-
1.发明申请ANTIBODY BOUND SYNTHETIC VESICLE CONTAINING MOLECULES FOR DELIVER TO CENTRAL AND PERIPHERAL NERVOUS SYSTEM CELLS 审中-公开含有分子转运至中央和外周神经系统细胞的抗体结合合成途径公开(公告)号：US20110097392A1
公开(公告)日：2011-04-28
申请号：US12988479
申请日：2009-04-17
IPC分类号： A61K9/127 , C12N5/0793 , C12N9/99 , A61K47/42 , A61K9/00 , A61K39/395 , A61P25/00
CPC分类号： C07K16/286 , A61K9/127 , A61K47/6913 , A61K49/0043 , A61K49/0054 , A61K49/0058 , A61K49/0084
摘要： A process is provided of delivering at least one active agent cargo molecule into an neuronal cell whereby a cargo molecule is placed within a synthetic vesicle such as a liposome and a biotinylated protein such as an antibody is bound to the synthetic vesicle to form a protein bound synthetic vesicle whereby the protein recognizes a receptor expressed on the surface of a neuronal cell, and exposing the protein bound synthetic vesicle to the cell until the cargo molecule is delivered into the neuronal cell. Numerous cargo molecules are delivered by the inventive synthetic vesicle including a calpain inhibitor and a caspase inhibitor. The protein illustratively targets a cellular receptor for a ligand such as glutamate, glycine, dopamine, nicotine, muscarine, acetylcholine, or serotonin, and the like.
摘要翻译： 提供了将至少一种活性剂货物分子递送到神经元细胞中的方法，由此将货物分子置于合成泡囊（例如脂质体）内，并且生物素化蛋白（例如抗体）与合成泡囊结合以形成结合蛋白 合成囊泡，由此蛋白质识别在神经元细胞表面上表达的受体，并将蛋白质结合的合成囊泡暴露于细胞，直到货物分子被递送到神经元细胞中。 许多货物分子由本发明的合成囊泡递送，包括钙蛋白酶抑制剂和胱天蛋白酶抑制剂。 该蛋白质说明性地靶向配体如谷氨酸，甘氨酸，多巴胺，尼古丁，毒蕈碱，乙酰胆碱或血清素等的细胞受体。
-
公开(公告)号：US20130029859A1
公开(公告)日：2013-01-31
申请号：US13379164
申请日：2010-06-21
IPC分类号： G01N33/566 , G01N21/64 , G01N33/573 , C40B30/04
CPC分类号： G01N33/6896 , G01N2333/70564 , G01N2800/28
摘要： A process and assay for determining the neurological condition in a subject is provided whereby the level of one or more neuroactive biomarkers is measured in a sample obtained from the subject. The processes and assay include measurement of multiple neuroactive biomarkers for synergistic determination of a neurological condition such as neurological damage due to injury, disease, contact with a compound, or other source.
摘要翻译： 提供了用于确定受试者的神经学病症的方法和测定法，其中在从受试者获得的样品中测量一种或多种神经活性生物标志物的水平。 方法和测定包括测量多种神经活性生物标志物，用于协同确定神经系统状况，例如由于损伤，疾病，与化合物或其它来源的接触引起的神经损伤。
-
3.发明申请MICRO-RNA, AUTOANTIBODY AND PROTEIN MARKERS FOR DIAGNOSIS OF NEURONAL INJURY 审中-公开用于诊断神经损伤的微RNA，自动抗体和蛋白质标记公开(公告)号：US20130022982A1
公开(公告)日：2013-01-24
申请号：US13395931
申请日：2010-09-14
CPC分类号： G01N33/6896 , C07K16/18 , C12Q1/6883 , C12Q2600/178 , G01N33/5308 , G01N33/564 , G01N2800/28
摘要： Processes and materials are provided for the detection, diagnosis, or determination of the severity of a neurological injury or condition, including traumatic brain injury, multiple-organ injury, stroke, Alzeimer's disease, Pakinson disease and Chronic Traumatic Encephalopathy (CTE). The processes and materials include biomarkers detected or measured in a biological sample such as whole blood, serum, plasma, or CSF. Such biomarkers include Tau and GFAP proteins, their proteolytic breakdown products, brain specific or enriched micro-RNA, and brain specific or enriched protein directed autoantibodies. The processes and materials are operable to detect the presence of absence of acute, subacute or chronic brain injuries and predict outcome for the brain injury.
