公开(公告)号：US06211340B1

公开(公告)日：2001-04-03

申请号：US09119827

申请日：1998-07-21

申请人： Kevin P. Campbell ,  Daniel Jung ,  Franck Duclos ,  Volker Straub ,  John McPherson

发明人： Kevin P. Campbell ,  Daniel Jung ,  Franck Duclos ,  Volker Straub ,  John McPherson

IPC分类号： C07K1618

CPC分类号： C07K14/4707

摘要： Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 35 kDa non-dystrophin component (&dgr;-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are the amino acid sequence and an immunogenic peptide of &dgr;-sarcoglycan. The peptide when used to immunize a mammal, stimulates the production of antibodies which bind specifically to the &dgr;-sarcoglycan. Methods to identify mutations in the &dgr;-sarcoglycan gene associated with autosomal recessive limb-girdle muscular dystrophy are also disclosed. The identification of such mutations enables the design of nucleic acid probes which hybridize specifically to a mutant form of &dgr;-sarcoglycan, or the complement thereof, but not to the DNA of the wild-type form of the gene (or the complement thereof), under stringent hybridization conditions. Such probes are useful, for example, in connection with the diagnosis of autosomal recessive limb-girdle muscular dystrophy. In addition, the identification of such mutations enables the diagnosis of autosomal recessive limb-girdle muscular dystrophy through the use of direct DNA sequencing techniques.

摘要翻译： 本文公开了编码肌营养不良蛋白 - 糖蛋白复合物的哺乳动物35kDa非肌营养不良蛋白成分（δ-莽草酸）的基本上纯的核酸序列。 还公开了δ-色氨酸的氨基酸序列和免疫原性肽。 当肽用于免疫哺乳动物时，刺激产生与δ-糖聚糖特异性结合的抗体。 还公开了鉴定与常染色体隐性遗传性肢体肌营养不良症相关的δ-色氨酸聚糖基因突变的方法。 这种突变的鉴定使得能够设计特异性地与δ-色氨酸聚糖或其互补体的突变形式杂交的核酸探针，而不与野生型形式的基因（或其互补物）的DNA杂交， 在严格的杂交条件下。 这样的探针可用于例如与常染色体隐性性腰带肌营养不良症的诊断有关。 此外，通过使用直接DNA测序技术，鉴定这种突变能够诊断常染色体隐性的腰带肌营养不良症。

公开(公告)号：US5837537A

公开(公告)日：1998-11-17

申请号：US719758

申请日：1996-09-25

申请人： Kevin P. Campbell ,  Daniel Jung ,  Franck Duclos ,  Volker Straub ,  John McPherson

发明人： Kevin P. Campbell ,  Daniel Jung ,  Franck Duclos ,  Volker Straub ,  John McPherson

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N15/63 ,  C12N15/85

CPC分类号： C07K14/4707

摘要： Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 35 kDa non-dystrophin component (.delta.-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are the amino acid sequence and an immunogenic peptide of .delta.-sarcoglycan. The peptide when used to immunize a mammal, stimulates the production of antibodies which bind specifically to the .delta.-sarcoglycan. Methods to identify mutations in the .delta.-sarcoglycan gene associated with autosomal recessive limb-girdle muscular dystrophy are also disclosed. The identification of such mutations enables the design of nucleic acid probes which hybridize specifically to a mutant form of .delta.-sarcoglycan, or the complement thereof, but not to the DNA of the wild-type form of the gene (or the complement thereof), under stringent hybridization conditions. Such probes are useful, for example, in connection with the diagnosis of autosomal recessive limb-girdle muscular dystrophy. In addition, the identification of such mutations enables the diagnosis of autosomal recessive limb-girdle muscular dystrophy through the use of direct DNA sequencing techniques.

