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    CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS
    1.
    发明申请
    CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 有权
    具有多极电极阵列用于肾神经调节和相关系统和方法的导管装置

    公开(公告)号：US20120116383A1

    公开(公告)日：2012-05-10

    申请号：US13281361

    申请日：2011-10-25

    申请人： Kevin Mauch ,  William Chang ,  Justin Goshgarian ,  Leonila Rivera ,  Martin Rothman

    发明人： Kevin Mauch ,  William Chang ,  Justin Goshgarian ,  Leonila Rivera ,  Martin Rothman

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0041 ,  A61M25/0074 ,  A61M25/0133 ,  A61M25/0138 ,  A61M25/0147

    摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

    摘要翻译： 本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。 例如，本技术的一个方面涉及具有被配置为输送到肾血管的多电极阵列的治疗装置。 阵列可以在传送或低轮廓状态（例如，大致直线形状）和展开状态（例如，径向膨胀，大致螺旋形状）之间选择性地变换。 多电极阵列的尺寸和形状使得当阵列处于部署（例如螺旋状态）时，电极或能量递送元件接触肾血管的内壁。 电极或能量输送元件构造成用于直接和/或间接施加热和/或电能以加热或以其他方式电调节有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构。

    BI-DIRECTIONAL DEPLOYMENT OF NEUROMODULATION DEVICES AND ASSOCIATED SYSTEMS AND METHODS
    5.
    发明申请
    BI-DIRECTIONAL DEPLOYMENT OF NEUROMODULATION DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
    神经修复装置和相关系统和方法的双向部署

    公开(公告)号：US20150230859A1

    公开(公告)日：2015-08-20

    申请号：US14183669

    申请日：2014-02-19

    申请人： Kevin Mauch

    发明人： Kevin Mauch

    IPC分类号： A61B18/14

    CPC分类号： A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/0091 ,  A61B2018/1435 ,  A61B2018/1467

    摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology, for example, is directed to bi-directional control of helical- or spiral-shaped neuromodulation devices. A system can include, for example, a catheter having an elongated shaft and a treatment assembly at a distal portion of the elongated shaft. The catheter can further include a first control member configured to deploy a distal region of the treatment assembly and a second control member configured to deploy a proximal region of the treatment assembly. The proximal and distal regions of the treatment assembly are selectively transformable independent of each other.

    摘要翻译： 本文公开了使用治疗性肾神经调节和相关联的装置，系统和方法治疗患者的方法。 例如，本技术的一个方面涉及螺旋形或螺旋状神经调节装置的双向控制。 系统可以包括例如具有细长轴的导管和在细长轴的远侧部分处的治疗组件。 导管还可包括构造成展开处理组件的远侧区域的第一控制构件和构造成展开处理组件的近侧区域的第二控制构件。 处理组件的近端区域和远端区域彼此独立地选择性地变换。

    Method of Forming Hollow Tubular Drug Eluting Medical Devices
    6.
    发明申请
    Method of Forming Hollow Tubular Drug Eluting Medical Devices 有权
    形成空心管状药物洗脱医疗器械的方法

    公开(公告)号：US20140091057A1

    公开(公告)日：2014-04-03

    申请号：US14038300

    申请日：2013-09-26

    申请人： Kevin Mauch ,  Sean Ward ,  Aram Jamous

    发明人： Kevin Mauch ,  Sean Ward ,  Aram Jamous

    IPC分类号： A61M31/00

    CPC分类号： A61M31/002 ,  A61F2/88 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L31/16 ,  Y10T29/49995

    摘要： A method of a forming a hollow, drug-eluting medical device includes utilizing a hollow wire having an outer member and a lumen of the outer member, and filling the lumen with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the outer member. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance.

    摘要翻译： 形成中空的药物洗脱医疗装置的方法包括利用具有外部构件的外部构件和内腔的中空丝，并且用流体填充内腔以形成支撑的中空丝。 支撑的中空丝被成形为支架图案。 开口通过外部构件形成。 处理支撑的中空丝线以从外部构件的内腔中除去流体，而不会对外部构件产生不利影响，从而将空心线材成形为支架图案。 管腔充满生物或药理活性物质。

    Percutanous Methods for Creating Native Tissue Venous Valves
    7.
    发明申请
    Percutanous Methods for Creating Native Tissue Venous Valves 审中-公开
    用于创建本土组织静脉瓣的经皮方法

    公开(公告)号：US20110155149A1

    公开(公告)日：2011-06-30

    申请号：US13041182

    申请日：2011-03-04

    申请人： Kevin Mauch

    发明人： Kevin Mauch

    IPC分类号： A61B17/00

    CPC分类号： A61F2/2475 ,  A61F2/958

    摘要： Percutaneous methods of forming a venous valve from autologous tissue are disclosed. The methods include percutaneously creating one or two subintimal dissections for forming one or two flaps of intimal tissue. In one method, a puncture element is delivered by a catheter based delivery system to a treatment site where a new venous valve is to be created. The puncture element is deployed to gain access to a subintimal layer of the vein wall. A dilation balloon is than positioned and inflated within the subintimal layer to create a flap and corresponding pocket/sinus in the vein, which than acts as a one-way monocuspid valve in the manner of a native venous valve. In a similar manner, methods of forming new bicuspid venous valves by subintimal dissections are also disclosed.

