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1.发明授权
公开(公告)号：US5639622A
公开(公告)日：1997-06-17
申请号：US478860
申请日：1995-06-07
申请人： Klaus Bosslet , Bernhard Auerbach , Helmut Peters
发明人： Klaus Bosslet , Bernhard Auerbach , Helmut Peters
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61P31/00 , A61P35/00 , C07K14/42 , C07K14/435 , C07K14/705 , C07K16/00 , C07K16/30 , C07K16/32 , C07K19/00 , C12N5/10 , C12N5/20 , C12N5/22 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577
CPC分类号： C07K14/705 , C07K16/30 , C07K16/3023 , A61K38/00
摘要： The invention relates to monoclonal antibodies (MAbs) and fragments thereof which bind to defined tumor-associated antigens, principally of small cell lung carcinoma (SCLC), of melanoma, of neuroblastoma and other tumors of neuroectodermal origin, to hybridoma cell lines for the preparation thereof, and to the antigens which can be defined and/or isolated with the aid of these antibodies or antibody fragments. The antibodies, antibody fragments and antigens can be used as diagnostic. aid, active substance or active substance carrier.
摘要翻译： 本发明涉及与确定的肿瘤相关抗原（主要是小细胞肺癌（SCLC）），黑素瘤，神经母细胞瘤和神经外胚层起源的其他肿瘤结合的单克隆抗体（MAb）及其片段，用于制备杂交瘤细胞系 以及可以借助于这些抗体或抗体片段定义和/或分离的抗原。 抗体，抗体片段和抗原可以用作诊断。 助剂，活性物质或活性物质载体。
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2.再颁专利公开(公告)号：USRE37596E1
公开(公告)日：2002-03-19
申请号：US09333987
申请日：1999-06-16
申请人： Klaus Bosslet , Bernhard Auerbach , Helmut Peters
发明人： Klaus Bosslet , Bernhard Auerbach , Helmut Peters
IPC分类号： G01N33574
CPC分类号： C07K14/705 , A61K38/00 , C07K16/30 , C07K16/3023
摘要： The invention relates to monoclonal antibodies (MAbs) and fragments thereof which bind to defined tumor-associated antigens, principally of small cell lung carcinoma (SCLC), of melanoma, of neuroblastoma and other tumors of neuroectodermal origin, to hybridoma cell lines for the preparation thereof, and to the antigens which can be defined and/or isolated with the aid of these antibodies or antibody fragments. The antibodies, antibody fragments and antigens can be used as diagnostic, aid, active substance or active substance carrier.
摘要翻译： 本发明涉及与确定的肿瘤相关抗原（主要是小细胞肺癌（SCLC）），黑素瘤，神经母细胞瘤和神经外胚层起源的其他肿瘤结合的单克隆抗体（MAb）及其片段，用于制备杂交瘤细胞系 以及可以借助于这些抗体或抗体片段定义和/或分离的抗原。 抗体，抗体片段和抗原可用作诊断，辅助，活性物质或活性物质载体。
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公开(公告)号：US5593898A
公开(公告)日：1997-01-14
申请号：US334035
申请日：1994-11-02
申请人： Bernhard Auerbach , Helmut Peters
发明人： Bernhard Auerbach , Helmut Peters
IPC分类号： G01N33/53 , G01N33/531 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6896 , G01N33/54306 , Y10S435/962
摘要： The invention relates to an improved diagnostic method for the immunological determination of NCAM by means of specific binding partners, the one specific binding partner being immobilized on a carrier and the extent of the binding of the analyte to the first specific binding partner being determined by means of a second binding partner which is specific for the analyte and which is labeled either directly or via further binding partners.
摘要翻译： 本发明涉及通过特异性结合配偶体免疫测定NCAM的改进的诊断方法，所述特异性结合配偶体固定在载体上，并且分析物与第一特异性结合配偶体的结合程度通过方法 的第二结合配偶体，其对于分析物是特异性的，并且其被直接标记或经由另外的结合配偶体标记。
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公开(公告)号：US08317912B2
公开(公告)日：2012-11-27
申请号：US13415892
申请日：2012-03-09
摘要： The present invention relates to an antimicrobial composition comprising an isothiazolin-3-one, such as 1,2-benzisothiazolin-3-one, a zinc compound selected from zinc salts, zinc oxide, zinc hydroxide or combinations thereof, a pyrithione salt or pyrithione acid, and a surfactant selected from the group consisting of (i) an anionic surfactant having a sulfate or sulfonate moiety attached to a straight or branched chain containing from about 10 to about 18 atoms at the backbone of the chain, (ii) an anionic surfactant being an alkylaryl sulfonic acid or salt thereof wherein the alkyl portion contains from about 10 to about 18 carbon atoms, and the aryl portion contains a benzyl or substituted benzyl group, and combinations thereof. This composition is particularly effective in preventing the growth of various microorganisms in mineral slurries such as aqueous calcium carbonate slurries.
