请号:US10428901
申请日:2003-05-02
申请人: Kevin D. Nelson , Brent B. Crow
发明人: Kevin D. Nelson , Brent B. Crow
CPC分类号: A61K9/70 , A61K9/0024 , A61K9/0051 , A61K47/6953 , A61K51/1213 , A61L15/16 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/145 , A61L31/16 , A61L31/18 , A61L2300/00 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/604 , A61L2430/02 , A61L2430/32 , D01F1/10 , D01F6/625 , D01F8/14 , D06M15/03 , D06M16/00
摘要: The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue engineering and drug-delivery compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The invention also relates to methods of manipulating the rate of therapeutic agent release by changing both the biodegradable polymer properties as well as altering the properties of the incorporated gel or hydrogel.
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公开(公告)号:US08062654B2
公开(公告)日:2011-11-22
申请号:US11347474
申请日:2006-02-03
申请人: Kevin D. Nelson , Brent B. Crow
发明人: Kevin D. Nelson , Brent B. Crow
IPC分类号: A61F2/02
CPC分类号: A61K9/70 , A61K9/0024 , A61K9/0051 , A61K47/6953 , A61K51/1213 , A61L15/16 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/145 , A61L31/16 , A61L31/18 , A61L2300/00 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/604 , A61L2430/02 , A61L2430/32 , D01F1/10 , D01F6/625 , D01F8/14 , D06M15/03 , D06M16/00
摘要: The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue engineering and drug-delivery compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The invention also relates to methods of manipulating the rate of therapeutic agent release by changing both the biodegradable polymer properties as well as altering the properties of the incorporated gel or hydrogel.
摘要翻译: 本发明涉及包含凝胶或水凝胶的纤维组合物。 本发明还涉及凝胶或水凝胶加载的可生物降解纤维的组合物和制造这种纤维的方法。 本发明进一步提供了用于生长细胞的三维基质用于体外和体内使用的组织工程和药物递送组合物和方法。 本发明还涉及通过改变可生物降解的聚合物性质以及改变掺入的凝胶或水凝胶的性质来操纵治疗剂释放速率的方法。
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公开(公告)号:US20110172755A1
公开(公告)日:2011-07-14
申请号:US13059968
申请日:2009-08-19
申请人: Kevin D. Nelson , Paula J. Taylor , Brent B. Crow
发明人: Kevin D. Nelson , Paula J. Taylor , Brent B. Crow
IPC分类号: A61F2/92
CPC分类号: A61F2/885 , A61F2/07 , A61F2/88 , A61F2002/075 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2250/006 , A61F2250/0067
摘要: The invention relates to a helical coil comprising multiple reversing sense helical coil units that are capable of drug elution, come in lengths appropriate for long, diffuse lesions, have the ability to have a step-wise tapering diameter, and provide all the benefits of a small closed cell stent design while maintaining high flexibility, high radial force and crush resistance due to an underlying helical coil.
摘要翻译: 本发明涉及一种螺旋线圈,其包括能够药物洗脱的多个反转感测螺旋线圈单元,其长度适合于长的扩散性损伤,具有逐步锥形直径的能力,并提供一个 小型闭孔支架设计,同时保持高柔韧性,高径向力和由于下面的螺旋线圈的抗压性。
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