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公开(公告)号：US08597892B2
公开(公告)日：2013-12-03
申请号：US12785216
申请日：2010-05-21
申请人： Jeffrey Shelton , Kevin Kelnar , Stephanie Volz , Alex Adai , David Brown
发明人： Jeffrey Shelton , Kevin Kelnar , Stephanie Volz , Alex Adai , David Brown
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178
摘要： This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing prostate disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as prostate cancer.
摘要翻译： 该应用描述了可用作血清或血浆生物标志物的miRNA，用于表征患者中的前列腺疾病。 这些miRNA生物标志物可以单独使用或与其它标志物组合使用，用于诊断，预后或监测前列腺癌等疾病。
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公开(公告)号：US20100297652A1
公开(公告)日：2010-11-25
申请号：US12785216
申请日：2010-05-21
申请人： Jeffrey Shelton , Kevin Kelnar , Stephanie Volz , Alex Adai , David Brown
发明人： Jeffrey Shelton , Kevin Kelnar , Stephanie Volz , Alex Adai , David Brown
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178
摘要： This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing prostate disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as prostate cancer.
摘要翻译： 该应用描述了可用作血清或血浆生物标志物的miRNA，用于表征患者中的前列腺疾病。 这些miRNA生物标志物可以单独使用或与其它标志物组合使用，用于诊断，预后或监测前列腺癌等疾病。
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公开(公告)号：US20100179213A1
公开(公告)日：2010-07-15
申请号：US12616616
申请日：2009-11-11
申请人： Lubna Patrawala , Dean G. Tang , Kevin Kelnar , Jason Wiggins , Stephanie Volz , Jeffrey Shelton , Can Liu , Andreas G. Bader , David Brown
发明人： Lubna Patrawala , Dean G. Tang , Kevin Kelnar , Jason Wiggins , Stephanie Volz , Jeffrey Shelton , Can Liu , Andreas G. Bader , David Brown
IPC分类号： A61K31/7088 , A61P35/04 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2310/141
摘要： The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of developing cancer by targeting cancer stem cells.
摘要翻译： 本发明涉及通过靶向癌症干细胞来治疗患有怀疑具有或具有发展癌症风险的患者的方法和组合物。
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4.发明申请COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS 有权与微血管调节或血管生成调节相关的组合物和方法公开(公告)号：US20090281167A1
公开(公告)日：2009-11-12
申请号：US12437899
申请日：2009-05-08
申请人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
发明人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
IPC分类号： A61K31/7052 , A61P9/00 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/141 , C12N2310/32 , C12N2310/351 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12Q1/6809 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
摘要翻译： 本发明涉及用于诊断和/或治疗包括癌症，心脏疾病，眼睛血管疾病和炎性疾病的血管疾病的方法和组合物。 该方法包括测量患者样品中一种或多种miRNA的水平，并使用测试结果诊断和/或预测患者的最佳治疗方案。 在本发明中描述的组合物包括起到miRNA或miRNA抑制剂的功能，可以根据需要引入患者以减少或增加血管形成。
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公开(公告)号：US20090092974A1
公开(公告)日：2009-04-09
申请号：US11953606
申请日：2007-12-10
申请人： Tim Davison , Dmitriy Ovcharenko , Jeffrey Shelton , Kevin Kelnar , David Brown
发明人： Tim Davison , Dmitriy Ovcharenko , Jeffrey Shelton , Kevin Kelnar , David Brown
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for identifying a miRNA profile for acute myeloid leukemia (AML), and using the profile in assessing the condition of a patient.
摘要翻译： 本发明涉及用于鉴定急性骨髓性白血病（AML）的miRNA谱的方法和组合物，并且在评估患者状况时使用该分布。
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6.发明申请公开(公告)号：US20130065951A1
公开(公告)日：2013-03-14
申请号：US13602933
申请日：2012-09-04
申请人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
发明人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/141 , C12N2310/32 , C12N2310/351 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12Q1/6809 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
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7.发明授权Compositions and methods related to miRNA modulation of neovascularization or angiogenesis 有权与新生血管形成或血管生成miRNA调控相关的组成和方法公开(公告)号：US08258111B2
公开(公告)日：2012-09-04
申请号：US12437899
申请日：2009-05-08
申请人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
发明人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/141 , C12N2310/32 , C12N2310/351 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12Q1/6809 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
摘要翻译： 本发明涉及用于诊断和/或治疗包括癌症，心脏疾病，眼睛血管疾病和炎性疾病的血管疾病的方法和组合物。 该方法包括测量患者样品中一种或多种miRNA的水平，并使用测试结果诊断和/或预测患者的最佳治疗方案。 在本发明中描述的组合物包括起到miRNA或miRNA抑制剂的功能，可以根据需要引入患者以减少或增加血管形成。
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公开(公告)号：US09222085B2
公开(公告)日：2015-12-29
申请号：US13365646
申请日：2012-02-03
申请人： Kevin Kelnar , David Brown
发明人： Kevin Kelnar , David Brown
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , C12N2310/141 , C12N2310/317 , C12N2310/321 , C12N2310/3521
摘要： Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand.
摘要翻译： 实施方案涉及涉及miR-124模拟物的方法和组合物。 在一些实施方案中，存在具有经修饰的核苷酸的双链RNA分子，其具有miR-124序列和补体乘客链的活性链。
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9.发明授权公开(公告)号：US08173611B2
公开(公告)日：2012-05-08
申请号：US11273640
申请日：2005-11-14
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
摘要翻译： 本发明涉及使用合成核酸分子将miRNA活性或功能引入细胞的方法和组合物。 此外，本发明涉及用于鉴定具有与治疗，诊断和预后应用相关的特定细胞功能的miRNA的方法和组合物，其中在文库筛选测定中使用合成的miRNA和/或miRNA抑制剂。
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公开(公告)号：US08946177B2
公开(公告)日：2015-02-03
申请号：US13299255
申请日：2011-11-17
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/113
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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