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1.发明授权Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture 有权取代的氨基 - 喹唑啉酮，包含所述化合物的药物，其用途及其制备方法公开(公告)号：US08664388B2
公开(公告)日：2014-03-04
申请号：US13523144
申请日：2012-06-14
申请人： Klaus Fuchs , Niklas Heine , Christian Eickmeier , Sandra Handschuh , Cornelia Dorner-Ciossek , Stefan Hoerer
发明人： Klaus Fuchs , Niklas Heine , Christian Eickmeier , Sandra Handschuh , Cornelia Dorner-Ciossek , Stefan Hoerer
IPC分类号： C07D239/95
CPC分类号： C07D239/95
摘要： The present invention relates to substituted amino-quinazolinones of general formula (I) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代氨基 - 喹唑啉酮，其中基团R 1至R 14和A如说明书和权利要求中所定义，以及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。
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2.发明授权Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture 有权取代的氨基 - 喹唑啉酮，包含所述化合物的药物，其用途及其制备方法公开(公告)号：US08222264B2
公开(公告)日：2012-07-17
申请号：US12667907
申请日：2008-07-03
申请人： Klaus Fuchs , Niklas Heine , Christian Eickmeier , Sandra Handschuh , Cornelia Dorner-Ciossek , Stefan Hoerer
发明人： Klaus Fuchs , Niklas Heine , Christian Eickmeier , Sandra Handschuh , Cornelia Dorner-Ciossek , Stefan Hoerer
IPC分类号： A61K31/517
CPC分类号： C07D239/95
摘要： The present invention relates to substituted amino-quinazolinones of general formula (I) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代氨基 - 喹唑啉酮，其中基团R 1至R 14和A如说明书和权利要求中所定义，以及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。
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3.发明申请SUBSTITUTED AMINO-QUINAZOLINONES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE 有权取代的氨基喹唑啉酮，包含化合物的药物，其使用及其制备方法公开(公告)号：US20100249158A1
公开(公告)日：2010-09-30
申请号：US12667907
申请日：2008-07-03
申请人： Klaus Fuchs , Niklas Heine , Christian Eickmeier , Sandra Handschuh , Cornelia Dorner-Ciossek , Stefan Hoerer
发明人： Klaus Fuchs , Niklas Heine , Christian Eickmeier , Sandra Handschuh , Cornelia Dorner-Ciossek , Stefan Hoerer
IPC分类号： A61K31/517 , C07D239/88 , A61P25/28
CPC分类号： C07D239/95
摘要： The present invention relates to substituted amino-quinazolinones of general formula (I) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代氨基 - 喹唑啉酮，其中基团R 1至R 14和A如说明书和权利要求中所定义，以及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。
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4.发明申请SUBSTITUTED AMINO-BENZIMIDAZOLES, MEDICAMENTS COMPRIMISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE 有权取代的氨基苯并咪唑，合并化合物的药物，其使用及其制造方法公开(公告)号：US20110288139A1
公开(公告)日：2011-11-24
申请号：US12812476
申请日：2009-01-21
申请人： Klaus Fuchs , Cornelia Dorner-Ciossek , Sandra Handschuh , Niklas Heine , Stefan Hoerer , Klaus Klinder
发明人： Klaus Fuchs , Cornelia Dorner-Ciossek , Sandra Handschuh , Niklas Heine , Stefan Hoerer , Klaus Klinder
IPC分类号： A61K31/4184 , C07D403/12 , A61P25/28 , C07D235/30
CPC分类号： C07D403/12 , C07D235/30 , C07D235/32
摘要： The present invention relates to substituted amino-benzimidazoles of general formula (1) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（1）的取代的氨基 - 苯并咪唑，其中基团R 1至R 14和A如说明书和权利要求中所定义，以及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。
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5.发明授权Substituted amino-benzimidazoles, medicaments comprimising said compound, their use and their method of manufacture 有权取代的氨基 - 苯并咪唑，包括所述化合物的药物，其用途及其制备方法公开(公告)号：US08426607B2
公开(公告)日：2013-04-23
申请号：US12812476
申请日：2009-01-21
