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    Rapid exchange catheters for embolic protection devices
    2.
    发明授权
    Rapid exchange catheters for embolic protection devices 有权
    快速交换导管用于栓塞保护装置

    公开(公告)号：US08167902B2

    公开(公告)日：2012-05-01

    申请号：US11837056

    申请日：2007-08-10

    申请人： Christopher G. Quinn ,  Sara K. Bakker ,  Steven G. Zaver ,  Kevin W. Anderson ,  Sengkham Sirivong

    发明人： Christopher G. Quinn ,  Sara K. Bakker ,  Steven G. Zaver ,  Kevin W. Anderson ,  Sengkham Sirivong

    IPC分类号： A61M29/00

    CPC分类号： A61F2/01 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0008 ,  A61F2230/0067 ,  A61M2025/0183

    摘要： Catheter having a first elongate tubular body having a lumen, a second elongate tubular body having a lumen, and an elongate member. The elongate member joins the first and second elongate tubular bodies. The first tubular body is fixedly attached on the distal portion of the elongate member, and the second elongate tubular body is disposed on the elongate member is slidable along a portion of the elongate member. The second elongate tubular body can be in a first position so that the first and second tubular bodies are not adjacent to each other and can be in a second position so that the first and second tubular bodies are adjacent to each other. The catheter may have a locking mechanism that can lock the first and second elongate tubular bodies to each other so that the lumens of the first and second elongate tubular bodies form one continuous lumen.

    摘要翻译： 导管具有具有内腔的第一细长管状体，具有内腔的第二细长管状体和细长构件。 细长构件连接第一和第二细长管状体。 第一管状体固定地附接在细长构件的远侧部分上，并且设置在细长构件上的第二细长管状体可沿细长构件的一部分滑动。 第二细长管状体可以处于第一位置，使得第一和第二管状体不彼此相邻并且可以处于第二位置，使得第一和第二管状体彼此相邻。 导管可以具有锁定机构，其可以将第一和第二细长管状体彼此锁定，使得第一和第二细长管状体的内腔形成一个连续的内腔。

    Method for controlling biooxidation reactions
    4.
    发明授权
    Method for controlling biooxidation reactions 失效
    控制生物氧化反应的方法

    公开(公告)号：US07270947B2

    公开(公告)日：2007-09-18

    申请号：US10756240

    申请日：2004-01-13

    申请人： Kevin W. Anderson ,  J. Douglas Wenzel

    发明人： Kevin W. Anderson ,  J. Douglas Wenzel

    IPC分类号： C12Q3/00 ,  C12P7/64 ,  C12P7/40 ,  C12P7/44

    CPC分类号： C12P7/6409 ,  C12P7/44 ,  C12P7/46

    摘要： Biooxidation reactions can be controlled by a method which comprises the steps of: (1) independently adding a substrate and a co-substrate at predetermined rates to a bioxidation reaction mixture comprised of a biocatalyst; (2) measuring the oxygen consumption rate and carbon dioxide evolution rate from the reaction mixture; (3) determining the instantaneous rates of substrate and cosubstrate consumption by solving simultaneous equations relating carbon dioxide evolution rate and oxygen consumption rate to the substrate oxidation stoichiometry, the cosubstrate combustion stoichiometry, and optionally the biomass formation stoichiometry; (4) simultaneously adjusting the substrate and cosubstrate addition rates to the rates of substrate oxidation and cosubstrate consumption in order to maximize the rate of product formation while simultaneously minimizing the rate of cosubstrate usage. The method provides a rapid means of controlling fed-batch biooxidation reactions which can employ in-line techniques and is broadly applicable for diverse oxidation reactions.

    摘要翻译： 生物氧化反应可以通过一种方法来控制，该方法包括以下步骤：（1）以包含生物催化剂的生物氧化反应混合物以预定速率独立地加入底物和共底物; （2）从反应混合物中测量氧气消耗速率和二氧化碳释放速率; （3）通过求解将二氧化碳进化速率和氧耗率与二氧化碳排放速率和氧消耗速率相关的联立方程与底物氧化化学计量法，同位素燃烧化学计量法和任选的生物质形成化学计量法来确定底物和辅助消耗的瞬时速率; （4）同时调整衬底并将衬底加入速率与底物氧化和辅助消耗的速率进行调和，以最大限度地提高产物形成速率，同时最大限度地降低衬底使用率。 该方法提供了控制补料分批生物氧化反应的快速方法，其可以使用在线技术并且广泛适用于多种氧化反应。

    Low profile inflatable package protection system
    5.
    发明授权
    Low profile inflatable package protection system 有权
    薄型充气包装保护系统

    公开(公告)号：US07168566B2

    公开(公告)日：2007-01-30

    申请号：US10295356

    申请日：2002-11-15

    申请人： Kevin W. Anderson ,  John T. Peterson ,  William A. Peper ,  Joseph T. Bartusiak ,  Gerald E. Mueller ,  Charles R. Kleissler

    发明人： Kevin W. Anderson ,  John T. Peterson ,  William A. Peper ,  Joseph T. Bartusiak ,  Gerald E. Mueller ,  Charles R. Kleissler

    IPC分类号： B65D81/03

    CPC分类号： B32B21/08 ,  B65D81/052 ,  Y10S206/821 ,  Y10T428/13 ,  Y10T428/1334 ,  Y10T428/1352

    摘要： A multi-chambered inflatable member formed by connecting the perimeters of two polymeric film layers includes a seal line spaced from the perimeter that interconnects the two film layers to form a perimeter inflatable channel along a portion of the perimeter. A plurality of inflatable cells extend between opposing portions of the inflatable channel and are in communication with one of the opposing portions of the inflatable channel. A check valve communicates with the inflatable channel to inflate the inflatable member. Articles being shipped or stored in a container can be placed between two or more inflatable members, the perimeter inflatable channels of which provide perimeter protection between the article and the container.

