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公开(公告)号:US08314250B2
公开(公告)日:2012-11-20
申请号:US12905120
申请日:2010-10-15
申请人: Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人: Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号: C07D285/01 , C07D417/06 , A61K31/425 , A61K31/4535 , A61K31/4523
CPC分类号: C07D275/06
摘要: The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译: 本发明涉及具有细胞毒活性的根据式1的化合物。 该化合物可用于治疗癌症。
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公开(公告)号:US20110124686A1
公开(公告)日:2011-05-26
申请号:US12905120
申请日:2010-10-15
申请人: Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人: Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号: A61K31/454 , A61K31/425 , C07D275/03 , C07D417/06 , A61P35/00
CPC分类号: C07D275/06
摘要: The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译: 本发明涉及具有细胞毒活性的根据式1的化合物。 该化合物可用于治疗癌症。
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公开(公告)号:US5482251A
公开(公告)日:1996-01-09
申请号:US288684
申请日:1994-08-11
申请人: John L. Roberts
发明人: John L. Roberts
CPC分类号: F16K35/06 , F16K5/0647
摘要: A rotatable control device or valve including a body housing a control mechanism and a rotatably mounted control shaft connected to the control mechanism. Stops are spaced circumferentially relative to the control shaft. A stop arm is operably connected to the control shaft and engages the stops to limit rotational movement of the control mechanism between first and second positions. An elongated extension is drivingly connected to the stop arm, and an elongated operating handle is connected to the extension with the orientation of the longitudinal axis of the operating handle corresponding in a predetermined relationship to the position of the control member. A registration mechanism permits the extension to be drivingly connected to the stop arm only when the orientation of the longitudinal axis of the operating handle corresponds in the predetermined relationship to the position of the control means.
摘要翻译: 一种旋转控制装置或阀,包括容纳控制机构的主体和连接到控制机构的可旋转地安装的控制轴。 止动件相对于控制轴在周向间隔开。 止动臂可操作地连接到控制轴并接合止动件以限制控制机构在第一和第二位置之间的旋转运动。 细长的延伸部驱动地连接到止动臂,并且细长的操作手柄连接到延伸部,其中操作手柄的纵向轴线的取向以对应于控制构件的位置的预定关系对应。 只有当操作手柄的纵向轴线的取向与控制装置的位置相对应的预定关系时,对准机构允许延伸部被驱动地连接到止动臂。
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公开(公告)号:US5469929A
公开(公告)日:1995-11-28
申请号:US415805
申请日:1995-04-03
申请人: Tony M. Dadak , John L. Roberts
发明人: Tony M. Dadak , John L. Roberts
IPC分类号: B62D5/083
CPC分类号: B62D5/083
摘要: A motor vehicle power steering gear having a spool shaft connected to a steering wheel, a pinion head connected to a steered wheel, a torsion bar between the spool shaft and the pinion head, a control valve for regulating a hydraulic steering assist boost pressure in response to rotation of the spool shaft from an on-center position relative to the pinion head against a restoring force of the torsion bar, and a quiet preload apparatus including a C-shaped spring around the spool shaft having a pair of resilient jaws, a drive pin on the spool shaft clamped with a preload between the resilient jaws, and a cushioned abutment on the pinion head clamped with the preload between the resilient jaws. The cushioned abutment includes a pair of radial cantilever springs which flex upon engagement with corresponding ones of the resilient jaws during forced oscillation of the pinion head back and forth through the on-center relative position of the spool shaft to minimize audible noise associated with such engagements and a radial reinforcement between the cantilever springs which limits flexure thereof to minimize the effect of the cantilever springs on the performance characteristics of the control valve.
