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公开(公告)号：US20070092521A1
公开(公告)日：2007-04-26
申请号：US11551679
申请日：2006-10-20
申请人： John McPherson , Tim Edmunds , Qun Zhou
发明人： John McPherson , Tim Edmunds , Qun Zhou
CPC分类号： C07K16/00 , C07K16/30 , C07K16/3023 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要： Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.
摘要翻译： 公开了具有增强的ADCC活性的产生抗体的治疗剂的方法。 增强的ADCC活性归因于本发明的抗体和Fc融合蛋白上的寡甘露糖型N-聚糖。 还公开了使用这种基于抗体的治疗剂来靶向杀死哺乳动物细胞的方法，包括治疗癌症，自身免疫性疾病和其它疾病的治疗方法。
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公开(公告)号：US07700321B2
公开(公告)日：2010-04-20
申请号：US11551679
申请日：2006-10-20
申请人： John M. McPherson , Tim Edmunds , Qun Zhou
发明人： John M. McPherson , Tim Edmunds , Qun Zhou
IPC分类号： C12P21/08
CPC分类号： C07K16/00 , C07K16/30 , C07K16/3023 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要： Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.
摘要翻译： 公开了具有增强的ADCC活性的产生抗体的治疗剂的方法。 增强的ADCC活性归因于本发明的抗体和Fc融合蛋白上的寡甘露糖型N-聚糖。 还公开了使用这种基于抗体的治疗剂来靶向杀死哺乳动物细胞的方法，包括治疗癌症，自身免疫性疾病和其它疾病的治疗方法。
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公开(公告)号：US08071336B2
公开(公告)日：2011-12-06
申请号：US12704990
申请日：2010-02-12
申请人： John M. McPherson , Tim Edmunds , Qun Zhou
发明人： John M. McPherson , Tim Edmunds , Qun Zhou
IPC分类号： C12P21/08
CPC分类号： C07K16/00 , C07K16/30 , C07K16/3023 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要： Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.
摘要翻译： 公开了具有增强的ADCC活性的产生抗体的治疗剂的方法。 增强的ADCC活性归因于本发明的抗体和Fc融合蛋白上的寡甘露糖型N-聚糖。 还公开了使用这种基于抗体的治疗剂来靶向杀死哺乳动物细胞的方法，包括治疗癌症，自身免疫性疾病和其它疾病的治疗方法。
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公开(公告)号：US20100184145A1
公开(公告)日：2010-07-22
申请号：US12704990
申请日：2010-02-12
申请人： John M. McPherson , Tim Edmunds , Qun Zhou
发明人： John M. McPherson , Tim Edmunds , Qun Zhou
IPC分类号： C12P21/00
CPC分类号： C07K16/00 , C07K16/30 , C07K16/3023 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要： Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.
摘要翻译： 公开了具有增强的ADCC活性的产生抗体的治疗剂的方法。 增强的ADCC活性归因于本发明的抗体和Fc融合蛋白上的寡甘露糖型N-聚糖。 还公开了使用这种基于抗体的治疗剂来靶向杀死哺乳动物细胞的方法，包括治疗癌症，自身免疫性疾病和其它疾病的治疗方法。
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公开(公告)号：US09654544B2
公开(公告)日：2017-05-16
申请号：US10894482
申请日：2004-07-19
申请人： Laurent D. Hasson , Jianren Li , Qun Zhou
发明人： Laurent D. Hasson , Jianren Li , Qun Zhou
CPC分类号： H04L67/06 , H04L67/14 , H04L67/143 , H04L67/145 , H04L67/34 , H04L69/28
摘要： A method, system and apparatus for time-out management for session-dependent applications. A time-out management system can include one or more of pages defining a session-dependent application. The system further can include a server-side time-out manager configured for use in a content server in detecting a time-out condition in the session-dependent application when the session-dependent application has been distributed to a content client. Finally, the system can include at least one client-side time-out manager configured to detect activity for the session-dependent application and to notify the content server when activity is detected in the session-dependent application when the session-dependent application has been distributed to the content client.
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6.发明申请Methods and apparatus for dynamic service discovery from Web services representation chain 审中-公开Web服务表示链动态服务发现的方法和装置公开(公告)号：US20050080768A1
公开(公告)日：2005-04-14
申请号：US10683783
申请日：2003-10-10
申请人： Liang-Jie Zhang , Qun Zhou , Tian-Jy Chao , John Sayah , Jen-Yao Chung , Hung-Yang Chang
发明人： Liang-Jie Zhang , Qun Zhou , Tian-Jy Chao , John Sayah , Jen-Yao Chung , Hung-Yang Chang
CPC分类号： H04L67/16 , G06F16/832 , G06F16/951 , G06F16/958
摘要： Techniques are provided for discovering services available in accordance with an information network. For example, the invention provides methods and apparatus for dynamic service discovery from at least one chain of one or more service description documents employing one or more of automatic change detection of the chain, result aggregation and caching capability. The invention enables businesses to easily retrieve up-to-date web services linked and nested multi-level deep in the service description documents.
摘要翻译： 提供技术来发现根据信息网络可用的服务。 例如，本发明提供了从使用链的自动变化检测，结果聚合和高速缓存能力中的一个或多个的至少一个链的一个或多个服务描述文档的动态服务发现的方法和装置。 本发明使企业能够轻松地检索服务描述文档中深入的链接和嵌套多层次的最新Web服务。
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公开(公告)号：US10370015B2
公开(公告)日：2019-08-06
申请号：US15950673
申请日：2018-04-11
申请人： Shu Tong Chu , Qun Zhou
发明人： Shu Tong Chu , Qun Zhou
IPC分类号： B61L23/34 , B61L25/08 , B61L25/02 , G08G1/00 , G08G1/16 , G08G1/137 , G08G1/123 , G08G1/133 , G08G1/0965 , G08G1/0967 , G08G1/0962 , G01S19/46 , B61L15/00 , B61L23/22
摘要： A method and system for determining a separation distance between a first object and a second object comprises using a search module associated with a first object comprising a first transponder having a unique address. The method includes using a reply module associated with a second object comprising a second transponder having a different, unique address. The method includes the search module transmitting a search signal on a first frequency, said search signal including the address of the first transponder and the address of the second transponder. The reply module receives the search signal and locally validates the address included in said received search signal for the second transponder, whereby, if the validation is positive; the reply module transmits a reply signal on a second, different frequency.