    摘要翻译： 通过连接两个聚合物膜层的周边形成的多室充气构件包括与周边隔开的密封线，该密封线将两个膜层互连，以形成沿着周边的一部分的周边可充气通道。 多个可充气单元在可充气通道的相对部分之间延伸并且与可充气通道的相对部分中的一个连通。 止回阀与充气通道连通，以使可膨胀构件膨胀。 运送或储存在容器中的物品可以放置在两个或更多个可膨胀构件之间，其可充气通道的周边可在物品和容器之间提供周边保护。

    Process for making polycarboxylic acids
    6.
    发明授权
    Process for making polycarboxylic acids 失效
    制备多元羧酸的方法

    公开(公告)号：US5962285A

    公开(公告)日：1999-10-05

    申请号：US106611

    申请日：1998-06-23

    申请人： Kevin W. Anderson ,  J. Douglas Wenzel ,  Richard G. Fayter ,  Kenneth R. McVay

    发明人： Kevin W. Anderson ,  J. Douglas Wenzel ,  Richard G. Fayter ,  Kenneth R. McVay

    IPC分类号： C12P7/44 ,  C12P7/46 ,  C12P7/64

    CPC分类号： C12P7/44 ,  C07C51/34 ,  C12P7/6409 ,  C12R1/74 ,  Y10S435/924

    摘要： Aliphatic polycarboxylic acids are made by a process comprising the steps of: (1) fermenting a beta-oxidation blocked C. tropicalis cell wherein both copies of the chromosomal POX5 gene and the chromosomal POX4A and POX4B genes are disrupted in a culture medium comprised of a nitrogen source, an organic substrate and a cosubstrate wherein the substrate is an unsaturated aliphatic compound having at least one internal carbon--carbon double bond and at least one terminal methyl group, a terminal carboxyl group and/or a terminal functional group which is oxidizable to a carboxyl group by biooxidation; (2) reacting the product of step (1) with an oxidizing agent to produce one or more polycarboxylic acids.

    摘要翻译： 脂肪族多羧酸通过包括以下步骤的方法制备：（1）发酵β-氧化阻断的热带假丝酵母细胞，其中染色体POX5基因和染色体POX4A和POX4B基因的两个拷贝在包含 氮源，有机底物和底物，其中所述底物是具有至少一个内部碳 - 碳双键和至少一个末端甲基，末端羧基和/或末端官能团的不饱和脂族化合物，其可氧化成 羧基通过生物氧化反应; （2）使步骤（1）的产物与氧化剂反应以产生一种或多种多元羧酸。

    Process for continuously splitting a glyceride into carboxylic acids and glycerin
    7.
    发明授权
    Process for continuously splitting a glyceride into carboxylic acids and glycerin 失效
    将甘油酯连续分解成羧酸和甘油的方法

    公开(公告)号：US5830719A

    公开(公告)日：1998-11-03

    申请号：US843968

    申请日：1997-04-17

    申请人： Kevin W. Anderson ,  J. Douglas Wenzel

    发明人： Kevin W. Anderson ,  J. Douglas Wenzel

    IPC分类号： C12P7/20 ,  C12P7/64 ,  C12N9/20 ,  C12P7/40

    CPC分类号： C12P7/6418

    摘要： Carboxylic acids and glycerine are made by a continuous splitting process which involves the formation of a presplitting mixture by separately adding the glyceride, an effective lipase in an amount sufficient to produce partial splitting of the glyceride, and water. The water used in the formation of the presplitting mixture is water that has been separated from the glycerin-water effluent stream from the pressure splitter and recycled. The next step involves the pressure splitting which entails mixing the partially split glyceride from the presplitter with water and heating under conditions of temperature and pressure effective to substantially complete the splitting of the glyceride into component fatty acids and a glycerin-water stream. The water is then separated from the glycerine-water stream and the water is recycled to the presplitter.

    摘要翻译： 羧酸和甘油通过连续分离方法制备，其包括通过单独加入甘油酯形成预分解混合物，该量为足以产生甘油酯部分裂解的量的有效脂肪酶和水。 用于形成预分裂混合物的水是已经从压力分配器与甘油 - 水流出物流分离并再循环的水。 下一步涉及压力分解，其需要将分解器中的部分分离的甘油酯与水混合，并在有效基本上完成将甘油酯分解成组分脂肪酸和甘油 - 水流的温度和压力的条件下加热。 然后将水从甘油 - 水流中分离出来并将水再循环到分解器中。

    Fermentation process
    10.
    发明授权
    Fermentation process 失效

    公开(公告)号：US06569670B2

    公开(公告)日：2003-05-27

    申请号：US09754158

    申请日：2001-01-04

    申请人： Kevin W. Anderson ,  J. Douglas Wenzel

    发明人： Kevin W. Anderson ,  J. Douglas Wenzel

    IPC分类号： C12N120

    CPC分类号： C12P7/6409 ,  C12N1/16 ,  C12P7/6436

    摘要： A fermentation medium containing: (a) a source of metabolizable carbon and energy; (b) a source of inorganic nitrogen; (c) a source of phosphate; (d) at least one metal selected from the group consisting of an alkali metal, an alkaline earth metal, a transition metal, and mixtures thereof; and (e) biotin, substantially free of particulate matter and bacteria. A fatty material may be added to an aqueous suspension containing at least one dicarboxylic acid to modify the rheological characteristics of the suspension.