摘要翻译: 一种机动车辆动力转向器,其具有连接到方向盘的卷轴,连接到转向轮的小齿轮头,卷轴和小齿轮头之间的扭杆,用于响应于调节液压转向辅助增压压力的控制阀 相对于扭杆的恢复力使卷筒轴从相对于小齿轮头的中心位置旋转,并且包括围绕卷轴的C形弹簧的安静的预加载装置具有一对弹性夹爪,驱动装置 销轴线夹在弹性夹爪之间的预紧力上,以及与弹性夹爪之间的预载夹紧的小齿轮头上的缓冲支座。 缓冲支座包括一对径向悬臂弹簧,其在相应的弹性夹爪的作用下与小齿轮头部的强制摆动相互弹跳,通过卷筒轴的中心相对位置来往复运动,以最小化与这种啮合相关联的可听见的噪音 以及在悬臂弹簧之间的径向加强件,其限制其挠曲,以最小化悬臂弹簧对控制阀的性能特性的影响。
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公开(公告)号:US5159077A
公开(公告)日:1992-10-27
申请号:US383783
申请日:1989-07-21
申请人: Dennis D. Keith , John L. Roberts , Chung-Chen Wei
发明人: Dennis D. Keith , John L. Roberts , Chung-Chen Wei
IPC分类号: C07D205/085 , C07D401/12 , C07D499/00 , C07D499/21 , C07D501/00 , C07D519/00
CPC分类号: C07D401/12 , C07D205/085 , C07D499/00 , C07D501/00
摘要: Antibacterial compounds of the formula ##STR1## in which R.sub.1 is a cyclic or secondary acyclic amino group which independently has antibacterial activity:R.sub.2 is hydrogen, lower alkoxy, lower alkylthio or formamido;R.sub.3 is hydrogen or an organic group bonded through carbon, oxygen, sulfur or nitrogen;R.sub.4 is an electronegative acidic group; or R.sub.3 and R.sub.4 together form a heterocycle; andR.sub.5 is a hydrogen or lower alkyl, except when R.sub.3 and R.sub.4 form a heterocycle, in which case R.sub.5 is hydrogen only; and methods of using same.
摘要翻译: R1是具有独立具有抗菌活性的环状或次级无环氨基的式Ⅰ的抗菌化合物:R2是氢,低级烷氧基,低级烷硫基或甲酰氨基; R3是氢或通过碳,氧,硫或氮键合的有机基团; R4是电负性酸性基团; 或R3和R4一起形成杂环; 并且R 5是氢或低级烷基,除了当R 3和R 4形成杂环时,其中R 5仅为氢; 和使用方法。
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公开(公告)号:US5579804A
公开(公告)日:1996-12-03
申请号:US541687
申请日:1995-10-10
申请人: John L. Roberts
发明人: John L. Roberts
IPC分类号: F16K35/06
CPC分类号: F16K35/06 , Y10T137/7256 , Y10T70/5624 , Y10T70/5637
摘要: A tamper-proof locking mechanism for a rotatable control device, such as a quarter turn valve, including a valve member connected to a stem rotatably mounted in a body housing the valve member and an operating handle connected to the stem via an elongated extension for rotating the valve member between open and closed positions. The locking mechanism includes a bracket mounted on the body and having a flange spaced outwardly from the body and generally perpendicularly to the rotational axis of the stem and including an aperture through which the extension extends and a pair of circumferentially spaced projections extending radially outwardly relative to the rotational axis of the stem at locations corresponding to the open and closed positions of the valve member. A slider member, slidably mounted on the intermediate portion of the handle for reciprocating movement between locked and unlocked positions, includes a latch element having an opening for receiving the projections and arranged to restrain both rotational and axial movement of the handle when the handle is in the open or closed position and the slider member is in the locked position.
摘要翻译: 一种用于可旋转控制装置(例如四分之一转换阀)的防篡改锁定机构,其包括连接到可旋转地安装在容纳阀构件的主体中的杆的阀构件和通过细长延伸部连接到杆的操作手柄, 阀构件在打开和关闭位置之间。 锁定机构包括安装在主体上的支架,其具有从主体向外间隔开并且大致垂直于杆的旋转轴线的凸缘,并且包括一个孔,该延伸部延伸穿过该孔,并且一对周向间隔开的突出部相对于 杆的旋转轴线对应于阀构件的打开和关闭位置的位置。 滑动构件,可滑动地安装在手柄的中间部分上,用于在锁定位置和未锁定位置之间往复运动,包括一个闩锁元件,该闩锁元件具有用于接收突起的开口,并被布置成当手柄处于手柄时能够抑制手柄的旋转和轴向运动 打开或关闭位置和滑动构件处于锁定位置。
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公开(公告)号:US5162523A
公开(公告)日:1992-11-10
申请号:US539359
申请日:1990-06-20
申请人: Dennis D. Keith , John L. Roberts , Chung-Chen Wei
发明人: Dennis D. Keith , John L. Roberts , Chung-Chen Wei
IPC分类号: A61K31/397 , A61K31/40 , A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , A61P31/12 , C07D205/085 , C07D205/095 , C07D401/02 , C07D401/12 , C07D401/14 , C07D499/00 , C07D499/21 , C07D501/00 , C07D501/16 , C07D501/59 , C07D519/00
CPC分类号: C07D401/12 , C07D205/085 , C07D499/00 , C07D501/00
摘要: Antibacterial compounds of the formula ##STR1## in which R.sub.1 is a cyclic or secondary acyclic amino group which independently has antibacterial activity;R.sub.2 is hydrogen, lower alkoxy, lower alkylthio or formamido;R.sub.3 is hydrogen or an organic group bonded through carbon, oxygen, sulfur or nitrogen;R.sub.4 is an electronegative acidic group; or R.sub.3 and R.sub.4 together form a heterocycle; andR.sub.5 is hydrogen or lower alkyl, except when R.sub.3 and R.sub.4 form a heterocycle, in which case R.sub.5 is hydrogen only; and methods of using same.
