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    Perfluorochemicals and process for preparing the same
    1.
    发明授权
    Perfluorochemicals and process for preparing the same 失效
    全氟化合物及其制备方法

    公开(公告)号：US4943595A

    公开(公告)日：1990-07-24

    申请号：US582448

    申请日：1984-02-22

    申请人： Kirby V. Scherer, Jr. ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama ,  Ryoichi Naito, deceased

    发明人： Kirby V. Scherer, Jr. ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama ,  Ryoichi Naito, deceased

    IPC分类号： C07C43/12 ,  C07C43/17 ,  C07C43/313

    CPC分类号： C07C43/12 ,  C07C43/123 ,  C07C43/126 ,  C07C43/17 ,  C07C43/313

    摘要： There is provided a novel perfluorochemical represented by the formula, ##STR1## wherein R.sub.F is a perfluoroalkyl group, a perfluoro alkoxyalkyl group or a perfluoroalkyloxy group, X and X' are same as or different from each other and are a fluorine atom or a perfluoroalkyl group, and Y is a perfluoroalkyloxy group or a perfluoro dialkylamino group, the total number of the carbon atoms contained being an integer of 8 to 11 inclusive. The perfluorochemical is prepared by perfluorinating the corresponding partially fluorinated compound which may have unsaturated hydrocarbon moiety, only with molecular fluorine in a stoichiometric excess amount in an inert solvent.The perfluorochemical is used for preparing a stable emulsion as blood substitutes or perfusion media.

    摘要翻译： 提供了由下式表示的新型全氟化合物，其中RF是全氟烷基，全氟烷氧基烷基或全氟烷氧基，X和X'彼此相同或不同，是氟原子或全氟烷基 基团，Y为全氟烷氧基或全氟二烷基氨基，所含碳原子总数为8〜11的整数。 全氟化合物是通过使具有不饱和烃部分的相应的部分氟化的化合物在惰性溶剂中仅以化学计量过量的分子氟全氟化来制备的。 全氟化合物用于制备稳定的乳液作为血液代用品或灌注介质。

    Perfluoro branched alkyl ethers and emulsions
    2.
    发明授权
    Perfluoro branched alkyl ethers and emulsions 失效
    全氟支链烷基醚和乳液

    公开(公告)号：US5214214A

    公开(公告)日：1993-05-25

    申请号：US860567

    申请日：1992-03-30

    申请人： Kirby V. Scherer, Jr. ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama ,  Kimie Naito

    发明人： Kirby V. Scherer, Jr. ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama ,  Kimie Naito

    IPC分类号： C07C43/12 ,  C07C43/17 ,  C07C43/313

    CPC分类号： C07C43/12 ,  C07C43/123 ,  C07C43/126 ,  C07C43/17 ,  C07C43/313

    摘要： There is provided a novel perfluorochemical represented by the formula, ##STR1## wherein R.sub.F is a perfluoroalkyl group, a perfluoro alkoxyalkyl group or a perfluoroalkyloxy group, X and X' are same as or different from each other and are a fluorine atom or a perfluoroalkyl group, and Y is a perfluoroalkyloxy group or a perfluoro dialkylamino group, the total number of the carbon atoms contained being an integer of 8 to 11 inclusive. The perfluorochemical is prepared by perfluorinating the corresponding partially fluorinated compound which may have unsaturated hydrocarbon moiety, only with molecular fluorine in a stoichiometric excess amount in an inert solvent.The perfluorochemical is used for preparing a stable emulsion as blood substitutes or perfusion media.

    摘要翻译： 提供了由下式表示的新型全氟化合物，其中RF是全氟烷基，全氟烷氧基烷基或全氟烷氧基，X和X'彼此相同或不同，是氟原子或全氟烷基 基团，Y为全氟烷氧基或全氟二烷基氨基，所含碳原子总数为8〜11的整数。 全氟化合物是通过使具有不饱和烃部分的相应的部分氟化的化合物在惰性溶剂中仅以化学计量过量的分子氟全氟化来制备的。 全氟化合物用于制备稳定的乳液作为血液代用品或灌注介质。

    Oxygen-transferable fluorocarbon emulsion
    7.
    发明授权
    Oxygen-transferable fluorocarbon emulsion 失效
    可转移氟碳乳液

    公开(公告)号：US4252827A

    公开(公告)日：1981-02-24

    申请号：US41794

    申请日：1979-05-23

    申请人： Kazumasa Yokoyama ,  Kouichi Yamanouchi ,  Ryoichiro Murashima ,  Yoshio Tsuda

    发明人： Kazumasa Yokoyama ,  Kouichi Yamanouchi ,  Ryoichiro Murashima ,  Yoshio Tsuda

    IPC分类号： A61K9/00 ,  A61K45/00

    CPC分类号： A61K9/0026 ,  Y10S514/937 ,  Y10S514/941 ,  Y10S514/943

    摘要： 50-95 Parts by weight of a perfluorocarbon compound such as perfluorodecalin, perfluoromethyldecalin, perfluoro alkylcyclohexanes having 3 to 5 carbon atoms in the alkyl, perfluoro alkyltetrahydrofurans having 5 to 7 carbon atoms in the alkyl, perfluoro alkyltetrahydropyrans having 4 to 6 carbon atoms in the alkyl, perfluoroalkanes having 9 to 11 carbon atoms, and 50-5 parts by weight of a perfluoro tert.-amine such as perfluoro tert.-alkylamines having 9-11 carbon atoms, perfluoro N-alkylpiperidines having 4 to 6 carbon atoms in the alkyl, and perfluoro N-alkylmorpholines having 5 to 7 carbon atoms in the alkyl are emulsified in an aqueous medium by the aid of a high-molecular-weight nonionic surfactant have a molecular weight of about 2,000 to 20,000, and phospholipids as emulsifying agent, and fatty acids having 8 to 22 carbon atoms or salts or monoglycerides thereof as emulsifying adjuvant.The resulting oxygen-transferable emulsion having a particle size of 0.05 to 0.25.mu. is very stable for a long period of time, can be mixed with plasma extenders, and retains for long time in the blood stream of animals when it is used as an artificial blood substitute while being excreted very rapidly.

    摘要翻译： 50-95重量份的全氟化碳化合物如全氟萘烷，全氟甲基考虑素，烷基中具有3至5个碳原子的全氟烷基环己烷，烷基中具有5至7个碳原子的全氟烷基四氢呋喃，全氟烷基四氢吡喃中的全氟烷基四氢吡喃 烷基，具有9至11个碳原子的全氟烷烃和50-5重量份的全氟叔胺如具有9-11个碳原子的全氟叔烷基胺，具有4-6个碳原子的全氟N-烷基哌啶在 烷基和烷基中具有5至7个碳原子的全氟N-烷基吗啉通过分子量约为2,000至20,000的高分子量非离子表面活性剂和作为乳化剂的磷脂在含水介质中乳化， 具有8-22个碳原子的脂肪酸或其盐或单甘油酯作为乳化佐剂。 所得到的氧化可转移乳液的粒径为0.05〜0.25μm，长时间非常稳定，可与等离子体增量剂混合，长时间保存在动物的血液中，当用作人造 血液替代物被排泄得很快。