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公开(公告)号：US08309077B2
公开(公告)日：2012-11-13
申请号：US11666709
申请日：2005-11-02
申请人： Kishore Murthy , Rainer Engelhardt
发明人： Kishore Murthy , Rainer Engelhardt
CPC分类号： A61K35/76 , A23K20/195 , A23K50/10 , A23K50/75 , A23K50/80 , C12N2795/00032 , C12N2795/00051 , Y02A40/818
摘要： Stabilized bacteriophage compositions, and methods for preparing stabilized bacteriophage compositions are provided. The method for producing an antibacterial composition involves adsorbing an aqueous solution of one or more bacteriophages, or one or more phage components, onto a matrix to produce a composition, and drying the composition to produce the antibacterial composition. An antibacterial composition comprising one or more strain of bacteriophage, or one or more phage component, adsorbed onto a matrix is also provided. The antibacterial composition, or the antibacterial composition embedded in a solid support, may be used within a cream, lotion or gel, be admixed with a pharmaceutical carrier and administered topically, orally, nasally, used as a powdered inhalant, or the antibacterial composition or encapsulated antibacterial composition, may be added to a feed for animal, aquatic or avian uses.
摘要翻译： 提供稳定的噬菌体组合物，以及制备稳定的噬菌体组合物的方法。 制备抗菌组合物的方法包括将一种或多种噬菌体或一种或多种噬菌体组分的水溶液吸附到基质上以产生组合物，并干燥组合物以产生抗菌组合物。 还提供了包含吸附在基质上的一种或多种噬菌体或一种或多种噬菌体组分的抗菌组合物。 嵌入固体支持物中的抗菌组合物或抗菌组合物可以在霜剂，洗剂或凝胶内使用，与药物载体混合并局部地，口服地，经鼻地用作粉末吸入剂，或抗菌组合物或 包封的抗菌组合物可以添加到用于动物，水生或禽类用途的饲料中。
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公开(公告)号：US20120258175A1
公开(公告)日：2012-10-11
申请号：US13528215
申请日：2012-06-20
申请人： Kishore Murthy , Rainer Engelhardt
发明人： Kishore Murthy , Rainer Engelhardt
CPC分类号： A61K35/76 , A23K20/195 , A23K50/10 , A23K50/75 , A23K50/80 , C12N2795/00032 , C12N2795/00051 , Y02A40/818
摘要： An encapsulated bacteriophage formulation and a method for preparing encapsulated bacteriophage formulation is provided. The method for producing the encapsulated bacteriophage composition involves injection of a molten coating substance comprising stearic acid and palmitic acid present at a ratio of 50:50, into a granulator chamber containing immobilized bacteriophages. The immobilized bacteriophage are agitated by rotation of a base of the chamber and swept by a flow of air at a temperature of between 10° C. and 50° C.
摘要翻译： 提供了包封的噬菌体制剂和制备包装的噬菌体制剂的方法。 包封的噬菌体组合物的制造方法包括将包含硬脂酸和棕榈酸的比例为50:50的熔融包衣物质注入含有固定化噬菌体的造粒室。 固定的噬菌体通过旋转室的基部并在10℃至50℃的温度下被空气流扫过来搅拌。
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公开(公告)号：US20080038322A1
公开(公告)日：2008-02-14
申请号：US11666709
申请日：2005-11-02
申请人： Kishore Murthy , Rainer Engelhardt
发明人： Kishore Murthy , Rainer Engelhardt
CPC分类号： A61K35/76 , A23K20/195 , A23K50/10 , A23K50/75 , A23K50/80 , C12N2795/00032 , C12N2795/00051 , Y02A40/818
摘要： Stabilized bacteriophage compositions, and methods for preparing stabilized bacteriophage compositions are provided. The method for producing an antibacterial composition involves adsorbing an aqueous solution of one or more bacteriophages, or one or more phage components, onto a matrix to produce a composition, and drying the composition to produce the antibacterial composition. An antibacterial composition comprising one or more strain of bacteriophage, or one or more phage component, adsorbed onto a matrix is also provided. The antibacterial composition may also be encapsulated. The antibacterial composition, or the encapsulated antibacterial composition, may be used within a cream, lotion or gel, be admixed with a pharmaceutical carrier and administered topically, orally, nasally, used as a powdered inhalant, or the antibacterial composition or encapsulated antibacterial composition, may be added to a feed for animal, aquatic or avian uses.
