Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture
    1.
    发明申请
    Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture 失效
    在水 - 有机溶剂混合物中合成柱状水凝胶胶体晶体

    公开(公告)号:US20100261814A1

    公开(公告)日:2010-10-14

    申请号:US11524703

    申请日:2006-09-21

    IPC分类号: C08K5/02 C08L33/24

    CPC分类号: C30B5/00 C30B29/58

    摘要: The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide (“PNIPAM”)-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.

    摘要翻译: 水凝胶胶体晶体的组成通过将聚-N-异丙基丙烯酰胺(“PNIPAM”) - 共 - 烯丙基胺微凝胶的水悬浮液与二氯甲烷混合,形成PNIPAM-共 - 烯丙基胺/二氯甲烷混合物来制备。 将PNIPAM-共 - 烯丙基胺/二氯甲烷混合物在给定温度下温育一段时间,形成胶体晶体材料。 可以通过将戊二醛溶液扩散到胶体晶体材料中来稳定胶体晶体。 聚合物基质微凝胶的浓度可以确定随机或柱状晶体的取向。

    Synthesis and use of heterogeneous polymer gels
    3.
    发明授权
    Synthesis and use of heterogeneous polymer gels 有权
    异构聚合物凝胶的合成与使用

    公开(公告)号:US06194073B1

    公开(公告)日:2001-02-27

    申请号:US09432137

    申请日:1999-11-02

    IPC分类号: C08F624

    摘要: Disclosed is a heterogeneous polymer gel comprising at least two gel networks. One embodiment of the present invention concerns a heterogeneous polymer gel comprising a first gel network comprising an environmentally-stable gel and a second gel network comprising an environmentally-unstable gel wherein the first gel network interpenetrates the second gel network. The heterogeneous polymer gel exhibits controlled changes in volume in response to environmental changes in condition, such as of temperature or of chemical composition.

    摘要翻译: 公开了包含至少两个凝胶网络的多相聚合物凝胶。 本发明的一个实施方案涉及包含第一凝胶网络的非均相聚合物凝胶,其包含环境稳定的凝胶和包含环境不稳定凝胶的第二凝胶网络,其中所述第一凝胶网络穿透所述第二凝胶网络。 异质聚合物凝胶响应于诸如温度或化学组成的条件的环境变化而显示出体积的受控变化。

    Synthesis and use of heterogeneous polymer gels
    4.
    发明授权
    Synthesis and use of heterogeneous polymer gels 失效
    异构聚合物凝胶的合成与使用

    公开(公告)号:US5976648A

    公开(公告)日:1999-11-02

    申请号:US768163

    申请日:1996-12-13

    摘要: Disclosed is a heterogeneous polymer gel comprising at least two gel networks. One embodiment of the present invention concerns a heterogeneous polymer gel comprising a first gel network comprising an environmentally-stable gel and a second gel network comprising an environmentally-unstable gel wherein the first gel network interpenetrates the second gel network. The heterogeneous polymer gel exhibits controlled changes in volume in response to environmental changes in condition, such as of temperature or of chemical composition.

    摘要翻译: 公开了包含至少两个凝胶网络的多相聚合物凝胶。 本发明的一个实施方案涉及包含第一凝胶网络的非均相聚合物凝胶,其包含环境稳定的凝胶和包含环境不稳定凝胶的第二凝胶网络,其中所述第一凝胶网络穿透所述第二凝胶网络。 异质聚合物凝胶响应于诸如温度或化学组成的条件的环境变化而显示出体积的受控变化。

    MONODISPERSE THERMO-RESPONSIVE MICROGELS OF POLY(ETHYLENE GLYCOL) ANALOGUE-BASED BIOPOLYMERS, THEIR MANUFACTURE, AND THEIR APPLICATIONS
    6.
    发明申请
    MONODISPERSE THERMO-RESPONSIVE MICROGELS OF POLY(ETHYLENE GLYCOL) ANALOGUE-BASED BIOPOLYMERS, THEIR MANUFACTURE, AND THEIR APPLICATIONS 审中-公开
    聚乙二醇(乙烯甘油)基于模拟物的生物聚合物的单体热响应微胶囊,其制备及其应用

    公开(公告)号:US20100076105A1

    公开(公告)日:2010-03-25

    申请号:US12502842

    申请日:2009-07-14

    IPC分类号: C08L33/10 C08F2/48

    摘要: Composition, processes, techniques, and apparatus for synthesizing monodisperse microgels based on poly(ethylene glycol) (PEG) derivative polymers by using precipitation polymerization. These microgels are hydrophilic and have the adjustable volume phase transition temperature in aqueous environment. Microgels can be added with various functional groups. These microgels in water can self-assemble into various phases, including a crystalline phase. Hydrogel films with iridescent colors were formed using these microgels as crosslinkers to connect poly(ethylene glycol) chains. The colors of these hydrogel films change with changes of environment such temperature, pH, salt concentration, etc.

    摘要翻译: 通过使用沉淀聚合法合成基于聚(乙二醇)(PEG)衍生物聚合物的单分散微凝胶的组合物,方法,技术和装置。 这些微凝胶是亲水性的,并且在水性环境中具有可调节的体积相转变温度。 微凝胶可以加入各种官能团。 水中的这些微凝胶可以自组装成各种相,包括结晶相。 使用这些微凝胶作为交联剂形成具有彩虹色的水凝胶膜以连接聚(乙二醇)链。 这些水凝胶膜的颜色随温度,pH,盐浓度等环境变化而变化。

    Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation
    9.
    发明申请
    Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation 失效
    具有逆热反应凝胶化的水凝胶纳米颗粒的水分散体

    公开(公告)号:US20070116765A1

    公开(公告)日:2007-05-24

    申请号:US10581678

    申请日:2004-12-09

    申请人: Zhibing Hu Xiaohu Xia

    发明人: Zhibing Hu Xiaohu Xia

    IPC分类号: C12N15/09 A61K9/14

    摘要: An aqueous dispersion of hydrogel nanoparticles and methods of making the aqueous dispersion of hydrogel nanoparticless having an interpenetrating polymer network (“IPN”) are described. The uniformed sized mono-disperse IPN nanoparticles have inverse thermo gelation properties that allow therapeutic medications to be uniformly distributed in a liquid form of the aqueous dispersion of hydrogel nanoparticles. Such medications can then be released from a solid form of the aqueous dispersion of hydrogel nanoparticles in time dependant manor.

    摘要翻译: 描述了水凝胶纳米颗粒的水分散体和制备具有互穿聚合物网络(“IPN”)的纳米级水凝胶的水性分散体的方法。 均匀尺寸的单分散IPN纳米颗粒具有逆热凝胶化性质,其允许治疗性药物均匀分布在液体形式的水凝胶纳米颗粒的水分散体中。 然后可以从固体形式的时间依赖性的水凝胶纳米颗粒的水分散体中释放这些药物。