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34 条记录 (耗时 0.032 秒)

    Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof
    3.
    发明申请
    Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof 审中-公开
    不可吸收的，原位形成的水凝胶的聚合物前体及其应用

    公开(公告)号：US20070202074A1

    公开(公告)日：2007-08-30

    申请号：US11709559

    申请日：2007-02-23

    申请人： Shalaby Shalaby

    发明人： Shalaby Shalaby

    IPC分类号： A61K31/787 ,  C08G63/91

    CPC分类号： A61L27/52 ,  A61K31/74 ,  A61L2400/06

    摘要： The present invention is directed toward an injectable, single- or multiple-component polymeric liquid precursor of an in situ-forming, non-absorbable, flexible, and resilient hydrogel or semi-solid that can be used in non-surgical, minimally invasive treatment of herniated disc.

    摘要翻译： 本发明涉及可以用于非手术，微创治疗的原位成形，不可吸收，柔性和弹性的水凝胶或半固体的可注射，单组分或多组分聚合物液体前体 的椎间盘突出症

    Surface functionalized absorbable medical devices
    4.
    发明申请
    Surface functionalized absorbable medical devices 审中-公开
    表面官能化可吸收医疗器械

    公开(公告)号：US20060211787A1

    公开(公告)日：2006-09-21

    申请号：US11378104

    申请日：2006-03-17

    申请人： Shalaby Shalaby

    发明人： Shalaby Shalaby

    IPC分类号： C08J3/28

    CPC分类号： C08J7/14 ,  A61L17/14 ,  A61L27/50 ,  A61L2400/18

    摘要： Absorbable, polymeric medical devices or components thereof are surface functionalized with succinic and/or homosuccinic acid anhydride groups which can be further hydrolyzed to the corresponding dicarboxylic acid groups for immobilizing multivalent metal ions, such as calcium ions, or reacted with hydroxyl- or amine-bearing reagents which can be biologically active.

    摘要翻译： 可吸收的聚合物医疗装置或其组分用琥珀酸和/或高琥珀酸酐基团进行表面官能化，其可以进一步水解成相应的二羧酸基团，以固定多价金属离子如钙离子，或与羟基或胺 - 具有生物活性的载体试剂。

    Inorganic-organic melted-extruded hybrid filaments and medical applications thereof
    6.
    发明申请
    Inorganic-organic melted-extruded hybrid filaments and medical applications thereof 有权
    无机 - 有机熔融挤出杂化丝及其医疗应用

    公开(公告)号：US20070110999A1

    公开(公告)日：2007-05-17

    申请号：US11599691

    申请日：2006-11-15

    申请人： Shalaby Shalaby ,  Kenneth Clinkscales ,  Kimberly Carpenter

    发明人： Shalaby Shalaby ,  Kenneth Clinkscales ,  Kimberly Carpenter

    IPC分类号： D02G3/00

    CPC分类号： D01F1/10 ,  A61L17/10 ,  A61L31/128 ,  A61L31/18 ,  Y10T428/249938 ,  Y10T428/2913 ,  Y10T428/2927 ,  Y10T428/298

    摘要： This invention deals with a family of inorganic-organic hybrid, melt-extruded filaments having variable cross-sectional geometry with a cross-sectional area ranging between 100 μ2 and 4 mm2, wherein the inorganic component comprises at least 10 weight percent of the total system and is present as dispersed micro-/nanoparticles in an organic absorbable or non-absorbable matrix representing no more than 90 weight percent. Hybrid filaments are particularly useful for the production of absorbable/disintegratable coil components of an absorbable/disintegratable endoureteral stent and radiopaque surgical markers or sutures.

    摘要翻译： 本发明涉及一种无机 - 有机杂化物，熔体挤出的细丝，其横截面积可变的横截面几何形状为横截面积为100-250mm 2 / 其中无机组分占总体系的至少10重量％，并且以分散的微/纳米颗粒的形式存在于不超过90重量％的有机可吸收或不可吸收的基质中。 混合细丝特别可用于生产可吸收/可分解的输尿​​管支架和不透射线外科标记物或缝合线的可吸收/可分解的线圈组件。

    Absorbable microparticles
    7.
    发明申请
    Absorbable microparticles 审中-公开
    可吸收的微粒

