公开(公告)号：US4252827A

公开(公告)日：1981-02-24

申请号：US41794

申请日：1979-05-23

申请人： Kazumasa Yokoyama ,  Kouichi Yamanouchi ,  Ryoichiro Murashima ,  Yoshio Tsuda

发明人： Kazumasa Yokoyama ,  Kouichi Yamanouchi ,  Ryoichiro Murashima ,  Yoshio Tsuda

IPC分类号： A61K9/00 ,  A61K45/00

CPC分类号： A61K9/0026 ,  Y10S514/937 ,  Y10S514/941 ,  Y10S514/943

摘要： 50-95 Parts by weight of a perfluorocarbon compound such as perfluorodecalin, perfluoromethyldecalin, perfluoro alkylcyclohexanes having 3 to 5 carbon atoms in the alkyl, perfluoro alkyltetrahydrofurans having 5 to 7 carbon atoms in the alkyl, perfluoro alkyltetrahydropyrans having 4 to 6 carbon atoms in the alkyl, perfluoroalkanes having 9 to 11 carbon atoms, and 50-5 parts by weight of a perfluoro tert.-amine such as perfluoro tert.-alkylamines having 9-11 carbon atoms, perfluoro N-alkylpiperidines having 4 to 6 carbon atoms in the alkyl, and perfluoro N-alkylmorpholines having 5 to 7 carbon atoms in the alkyl are emulsified in an aqueous medium by the aid of a high-molecular-weight nonionic surfactant have a molecular weight of about 2,000 to 20,000, and phospholipids as emulsifying agent, and fatty acids having 8 to 22 carbon atoms or salts or monoglycerides thereof as emulsifying adjuvant.The resulting oxygen-transferable emulsion having a particle size of 0.05 to 0.25.mu. is very stable for a long period of time, can be mixed with plasma extenders, and retains for long time in the blood stream of animals when it is used as an artificial blood substitute while being excreted very rapidly.

摘要翻译： 50-95重量份的全氟化碳化合物如全氟萘烷，全氟甲基考虑素，烷基中具有3至5个碳原子的全氟烷基环己烷，烷基中具有5至7个碳原子的全氟烷基四氢呋喃，全氟烷基四氢吡喃中的全氟烷基四氢吡喃 烷基，具有9至11个碳原子的全氟烷烃和50-5重量份的全氟叔胺如具有9-11个碳原子的全氟叔烷基胺，具有4-6个碳原子的全氟N-烷基哌啶在 烷基和烷基中具有5至7个碳原子的全氟N-烷基吗啉通过分子量约为2,000至20,000的高分子量非离子表面活性剂和作为乳化剂的磷脂在含水介质中乳化， 具有8-22个碳原子的脂肪酸或其盐或单甘油酯作为乳化佐剂。 所得到的氧化可转移乳液的粒径为0.05〜0.25μm，长时间非常稳定，可与等离子体增量剂混合，长时间保存在动物的血液中，当用作人造 血液替代物被排泄得很快。

公开(公告)号：US4605650A

公开(公告)日：1986-08-12

申请号：US751850

申请日：1983-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  A61K31/40

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4713459A

公开(公告)日：1987-12-15

申请号：US830094

申请日：1986-02-18

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Tadakazu Suyama

IPC分类号： A01N1/02 ,  A61K9/00 ,  C07D209/30 ,  C07D209/44 ,  C07D209/52 ,  C07D215/18 ,  C07D217/22 ,  C07D221/04 ,  C25B3/08 ,  A61K31/47 ,  A61K31/40 ,  C07D209/10

CPC分类号： A61K9/0026 ,  A01N1/02 ,  A01N1/0226 ,  C07D209/30 ,  C07D209/44 ,  C07D209/52 ,  C07D215/18 ,  C07D217/22 ,  C07D221/04 ,  C25B3/08

摘要： A novel compound of the formula, ##STR1## wherein R denotes a lower perfluoroalkyl group, l is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4654337A

公开(公告)日：1987-03-31

申请号：US751880

申请日：1985-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  C07D223/00 ,  A61K31/435

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4591599A

公开(公告)日：1986-05-27

申请号：US670971

申请日：1984-11-13

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C25B3/08 ,  C07D487/06 ,  A61K31/40

CPC分类号： A61K9/0026 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C25B3/08

摘要： A perfluorobicyclo compound of the general formula: ##STR1## wherein either or both of Ring A and Ring B may optionally be substituted with lower perfluoroalkyl group (s) and m and n each represent 3 or 4.