摘要翻译： 提供过程和材料用于检测，诊断或确定神经损伤或病症的严重程度，包括创伤性脑损伤，多器官损伤，中风，阿尔茨海默病，帕金森病和慢性创伤性脑病（CTE）。 方法和材料包括在生物样品如全血，血清，血浆或CSF中检测或测量的生物标志物。 这些生物标志物包括Tau和GFAP蛋白质，它们的蛋白水解分解产物，脑特异性或富集的微RNA，以及脑特异性或富集的蛋白质定向自身抗体。 该过程和材料可用于检测是否存在急性，亚急性或慢性脑损伤，并预测脑损伤的结果。
-
公开(公告)号：US20140178351A1
公开(公告)日：2014-06-26
申请号：US14116817
申请日：2011-01-26
IPC分类号： A61K38/53 , G01N33/573
CPC分类号： A61K38/53 , A61K38/45 , A61K47/48215 , A61K47/60 , C12Q1/25 , C12Y603/04005 , G01N33/573 , G01N2333/9015 , G01N2800/26 , G01N2800/42
摘要： Processes and compositions for the therapeutic treatment of pathogenic Gram-negative bacterial infection are provided whereby arginino succinate synthetase or PEGylated arginino succinate synthetase is administered to a subject to inactivate endotoxin thereby reducing the likelihood of bacterial sepsis and improving patient outcome.
摘要翻译： 提供用于治疗性治疗病原性革兰氏阴性细菌感染的方法和组合物，其中将精氨酸琥珀酸合成酶或聚乙二醇化的精氨酸琥珀酸合成酶施用于受试者以灭活内毒素，从而降低细菌败血症的可能性并改善患者的结果。
-
5.发明申请EXOGENOUS MATRIX-SUPPORTED TOPICAL APPLICATION OF STEM CELLS TO ORGAN SURFACE 审中-公开外源基质支持的局部应用干细胞到有机表面公开(公告)号：US20110296542A1
公开(公告)日：2011-12-01
申请号：US13149186
申请日：2011-05-31
申请人： Kevin Ka-wang Wang , Lam Ping Kuen , Ng Chi Fai , Ng Siu Man Simon , Mak Wing Chung Tony , Poon Wai Sang , Lai Bo San Paul
发明人： Kevin Ka-wang Wang , Lam Ping Kuen , Ng Chi Fai , Ng Siu Man Simon , Mak Wing Chung Tony , Poon Wai Sang , Lai Bo San Paul
IPC分类号： A01K67/027 , A61P43/00 , A61K35/44 , A61K35/12 , A61K35/14
CPC分类号： A61K35/28 , A61K38/4833 , A61K38/57 , A61K2300/00
摘要： A process of tissue regeneration is provided that includes the administration of a stem cell topically to a surface of a tissue. The tissue being in vivo in a subject or in vitro. The tissue has a biocompatible matrix applied around the stem cell and in contact with the surface. After sufficient time, the stem cell infiltrates and regenerates the tissue. A composition is also provided that includes an injured or diseased tissue with a plurality of stem cells proximal to the tissue surface in a biocompatible. A process of increasing a level of cytokines, chemokines, growth factors, anti-apoptotic or anti-necrotic factors in a tissue is provided that includes the administration of a stem cell topically to a surface of a tissue in a biocompatible matrix. After sufficient time, the stem cell releases soluble pro-regenerative factors to increase the levels in the tissue.
摘要翻译： 提供组织再生的过程，其包括向组织表面局部施用干细胞。 组织在受试者或体外体内。 组织具有围绕干细胞施加并与表面接触的生物相容性基质。 在足够的时间之后，干细胞渗透并再生组织。 还提供了一种组合物，其包括在生物相容性中具有靠近组织表面的多个干细胞的损伤或患病组织。 提供了增加组织中细胞因子，趋化因子，生长因子，抗凋亡或抗坏死因子水平的方法，其包括向生物相容性基质中的组织表面局部施用干细胞。 在足够的时间之后，干细胞释放可溶性促再生因子以增加组织中的水平。
-
公开(公告)号：US09682132B2
公开(公告)日：2017-06-20
申请号：US14116817
申请日：2011-01-26
IPC分类号： A61K38/53 , A61K38/45 , C12Q1/25 , G01N33/573 , A61K47/48
CPC分类号： A61K38/53 , A61K38/45 , A61K47/48215 , A61K47/60 , C12Q1/25 , C12Y603/04005 , G01N33/573 , G01N2333/9015 , G01N2800/26 , G01N2800/42
摘要： Processes and compositions for the therapeutic treatment of pathogenic Gram-negative bacterial infection are provided whereby arginino succinate synthetase or PEGylated arginino succinate synthetase is administered to a subject to inactivate endotoxin thereby reducing the likelihood of bacterial sepsis and improving patient outcome.