摘要翻译： 本文公开了编码肌营养不良蛋白 - 糖蛋白复合物的哺乳动物35kDa非肌营养不良蛋白成分（δ-聚糖）的基本上纯的核酸序列。 还公开了δ-聚糖的氨基酸序列和免疫原性肽。 当肽用于免疫哺乳动物时，刺激产生与δ-聚糖结合特异性的抗体。 还公开了鉴定与常染色体隐性遗传性肢体肌营养不良症相关的δ-聚糖基因突变的方法。 这种突变的鉴定使得能够设计与δ-聚糖或其互补体的突变形式特异性杂交的核酸探针，而不与野生型形式的基因（或其补体）的DNA杂交， 在严格的杂交条件下。 这样的探针可用于例如与常染色体隐性性腰带肌营养不良症的诊断有关。 此外，通过使用直接DNA测序技术，鉴定这种突变能够诊断常染色体隐性的腰带肌营养不良症。

公开(公告)号：US20070092521A1

公开(公告)日：2007-04-26

申请号：US11551679

申请日：2006-10-20

申请人： John McPherson ,  Tim Edmunds ,  Qun Zhou

发明人： John McPherson ,  Tim Edmunds ,  Qun Zhou

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K17/14 ,  C12N5/06 ,  C07K16/46 ,  C07K16/30

CPC分类号： C07K16/00 ,  C07K16/30 ,  C07K16/3023 ,  C07K2317/41 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/92

摘要： Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.

摘要翻译： 公开了具有增强的ADCC活性的产生抗体的治疗剂的方法。 增强的ADCC活性归因于本发明的抗体和Fc融合蛋白上的寡甘露糖型N-聚糖。 还公开了使用这种基于抗体的治疗剂来靶向杀死哺乳动物细胞的方法，包括治疗癌症，自身免疫性疾病和其它疾病的治疗方法。

公开(公告)号：US20060155739A1

公开(公告)日：2006-07-13

申请号：US10905604

申请日：2005-01-12

申请人： Andrei Broder ,  Marcus Fontoura ,  Michael Herscovici ,  Ronny Lempel ,  John McPherson ,  Andreas Neumann ,  Runping Qi ,  Eugene Shekita

发明人： Andrei Broder ,  Marcus Fontoura ,  Michael Herscovici ,  Ronny Lempel ,  John McPherson ,  Andreas Neumann ,  Runping Qi ,  Eugene Shekita

IPC分类号： G06F17/00

CPC分类号： G06F17/30622

摘要： A method for indexing a plurality of documents, that includes a plurality of duplicate documents, first identifies one or more duplicate groups of documents from among the plurality of documents. Then, one index of content for the duplicate group is created instead of indexing the content from every document within the duplicate group. However, in contrast to the content index, an index of metadata for each of the documents in the duplicate group is created. Thus the content of each duplicate group is indexed only once, while a search engine using such indexing techniques retains the capability to answer queries as if the duplicated content was indexed for each document of the group.

摘要翻译： 一种用于索引多个文档（包括多个重复文档）的方法首先从多个文档中识别一个或多个文档重复组。 然后，创建重复组的一个内容索引，而不是从重复组中的每个文档索引内容。 然而，与内容索引相反，创建了重复组中的每个文档的元数据索引。 因此，每个重复组的内容仅被索引一次，而使用这种索引技术的搜索引擎保留回答查询的能力，就好像为组中的每个文档索引了重复的内容。

公开(公告)号：US20050165718A1

公开(公告)日：2005-07-28

申请号：US10764772

申请日：2004-01-26

申请人： Marcus Fontoura ,  Reiner Kraft ,  Tony Leung ,  John McPherson ,  Andreas Neumann ,  Runping Qi ,  Sridhar Rajagopalan ,  Eugene Shekita ,  Jason Zien

发明人： Marcus Fontoura ,  Reiner Kraft ,  Tony Leung ,  John McPherson ,  Andreas Neumann ,  Runping Qi ,  Sridhar Rajagopalan ,  Eugene Shekita ,  Jason Zien

IPC分类号： G06F7/00 ,  G06F17/30

CPC分类号： G06F17/30864 ,  Y10S707/99931 ,  Y10S707/99943

摘要： Disclosed is a technique for building an index in which global analysis computations and index creation are pipelined, wherein the global analysis computations share intermediate results.

