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1.发明授权
公开(公告)号：US5639622A
公开(公告)日：1997-06-17
申请号：US478860
申请日：1995-06-07
申请人： Klaus Bosslet , Bernhard Auerbach , Helmut Peters
发明人： Klaus Bosslet , Bernhard Auerbach , Helmut Peters
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61P31/00 , A61P35/00 , C07K14/42 , C07K14/435 , C07K14/705 , C07K16/00 , C07K16/30 , C07K16/32 , C07K19/00 , C12N5/10 , C12N5/20 , C12N5/22 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577
CPC分类号： C07K14/705 , C07K16/30 , C07K16/3023 , A61K38/00
摘要： The invention relates to monoclonal antibodies (MAbs) and fragments thereof which bind to defined tumor-associated antigens, principally of small cell lung carcinoma (SCLC), of melanoma, of neuroblastoma and other tumors of neuroectodermal origin, to hybridoma cell lines for the preparation thereof, and to the antigens which can be defined and/or isolated with the aid of these antibodies or antibody fragments. The antibodies, antibody fragments and antigens can be used as diagnostic. aid, active substance or active substance carrier.
摘要翻译： 本发明涉及与确定的肿瘤相关抗原（主要是小细胞肺癌（SCLC）），黑素瘤，神经母细胞瘤和神经外胚层起源的其他肿瘤结合的单克隆抗体（MAb）及其片段，用于制备杂交瘤细胞系 以及可以借助于这些抗体或抗体片段定义和/或分离的抗原。 抗体，抗体片段和抗原可以用作诊断。 助剂，活性物质或活性物质载体。
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2.再颁专利公开(公告)号：USRE37596E1
公开(公告)日：2002-03-19
申请号：US09333987
申请日：1999-06-16
申请人： Klaus Bosslet , Bernhard Auerbach , Helmut Peters
发明人： Klaus Bosslet , Bernhard Auerbach , Helmut Peters
IPC分类号： G01N33574
CPC分类号： C07K14/705 , A61K38/00 , C07K16/30 , C07K16/3023
摘要： The invention relates to monoclonal antibodies (MAbs) and fragments thereof which bind to defined tumor-associated antigens, principally of small cell lung carcinoma (SCLC), of melanoma, of neuroblastoma and other tumors of neuroectodermal origin, to hybridoma cell lines for the preparation thereof, and to the antigens which can be defined and/or isolated with the aid of these antibodies or antibody fragments. The antibodies, antibody fragments and antigens can be used as diagnostic, aid, active substance or active substance carrier.
摘要翻译： 本发明涉及与确定的肿瘤相关抗原（主要是小细胞肺癌（SCLC）），黑素瘤，神经母细胞瘤和神经外胚层起源的其他肿瘤结合的单克隆抗体（MAb）及其片段，用于制备杂交瘤细胞系 以及可以借助于这些抗体或抗体片段定义和/或分离的抗原。 抗体，抗体片段和抗原可用作诊断，辅助，活性物质或活性物质载体。
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公开(公告)号：US5593898A
公开(公告)日：1997-01-14
申请号：US334035
申请日：1994-11-02
申请人： Bernhard Auerbach , Helmut Peters
发明人： Bernhard Auerbach , Helmut Peters
IPC分类号： G01N33/53 , G01N33/531 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6896 , G01N33/54306 , Y10S435/962
摘要： The invention relates to an improved diagnostic method for the immunological determination of NCAM by means of specific binding partners, the one specific binding partner being immobilized on a carrier and the extent of the binding of the analyte to the first specific binding partner being determined by means of a second binding partner which is specific for the analyte and which is labeled either directly or via further binding partners.
摘要翻译： 本发明涉及通过特异性结合配偶体免疫测定NCAM的改进的诊断方法，所述特异性结合配偶体固定在载体上，并且分析物与第一特异性结合配偶体的结合程度通过方法 的第二结合配偶体，其对于分析物是特异性的，并且其被直接标记或经由另外的结合配偶体标记。
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4.发明授权Monoclonal antibodies (MAbs) against tumor-associated antigens, the preparation and use thereof 失效针对肿瘤相关抗原的单克隆抗体（MAb），其制备和应用公开(公告)号：US06926896B2
公开(公告)日：2005-08-09
申请号：US08356791
申请日：1994-12-13
IPC分类号： A61K38/00 , A61K39/395 , A61K47/00 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07K16/00 , C07K16/30 , C07K19/00 , C12P21/08 , G01N33/577
CPC分类号： C07K16/3084 , A61K38/00 , A61K47/68 , A61K47/6815 , A61K47/6817 , A61K47/6851 , A61K51/1045 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
摘要翻译： 本发明涉及针对肿瘤相关抗原的鼠单克隆抗体（MAb），A，B，C和D。 描述了这些MAb的V基因的几乎完整的核苷酸序列，使得相关的可变结构域可以放在一起以产生嵌合的MAb，或者通过将高变区（互补决定区= CDR）插入到 人类的MAb框架。 这种类型的抗体构建体可以用于人类治疗和体内诊断，而不存在用鼠MAb观察到的缺点。
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5.发明授权Chimeric antibody against tumor associated antigens and its use in diagnosing tumors 失效针对肿瘤相关抗原的嵌合抗体及其在诊断肿瘤中的应用公开(公告)号：US07662383B2
公开(公告)日：2010-02-16
申请号：US12068545
申请日：2008-02-07
IPC分类号： A61K39/395 , C07K16/30 , C12P21/08
CPC分类号： C07K16/3084 , A61K38/00 , A61K47/68 , A61K47/6815 , A61K47/6817 , A61K47/6851 , A61K51/1045 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
摘要翻译： 本发明涉及针对肿瘤相关抗原的鼠单克隆抗体（MAb），A，B，C和D。 描述了这些MAb的V基因的几乎完整的核苷酸序列，使得相关的可变结构域可以放在一起以产生嵌合的MAb，或者通过将高变区（互补决定区= CDR）插入到 人类的MAb框架。 这种类型的抗体构建体可以用于人类治疗和体内诊断，而不存在用鼠MAb观察到的缺点。
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公开(公告)号：US5589395A
公开(公告)日：1996-12-31
申请号：US46908
申请日：1993-04-15
CPC分类号： G01N33/6872 , G01N33/53 , G01N33/68 , G01N33/86 , G01N2333/4718 , G01N2400/40 , Y10T436/105831 , Y10T436/108331 , Y10T436/2525
摘要： A method for stabilizing the functional activity of annexins in a biological fluid sample is provided.