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公开(公告)号：US20180290673A1
公开(公告)日：2018-10-11
申请号：US15950673
申请日：2018-04-11
申请人： Shu Tong Chu , Qun Zhou
发明人： Shu Tong Chu , Qun Zhou
CPC分类号： B61L23/34 , B61L15/009 , B61L23/22 , B61L25/023 , B61L25/08 , B61L2205/04 , G01S19/46 , G01S2205/002 , G08G1/09623 , G08G1/0965 , G08G1/096708 , G08G1/096716 , G08G1/096725 , G08G1/123 , G08G1/133 , G08G1/137 , G08G1/161 , G08G1/163 , G08G1/20 , G08G1/22
摘要： Provided is a method and system for determining a separation distance between a first object and a second object. It is envisaged that at least one of the objects is a movable vehicle such as a train. The method comprises using a search module associated with a first object where said search module comprises a first transponder having a unique address. The method includes using a reply module associated with a second object where said reply module comprises a second transponder having a different, unique address. The method includes the search module transmitting a search signal on a first frequency, said search signal including the address of the first transponder and the address of the second transponder. The reply module receives the search signal and locally validates the address included in said received search signal for the second transponder, whereby, if the validation is positive; the reply module transmits a reply signal on a second, different frequency, said reply signal including the address of the second transponder and the address of the first transponder. The search module receives the reply signal and locally validates the address included in said received reply signal for at least the second transponder whereby, if the validation is positive, the search module determines a separation distance between the first object and the second object based on a time taken from transmission of the search signal to receipt of the reply signal at said search module. The local validation of the address of the second transponder at the reply module and then at the search module improves reliability of processing of reply signals and allows the method to be implemented in a stand-alone configuration not reliant on signals from external systems.
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公开(公告)号：US09475164B2
公开(公告)日：2016-10-25
申请号：US12671795
申请日：2008-06-06
申请人： Robert Simm , Weihong Li , Qun Zhou , Yi Lv , Gendang Zhang , Achim Duesselberg , Xuejing Chen
发明人： Robert Simm , Weihong Li , Qun Zhou , Yi Lv , Wei Liu , Gendang Zhang , Achim Duesselberg , Xuejing Chen
CPC分类号： B23Q11/0071 , A47L9/1409 , A47L9/1454 , B23Q11/0046 , Y02P70/171
摘要： A hand-held power tool is equipped with a dust extraction device which includes a dust box for holding dust. A closing flap is arranged in a tube section which lies in the flow path to the dust box, and this closing flap can be adjusted between the closed position and the open position. The closing flap is pivotably held in the region of the inner wall of the tube section and can be opened in the direction of the dust box. In the closed position, the closing flap bears against a stop which protrudes into the tube section, extends at an angle with respect to the direction of flow through the tube connection piece, and forms a stop line or stop area against which the closing flap correspondingly bears.
摘要翻译： 手持式电动工具配备有除尘装置，该装置包括用于保持灰尘的集尘箱。 闭合翼片设置在位于集尘箱的流动路径中的管部分中，并且该关闭翼片可以在关闭位置和打开位置之间调节。 闭合翼片可枢转地保持在管部分的内壁的区域中，并且可以在集尘箱的方向上打开。 在关闭位置，封闭翼片靠在突出到管部分中的止动件上，相对于通过管连接件的流动方向以一定角度延伸，并形成停止线或停止区域 熊
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公开(公告)号：US20130319711A1
公开(公告)日：2013-12-05
申请号：US12671795
申请日：2008-06-06
申请人： Robert Simm , Weihong Li , Qun Zhou , Yi Lv , Wei Liu , Gendang Zhang , Achim Duesselberg , Xuejing Chen
发明人： Robert Simm , Weihong Li , Qun Zhou , Yi Lv , Wei Liu , Gendang Zhang , Achim Duesselberg , Xuejing Chen
IPC分类号： B23Q11/00
CPC分类号： B23Q11/0071 , A47L9/1409 , A47L9/1454 , B23Q11/0046 , Y02P70/171
摘要： A hand-held power tool is equipped with a dust extraction device which includes a dust box for holding dust. A closing flap is arranged in a tube section which lies in the flow path to the dust box, and this closing flap can be adjusted between the closed position and the open position. The closing flap is pivotably held in the region of the inner wall of the tube section and can be opened in the direction of the dust box. In the closed position, the closing flap bears against a stop which protrudes into the tube section, extends at an angle with respect to the direction of flow through the tube connection piece, and forms a stop line or stop area against which the closing flap correspondingly bears.
摘要翻译： 手持式电动工具配备有除尘装置，该装置包括用于保持灰尘的集尘箱。 闭合翼片设置在位于集尘箱的流动路径中的管部分中，并且该关闭翼片可以在关闭位置和打开位置之间调节。 闭合翼片可枢转地保持在管部分的内壁的区域中，并且可以在集尘箱的方向上打开。 在关闭位置，封闭翼片靠在突出到管部分中的止动件上，相对于通过管连接件的流动方向以一定角度延伸，并形成停止线或停止区域 熊
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