公开(公告)号：US07499830B2

公开(公告)日：2009-03-03

申请号：US11274579

申请日：2005-11-15

申请人： Kevin George Harding ,  Jianming Zheng ,  Yongqing Li ,  Ming Jia ,  Guiju Song ,  Joseph Benjamin Ross ,  Ralph Gerald Isaacs

发明人： Kevin George Harding ,  Jianming Zheng ,  Yongqing Li ,  Ming Jia ,  Guiju Song ,  Joseph Benjamin Ross ,  Ralph Gerald Isaacs

IPC分类号： G06F19/00

CPC分类号： G01B11/255 ,  G06T7/64 ,  G06T2207/10028 ,  G06T2207/30108

摘要： A computer-implemented method, system, and computer program code are provided for characterizing an edge break, e.g., part features and/or geometric discontinuities that could give rise to edge sharpness, as may be encountered in a chamfer, bevel, fillet and other part features. The methodology enables to accurately and consistently determine in a manufacturing setting, for example, any applicable geometric parameter for characterizing the edge break.

摘要翻译： 提供了计算机实现的方法，系统和计算机程序代码，用于表征边缘断裂，例如可能产生边缘锐度的部分特征和/或几何不连续性，如在倒角，斜角，圆角和其他 零件特征。 该方法使得能够在制造设置中准确和一致地确定，例如用于表征边缘断裂的任何适用的几何参数。

公开(公告)号：US20070112543A1

公开(公告)日：2007-05-17

申请号：US11274579

申请日：2005-11-15

申请人： Kevin Harding ,  Jianming Zheng ,  Yongqing Li ,  Ming Jia ,  Guiju Song ,  Joseph Ross ,  Ralph Isaacs

发明人： Kevin Harding ,  Jianming Zheng ,  Yongqing Li ,  Ming Jia ,  Guiju Song ,  Joseph Ross ,  Ralph Isaacs

IPC分类号： G01B11/24

CPC分类号： G01B11/255 ,  G06T7/64 ,  G06T2207/10028 ,  G06T2207/30108

摘要： A computer-implemented method, system, and computer program code are provided for characterizing an edge break, e.g., part features and/or geometric discontinuities that could give rise to edge sharpness, as may be encountered in a chamfer, bevel, fillet and other part features. The methodology enables to accurately and consistently determine in a manufacturing setting, for example, any applicable geometric parameter for characterizing the edge break.

摘要翻译： 提供了计算机实现的方法，系统和计算机程序代码，用于表征边缘断裂，例如可能产生边缘锐度的部分特征和/或几何不连续性，如在倒角，斜角，圆角和其他 零件特征。 该方法使得能够在制造设置中准确和一致地确定，例如用于表征边缘断裂的任何适用的几何参数。

公开(公告)号：US20140057829A1

公开(公告)日：2014-02-27

申请号：US13981032

申请日：2012-02-01

申请人： Hasan B. Alam ,  Yongqing Li

发明人： Hasan B. Alam ,  Yongqing Li

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6875 ,  G01N2440/18 ,  G01N2800/26 ,  G01N2800/32 ,  G01N2800/52 ,  G01N2800/56

摘要： Methods of diagnosing sepsis, severe sepsis, or septic shock and predicting prognosis in subjects with septic shock, based on levels of citrullinated histone H3 (Cit H3) in the subject, e.g., in a sample comprising serum (e.g., whole blood, serum, or plasma), cerebrospinal fluid, urine, saliva, or peritoneal fluid from the subject.