摘要翻译： 一种具有下列通式的全氟二环化合物：其中环A和环B中的任一个或两者可以任选地被低级全氟烷基取代，m和n各自表示3或4。

公开(公告)号：US4425347A

公开(公告)日：1984-01-10

申请号：US454105

申请日：1982-12-28

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A01N1/02 ,  A61K9/10 ,  A61K31/435 ,  A61P7/08 ,  B01F17/14 ,  C07D455/02

CPC分类号： C07D455/02 ,  A01N1/021 ,  A61K31/435 ,  Y10S514/832

摘要： A perfluorobicyclo compound emulsion preparation having oxygen carrying ability containing a perfluorobicyclo compound of the general formula: ##STR1## wherein R represents a perfluoromethyl group or perfluoroethyl group, as an oxygen carrying component.

摘要翻译： 一种全氟双环化合物乳液制剂，其具有含有下列通式的全氟二环化合物的氧承载能力：其中R表示全氟甲基或全氟乙基，作为携氧组分。

公开(公告)号：US4613605A

公开(公告)日：1986-09-23

申请号：US751948

申请日：1985-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  A61K31/445 ,  C07D453/00

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4530926A

公开(公告)日：1985-07-23

申请号：US505324

申请日：1983-06-17

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A01N1/02 ,  C07D455/03 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  A61K31/55 ,  A61K31/40 ,  A61K31/445 ,  C07D455/06

CPC分类号： C07D455/00 ,  A01N1/021 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

摘要： A novel compound of the formula, ##STR1## wherein k, j, l and m are zero or an integer of from 1 to 3, and n is an integer of from 1 to 3, the rings A, B and C being optionally substituted with at least one trifluoromethyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

摘要翻译： 式（I）的新颖化合物，其中k，j，l和m为0或1〜3的整数，n为1〜3的整数，环A，B，C 任选地被至少一个三氟甲基取代，其通过使相应的全氢化合物与氟反应制备，可用作能够在水乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内脏。

公开(公告)号：US4280996A

公开(公告)日：1981-07-28

申请号：US75684

申请日：1979-09-13

申请人： Hiroyuki Okamoto ,  Yoshio Tsuda ,  Kazumasa Yokoyama

发明人： Hiroyuki Okamoto ,  Yoshio Tsuda ,  Kazumasa Yokoyama

IPC分类号： A61K47/44 ,  A23L1/30 ,  A61K9/00 ,  A61K9/10 ,  A61K9/107 ,  A61K31/16 ,  A61K31/20 ,  A61K31/23 ,  A61K31/685 ,  A61K35/54 ,  A61K36/00 ,  A61K36/48 ,  A61K38/00 ,  A61K47/28 ,  A61P3/06 ,  B01F17/14 ,  A61K31/56 ,  B01J13/00

CPC分类号： A61K9/0029 ,  A61K31/685 ,  A61K36/48

摘要： A stable fat emulsion having low side effects, which is suitable as nutritive infusion fluid for intravenous injection, is provided. The emulsion contains 5-50 (W/V) % of soybean oil, yolk phospholipids in a weight ratio to the soybean oil of 1/4-1/25, 0.01-0.30 (W/V) % of a fatty acid or salt thereof having 12-20 carbon atoms and the balance of water.

摘要翻译： 提供了一种适用作静脉注射用营养输液的稳定的副作用低的脂肪乳剂。 该乳液含有5-50（W / V）％的大豆油，与大豆油的重量比为1 / 4-1 / 25,2.01-0.30（W / V）％的脂肪酸​​或盐的蛋黄磷脂 其具有12-20个碳原子，余量为水。

公开(公告)号：US4542147A

公开(公告)日：1985-09-17

申请号：US505322

申请日：1983-06-17

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  C07D209/94 ,  A61K31/40

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

摘要翻译： 一种下式的新化合物，其中k为0或1〜2的整数，j为1〜3的整数，l和m分别为0或1〜3的整数，n为 通过使与其对应的全氟化合物与氟反应来制备环A，B和C任选被至少一个三氟甲基或四氟乙基取代的整数。 该化合物可用作能够在水性乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内部器官。