    公开(公告)号：US20060210641A1

    公开(公告)日：2006-09-21

    申请号：US11385030

    申请日：2006-03-20

    申请人： Shalaby Shalaby

    发明人： Shalaby Shalaby

    IPC分类号： A61K9/50 ,  A61K9/16 ,  A61K38/31 ,  A61K38/09

    CPC分类号： A61K47/6927 ,  A61K47/585

    摘要： This invention pertains to a sustained release complex of one or more peptides, one or more proteins or a combination thereof immobilized on an absorbable polymer microparticle optionally having an absorbable polymer coating. The microparticle complex of this invention comprises a peptide(s) and/or protein(s) which have at least one amino group and/or at least one carboxyl group per molecule and a solid absorbable polyester microparticle having surface and subsurface carboxylic group or amino groups in sufficient amounts to bind the peptide(s) and/or protein(s) so that the immobilized peptide(s) or protein(s) represent 0.1% to 30% of the total mass of the microparticle complex. The microparticle complex with immobilized peptide(s) and/or protein(s) are optionally further encased individually or in groups with an absorbable polymer to control, further, the release of the immobilized peptide(s) and/or protein(s). To control the release of the immobilized peptide(s) and/or protein(s) even further, the encased microparticles can be incorporated into a composition with an absorbable gel-forming liquid that transforms to a flexible gel or semi-solid upon contacting water in the biologic environment.

    摘要翻译： 本发明涉及一种或多种肽，一种或多种蛋白质或其组合的持续释放复合物，其固定在任选具有可吸收聚合物涂层的可吸收聚合物微粒上。 本发明的微粒复合物包含每分子具有至少一个氨基和/或至少一个羧基的肽和/或蛋白质，以及具有表面和表面下的羧基或氨基的固体可吸收的聚酯微粒 基团的量足以结合肽和/或蛋白质，使得固定的肽或蛋白质占微粒复合物总质量的0.1％至30％。 具有固定化肽和/或蛋白质的微粒子复合物任选地进一步单独地或与可吸收聚合物组合包装以进一步控制固定化肽和/或蛋白质的释放。 为了进一步控制固定化肽和/或蛋白质的释放，可以将包封的微粒与可吸收的形成凝胶的液体一起掺入到组合物中，在与水接触时转变成柔性凝胶或半固体 在生物环境中。

    Tissue protecting spray-on copolymeric film composition
    9.
    发明申请
    Tissue protecting spray-on copolymeric film composition 有权
    组织保护喷雾共聚膜组成

    公开(公告)号：US20060025516A1

    公开(公告)日：2006-02-02

    申请号：US11175636

    申请日：2005-07-05

    申请人： Shalaby Shalaby ,  James Lindsey

    发明人： Shalaby Shalaby ,  James Lindsey

    IPC分类号： C08L31/00

    CPC分类号： A61L26/0014 ,  A61L26/0076 ,  C08F293/005 ,  C08L53/00 ,  C08L2666/02

    摘要： This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.

    摘要翻译： 本发明涉及包含形成至少一种水溶性单体和至少另一种水不溶性单体的两亲成膜，分段/嵌段共聚物的组织保护喷涂膜组合物，其中该膜可由 水溶性有机溶剂如2-丙醇，丙酮和乙酸乙酯。 该膜可以含有包括具有抗微生物剂，麻醉剂，抗炎和伤口愈合活性的生物活性剂。

    Amorphus polymeric polyaxial initiators and compliant crystalline copolymers therefrom
    10.
    发明申请
    Amorphus polymeric polyaxial initiators and compliant crystalline copolymers therefrom 有权
    无定形聚合多轴引发剂和顺应性结晶共聚物

    公开(公告)号：US20050261466A1

    公开(公告)日：2005-11-24

    申请号：US10630211

    申请日：2003-07-30

    申请人： Shalaby Shalaby

    发明人： Shalaby Shalaby

    IPC分类号： A61L17/12 ,  A61L31/06 ,  C08G63/08 ,  C08G63/64

    CPC分类号： C08G63/64 ,  A61L17/12 ,  A61L31/06 ,  C08G63/08 ,  Y10T428/13 ,  Y10T428/139 ,  Y10T428/31504 ,  Y10T428/31786 ,  C08L67/04

    摘要： An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.

    摘要翻译： 包含中心碳原子或氮原子和至少三个轴的可吸收结晶的单中心多轴共聚物，每个轴包括邻近并源自中心原子的无定形柔性组分和从无定形柔性组分向外延伸的刚性可结晶组分。 公开了在可能含有生物活性剂的医疗装置中使用这种共聚物。 本发明还涉及由多轴共聚物制成的缝合线，支架，支架罩和密封装置。