申请人： Klaus Fuchs , Cornelia Dorner-Ciossek , Sandra Handschuh , Niklas Heine , Stefan Hoerer , Klaus Klinder
发明人： Klaus Fuchs , Cornelia Dorner-Ciossek , Sandra Handschuh , Niklas Heine , Stefan Hoerer , Klaus Klinder
IPC分类号： A61K31/4184 , C07D235/30 , C07D407/12
CPC分类号： C07D403/12 , C07D235/30 , C07D235/32
摘要： The present invention relates to substituted amino-benzimidazoles of general formula (1) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（1）的取代的氨基 - 苯并咪唑，其中基团R 1至R 14和A如说明书和权利要求中所定义，以及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。
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公开(公告)号：US08614308B2
公开(公告)日：2013-12-24
申请号：US13617248
申请日：2012-09-14
申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
发明人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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公开(公告)号：US08337845B2
公开(公告)日：2012-12-25
申请号：US13038471
申请日：2011-03-02
申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
发明人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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8.发明申请Cycloalkyl - containing 5-acylindolinones, the preparation thereof and their use as medicaments 有权含环烷基的5-丙烯基吲哚酮，其制备及其作为药物的用途公开(公告)号：US20050203104A1
公开(公告)日：2005-09-15
申请号：US11077355
申请日：2005-03-10
申请人： Armin Heckel , Gerald Roth , Joerg Kley , Stefan Hoerer , Ingo Uphues
发明人： Armin Heckel , Gerald Roth , Joerg Kley , Stefan Hoerer , Ingo Uphues
IPC分类号： A61K31/404 , A61K31/454 , A61K31/496 , C07D209/34 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/14 , C07D451/14
CPC分类号： C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/14 , C07D451/14
摘要： The present invention relates to cycloalkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
摘要翻译： 本发明涉及通式如下的环烷基5-丙烯基吲哚酮：其中R 1至R 3定义如权利要求1至6中所述，互变异构体，对映异构体， 具有有价值的药理学特性，特别是对蛋白激酶的抑制作用，特别是对糖原合酶激酶（GSK-3）的活性的抑制作用的非对映异构体，其混合物及其盐。
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9.发明授权Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments 有权含芳基的5-丙烯基吲哚酮，其制备及其作为药物的用途公开(公告)号：US07176231B2
公开(公告)日：2007-02-13
申请号：US11077259
申请日：2005-03-10
申请人： Armin Heckel , Gerald Juergen Roth , Joerg Kley , Stefan Hoerer , Ingo Uphues
发明人： Armin Heckel , Gerald Juergen Roth , Joerg Kley , Stefan Hoerer , Ingo Uphues
IPC分类号： A61K31/40 , C07D209/34
CPC分类号： C07D209/34 , C07D403/12 , C07D405/06
摘要： The present invention relates to aryl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
摘要翻译： 本发明涉及通式为其中R 1至R 3的芳基的含5-羟基吲哚酮，其互变异构体，对映异构体，非对映异构体，其混合物 其具有有价值的药理学特性，特别是对蛋白激酶的抑制作用，特别是对糖原合酶激酶（GSK-3）的活性的抑制作用。
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10.发明申请Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments 有权含烷基的5-丙烯基吲哚酮，其制备及其作为药物的用途公开(公告)号：US20050209302A1
公开(公告)日：2005-09-22
申请号：US11077399
申请日：2005-03-10
申请人： Armin Heckel , Gerald Roth , Joerg Kley , Stefan Hoerer , Ingo Uphues
发明人： Armin Heckel , Gerald Roth , Joerg Kley , Stefan Hoerer , Ingo Uphues
IPC分类号： A61K31/404 , A61K31/4045 , A61K31/501 , A61P3/10 , A61P25/28 , C07D209/34 , C07D209/36 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D407/06 , C07D407/14 , C07D45/02
CPC分类号： C07D401/06 , C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14
摘要： The present invention relates to alkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
摘要翻译： 本发明涉及通式为其中R 1至R 3的烷基的5-丙烯基吲哚酮，其互变异构体，对映异构体，非对映异构体，其混合物 其具有有价值的药理学特性，特别是对蛋白激酶的抑制作用，特别是对糖原合酶激酶（GSK-3）的活性的抑制作用。
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