摘要翻译： 基于受试者的瓜氨酸化组蛋白H3（Cit H3）的水平，例如在含有血清（例如全血，血清，血清，血清，血清， 或血浆），脑脊液，尿液，唾液或腹膜液。

公开(公告)号：US20100080214A1

公开(公告)日：2010-04-01

申请号：US12242349

申请日：2008-09-30

申请人： Yongqing Li ,  Ilan Vardi

发明人： Yongqing Li ,  Ilan Vardi

IPC分类号： H04L12/66

CPC分类号： H04W84/105 ,  H04M3/42314 ,  H04M7/006 ,  H04M2203/1091 ,  H04M2203/4509 ,  H04W84/16

摘要： In one embodiment, a communication system includes a private cellular base station subsystem to communicate, using a cellular radio frequency air radio interface, with home cellular wireless devices and visiting cellular wireless devices located within a coverage area associated with the private cellular base station subsystem. Each of the home cellular wireless devices having associated therewith (i) a public cellular number from a home public land mobile network, and (ii) a private cellular number from a private network associated with the communication system. The communication system further includes a private cellular switching subsystem to provide cellular switching functionality within the private network for the home cellular wireless devices in connection with sessions that are associated with the respective private cellular numbers of the respective home cellular wireless devices. The communication system further includes unified communications (UC) functionality to interface the private cellular switching subsystem to a unified communications server in order to provide unified communications services using the home cellular wireless devices.

摘要翻译： 在一个实施例中，通信系统包括专用蜂窝基站子系统，用于使用蜂窝无线电频率无线电接口与位于与专用蜂窝基站子系统相关联的覆盖区域内的家庭蜂窝无线设备和访问蜂窝无线设备进行通信。 每个家庭蜂窝无线设备具有与其相关联的（i）来自家庭公共陆地移动网络的公共蜂窝号码，以及（ii）来自与通信系统相关联的专用网络的专用蜂窝号码。 通信系统还包括私有蜂窝交换子系统，用于为家庭蜂窝无线设备提供专用网络内的蜂窝交换功能，该蜂窝交换子系统与相应家庭蜂窝无线设备的相应专用蜂窝号码相关联的会话结合。 通信系统还包括统一通信（UC）功能，以将私有蜂窝交换子系统接入统一通信服务器，以便使用家庭蜂窝无线设备提供统一的通信服务。

公开(公告)号：US20140189995A1

公开(公告)日：2014-07-10

申请号：US13980800

申请日：2011-11-04

申请人： Xuancui Liang ,  Weihua Liu ,  Jian Li ,  Peike Dong ,  Dunquan Tan ,  Yongqing Li ,  Haibing Ju ,  Rongmin Wang ,  Hongbing Wei ,  Bin Xu ,  Rui Gou ,  Yunyang Li ,  Wei Li ,  Qiang Guo ,  Mingbao Qin ,  Xiao Wang

发明人： Xuancui Liang ,  Weihua Liu ,  Jian Li ,  Peike Dong ,  Dunquan Tan ,  Yongqing Li ,  Haibing Ju ,  Rongmin Wang ,  Hongbing Wei ,  Bin Xu ,  Rui Gou ,  Yunyang Li ,  Wei Li ,  Qiang Guo ,  Mingbao Qin ,  Xiao Wang

IPC分类号： G21C21/00

CPC分类号： G21C21/00 ,  G21C13/02 ,  G21C13/032 ,  G21C17/00 ,  Y02E30/40 ,  Y10T29/49826

摘要： Method for installing reactor coolant loop (RCL) piping of a reactor coolant system (RCS) system in a pressurized water reactor (PWR) nuclear power plant by positioning the reactor vessel, steam generator, or both, into position after attaching one or more coolant pumps, surveying coolant loop piping and a plurality of nozzles on the reactor vessel, the steam generator and coolant pump casing, or a combination thereof, with a precise measurement and 3D modeling technology for positioning data, then performing weld prep machining for the coolant loop piping on the reactor vessel side, and machining for the coolant loop piping on the steam generator side and coolant pump side based on the positioning data, and installing temporary supports for coolant loop piping and finishing the fit-up and welding between the coolant loop piping and the reactor vessel, steam generator, and each coolant pump.

