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    Application using non-covalent bond between a cucurbituril derivative and a ligand
    1.
    发明授权
    Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
    在葫芦巴衍生物和配体之间使用非共价键的应用

    公开(公告)号：US07479254B2

    公开(公告)日：2009-01-20

    申请号：US11407143

    申请日：2006-04-20

    申请人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Iiha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    发明人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Iiha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    IPC分类号： B01L3/00 ,  A61K9/36 ,  A61K45/00 ,  C12Q1/68 ,  G01N15/06 ,  G01N33/53

    CPC分类号： C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    摘要翻译： 本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自 由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物， 金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

    Application using non-covalent bond between a cucurbituril derivative and a ligand
    2.
    发明授权
    Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
    在葫芦巴衍生物和配体之间使用非共价键的应用

    公开(公告)号：US07718128B2

    公开(公告)日：2010-05-18

    申请号：US12339944

    申请日：2008-12-19

    申请人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Ilha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    发明人： Kimoon Kim ,  Kangkyun Baek ,  Jeeyeon Kim ,  Ilha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    IPC分类号： G01N15/06 ,  A61K9/14 ,  A61K45/00 ,  B01L3/00 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    摘要翻译： 本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自 由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物， 金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

    APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND
    3.
    发明申请
    APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND 有权
    使用CUCURBITURIL衍生物和配体之间的非共价键的应用

    公开(公告)号：US20090095677A1

    公开(公告)日：2009-04-16

    申请号：US12339944

    申请日：2008-12-19

    申请人： Kimoon KIM ,  Kangkyun Baek ,  Jeeyeon Kim ,  Ilha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    发明人： Kimoon KIM ,  Kangkyun Baek ,  Jeeyeon Kim ,  Ilha Hwang ,  Young Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan ,  Kyeng Min Park

    IPC分类号： B01D15/32 ,  C12N9/96 ,  C12N11/14 ,  C12N11/08 ,  C12N11/10 ,  B01J31/12

    CPC分类号： C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    摘要翻译： 本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自 由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物， 金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

    Method of separating and purifying cellular components using non-covalent bond between cucurbituril derivative and guest compound and apparatus using the same
    5.
    发明授权
    Method of separating and purifying cellular components using non-covalent bond between cucurbituril derivative and guest compound and apparatus using the same 有权
    使用葫芦素衍生物和客体化合物之间的非共价键分离和纯化细胞成分的方法和使用其的装置

    公开(公告)号：US09073972B2

    公开(公告)日：2015-07-07

    申请号：US12988254

    申请日：2009-04-15

    申请人： Ki Moon Kim ,  Don Wook Lee ,  Sung Ho Ryu ,  Sang Hoon Ha ,  Hyun Tae Jung ,  Banerjee Mainak ,  Narayanan Selvapalam ,  Kyeng Min Park

    发明人： Ki Moon Kim ,  Don Wook Lee ,  Sung Ho Ryu ,  Sang Hoon Ha ,  Hyun Tae Jung ,  Banerjee Mainak ,  Narayanan Selvapalam ,  Kyeng Min Park

    IPC分类号： C12N15/10 ,  C12N9/00 ,  C07K1/30 ,  B01J8/00 ,  C07K1/22

    CPC分类号： C07K1/22

    摘要： Provided is a method of separating cellular components, the method including: a) contacting a guest compound-bound reactive compound with cells; b) lysing the cells; c) adding a host compound-bound solid phase to a solution including the lysates of the cells to prepare a mixture; d) separating binding pairs of the guest compound bound to cellular components and the host compound bound to the solid phase from the mixture, and purifying the binding pairs; and e) separating the cellular components from the binding pairs, wherein the guest compound-bound reactive compound is obtained through a covalent bond between a reactive compound and a guest compound represented by Formula 2 below guest, the host compound-bound solid phase is obtained through a covalent bond between a solid phase and a host compound represented by Formula 1 below, and the reactive compound includes at least one selected from the group consisting of a biomolecule, N-hydroxysuccimide, an antigen, an antibody, an aptamer, folic acid, transferrin, and any mixtures thereof.