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公开(公告)号:US5483744A
公开(公告)日:1996-01-16
申请号:US567993
申请日:1990-08-16
申请人: John L. Roberts
发明人: John L. Roberts
CPC分类号: F16C33/385 , F16C43/06 , G01C19/16 , Y10T29/49638 , Y10T29/4965 , Y10T29/49696
摘要: A method and apparatus which provides a bearing design with an irregular or semi-rhythmic ball spacing. The method of the invention includes the steps of a) choosing an initial pattern for the position of the balls with an arbitrary irregular spacing therebetween; b) determining the degree to which the bearing is suitable for a given application with the chosen spacing between the balls; c) moving the balls in the pattern to change the spacing therebetween and d) repeating steps b) and c) until the bearing is suitable for a given application.
摘要翻译: 提供具有不规则或半节奏球间距的轴承设计的方法和装置。 本发明的方法包括以下步骤:a)选择具有任意不规则间距的球的位置的初始图案; b)确定轴承适用于具有球之间所选间距的给定应用的程度; c)以图案移动球以改变它们之间的间隔,并且d)重复步骤b)和c),直到轴承适合于给定的应用。
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公开(公告)号:US4976056A
公开(公告)日:1990-12-11
申请号:US356640
申请日:1989-05-11
申请人: John L. Roberts
发明人: John L. Roberts
CPC分类号: G09F19/00 , G09F3/10 , Y10T428/1405 , Y10T428/1462
摘要: An advertising or promotional item comprises a body (2) from one side of which extends a flag (3) carrying an advertising message, the body (2) having a foot (1) by which it may be adhered to a support. According to the invention the body (2) is a flattened mass of fibers (5), so that the item is small enough to be posted in an envelope in the mail. A face (4) may be adhered to the body (2) to keep the item flat.
摘要翻译: 一种广告或促销品包括从其一侧延伸有承载广告消息的标志(3)的主体(2),所述主体(2)具有脚(1),通过该脚可以将其附着到支撑件。 根据本发明,主体(2)是扁平的纤维块(5),使得该物品足够小以便张贴在邮件的信封中。 面(4)可以粘附到主体(2)上以保持物品平坦。
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公开(公告)号:US5183073A
公开(公告)日:1993-02-02
申请号:US862330
申请日:1992-04-02
申请人: John L. Roberts
发明人: John L. Roberts
CPC分类号: F16K5/0647 , F16K35/025 , F16K35/06 , Y10T137/7256 , Y10T70/5624 , Y10T70/5637 , Y10T70/5779
摘要: A rotatable control device including a body housing a control structure and having an external box; a control shaft journalled in the boss for rotation about an axis and having an internal portion connected to the control structure and an external portion extending outwardly from the boss; an operating handle having an inner end portion connected to the external portion of the control shaft, a gripping end portion for rotating the control structure between first and second positions and an intermediate portion; first and second locking structure circumferentially spaced on the body at locations corresponding to the positions of the intermediate portion of the handle when the control structure is in the first and second positions, respectively; a slider member slidably mounted on the intermediate portion of the handle for reciprocative movement between locked and unlocked positions; interlocking structure for cooperating with the first and second locking structure, when the handle is in the first and second position, respectively, and the slider member is in the locking position, to restrain rotational movement of the handle; and bias structure for biasing the slider member toward the locked position irrespective of the orientation of the handle.
摘要翻译: 一种可旋转控制装置,包括容纳控制结构并具有外部盒的主体; 控制轴轴颈安装在凸台中,用于围绕轴线旋转并具有连接到控制结构的内部部分和从凸台向外延伸的外部部分; 具有连接到所述控制轴的外部的内端部的操作手柄,用于使所述控制结构在第一位置与所述第二位置之间旋转的夹持端部和中间部; 第一和第二锁定结构,当控制结构分别处于第一和第二位置时,在对应于手柄的中间部分的位置的位置处,在主体上周向间隔开; 滑动构件,可滑动地安装在所述手柄的中间部分上,用于在锁定位置和解锁位置之间往复移动; 当手柄分别处于第一和第二位置并且滑动构件处于锁定位置时,用于与第一和第二锁定结构配合的互锁结构,以限制手柄的旋转运动; 以及偏置结构,用于将滑块构件朝向锁定位置偏置,而与手柄的取向无关。
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