摘要翻译： 将反应堆冷却液系统（RCS）系统的反应堆冷却剂回路（RCL）管道安装在压水反应堆（PWR）核电站中的方法，将反应堆容器，蒸汽发生器或两者置于安装一个或多个冷却剂 泵，测量冷却剂回路管道和反应堆容器上的多个喷嘴，蒸汽发生器和冷却剂泵壳体或其组合，具有用于定位数据的精确测量和3D建模技术，然后对冷却剂回路执行焊接准备加工 基于定位数据对反应堆容器侧的管道以及蒸汽发生器侧和冷却剂泵侧的冷却剂回路管道的加工，以及安装用于冷却剂回路管道的临时支撑件并完成冷却剂回路管道之间的装配和焊接 和反应堆容器，蒸汽发生器和每个冷却剂泵。

公开(公告)号：US20130108657A1

公开(公告)日：2013-05-02

申请号：US13696303

申请日：2011-11-10

申请人： Cassian Yee ,  Yongqing Li ,  C. Siddiq Abdul-Alim

发明人： Cassian Yee ,  Yongqing Li ,  C. Siddiq Abdul-Alim

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K2039/515 ,  A61K2039/57 ,  A61K2039/572 ,  C07K14/4748

摘要： What is described is a novel genetic screen, involving recombinant technology and class I antigen cross-presentation, to search for supraoptimal superagonists of the 27L MART-1 mutant selecting for single amino acid substitution mutants of 27L that activate human antigen-specific CTL clones recognizing the wild-type MART-126-35 epitope. Three novel mutant epitopes are identified with superagonist properties that are functionally superior to 27L. The ability of a given analog to act as superagonist varies among patients. Also described is the use of methods to establish panels of potential superagonist APLs to individualize tumor peptide vaccines among patients. The methodology is replicated to identify APL to NY-ESO-1157-165 and NY-ESO-1157-170 tumor epitopes. A general method is described that is useful to produce a tumor vaccine to any tumor epitope.

摘要翻译： 描述的是一种新型遗传筛选，涉及重组技术和I类抗原交叉呈递，以搜索27L MART-1突变体的超最佳超抗体，其选择27L的单个氨基酸取代突变体，其激活识别的人抗原特异性CTL克隆 野生型MART-126-35表位。 三个新的突变体表位被鉴定为具有功能优于27L的超强度属性。 给予类似物作为超级运动员的能力因患者而异。 还描述了使用方法来建立潜在的超级拮抗剂APL的小组，以在患者之间个体化肿瘤肽疫苗。 该方法被复制以鉴定到NY-ESO-1157-165和NY-ESO-1157-170肿瘤表位的APL。 描述了可用于产生任何肿瘤表位的肿瘤疫苗的一般方法。

公开(公告)号：US11052140B2

公开(公告)日：2021-07-06

申请号：US16450302

申请日：2019-06-24

申请人： Cassian Yee ,  Yongqing Li ,  C. Siddiq Abdul-Alim

发明人： Cassian Yee ,  Yongqing Li ,  C. Siddiq Abdul-Alim

IPC分类号： A61K39/00 ,  C07K14/47

摘要： What is described is a method of treatment of a patient with a tumor, comprising administering a cell responsive to a peptide comprising a tumor epitope, wherein the tumor epitope comprises an amino acid substitution in a tumor antigen. The tumor antigen is preferably selected from the group consisting of NYESO-I157-165, NYESO-II157-170, or MART-126-35, preferably SEQ ID NOS: 1-351, 361-376, and 392-401.