摘要翻译： 公开了一种用于构建其中全局分析计算和索引创建被流水线的索引的技术，其中全局分析计算共享中间结果。

公开(公告)号：US20120109596A1

公开(公告)日：2012-05-03

申请号：US13283729

申请日：2011-10-28

申请人： Richard Gladstone ,  Adam Sills ,  John McPherson

发明人： Richard Gladstone ,  Adam Sills ,  John McPherson

IPC分类号： G06F17/50

CPC分类号： G06Q30/0621 ,  G06F17/5004 ,  G06Q30/0283

摘要： A method and system for optimizing surface coverings having user input representative of a construction project, floor plans representative of the project including optional configurations of the plans, user input for selection from a plurality of the plans and options and creating data points representative of one of the plans, merging the plan and options into a set of data points representative of a final plan set, determining room surface selections from user input, deriving contiguity data from the surface areas representative of the surface selections; and optimizing price of floor materials for selected criteria based on pre-determined rules. The system and method weights traffic flow based on room configurations and determines optimal cuts of materials to minimize seams. Further, the system packs the cut materials optimally to fit standard sheet material such as carpet and vinyl.

摘要翻译： 一种用于优化具有代表施工项目的用户输入的表面覆盖物的方法和系统，代表项目的平面图计划包括计划的可选配置，用于从多个计划和选项中选择的用户输入，以及创建表示以下 计划，将计划和选项合并成一组表示最终计划集合的数据点，从用户输入确定房间表面选择，从表示表面选择的表面区域导出邻接数据; 并根据预先确定的规则优化选定标准的地板材料价格。 系统和方法基于房间配置来重量交通流量，并确定最佳切割材料以最小化接缝。 此外，系统最佳地包装切割材料以适合标准片材，例如地毯和乙烯基。

公开(公告)号：US20070016583A1

公开(公告)日：2007-01-18

申请号：US11182334

申请日：2005-07-14

申请人： Ronny Lempel ,  Todd Leyba ,  John McPherson ,  Justo Perez

发明人： Ronny Lempel ,  Todd Leyba ,  John McPherson ,  Justo Perez

IPC分类号： G06F17/30

CPC分类号： G06F21/6218 ,  G06F21/6227

摘要： Techniques are provided for processing a search request. One or more indexed levels of access control list information are stored in a search index for each document identified in the search index. An interim result set is generated by matching the one or more indexed levels of access control list information associated with each said document to one or more security groups associated with the search request. A final result set is generated from the interim result set by performing impersonation.

摘要翻译： 提供了处理搜索请求的技术。 一个或多个索引级别的访问控制列表信息被存储在搜索索引中，用于在搜索索引中标识的每个文档。 通过将与每个所述文档相关联的一个或多个索引级别的访问控制列表信息与与搜索请求相关联的一个或多个安全组匹配来生成中间结果集。 通过执行模拟从中期结果集生成最终结果集。

公开(公告)号：US20060052303A1

公开(公告)日：2006-03-09

申请号：US11190465

申请日：2005-07-27

申请人： Kuber Sampath ,  John McPherson

发明人： Kuber Sampath ,  John McPherson

IPC分类号： A61K38/22

CPC分类号： A61K38/24 ,  A61K38/29 ,  A61K2300/00

摘要： The invention provides methods for treating or preventing bone degenerative disorders. The disorders treated or prevented include, for example, osteopenia, osteomalacia, osteoporosis, osteomyeloma, osteodystrophy, Paget's disease, osteogenesis imprerfecta, and bone degenerative disorders associated with chronic renal disease, hyperparathyroidism, high levels of endogenous thyrotropin, and long-term use of corticosteroids. The disclosed therapeutic methods include administering to a mammal a TSHR agonist in an amount effective to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) stimulate new bone formation; and/or (5) maintain bone mass and/or bone quality. TSHR agonists such as thyrotropin and its modified forms are provided along with other compounds, such as anti-resorptive agent and bone metabolic agents.