摘要翻译： 本发明涉及包含异噻唑啉-3-酮如1,2-苯并异噻唑啉-3-酮，选自锌盐，氧化锌，氢氧化锌或其组合的锌化合物的抗微生物组合物，吡啶硫酮盐或吡啶硫酮 酸和选自以下的表面活性剂：（i）在链的主链上具有连接到含有约10至约18个原子的直链或支链的硫酸盐或磺酸盐部分的阴离子表面活性剂，（ii）阴离子 表面活性剂是烷基芳基磺酸或其盐，其中烷基部分含有约10至约18个碳原子，芳基部分含有苄基或取代的苄基，及其组合。 该组合物特别有效地防止矿物浆料中的各种微生物如碳酸钙水泥浆料的生长。
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公开(公告)号：US6120990A
公开(公告)日：2000-09-19
申请号：US90190
申请日：1998-06-04
申请人： Stefan Brust , Hans-Peter Hauser , Stefan Knapp , Helmut Peters
发明人： Stefan Brust , Hans-Peter Hauser , Stefan Knapp , Helmut Peters
IPC分类号： G01N33/53 , G01N33/531 , G01N33/543 , G01N33/68 , C12Q1/70 , C12Q1/04
CPC分类号： G01N33/6854 , G01N33/53 , G01N33/531 , G01N33/54306
摘要： The present invention is directed to an immunochemical method for qualitatively or quantitatively detecting an analyte in which a first and a second binding component are contacted with the analyte, followed by detection of the binding of the binding components to the analyte. According to the invention, both of the binding components are prepared recombinantly in the same host using different vectors (V1 and V2) for expressing fusion proteins, with the first binding component being expressed as a fusion protein F1 in vector V1 and the second binding component being expressed as a fusion protein F2 in vector V2. The novel method, which can also be employed for simultaneously determining several analytes, is more sensitive and specific than prior known methods.
摘要翻译： 本发明涉及用于定性或定量检测其中第一和第二结合组分与分析物接触的分析物的免疫化学方法，然后检测结合组分与分析物的结合。 根据本发明，使用不同的载体（V1和V2）在同一宿主中重组制备两种结合成分，用于表达融合蛋白，其中第一结合成分在载体V1中表达为融合蛋白F1，第二结合成分 在载体V2中表达为融合蛋白F2。 也可以用于同时测定多种分析物的新方法比现有已知的方法更敏感和特异。
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公开(公告)号：US20120247364A1
公开(公告)日：2012-10-04
申请号：US13415892
申请日：2012-03-09
摘要： The present invention relates to an antimicrobial composition comprising an isothiazolin-3-one, such as 1,2-benzisothiazolin-3-one, a zinc compound selected from zinc salts, zinc oxide, zinc hydroxide or combinations thereof, a pyrithione salt or pyrithione acid, and a surfactant selected from the group consisting of (i) an anionic surfactant having a sulfate or sulfonate moiety attached to a straight or branched chain containing from about 10 to about 18 atoms at the backbone of the chain, (ii) an anionic surfactant being an alkylaryl sulfonic acid or salt thereof wherein the alkyl portion contains from about 10 to about 18 carbon atoms, and the aryl portion contains a benzyl or substituted benzyl group, and combinations thereof. This composition is particularly effective in preventing the growth of various microorganisms in mineral slurries such as aqueous calcium carbonate slurries.
摘要翻译： 本发明涉及包含异噻唑啉-3-酮如1,2-苯并异噻唑啉-3-酮，选自锌盐，氧化锌，氢氧化锌或其组合的锌化合物，吡啶硫酮盐或吡啶硫酮的抗微生物组合物 酸和选自以下的表面活性剂：（i）在链的主链上具有连接到含有约10至约18个原子的直链或支链的硫酸盐或磺酸盐部分的阴离子表面活性剂，（ii）阴离子 表面活性剂是烷基芳基磺酸或其盐，其中烷基部分含有约10至约18个碳原子，芳基部分含有苄基或取代的苄基，及其组合。 该组合物特别有效地防止矿物浆料中的各种微生物如碳酸钙水泥浆料的生长。
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