摘要翻译： 提供稳定的噬菌体组合物，以及制备稳定的噬菌体组合物的方法。 制备抗菌组合物的方法包括将一种或多种噬菌体或一种或多种噬菌体组分的水溶液吸附到基质上以产生组合物，并干燥组合物以产生抗菌组合物。 还提供了包含吸附在基质上的一种或多种噬菌体或一种或多种噬菌体组分的抗菌组合物。 抗菌组合物也可以被包封。 抗菌组合物或包封的抗菌组合物可以在乳膏，洗剂或凝胶内使用，与药物载体混合并局部，口服，鼻腔，粉末吸入剂或抗菌组合物或包封的抗菌组合物， 可以添加到动物，水生或禽类用途的饲料中。
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公开(公告)号：US20090130196A1
公开(公告)日：2009-05-21
申请号：US11666704
申请日：2005-11-02
申请人： Kishore Murthy , Rainer Engelhardt
发明人： Kishore Murthy , Rainer Engelhardt
CPC分类号： A23L3/3463 , A23K20/195 , A23K40/30 , A23L29/065 , A23P10/30 , A23P10/35 , A61K9/5015 , A61K9/5073 , A61K9/5078 , A61K35/76
摘要： Bacteriophage compositions, and methods for preparing bacteriophage compositions are provided. The method for producing an antibacterial composition involves adsorbing an aqueous solution of one or more bacteriophages, or one or more phage components, onto a matrix to produce a composition, and drying the composition to produce the antibacterial composition. An antibacterial composition comprising one or more strain of bacteriophage, or one or more phage component, adsorbed onto a matrix is also provided. The antibacterial composition may also be encapsulated. The antibacterial composition, or the encapsulated antibacterial composition, may be used within a cream, lotion or gel, be admixed with a pharmaceutical carrier and administered topically, orally, nasally, used as a powdered inhalant, or the antibacterial composition or encapsulated antibacterial composition, may be added to a feed for animal, aquatic or avian uses.
摘要翻译： 提供噬菌体组合物和制备噬菌体组合物的方法。 制备抗菌组合物的方法包括将一种或多种噬菌体或一种或多种噬菌体组分的水溶液吸附到基质上以产生组合物，并干燥组合物以产生抗菌组合物。 还提供了包含吸附在基质上的一种或多种噬菌体或一种或多种噬菌体组分的抗菌组合物。 抗菌组合物也可以被包封。 抗菌组合物或包封的抗菌组合物可以在乳膏，洗剂或凝胶内使用，与药物载体混合并局部，口服，鼻腔，粉末吸入剂或抗菌组合物或包封的抗菌组合物， 可以添加到动物，水生或禽类用途的饲料中。
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公开(公告)号：US20080318311A1
公开(公告)日：2008-12-25
申请号：US11666706
申请日：2005-11-02
申请人： Kishore Murthy , Rainer Engelhardt
发明人： Kishore Murthy , Rainer Engelhardt
IPC分类号： C12N15/74
CPC分类号： A61K35/76 , A23K20/195 , A23K50/10 , A23K50/75 , A23K50/80 , C12N2795/00032 , C12N2795/00051 , Y02A40/818
摘要： An encapsulated bacteriophage formulation and a method for preparing encapsulated bacteriophage formulation is provided. The method for producing the encapsulated bacteriophage composition involves injection of a molten coating substance comprising stearic acid and palmitic acid present at a ratio of 50:50, into a granulator chamber containing immobilized bacterio-phages. The immobilized bacteriophage are agitated by rotation of a base of the chamber and swept by a flow of air at a temperature of between 10° C. and 50° C.
摘要翻译： 提供了包封的噬菌体制剂和制备包装的噬菌体制剂的方法。 包装的噬菌体组合物的制造方法包括将包含硬脂酸和棕榈酸的比例为50:50的熔融包衣物质注入含有固定化细菌噬菌体的造粒室。 固定的噬菌体通过旋转室的基部并在10℃至50℃的温度下被空气流扫过来搅拌。
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公开(公告)号：US20140234391A1
公开(公告)日：2014-08-21
申请号：US14130045
申请日：2012-06-29
申请人： Kishore Murthy
发明人： Kishore Murthy
IPC分类号： A61K35/76
CPC分类号： A61K35/76 , A23K10/18 , A23K40/20 , A23K40/25 , A23K40/30 , A23K50/30 , A23K50/40 , A23K50/60 , A23K50/75 , A23K50/80 , Y02A40/818
摘要： A method for reducing the population of pathogenic bacteria in an animal being reared in an animal rearing facility is provided. The method involves using one or more than one naturally-occurring location-specific bacteriophages selected to be highly specific to the strains of the one or more than one pathogen present in the facility, a phage component derived from the one or more than one naturally-occurring location-specific bacteriophages, or a combination thereof, to produce a location-specific bacteriophage preparation. The preparation is administered to the animal, to reduce the one or more than one pathogenic bacteria. The method may also involve a step of identifying location-specific isolates of the one or more than one pathogenic bacteria at or near the animal rearing facility.
