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    Application using non-covalent bond between a cucurbituril derivative and a ligand
    1.
    发明授权
    Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
    在葫芦巴衍生物和配体之间使用非共价键的应用

    公开(公告)号：US07718128B2

    公开(公告)日：2010-05-18

    申请号：US12339944

    申请日：2008-12-19

    申请人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Ilha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    发明人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Ilha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    IPC分类号： G01N15/06 ,  A61K9/14 ,  A61K45/00 ,  B01L3/00 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    摘要翻译： 本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自 由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物， 金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

    APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND
    2.
    发明申请
    APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND 有权
    使用CUCURBITURIL衍生物和配体之间的非共价键的应用

    公开(公告)号：US20090095677A1

    公开(公告)日：2009-04-16

    申请号：US12339944

    申请日：2008-12-19

    申请人： Kimoon KIM ,  Kangkyun Baek ,  Jeeyeon Kim ,  Ilha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    发明人： Kimoon KIM ,  Kangkyun Baek ,  Jeeyeon Kim ,  Ilha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    IPC分类号： B01D15/32 ,  C12N9/96 ,  C12N11/14 ,  C12N11/08 ,  C12N11/10 ,  B01J31/12

    CPC分类号： C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    摘要翻译： 本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自 由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物， 金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

    Application using non-covalent bond between a cucurbituril derivative and a ligand
    3.
    发明授权
    Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
    在葫芦巴衍生物和配体之间使用非共价键的应用

    公开(公告)号：US07479254B2

    公开(公告)日：2009-01-20

    申请号：US11407143

    申请日：2006-04-20

    申请人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Iiha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    发明人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Iiha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    IPC分类号： B01L3/00 ,  A61K9/36 ,  A61K45/00 ,  C12Q1/68 ,  G01N15/06 ,  G01N33/53

    CPC分类号： C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    摘要翻译： 本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自 由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物， 金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

    Stationary phase and column using cucurbituril bonded silica gel, and separation method of taxol using the column
    4.
    发明授权
    Stationary phase and column using cucurbituril bonded silica gel, and separation method of taxol using the column 失效
    使用葫芦素结合硅胶固定相和柱，并用色谱柱分离紫杉醇

    公开(公告)号：US08002987B2

    公开(公告)日：2011-08-23

    申请号：US12092663

    申请日：2006-03-24

    申请人： Kimoon Kim ,  Kyeng-Min Park ,  Young-Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R Nagarajan

    发明人： Kimoon Kim ,  Kyeng-Min Park ,  Young-Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R Nagarajan

    IPC分类号： B01D15/08

    CPC分类号： C07D487/04 ,  B01J20/286 ,  C07D305/14

    摘要： Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.

    摘要翻译： 提供了使用葫芦巴结合的硅胶的固定相和柱，以及使用该柱分离紫杉烷的方法。 紫杉烷分离方法包括：制备紫杉烷分离柱，该柱用包含葫芦素结合硅胶的固定相填充，其中由式1或2表示的葫芦巴与由式3表示的改性硅胶共价结合 ; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含有紫杉烷的溶液应用于色谱柱; 向柱中提供流动相溶剂以从柱中获得紫杉烷提取物; 并从紫杉烷提取物中纯化紫杉烷。 因此，高纯度的紫杉烷可以与低纯度的紫杉烷提取物分离。

    Stationary Phase and Column Using Cucurbituril Bonded Silica Gel, and Separation Method of Taxol Using the Column
    5.
    发明申请
    Stationary Phase and Column Using Cucurbituril Bonded Silica Gel, and Separation Method of Taxol Using the Column 失效
    使用葫芦素结合硅胶的固定相和柱，以及使用柱的紫杉醇的分离方法

    公开(公告)号：US20080290028A1

    公开(公告)日：2008-11-27

    申请号：US12092663

    申请日：2006-03-24

    申请人： Kimoon Kim ,  Young-Ho Ko ,  Kyeng-Min Park ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan

    发明人： Kimoon Kim ,  Young-Ho Ko ,  Kyeng-Min Park ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan

    IPC分类号： B01D15/08

    CPC分类号： C07D487/04 ,  B01J20/286 ,  C07D305/14

    摘要： Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.

    摘要翻译： 提供了使用葫芦巴结合的硅胶的固定相和柱，以及使用该柱分离紫杉烷的方法。 紫杉烷分离方法包括：制备紫杉烷分离柱，该柱用包含葫芦素结合硅胶的固定相填充，其中由式1或2表示的葫芦巴与由式3表示的改性硅胶共价结合 ; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含紫杉烷的溶液应用于色谱柱; 向柱中提供流动相溶剂以从柱中获得紫杉烷提取物; 并从紫杉烷提取物中纯化紫杉烷。 因此，高纯度的紫杉烷可以与低纯度的紫杉烷提取物分离。

    Application using non-covalent bond between a cucurbituril derivative and a ligand
    7.
    发明申请
    Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
    在葫芦巴衍生物和配体之间使用非共价键的应用

    公开(公告)号：US20070092867A1

    公开(公告)日：2007-04-26

    申请号：US11407143

    申请日：2006-04-20

    申请人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Iiha Hwang ,  Young Ko ,  Narayanan Selvapalam ,  Erumaipatty Nagarajan ,  Kyeng Park

    发明人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Iiha Hwang ,  Young Ko ,  Narayanan Selvapalam ,  Erumaipatty Nagarajan ,  Kyeng Park

    IPC分类号： C12Q1/70 ,  C12Q1/68 ,  G01N33/53 ,  C07F5/00 ,  C12M1/34 ,  C07D487/22

    CPC分类号： C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    摘要翻译： 本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自 由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物， 金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。