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公开(公告)号:US5955100A
公开(公告)日:1999-09-21
申请号:US449021
申请日:1995-05-24
申请人: Klaus Bosslet , Jorg Czech , Dieter Hoffmann , Cenek Kolar , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
发明人: Klaus Bosslet , Jorg Czech , Dieter Hoffmann , Cenek Kolar , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
IPC分类号: A61K31/70 , A23B4/03 , A61K9/127 , A61K31/7024 , A61K31/7028 , A61K31/7034 , A61K31/715 , A61K38/00 , A61K38/16 , A61K45/00 , A61K47/48 , A61P35/00 , A61P37/00 , A61P43/00 , C07H13/08 , C07H13/12 , C07H15/00 , C07H15/04 , C07H15/203 , C07H15/207
CPC分类号: C07H13/08 , A61K47/48 , A61K47/48092 , C07H13/12 , C07H15/203 , Y02P20/55 , Y10S514/01
摘要: Glycosyl-spacer-drugs compounds (prodrugs), their preparation and their use as pharmaceuticals are described.
摘要翻译: 描述了糖基间隔物药物化合物(前药),其制备及其作为药物的用途。
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公开(公告)号:US6146658A
公开(公告)日:2000-11-14
申请号:US859084
申请日:1997-05-20
申请人: Klaus Bosslet , Jorg Czech , Dieter Hoffmann , Cenek Kolar , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
发明人: Klaus Bosslet , Jorg Czech , Dieter Hoffmann , Cenek Kolar , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
IPC分类号: A61K31/70 , A23B4/03 , A61K9/127 , A61K31/7024 , A61K31/7028 , A61K31/7034 , A61K31/715 , A61K38/00 , A61K38/16 , A61K45/00 , A61K47/48 , A61P35/00 , A61P37/00 , A61P43/00 , C07H13/08 , C07H13/12 , C07H15/00 , C07H15/04 , C07H15/203 , C07H15/207
CPC分类号: C07H13/08 , A61K47/48 , A61K47/48092 , C07H13/12 , C07H15/203 , Y02P20/55 , Y10S514/01
摘要: Glycosyl-spacer-drugs compounds (prodrugs), their preparation and their use as pharmaceuticals are described.
摘要翻译: 描述了糖基间隔物药物化合物(前药),其制备及其作为药物的用途。
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公开(公告)号:US5877158A
公开(公告)日:1999-03-02
申请号:US309035
申请日:1994-09-20
申请人: Klaus Bosslet , Jorg Czech , Dieter Hoffmann , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
发明人: Klaus Bosslet , Jorg Czech , Dieter Hoffmann , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
IPC分类号: C07H15/244 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K47/48 , A61P43/00
CPC分类号: B82Y5/00 , A61K47/48092 , A61K47/48192 , A61K47/48215 , A61K47/48223 , A61K47/48315 , A61K47/48761
摘要: Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.
摘要翻译: 描述了适合于药物的位点特异性递送的基质 - 间隔物前药化合物(前体前药),其制备方法及其应用。
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公开(公告)号:US5621002A
公开(公告)日:1997-04-15
申请号:US302459
申请日:1994-09-09
申请人: Klaus Bosslet , J org Czech , Dieter Hoffmann , Andrea Vasella , Roland Hoos , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
发明人: Klaus Bosslet , J org Czech , Dieter Hoffmann , Andrea Vasella , Roland Hoos , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
IPC分类号: C07H15/203 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K47/48 , A61P35/00 , A61P43/00 , C07H15/244 , A61K31/335 , A61K31/34
CPC分类号: B82Y5/00 , A61K47/48092 , A61K47/48761 , Y10S514/01
摘要: Enzymatically clearable prodrugs with reduced Michaelis-Menten constant (Km) are described.
摘要翻译: 描述了具有降低的Michaelis-Menten常数(Km)的可酶促清除的前药。
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公开(公告)号:US5561119A
公开(公告)日:1996-10-01
申请号:US137167
申请日:1994-05-27
申请人: Jean-Claude Jacquesy , Jean-Pierre Gesson , Claude Monneret , Martine Mondon , Brigitte Renoux , Jean-Claude Florent , Michel Koch , Fran.cedilla.ois Tillequin , Hans H. Sedlacek , Manfred Gerken , Cenek Kolar , Gilbert Gaudel , Klaus Bosslet , J org Czech , Dieter Hoffman , Gerhard Seemann , Hans-Ulrich Schorlemmer , Gerhard Dickneite
发明人: Jean-Claude Jacquesy , Jean-Pierre Gesson , Claude Monneret , Martine Mondon , Brigitte Renoux , Jean-Claude Florent , Michel Koch , Fran.cedilla.ois Tillequin , Hans H. Sedlacek , Manfred Gerken , Cenek Kolar , Gilbert Gaudel , Klaus Bosslet , J org Czech , Dieter Hoffman , Gerhard Seemann , Hans-Ulrich Schorlemmer , Gerhard Dickneite
IPC分类号: A61K38/22 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K38/46 , A61K39/395 , A61P35/00 , A61P43/00 , C07F7/18 , C07H15/203 , C07H15/252 , C07H15/26 , A61K39/44 , C07C50/18 , C07H5/04
CPC分类号: C07H15/203 , C07F7/1852 , C07F7/1856 , C07H15/252 , C07H15/26
摘要: Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I). ##STR1##
摘要翻译: PCT No.PCT / FR92 / 00385 Sec。 371日期:1994年5月27日 102(e)日期1994年5月27日PCT提交1992年4月29日PCT公布。 出版物WO92 / 19639 日期:1992年11月12日描述了糖基化前体药物及其制备方法及其与肿瘤特异性免疫酶联用物质治疗癌症的用途。 这些蒽环类前体具有式(I)。 (一)
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公开(公告)号:US5567707A
公开(公告)日:1996-10-22
申请号:US389798
申请日:1995-02-16
申请人: Michel Koch , Fran.cedilla.ois Tillequin , Alexios-Leandros Skaltsounis , Yves Rolland , Alain Pierre , Ghanem Atassi
发明人: Michel Koch , Fran.cedilla.ois Tillequin , Alexios-Leandros Skaltsounis , Yves Rolland , Alain Pierre , Ghanem Atassi
IPC分类号: A61K31/47 , A61P35/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/153
CPC分类号: C07D491/04 , C07D491/14
摘要: Compounds of formula (I): ##STR1## wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and Y are defined in the description.Those compounds are used therapeutically in the treatment of cancerous tumours.
摘要翻译: 式(I)化合物:其中R 3,R 4,R 5,R 6,X和Y在说明书中定义。 那些化合物治疗性地用于癌性肿瘤。
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