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公开(公告)号：US08314250B2
公开(公告)日：2012-11-20
申请号：US12905120
申请日：2010-10-15
申请人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号： C07D285/01 , C07D417/06 , A61K31/425 , A61K31/4535 , A61K31/4523
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译： 本发明涉及具有细胞毒活性的根据式1的化合物。 该化合物可用于治疗癌症。
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公开(公告)号：US20110124686A1
公开(公告)日：2011-05-26
申请号：US12905120
申请日：2010-10-15
申请人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号： A61K31/454 , A61K31/425 , C07D275/03 , C07D417/06 , A61P35/00
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译： 本发明涉及具有细胞毒活性的根据式1的化合物。 该化合物可用于治疗癌症。
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公开(公告)号：US07851626B2
公开(公告)日：2010-12-14
申请号：US11604558
申请日：2006-11-27
申请人： Qingjie Ding , Bradford James Graves , Norman Kong , Jin-Jun Liu , Allen John Lovey , Giacomo Pizzolato , John Lawson Roberts , Sung-Sau So , Binh Thanh Vu , Peter Michael Wovkulich
发明人： Qingjie Ding , Bradford James Graves , Norman Kong , Jin-Jun Liu , Allen John Lovey , Giacomo Pizzolato , John Lawson Roberts , Sung-Sau So , Binh Thanh Vu , Peter Michael Wovkulich
IPC分类号： C07D403/02 , C07D233/06 , A61K31/497 , A01N43/50
CPC分类号： C07D233/22 , C07D233/26 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D407/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯，其中本文描述了X1，X2，R1，R2，R3，R4，R5和R6。 化合物表现出抗癌作用。
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公开(公告)号：US20070129416A1
公开(公告)日：2007-06-07
申请号：US11604558
申请日：2006-11-27
申请人： Qingjie Ding , Bradford Graves , Norman Kong , Jin-Jun Liu , Allen Lovey , Giacomo Pizzolato , John Roberts , Sung-Sau So , Binh Vu , Peter Wovkulich
发明人： Qingjie Ding , Bradford Graves , Norman Kong , Jin-Jun Liu , Allen Lovey , Giacomo Pizzolato , John Roberts , Sung-Sau So , Binh Vu , Peter Wovkulich
IPC分类号： A61K31/4164 , C07D233/22 , C07D233/06
CPC分类号： C07D233/22 , C07D233/26 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D407/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯，其中X 1，X 2，R 1，R 2， > 2，R 3，R 4，R 5和R 6在本文中进行了描述。 化合物表现出抗癌作用。
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公开(公告)号：US20100137250A1
公开(公告)日：2010-06-03
申请号：US12614478
申请日：2009-11-09
申请人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
发明人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/69 , C07C63/33 , A61K31/18 , C07D295/00 , A61K31/535 , C07C69/76 , C07D239/00 , C07D239/42
CPC分类号： C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 6在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症，例如哮喘。
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公开(公告)号：US08268870B2
公开(公告)日：2012-09-18
申请号：US13324650
申请日：2011-12-13
申请人： Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
发明人： Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D231/56 , C07D401/12
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
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公开(公告)号：US08263656B2
公开(公告)日：2012-09-11
申请号：US12540839
申请日：2009-08-13
申请人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, Jr. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
发明人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, Jr. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
IPC分类号： A61K31/195 , C07C317/12
CPC分类号： C07C311/29 , C07C311/20 , C07C317/14 , C07C2602/10 , C07D213/34
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R4 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1 -R 4在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US08138208B2
公开(公告)日：2012-03-20
申请号：US12497807
申请日：2009-07-06
申请人： Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
发明人： Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
IPC分类号： A61K31/4439 , A61K31/416 , C07D231/54 , C07D401/02
CPC分类号： C07D231/56 , C07D401/12 , C07D413/12
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中Q，W，X，R 1 -R 5和n在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US08124629B2
公开(公告)日：2012-02-28
申请号：US12614478
申请日：2009-11-09
申请人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
发明人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/44 , A61K31/192 , C07D211/54 , C07C63/64
CPC分类号： C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 6在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症，例如哮喘。
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公开(公告)号：US20100041760A1
公开(公告)日：2010-02-18
申请号：US12540780
申请日：2009-08-13
申请人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Song Pan , Sung-Sau So , HongYing Yun
发明人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Song Pan , Sung-Sau So , HongYing Yun
IPC分类号： A61K31/18 , C07C311/00
CPC分类号： C07D295/08 , C07C311/20 , C07C311/29 , C07C311/43 , C07C317/14 , C07C323/66 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2602/10
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1，R 2和R 3在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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