    摘要翻译： 提供分离细胞成分的方法，该方法包括：a）使客体化合物结合的反应性化合物与细胞接触; b）裂解细胞; c）将宿主化合物结合的固相加入到包含细胞的裂解物的溶液中以制备混合物; d）分离与细胞组分结合的客体化合物和与固体结合的宿主化合物的结合对，并纯化结合对; e）从结合对分离细胞成分，其中客体化合物结合的反应性化合物通过反应性化合物与客体下面的式2表示的客体化合物之间的共价键获得，得到与主体化合物结合的固相 通过下述通式1所示的固相和宿主化合物之间的共价键，反应性化合物包括选自生物分子，N-羟基琥珀酰亚胺，抗原，抗体，适体，叶酸中的至少一种 ，转铁蛋白及其任何混合物。

    METHOD OF SEPARATING AND PURIFYING CELLULAR COMPONENTS USING NON-COVALENT BOND BETWEEN CUCURBITAL DERIVATIVE AND GUEST COMPOUND AND APPARATUS USING THE SAME
    6.
    发明申请
    METHOD OF SEPARATING AND PURIFYING CELLULAR COMPONENTS USING NON-COVALENT BOND BETWEEN CUCURBITAL DERIVATIVE AND GUEST COMPOUND AND APPARATUS USING THE SAME 有权
    使用CUCURBITAL DERIVATIVE和顾客化合物之间的非共价键和使用其的装置分离和纯化细胞组分的方法

    公开(公告)号：US20110092680A1

    公开(公告)日：2011-04-21

    申请号：US12988254

    申请日：2009-04-15

    申请人： Ki Moon Kim ,  Don Wook Lee ,  Sung Ho Ryu ,  Sang Hoon Ha ,  Hyun Tae Jung ,  Banerjee Mainak ,  Narayanan Selvapalam ,  Kyeng Min Park

    发明人： Ki Moon Kim ,  Don Wook Lee ,  Sung Ho Ryu ,  Sang Hoon Ha ,  Hyun Tae Jung ,  Banerjee Mainak ,  Narayanan Selvapalam ,  Kyeng Min Park

    IPC分类号： C07K1/30 ,  C12N9/00 ,  C12N7/00 ,  B01J8/00

    CPC分类号： C07K1/22

    摘要： Provided is a method of separating cellular components, the method including: a) contacting a guest compound-bound reactive compound with cells; b) lysing the cells; c) adding a host compound-bound solid phase to a solution including the lysates of the cells to prepare a mixture; d) separating binding pairs of the guest compound bound to cellular components and the host compound bound to the solid phase from the mixture, and purifying the binding pairs; and e) separating the cellular components from the binding pairs, wherein the guest compound-bound reactive compound is obtained through a covalent bond between a reactive compound and a guest compound represented by Formula 2 below guest, the host compound-bound solid phase is obtained through a covalent bond between a solid phase and a host compound represented by Formula 1 below, and the reactive compound includes at least one selected from the group consisting of a biomolecule, N-hydroxysuccimide, an antigen, an antibody, an aptamer, folic acid, transferrin, and any mixtures thereof.

    摘要翻译： 提供分离细胞成分的方法，该方法包括：a）使客体化合物结合的反应性化合物与细胞接触; b）裂解细胞; c）将宿主化合物结合的固相加入到包含细胞的裂解物的溶液中以制备混合物; d）分离与细胞组分结合的客体化合物和与固体结合的宿主化合物的结合对，并纯化结合对; e）从结合对分离细胞成分，其中客体化合物结合的反应性化合物通过反应性化合物与客体下面的式2表示的客体化合物之间的共价键获得，得到与主体化合物结合的固相 通过下述通式1所示的固相和宿主化合物之间的共价键，反应性化合物包括选自生物分子，N-羟基琥珀酰亚胺，抗原，抗体，适体，叶酸中的至少一种 ，转铁蛋白及其任何混合物。