摘要翻译： 提供了一种用于稳定生物流体样品中膜联蛋白功能活性的方法。
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7.发明申请Monoclonal antibodies (MAbs) against tumor-associated antigens, the preparation and use thereof 失效针对肿瘤相关抗原的单克隆抗体（MAb），其制备和应用公开(公告)号：US20090246132A1
公开(公告)日：2009-10-01
申请号：US12068545
申请日：2008-02-07
IPC分类号： A61K51/10 , C07K16/18 , C12N9/00 , A61K39/395 , C07K19/00 , C07K16/46 , C12P21/02 , A61P35/00 , G01N33/53
CPC分类号： C07K16/3084 , A61K38/00 , A61K47/68 , A61K47/6815 , A61K47/6817 , A61K47/6851 , A61K51/1045 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
摘要翻译： 本发明涉及针对肿瘤相关抗原的鼠单克隆抗体（MAb），A，B，C和D。 描述了这些MAb的V基因的几乎完整的核苷酸序列，使得相关的可变结构域可以放在一起以产生嵌合的MAb，或者通过将高变区（互补决定区= CDR）插入到 人类的MAb框架。 这种类型的抗体构建体可以用于人类治疗和体内诊断，而不存在用鼠MAb观察到的缺点。
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公开(公告)号：US5643731A
公开(公告)日：1997-07-01
申请号：US467943
申请日：1995-06-06
申请人： Klaus Bosslet , Peter Hermentin , Hans Harald Sedlacek , Bernhard Auerbach , Peter Pfleiderer , Rolf Muller
发明人： Klaus Bosslet , Peter Hermentin , Hans Harald Sedlacek , Bernhard Auerbach , Peter Pfleiderer , Rolf Muller
IPC分类号： G01N33/53 , G01N33/532 , G01N33/543 , G01N33/574 , G01N33/68
CPC分类号： G01N33/54306 , G01N33/532 , G01N33/57473 , G01N2333/82 , Y10S435/969 , Y10S435/971 , Y10S435/975 , Y10S436/824
摘要： The invention relates to a method of using a pair of leucine zipper peptides for in vitro diagnosis, in particular, for the immunochemical detection and determination of an analyte in a biological liquid. In one method, the first leucine zipper peptide is immobilized by attaching it to a solid support, the second leucine zipper peptide is coupled to a specific binding partner for the analyte, the two peptides are brought into contact, the sample of the biological liquid is brought into contact with the immobilized first peptide and the specific binding partner for the analyte, and the amount of analyte bound to the binding partner is determined. The leucine zipper peptides are preferably v-fos and c-jun.
摘要翻译： 本发明涉及一种使用一对亮氨酸拉链肽进行体外诊断的方法，特别是用于生物液体中分析物的免疫化学检测和测定。 在一种方法中，通过将第一亮氨酸拉链肽连接到固体支持物上来固定第一亮氨酸拉链肽，将第二亮氨酸拉链肽与分析物的特异性结合配偶体偶联，使两个肽接触，生物液体的样品为 与固定化的第一肽和分析物的特异性结合配偶体接触，并测定与结合配偶体结合的分析物的量。 亮氨酸拉链肽优选为v-fos和c-jun。
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9.发明申请Monoclonal antibodies (MAbs) against tumor-associated antigens, the preparation and use thereof 审中-公开针对肿瘤相关抗原的单克隆抗体（MAb），其制备和应用公开(公告)号：US20060159682A1
公开(公告)日：2006-07-20
申请号：US10942929
申请日：2004-09-17
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/3084 , A61K38/00 , A61K47/68 , A61K47/6815 , A61K47/6817 , A61K47/6851 , A61K51/1045 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions ═CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
摘要翻译： 本发明涉及针对肿瘤相关抗原的鼠单克隆抗体（MAb），A，B，C和D。 描述了这些MAb的V基因的几乎完整的核苷酸序列，使得相关的可变结构域可以放在一起以产生嵌合的MAb，或者通过将高变区（互补决定区-CDR）插入到 人类的MAb框架。 这种类型的抗体构建体可以用于人类治疗和体内诊断，而不存在用鼠MAb观察到的缺点。
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