公开(公告)号：US20130149713A1

公开(公告)日：2013-06-13

申请号：US13696530

申请日：2011-05-11

申请人： Hasan B. Alam ,  Yongqing Li

发明人： Hasan B. Alam ,  Yongqing Li

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/92 ,  G01N2800/32

摘要： Methods for the use of keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) (KC/GRO), apolipoprotein A2 (APOA2), angiotensinogen r (AGT), thyroglobulin (TG), disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), anionic trypsin-1 (PRSS1), complement C4 (C4A), zona pellucida sperm-binding protein 1 (ZP1), neuropilin-2 (NRP2), solute carrier family 13 member 2 (SLC13A2), glucagon-like peptide 2 receptor (GLP2R), lipoma high mobility group protein isoform I-C (HMGIC) fusion partner-like protein 4 (LHFPL4), and claudin-3 (CLDN3) as biomarkers for diagnosis and prognosis, and for monitoring the efficacy of treatment, in hemorrhagic shock (HS).

摘要翻译： 使用角质形成细胞趋化因子（KC）/人生长调节癌基因（GRO）（KC / GRO），载脂蛋白A2（APOA2），血管紧张素原r（AGT），甲状腺球蛋白（TG），去整合素和金属蛋白酶结构域的蛋白17 （ADAM17），阴离子胰蛋白酶-1（PRSS1），补体C4（C4A），透明带精子结合蛋白1（ZP1），神经蛋白-2（NRP2），溶质载体家族13成员2（SLC13A2），胰高血糖素样肽 2受体（GLP2R），脂肪瘤高迁移率组蛋白质同种型IC（HMGIC）融合伴侣蛋白4（LHFPL4）和克劳丁-3（CLDN3）作为诊断和预后的生物标志物，并用于监测治疗出血性功能 休克（HS）。

公开(公告)号：US09809797B2

公开(公告)日：2017-11-07

申请号：US12677035

申请日：2008-09-25

申请人： Cassian Yee ,  Yongqing Li

发明人： Cassian Yee ,  Yongqing Li

IPC分类号： C12N5/0783 ,  A61K31/41 ,  A61K39/00 ,  A61K35/17 ,  A61K35/12

CPC分类号： C12N5/0638 ,  A61K31/41 ,  A61K35/12 ,  A61K35/17 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/51 ,  A61K2039/5154 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/2321 ,  C12N2501/998

摘要： A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.

公开(公告)号：US09435813B2

公开(公告)日：2016-09-06

申请号：US13696530

申请日：2011-05-11

申请人： Hasan B. Alam ,  Yongqing Li

发明人： Hasan B. Alam ,  Yongqing Li

IPC分类号： G01N33/68 ,  G01N33/15 ,  C40B40/10 ,  G01N33/92

CPC分类号： G01N33/6893 ,  G01N33/92 ,  G01N2800/32

摘要： Methods for the use of keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) (KC/GRO), apolipoprotein A2 (APOA2), angiotensinogen r (AGT), thyroglobulin (TG), disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), anionic trypsin-1 (PRSS1), complement C4 (C4A), zona pellucida sperm-binding protein 1 (ZP1), neuropilin-2 (NRP2), solute carrier family 13 member 2 (SLC13A2), glucagon-like peptide 2 receptor (GLP2R), lipoma high mobility group protein isoform I-C (HMGIC) fusion partner-like protein 4 (LHFPL4), and claudin-3 (CLDN3) as biomarkers for diagnosis and prognosis, and for monitoring the efficacy of treatment, in hemorrhagic shock (HS).

摘要翻译： 使用角质形成细胞趋化因子（KC）/人生长调节癌基因（GRO）（KC / GRO），载脂蛋白A2（APOA2），血管紧张素原r（AGT），甲状腺球蛋白（TG），去整合素和金属蛋白酶结构域的蛋白17 （ADAM17），阴离子胰蛋白酶-1（PRSS1），补体C4（C4A），透明带精子结合蛋白1（ZP1），神经蛋白-2（NRP2），溶质载体家族13成员2（SLC13A2），胰高血糖素样肽 2受体（GLP2R），脂肪瘤高迁移率组蛋白质同种型IC（HMGIC）融合伴侣蛋白4（LHFPL4）和克劳丁-3（CLDN3）作为诊断和预后的生物标志物，并用于监测治疗出血性功能 休克（HS）。