-
公开(公告)号：US20110143375A1
公开(公告)日：2011-06-16
申请号：US13058748
申请日：2009-08-11
IPC分类号： G01N33/53 , G01N33/573 , C12M1/34 , B01J19/00
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2871 , G01N2800/60
摘要： The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage.
摘要翻译： 本发明提供用于诊断受试者神经病症的鲁棒，定量和可再现的方法和测定。 本发明提供生物流体如CSF或血清中的两种或更多种生物标志物的测量，从而产生用于确定具有异常神经病症状况的受试者的神经损伤程度和受到损伤的辨别性亚型或组织类型的神经损伤程度的协同机制。
-
公开(公告)号：US20130029362A1
公开(公告)日：2013-01-31
申请号：US13638611
申请日：2011-04-01
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , G01N33/6896 , G01N2333/47 , G01N2333/91142 , G01N2333/96425 , G01N2500/10 , G01N2800/28
摘要： A process and assay for diagnosing neurotoxicity in a subject is provided. The extent of a neurotoxic insult to a subject is assessed through the measurement of one or more biomarkers in a biological fluid, such as CSF or serum. Other uses and advantages afforded include pre-market drug discovery, monitoring, drug neurotoxicity screening and post market assessment of safety and monitoring for drug of known potential neurotoxicity.
摘要翻译： 提供了用于诊断受试者的神经毒性的方法和测定法。 通过测量生物流体如CSF或血清中的一种或多种生物标志物来评估对受试者的神经毒性损伤的程度。 提供的其他用途和优点包括市场前药物发现，监测，药物神经毒性筛选和市场后评估安全性和已知潜在神经毒性药物监测。
-
公开(公告)号：US20110191039A1
公开(公告)日：2011-08-04
申请号：US12975576
申请日：2010-12-22
申请人： Stanislav I. Svetlov , Daniel R. Kirk , Hector Gutierrez , Kevin Ka-wang Wang , Ronald L. Hayes
发明人： Stanislav I. Svetlov , Daniel R. Kirk , Hector Gutierrez , Kevin Ka-wang Wang , Ronald L. Hayes
IPC分类号： G06F19/00
CPC分类号： G16Z99/00
摘要： A process of measuring blast shock includes exposing a shock model to an output of a shockwave generator. The propagation of the output is sensed with a sensor platform to generate sensor wave propagation data. The data recorded by the sensor platform is analyzed to measure the blast shock. The blast shock alone or as a component of a cumulative blast exposure can be correlated with an injury metric. A system for measuring cumulative blast shock is provided that includes a sensor platform and an algorithm operating on a microprocessor for analyzing the data recorded by the sensor platform to measure the cumulative blast exposure to injury metrics.
摘要翻译： 测量爆炸冲击的过程包括将冲击模型暴露给冲击波发生器的输出。 用传感器平台感测输出的传播，以产生传感器波传播数据。 分析由传感器平台记录的数据，以测量爆炸冲击。 爆炸冲击单独或作为累积爆炸暴露的一个组成部分可以与损伤度量相关联。 提供了一种用于测量累积爆炸冲击的系统，其包括传感器平台和在微处理器上操作的算法，用于分析由传感器平台记录的数据以测量损伤度量的累积爆炸暴露。
-
公开(公告)号：US20110082203A1
公开(公告)日：2011-04-07
申请号：US12866120
申请日：2009-02-04
IPC分类号： A61K31/215 , G01N33/53 , G01N33/566 , A61P25/00 , A61P43/00
CPC分类号： G01N33/6896 , G01N2333/914 , G01N2800/28 , G01N2800/2871
摘要： A process for diagnosing and treating a neurological condition in a subject is provided that includes assaying a biological sample of a subject for the presence of one or more biomarkers; diagnosing a neurological condition based on a ratio of one or more of the biomarkers in the sample; and administering a therapeutic to the subject to alter the ratio of one or more biomarkers. The diagnosis numerous neurological conditions such as brain injury, or multiple organ injury is provided.
摘要翻译： 提供了用于诊断和治疗受试者的神经病症的方法，其包括测定受试者的生物样品以存在一种或多种生物标志物; 基于样品中一种或多种生物标志物的比例诊断神经病症; 以及向受试者施用治疗剂以改变一种或多种生物标志物的比例。 提供了许多神经学病症如脑损伤或多器官损伤的诊断。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.027 秒)