摘要翻译： 提供了一种减少在动物饲养设备中饲养的动物中的致病细菌群体的方法。 该方法包括使用一种或多于一种天然存在的位置特异性噬菌体，其被选择为对设施中存在的一种或多于一种病原体的菌株具有高度特异性，衍生自一种或多于一种天然存在的噬菌体组分， 发生的位置特异性噬菌体或其组合，以产生位置特异性噬菌体制剂。 将该制剂施用于动物，以减少一种或多于一种致病菌。 该方法还可以涉及鉴定动物饲养设施处或附近的一种或多于一种病原菌的位置特异性分离物的步骤。
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公开(公告)号：US20080311082A1
公开(公告)日：2008-12-18
申请号：US11915281
申请日：2006-05-26
申请人： Kishore Murthy , Rainer Englehardt
发明人： Kishore Murthy , Rainer Englehardt
CPC分类号： A01C3/00 , A01N63/00 , C02F2103/20 , A01N25/26 , A01N2300/00
摘要： The present invention is directed to a process for reducing a population of one, or more than one target pathogen present in animal waste, including livestock manure , comprising administering one, or more than one protected bacteriophage strain to livestock. The one, or more than one bateriophage strain is capable of adsorbing to and killing the target pathogen, is released in vivo, and acts to clear the one or more than one pathogen from livestock gut and waste. The one, or more than one bacteriophage it further reduces the population of the one or more than one target pathogen in the waste or manure. The present invention also relates to a process for reducing a population of one, or more than one target pathogen present in liquid manure comprising treating the animal waste such as liquid manure with one, or more than one protected bateriophage strain, or phage components, or a combination thereof.
摘要翻译： 本发明涉及减少存在于动物废物中的一种或多于一种目标病原体的种群的方法，包括家畜粪便，其包括向家畜施用一种或多种受保护的噬菌体菌株。 能够吸附和杀死靶病原体的一种或多于一种的噬菌体菌株在体内被释放，并且用于从家畜肠道和废物中清除一种或多于一种的病原体。 一种或多于一种噬菌体，它进一步降低了废物或粪便中一种或多种靶病原体的种群。 本发明还涉及减少存在于液体肥料中的一种或多于一种目标病原体的种群的方法，包括用一种或多于一种受保护的噬菌体菌株或噬菌体组分处理动物废物如液体粪便，或 其组合。
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公开(公告)号：US20080260697A1
公开(公告)日：2008-10-23
申请号：US11915272
申请日：2006-05-26
申请人： Kishore Murthy , Rainer Englehardt
发明人： Kishore Murthy , Rainer Englehardt
CPC分类号： A61K35/76 , A23K20/195 , C12N2795/00032 , C12N2795/00051 , Y02A50/473
摘要： The present invention is directed to method for reducing a population of a target pathogen in an animal or within a feedlot. The method involves administering one or more than one controlled release bacteriophage strain or phage component, or both, to the animal, so that the one, or more than one bacteriophage strain is released in vivo and adsorbs to the one or more than one target pathogen, thereby reducing the one, or more than one pathogen from the animal. The controlled release bacteriophage strain or phage component may be administered as a treatment dose prior to further processing of the animal, a treatment dose followed by a maintenance dose, or a maintenance dose, to manage feedlot target pathogens.
摘要翻译： 本发明涉及减少动物或饲养场内目标病原体群体的方法。 该方法包括向动物施用一种或多于一种的控释菌株或噬菌体组分或两者，使得一种或多于一种噬菌体菌株在体内释放并吸附至一种或多种靶病原体 从而减少来自动物的一种或多于一种的病原体。 受控释放的噬菌体菌株或噬菌体组分可以在进一步处理动物之前，治疗剂量，随后维持剂量或维持剂量，作为治疗剂量施用以管理饲养场病原体。
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