    摘要翻译： 公开了从自体组织形成静脉瓣的经皮方法。 所述方法包括经皮创建一个或两个内膜消融以形成一个或两个内膜组织瓣。 在一种方法中，穿刺元件通过基于导管的递送系统递送到将要创建新的静脉瓣的治疗部位。 部分穿刺元件以进入静脉壁的内膜层。 扩张气囊不是在内膜层内定位和充气，以在静脉中产生瓣和相应的口袋/窦，其以天然静脉瓣的方式用作单向单瓣阀。 以类似的方式，还公开了通过底内夹层形成新的二尖瓣静脉瓣的方法。

    Percutaneous methods for apparatus for creating native tissue venous valves
    9.
    发明授权
    Percutaneous methods for apparatus for creating native tissue venous valves 有权
    用于创建天然组织静脉瓣的装置的经皮方法

    公开(公告)号：US08460323B2

    公开(公告)日：2013-06-11

    申请号：US12767938

    申请日：2010-04-27

    申请人： Kevin Mauch ,  Maria Arreguin

    发明人： Kevin Mauch ,  Maria Arreguin

    IPC分类号： A61B17/32

    CPC分类号： A61B17/320725 ,  A61B8/0841 ,  A61B8/12 ,  A61B17/3209 ,  A61B2017/00783 ,  A61B2017/22061 ,  A61F2/2463 ,  A61F2/2475 ,  A61M25/0105 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/1075 ,  A61M2025/1081

    摘要： Percutaneous methods and apparatuses for forming a venous valve from autologous tissue. A catheter having a retractable dissecting system received therein is delivered to a target location where a new venous valve is to be created. A distal balloon or other radially-expandable component mounted on the catheter is expanded against the vein wall, and the dissecting system is proximally retracted to deploy one or more dissecting components that dissect a subintimal layer of the vein wall. Radial expansion of the dissecting component(s) within the vein wall creates one or more leaflets and corresponding pocket/sinuses in the vein that collectively act as a venous valve, and/or the radially-expandable component of the catheter is subsequently collapsed such that the dissecting component(s) each pull a flap of the dissected tissue towards the vein lumen to create one or more leaflet(s) and corresponding pocket/sinuses in the vein.

    摘要翻译： 用于从自体组织形成静脉瓣的经皮方法和装置。 将其中容纳有可伸缩解剖系统的导管输送到要创建新静脉瓣的目标位置。 安装在导管上的远端球囊或其他可径向扩张的部件相对于静脉壁膨胀，并且解剖系统向近端缩回以展开解剖静脉壁的内膜层的一个或多个解剖部件。 静脉壁内的解剖组件的径向扩张在静脉中产生一个或多个小叶和静脉中相应的口袋/鼻窦，其共同作为静脉瓣，并且/或导管的可径向扩张的组件随后被塌缩，使得 解剖组件每个将解剖组织的瓣片拉向静脉腔，以在静脉中产生一个或多个小叶和相应的口袋/鼻窦。

    Percutaneous Methods for Creating Native Tissue Venous Valves
    10.
    发明申请
    Percutaneous Methods for Creating Native Tissue Venous Valves 有权
    用于创建本土组织静脉瓣的经皮方法

    公开(公告)号：US20100152843A1

    公开(公告)日：2010-06-17

    申请号：US12335786

    申请日：2008-12-16

    申请人： Kevin Mauch ,  Maria Arreguin

    发明人： Kevin Mauch ,  Maria Arreguin

    IPC分类号： A61F2/24 ,  A61B19/00 ,  A61F2/06

    CPC分类号： A61F2/24 ,  A61F2/2475 ,  A61F2/958

    摘要： Percutaneous methods of forming a venous valve from autologous tissue are disclosed. The methods include percutaneously creating one or two subintimal dissections for forming one or two flaps of intimal tissue. In one method, a puncture element is delivered by a catheter based delivery system to a treatment site where a new venous valve is to be created. The puncture element is deployed to gain access to a subintimal layer of the vein wall. A dilation balloon is than positioned and inflated within the subintimal layer to create a flap and corresponding pocket/sinus in the vein, which than acts as a one-way monocuspid valve in the manner of a native venous valve. In a similar manner, methods of forming new bicuspid venous valves by subintimal dissections are also disclosed.

    摘要翻译： 公开了从自体组织形成静脉瓣的经皮方法。 所述方法包括经皮创建一个或两个内膜消融以形成一个或两个内膜组织瓣。 在一种方法中，穿刺元件通过基于导管的递送系统递送到将要创建新的静脉瓣的治疗部位。 部分穿刺元件以进入静脉壁的内膜层。 扩张气囊不是在内膜层内定位和充气，以在静脉中产生瓣和相应的口袋/窦，其以天然静脉瓣的方式用作单向单瓣阀。 以类似的方式，还公开了通过底内夹层形成新的二尖瓣静脉瓣的方法。