摘要翻译： 本发明提供治疗或预防骨退行性疾病的方法。 所治疗或预防的疾病包括例如骨质减少症，骨软化症，骨质疏松症，骨软骨病，骨营养不良，佩吉特氏病，成骨发生不全症以及与慢性肾脏病，甲状旁腺功能亢进，高水平的内源性促甲状腺激素相关的骨退行性疾病，以及长期使用 皮质类固醇。 所公开的治疗方法包括向哺乳动物施用有效量的TSHR激动剂：（1）治疗或预防骨退行性疾病; （2）慢骨退化; （3）恢复失骨; （4）刺激新骨形成; 和/或（5）维持骨量和/或骨质量。 TSHR激动剂如促甲状腺激素及其修饰形式与其他化合物一起提供，如抗吸收剂和骨代谢剂。

公开(公告)号：US06944167B1

公开(公告)日：2005-09-13

申请号：US09695109

申请日：2000-10-24

申请人： John McPherson

发明人： John McPherson

IPC分类号： H04L29/12 ,  H04L12/56

CPC分类号： H04L29/12273 ,  H04L29/12066 ,  H04L29/12216 ,  H04L29/12283 ,  H04L29/12301 ,  H04L29/12462 ,  H04L29/12471 ,  H04L29/12509 ,  H04L29/12528 ,  H04L61/1511 ,  H04L61/2007 ,  H04L61/2053 ,  H04L61/2061 ,  H04L61/2076 ,  H04L61/255 ,  H04L61/2553 ,  H04L61/2567 ,  H04L61/2575

摘要： According to the invention, a method and apparatus are disclosed for dynamically assigning a public network address for a private network host in response to a request generated external to the private network. A requesting host desiring access to a host with the private network queries a domain name server for the public network address of the private network host. Then, the domain name sever queries a network address translator of the private network, and receives a reply indicating a dynamically allocated public network address for the specified private network host. The requesting host can then use this returned public network address for communicating with the private network host. In this manner, a set of public addresses can be shared, with a public network address being dynamically allocated to a private network host in response to a request for access by a host external to the private network. Moreover, a public network address is assigned to a private network host for a limited period of time. This time period can be specified as a period of network inactivity related to the public network address, or a specified time duration (e.g., for one hour, from 3:00 PM to 5:00 PM). The aging of these assigned public addresses is processed by the domain name server itself, or by the network address translator which sends a message to the domain name server when an assigned public address is no longer valid for a particular private network host.

摘要翻译： 根据本发明，公开了一种用于响应于专用网络外部产生的请求为专用网络主机动态分配公网地址的方法和装置。 希望访问具有私有网络的主机的请求主机向专用网络主机的公共网络地址查询域名服务器。 然后，域名服务器查询专网的网络地址转换器，并接收到指定专用网络主机动态分配的公网地址的应答。 然后，请求主机可以使用该返回的公网地址与专用网络主机通信。 以这种方式，可以共享一组公共地址，其中公共网络地址被动态地分配给专用网络主机以响应由专用网络外部的主机访问的请求。 此外，公共网络地址在有限的时间段内分配给专用网络主机。 该时间段可以被指定为与公共网络地址相关联的网络不活动时段，或指定的持续时间（例如，从3:00 PM到5:00 PM为一小时）。 这些分配的公共地址的老化由域名服务器本身或由分配的公共地址对于特定专用网络主机不再有效时的网络地址转换器来处理，该转换器向域名服务器发送消息。

公开(公告)号：US11487335B1

公开(公告)日：2022-11-01

申请号：US17216331

申请日：2021-03-29

申请人： John McPherson ,  Stephen C Roberts

发明人： John McPherson ,  Stephen C Roberts

IPC分类号： G06F1/20 ,  H05K7/20 ,  F25B21/02

摘要： A tablet cooling device includes a copper plate, having a fan mounted on the coper plate to direct airflow; a heat sink secured directly under the fan; a thermal control board to control and regulate the fan and heat sink; and a peltier cooler secured underneath the heat sink; a sub cooling plate, having a circulation channel embedded in the sub cooling plate; a liquid mixture is circulated through the circulation channel; a power source; the thermal control board detects temperature to maintain a predetermined temperature range via active and passive cooling.